{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:41:39Z","timestamp":1791214899915,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002632","name":"Hallym University","doi-asserted-by":"publisher","award":["HURF-2018-55"],"award-info":[{"award-number":["HURF-2018-55"]}],"id":[{"id":"10.13039\/501100002632","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health and Welfare","award":["Translational Research Program for Rehabilitation Robots(NRCTR-EX19002)"],"award-info":[{"award-number":["Translational Research Program for Rehabilitation Robots(NRCTR-EX19002)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study investigated the effects of robot-assisted gait training (RAGT) on gait function in burn patients. Briefly, 40 burn patients were randomly divided into an RAGT group or a conventional training (CON) group. SUBAR\u00ae (Cretem, Korea) is a wearable robot with a footplate that simulates normal gait cycles. The RAGT group underwent 30 min of robot-assisted training using SUBAR\u00ae with 30 min of conventional physiotherapy once a day, 5 days a week for 12 weeks. Patients in the CON group received 30 min of overground gait training and range-of-motion (ROM) exercises twice a day for 5 days a week for 12 weeks. The RAGT group and the CON group underwent 60 min of training per day. The intervention frequency and duration did not differ between the RAGT group and the CON group. The main outcomes were functional ambulatory category (FAC); 6-min walking test (6MWT); visual analogue scale (VAS) during gait movement; ROM; and isometric forces of bilateral hip, knee, and ankle muscles before and after 12 weeks of training. The results of the VAS, FAC, and 6MWT (8.06 \u00b1 0.66, 1.76 \u00b1 0.56, and 204.41 \u00b1 85.60) before training in the RAGT group improved significantly (4.41 \u00b1 1.18, 4.18 \u00b1 0.39, and 298.53 \u00b1 47.75) after training (p &lt; 0.001, p &lt; 0.001, and p &lt; 0.001). The results of the VAS, FAC, and 6MWT (8.00 \u00b1 1.21, 1.75 \u00b1 0.58, and 220.94 \u00b1 116.88) before training in the CON group improved significantly (5.00 \u00b1 1.03, 3.81 \u00b1 1.05, and 272.19 \u00b1 110.14) after training (p &lt; 0.001, p &lt; 0.001, and p = 0.05). There were differences in the improvement of results of the VAS, FAC, and 6MWT between groups after training, but they were not statistically significant (p = 0.23, p = 0.14, and p = 0.05). The isometric strengths of the right hip extensor (p = 0.02), bilateral knee flexor (p = 0.04 in the right, and p = 0.001 in the left), bilateral knee extensor (p = 0.003 in the right, and p = 0.002 in the left), bilateral ankle dorsiflexor (p = 0.04 in the right, and p = 0.02 in the left), and bilateral ankle plantarflexor (p = 0.001 in the right, and p = 0.008 in the left) after training were significantly improved compared with those before training in the RAGT group. The ROMs of the right knee extension (p = 0.03) and bilateral ankle plantarflexion (p = 0.008 in the right, and p = 0.03 in the left) were significantly improved compared with measurements before training in the RAGT. There were no significant differences of the isometric strengths and ROMs of the bilateral hip, knee, and ankle muscles after training in the CON group. There were significant improvements in the isometric strengths of the left knee flexor (p = 0.01), left ankle dorsiflexor (p = 0.01), and left ankle plantarflexor (p = 0.003) between the two groups. The results suggested that RAGT is effective to facilitate early recovery of muscles strength after a burn injury. This is the first study to evaluate the effectiveness of RAGT in patients with burns compared with those receiving conventional training. The absence of complications in burn patients provides an opportunity to enlarge the application area of RAGT.<\/jats:p>","DOI":"10.3390\/jcm9092813","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T08:11:19Z","timestamp":1598861479000},"page":"2813","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of Robot-Assisted Gait Training in Patients with Burn Injury on Lower Extremity: A Single-Blind, Randomized Controlled Trial"],"prefix":"10.3390","volume":"9","author":[{"given":"So Young","family":"Joo","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 07247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yeol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Soonchunhyang University Hospital, Bucheon 14584, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Soo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 07247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-9640","authenticated-orcid":false,"given":"Kuem Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation &amp; Assistive Technology, Korea National Rehabilitation Research Institute, National Rehabilitation Center, Seoul 01022, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4091-6382","authenticated-orcid":false,"given":"Cheong Hoon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 07247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/jep.12629","article-title":"Minimal clinically important difference for change in 6-min walk test distance of adults with pathology: A systematic review","volume":"23","author":"Bohannon","year":"2017","journal-title":"J. Eval. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.burns.2017.07.005","article-title":"Early ambulation after-grafting of lower extremity burns","volume":"44","author":"Gawaziuk","year":"2018","journal-title":"Burn. J. Int. Soc. Burn Inj."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s41038-019-0151-6","article-title":"Joint contractures in severe burn patients with early rehabilitation intervention in one of the largest burn intensive care unit in China: A descriptive analysis","volume":"7","author":"Tan","year":"2019","journal-title":"Burns Trauma."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13063-018-3123-4","article-title":"Effects of robot-assisted gait training in patients with Parkinson\u2019s disease: Study protocol for a randomized controlled trial","volume":"20","author":"Kang","year":"2019","journal-title":"Trials"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1743-0003-3-29","article-title":"Recent trends in robot-assisted therapy environments to improve real-life functional performance after stroke","volume":"3","author":"Johnson","year":"2006","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.5535\/arm.2017.41.2.178","article-title":"Feasibility of rehabilitation training with a newly Developed, portable, gait assistive robot for balance function in hemiplegic patients","volume":"41","author":"Sung","year":"2017","journal-title":"Ann. Rehabil. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12984-015-0058-9","article-title":"HAL(R) exoskeleton training improves walking parameters and normalizes cortical excitability in primary somatosensory cortex in spinal cord injury patients","volume":"12","author":"Aach","year":"2015","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_8","first-page":"CD006185","article-title":"Electromechanical-assisted training for walking after stroke","volume":"5","author":"Mehrholz","year":"2017","journal-title":"Cochrane Database Syst Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12984-016-0214-x","article-title":"The effectiveness of robotic-assisted gait training for paediatric gait disorders: Systematic review","volume":"14","author":"Lefmann","year":"2017","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/10400435.2016.1219883","article-title":"Feasibility of rehabilitation using the single-joint hybrid assistive limb to facilitate early recovery following total knee arthroplasty: A pilot study","volume":"29","author":"Goto","year":"2017","journal-title":"Assist Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2050312117712888","DOI":"10.1177\/2050312117712888","article-title":"Improvement of walking ability during postoperative rehabilitation with the hybrid assistive limb after total knee arthroplasty: A randomized controlled study","volume":"5","author":"Tanaka","year":"2017","journal-title":"SAGE Open Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1743-0003-10-30","article-title":"Effectiveness of robot-assisted therapy on ankle rehabilitation\u2014A systematic review","volume":"10","author":"Zhang","year":"2013","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/1545968308317437","article-title":"Assisted movement with enhanced sensation (AMES): Coupling motor and sensory to remediate motor deficits in chronic stroke patients","volume":"23","author":"Cordo","year":"2009","journal-title":"Neurorehabil. Neural. Repair."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12984-016-0180-3","article-title":"Robot-aided assessment of lower extremity functions: A review","volume":"13","author":"Maggioni","year":"2016","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.math.2016.07.010","article-title":"Intrarater reliability of hand held dynamometry in measuring lower extremity isometric strength using a portable stabilization device","volume":"27","author":"Jackson","year":"2017","journal-title":"Musculoskelet Sci. Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.gaitpost.2006.10.003","article-title":"The influence of different Lokomat walking conditions on the energy expenditure of hemiparetic patients and healthy subjects","volume":"26","author":"Krewer","year":"2007","journal-title":"Gait Posture"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1152\/japplphysiol.01004.2004","article-title":"Effects of body weight-supported treadmill training on heart rate variability and blood pressure variability in individuals with spinal cord injury","volume":"98","author":"Ditor","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.2147\/COPD.S174248","article-title":"Intra- and inter-rater reproducibility of the 6-min walk test and the 30-s sit-to-stand test in patients with severe and very severe COPD","volume":"13","author":"Hansen","year":"2018","journal-title":"Int. J. Chron. Obstruct Pulmon. Dis."},{"key":"ref_19","first-page":"111","article-title":"Use of the robot assisted gait therapy in rehabilitation of patients with stroke and spinal cord injury","volume":"48","author":"Sale","year":"2012","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fnhum.2014.00207","article-title":"Effects of robot assisted gait training in progressive supranuclear palsy (PSP): A preliminary report","volume":"8","author":"Sale","year":"2014","journal-title":"Front Hum. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12984-017-0236-z","article-title":"Overground vs. treadmill-based robotic gait training to improve seated balance in people with motor-complete spinal cord injury: A case report","volume":"14","author":"Chisholm","year":"2017","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.apmr.2005.12.042","article-title":"The relation between ankle impairments and gait velocity and symmetry in people with stroke","volume":"87","author":"Lin","year":"2006","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13256-017-1367-3","article-title":"Robotic device-assisted knee extension training during the early postoperative period after opening wedge high tibial osteotomy: A case report","volume":"11","author":"Yoshioka","year":"2017","journal-title":"J. Med. Case Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.2522\/ptj.20060310","article-title":"Effects of task-specific locomotor and strength training in adults who were ambulatory after stroke: Results of the STEPS randomized clinical trial","volume":"87","author":"Sullivan","year":"2007","journal-title":"Phys. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3233\/NRE-130885","article-title":"Effects of robot-guided passive stretching and active movement training of ankle and mobility impairments in stroke","volume":"32","author":"Waldman","year":"2013","journal-title":"NeuroRehabilitation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"719","DOI":"10.5535\/arm.2014.38.6.719","article-title":"Effect of robotic-assisted gait training in patients with incomplete spinal cord injury","volume":"38","author":"Shin","year":"2014","journal-title":"Ann. Rehabil. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1177\/1545968312448232","article-title":"Lokomat robotic-assisted versus overground training within 3 to 6 months of incomplete spinal cord lesion: Randomized controlled trial","volume":"26","year":"2012","journal-title":"Neurorehabil. Neural. Repair."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1589\/jpts.26.1949","article-title":"Effects of robot-assisted gait training combined with functional electrical stimulation on recovery of locomotor mobility in chronic stroke patients: A randomized controlled trial","volume":"26","author":"Bae","year":"2014","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bandc.2017.04.002","article-title":"Effects of aging on prefrontal brain activation during challenging walking conditions","volume":"115","author":"Mirelman","year":"2017","journal-title":"Brain Cogn."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00590-012-1159-9","article-title":"A pilot study of post-total knee replacement gait rehabilitation using lower limbs robot-assisted training system","volume":"24","author":"Li","year":"2014","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12984-017-0232-3","article-title":"Robot-assisted gait training (Lokomat) improves walking function and activity in people with spinal cord injury: A systematic review","volume":"14","author":"Nam","year":"2017","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.pmrj.2016.12.010","article-title":"A comparison of locomotor therapy interventions: Partial-body weight-supported treadmill, lokomat, and G-EO Training in people with traumatic brain injury","volume":"9","author":"Esquenazi","year":"2017","journal-title":"PM R"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/9\/2813\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:04:59Z","timestamp":1760177099000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/9\/2813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["jcm9092813"],"URL":"https:\/\/doi.org\/10.3390\/jcm9092813","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,31]]}}}