{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:34:06Z","timestamp":1792701246679,"version":"4.5.0"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: An accurate measurement of disease activity is essential for the appropriate management of a patient with rheumatoid arthritis (RA). Hematological markers of systemic inflammation (Neutrophil-to-Lymphocyte (NLR), Platelet-to-Lymphocyte (PLR) and Lymphocyte-to-Monocyte (LMR) ratios) are reported to be novel, sensitive measures of inflammatory response, in addition to conventional markers (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Disease Activity Score (DAS28)). The goal of the study was to assess the relationship of NLR, PLR, and LMR with ultrasonography (US) parameters of disease activity in RA patients. Methods: The study group consisted of 126 consecutive RA patients (100 women, 26 men). The following assessments were performed: joint counts, DAS28, complete blood cell counts, ESR, CRP, and US of 24 small joints. Results: NLR and PLR were significantly positively correlated with all US parameters of disease activity (Grey Scale US, Power Doppler US, and Global scores). The mean values of NLR and PLR were significantly higher in patients with poor prognostic factors: moderate\/high vs. low disease activity (NLR: p &lt; 0.001; PLR: p = 0.007), anti-CCP positive vs. anti-CCP negative (NLR: p = 0.01; PLR: p = 0.006). In multiple regression tests, significant correlations were confirmed for: NLR and DAS28 (p = 0.04), and CRP (p = 0.001); PLR and Power Doppler US (p = 0.04), and ESR (p = 0.02). No correlation was found for LMR. Conclusion: NLR and PLR are associated with US disease activity parameters and may serve as reliable, inexpensive markers, with prognostic significance in RA.<\/jats:p>","DOI":"10.3390\/jcm9092760","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T09:05:37Z","timestamp":1598432737000},"page":"2760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["The Relationship between Hematological Markers of Systemic Inflammation (Neutrophil-To-Lymphocyte, Platelet-To-Lymphocyte, Lymphocyte-To-Monocyte Ratios) and Ultrasound Disease Activity Parameters in Patients with Rheumatoid Arthritis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3916-4291","authenticated-orcid":false,"given":"Bo\u017cena","family":"Targo\u0144ska-St\u0119pniak","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zwolak","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Piotrowski","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Grzechnik","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Connective Tissue Diseases, Independent Public Teaching Hospital No 4, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4345-1675","authenticated-orcid":false,"given":"Maria","family":"Majdan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/1756-185X.12582","article-title":"Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio","volume":"18","author":"Uslu","year":"2015","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/1756-185X.13157","article-title":"Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis","volume":"20","author":"Chandrashekara","year":"2017","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/annrheumdis-2016-210715","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update","volume":"76","author":"Smolen","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejr.2017.05.001","article-title":"Association of neutrophil to lymphocyte ratio with disease activity indices and musculoskeletal ultrasound findings in recent onset rheumatoid arthritis patients","volume":"39","author":"Fawzy","year":"2017","journal-title":"Egypt. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e0144","DOI":"10.1097\/MD.0000000000010144","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in gastric cancer","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e3832","DOI":"10.1097\/MD.0000000000003832","article-title":"Elevated neutrophil to lymphocyte ratio predicts mortality in medical inpatients with multiple chronic conditions","volume":"95","author":"Isaac","year":"2016","journal-title":"Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/jdi.12541","article-title":"High neutrophil-to-lymphocyte ratio is associated with increased carotid artery intima-media thickness in type 2 diabetes","volume":"8","author":"Li","year":"2017","journal-title":"J. Diabetes Investig."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Cho, J.H., Cho, H.J., Lee, H.Y., Ki, Y.J., Jeon, E.S., Hwang, K.K., Chae, S.C., Baek, S.H., Kang, S.M., and Choi, D.J. (2020). Neutrophil-Lymphocyte Ratio in Patients with Acute Heart Failure Predicts In-Hospital and Long-Term Mortality. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020557"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10238-018-0538-x","article-title":"Associations between the neutrophil-to-lymphocyte and the platelet-to-lymphocyte ratios and the presence and severity of psoriasis: A systematic review and meta-analysis","volume":"19","author":"Paliogiannis","year":"2019","journal-title":"Clin. Exp. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/apm.12722","article-title":"Comparisons of neutrophil-, monocyte-, eosinophil-, and basophil- lymphocyte ratios among various systemic autoimmune rheumatic diseases","volume":"125","author":"Yang","year":"2017","journal-title":"APMIS"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s00296-018-4125-y","article-title":"Platelet to lymphocyte ratio is associated with the current activity of ANCA-associated vasculitis at diagnosis: A retrospective monocentric study","volume":"38","author":"Park","year":"2018","journal-title":"Rheumatol. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1007\/s10067-017-3815-2","article-title":"The association between the lymphocyte-monocyte ratio and disease activity in rheumatoid arthritis","volume":"36","author":"Du","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mae, Y., Takata, T., Ida, A., Ogawa, M., Taniguchi, S., Yamamoto, M., Iyama, T., Fukuda, S., and Isomoto, H. (2020). Prognostic Value of Neutrophil-To-Lymphocyte Ratio and Platelet-To-Lymphocyte Ratio for Renal Outcomes in Patients with Rapidly Progressive Glomerulonephritis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041128"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e13037","DOI":"10.1111\/eci.13037","article-title":"Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis","volume":"49","author":"Erre","year":"2019","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00296-019-04276-x","article-title":"Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as predictors of 12-week treatment response and drug persistence of anti-tumor necrosis factor-\u03b1 agents in patients with rheumatoid arthritis: A retrospective chart review analysis","volume":"39","author":"Lee","year":"2019","journal-title":"Rheumatol. Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/art.1780380107","article-title":"Modified disease activity scores that include twenty-eight-joint counts: Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis","volume":"38","author":"Prevoo","year":"1995","journal-title":"Arthritis Rheum."},{"key":"ref_18","first-page":"1432","article-title":"Further development of a physical function scale on a MDHAQ [corrected] for standard care of patients with rheumatic diseases","volume":"32","author":"Pincus","year":"2005","journal-title":"J. Rheumatol."},{"key":"ref_19","first-page":"261","article-title":"How to read radiographs according to the Sharp\/van der Heijde method","volume":"27","year":"2000","journal-title":"J. Rheumatol."},{"key":"ref_20","first-page":"e000428","article-title":"Scoring ultrasound synovitis in rheumatoid arthritis: A EULAR-OMERACT ultrasound taskforce-Part 1: Definition and development of a standardised, consensus-based scoring system","volume":"3","author":"Terslev","year":"2017","journal-title":"Rheum. Musculoskelet. Dis. Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/ard.60.7.641","article-title":"Guidelines for musculoskeletal ultrasound in rheumatology","volume":"60","author":"Backhaus","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/rheumatology\/kev211","article-title":"Power Doppler ultrasound monitoring of response to anti-tumour necrosis factor alpha treatment in patient with rheumatoid arthritis","volume":"54","author":"Iagnocco","year":"2015","journal-title":"Rheumatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1136\/annrheumdis-2019-215321","article-title":"Swollen, but not tender joints, are independently associated with ultrasound synovitis: Results from a longitudinal observational study of patients with established rheumatoid arthritis","volume":"78","author":"Hammer","year":"2019","journal-title":"Ann. Rheum. Dis."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/9\/2760\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:06:45Z","timestamp":1760177205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/9\/2760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,26]]},"references-count":23,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["jcm9092760"],"URL":"https:\/\/doi.org\/10.3390\/jcm9092760","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,26]]}}}