{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:11:13Z","timestamp":1790665873485,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Bone loss and bone fractures are common complications after organ transplantation. Many factors contribute to the pathogenesis of transplant osteoporosis, such as bone disease preceding transplantation, immunosuppressive medications, and nutritional and lifestyle factors. This study aimed to assess the incidence of vertebral fractures before and after lung and heart transplantation. This longitudinal study analyzed 213 electronic medical records of patients who underwent lung transplantation (n = 128) and heart transplantation (n = 85) at Siena University Medical Center between January 2000 and December 2018. In lung and heart transplant recipients, the bone mineral density in the femoral sub-regions show a significant decrease at post-transplantation and at follow up visits. In both lung and heart recipients, we found an increase in the fracture incidence in the first period after transplantation (19.5% vs. 50.4% in lung recipients; 9.6% vs. 25.7% in heart recipients). Moreover, in lung recipients, vertebral fractures were predicted primarily by age, BMD at the femur, and any history of fracture. In heart recipients, vertebral fractures were predicted only by history of fracture. Our study supports the recommendations for pre-transplant osteoporosis screening in patients undergoing lung transplants, and in the first period after transplantation in heart transplant recipients.<\/jats:p>","DOI":"10.3390\/jcm9092941","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T09:05:16Z","timestamp":1599815116000},"page":"2941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Timing of Osteoporotic Vertebral Fractures in Lung and Heart Transplantation: A Longitudinal Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Carla","family":"Caffarelli","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D.","family":"Tomai Pitinca","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Alessandri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-2882","authenticated-orcid":false,"given":"Paolo","family":"Cameli","sequence":"additional","affiliation":[{"name":"Respiratory Diseases and Lung Transplantation Unit, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-3703","authenticated-orcid":false,"given":"Elena","family":"Bargagli","sequence":"additional","affiliation":[{"name":"Respiratory Diseases and Lung Transplantation Unit, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bennett","sequence":"additional","affiliation":[{"name":"Respiratory Diseases and Lung Transplantation Unit, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Fossi","sequence":"additional","affiliation":[{"name":"Respiratory Diseases and Lung Transplantation Unit, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bernazzali","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gonnelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1210\/jc.2004-1978","article-title":"Osteoporosis after solid organ transplantation","volume":"90","author":"Maalouf","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s00198-015-3367-8","article-title":"Osteoporosis in the adult solid organ transplant population: Underlying mechanisms and available treatment options","volume":"27","author":"Early","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1210\/jc.2011-1448","article-title":"Prevention of fractures after solid organ transplantation: A meta-analysis","volume":"96","author":"Stein","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0002-9343(96)00155-6","article-title":"Osteoporosis in lung transplantation candidates with end-stage pulmonary disease","volume":"101","author":"Shane","year":"1996","journal-title":"Am. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11739-018-1874-2","article-title":"Guidelines for the management of osteoporosis and fragility fractures","volume":"14","author":"Nuti","year":"2019","journal-title":"Intern. Emerg. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0002-9343(97)00142-3","article-title":"Bone mass, vitamin D deficiency, and hyperparathyroidism in congestive heart failure","volume":"103","author":"Shane","year":"1997","journal-title":"Am. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Adachi, J.D., Ioannidis, G., Olszynski, W.P., Brown, J.P., Hanley, D.A., Sebaldt, R.J., Petrie, A., Tenenhouse, A., Stephenson, G.F., and Papaioannou, A. (2002). The impact of incident vertebral and nonvertebral fractures on health related quality of life in postmenopausal women. BMC Musculoskelet Disord., 3.","DOI":"10.1186\/1471-2474-3-11"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jocd.2015.02.004","article-title":"Relationship between Vertebral Fracture Burden, Height Loss, and Pulmonary Function in Postmenopausal Women with Osteoporosis","volume":"18","author":"Krege","year":"2015","journal-title":"J. Clin. Densitom."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1359\/jbmr.040912","article-title":"Management of bone loss after organ transplantation","volume":"19","author":"Cohen","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00198-003-1426-z","article-title":"Osteoporosis after solid organ and bone marrow transplantation","volume":"14","author":"Cohen","year":"2003","journal-title":"Osteoporos. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"413169","DOI":"10.1155\/2015\/413169","article-title":"Current Status of Research on Osteoporosis after Solid Organ Transplantation: Pathogenesis and Management","volume":"2015","author":"Lan","year":"2015","journal-title":"Biomed Res. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","article-title":"Vertebral fracture assessment using a semiquantitative technique","volume":"8","author":"Genant","year":"1993","journal-title":"J. Bone Min. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.mayocp.2014.02.017","article-title":"Osteoporosis and fractures after solid organ transplantation: A nationwide population-based cohort study","volume":"89","author":"Yu","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Rosen, C. (2013). Transplantation osteoporosis. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, American Society for Bone and Mineral Research, Wiley-Blackwell.","DOI":"10.1002\/9781118453926"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.transproceed.2012.09.117","article-title":"Bone density in heart or lung transplant recipients-A longitudinal study","volume":"45","author":"Wang","year":"2013","journal-title":"Transpl. Proc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1590\/0004-2730000003343","article-title":"Bone disease after transplantation: Osteoporosis and fractures risk","volume":"58","author":"Kulak","year":"2014","journal-title":"Arq. Bras. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"573041","DOI":"10.1155\/2014\/573041","article-title":"Incidence of fractures after cardiac and lung transplantation: A single center experience","volume":"2014","author":"Hariman","year":"2014","journal-title":"J. Osteoporos."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bone.2019.07.006","article-title":"Bone disease following solid organ transplantation: A narrative review and recommendations for management from The European Calcified Tissue Society","volume":"127","author":"Anastasilakis","year":"2019","journal-title":"Bone"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1399-0012.2010.01263.x","article-title":"Osteoporosis in lung transplant candidates compared to matched healthy controls","volume":"25","author":"Lakey","year":"2011","journal-title":"Clin. Transpl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1210\/er.2018-00097","article-title":"Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy","volume":"39","author":"Hardy","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00198-007-0355-7","article-title":"Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass","volume":"18","author":"Vrieze","year":"2007","journal-title":"Osteoporos. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1007\/s00198-018-4643-1","article-title":"Bone mineral density and vertebral fractures and their relationship with pulmonary dysfunction in patients with chronic obstructive pulmonary disease","volume":"29","author":"Costa","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s00198-018-4483-z","article-title":"Increased rate of osteoporosis, low lean mass, and fragility fractures in COPD patients: Association with disease severity","volume":"29","author":"Graumam","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1183\/09031936.96.09112378","article-title":"Osteoporosis in patients undergoing lung transplantation","volume":"9","author":"Ferrari","year":"1996","journal-title":"Eur. Respir. J."},{"key":"ref_25","first-page":"220","article-title":"Bone loss and fracture after lung transplantation","volume":"68","author":"Shane","year":"1999","journal-title":"Clin. Transplant."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1378\/chest.117.2.476","article-title":"Osteoporosis and lung transplantation: A prospective study","volume":"117","author":"Spira","year":"2000","journal-title":"Chest"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00198-019-04893-z","article-title":"Bone involvement in young adults with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure","volume":"30","author":"Cairoli","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1432-2277.1995.tb01503.x","article-title":"Timing and quantification of bone loss in cardiac transplant recipients","volume":"8","author":"Daenen","year":"1995","journal-title":"Transpl. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1210\/jc.2009-0205","article-title":"Approach to the patient with transplantation-related bone loss","volume":"94","author":"Ebeling","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_30","first-page":"1740","article-title":"Fracture after cardiac transplantation: A prospective longitudinal study","volume":"81","author":"Shane","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1432-2277.2007.00598.x","article-title":"Unexpected low incidence of vertebral fractures in heart transplant recipients: Analysis of bone turnover","volume":"21","author":"Ruzicka","year":"2008","journal-title":"Transpl. Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0140-6736(00)03641-2","article-title":"Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: A follow-up study","volume":"357","author":"Hosch","year":"2001","journal-title":"Lancet"},{"key":"ref_33","first-page":"215","article-title":"Relationship between various measures of bone mineral density and vertebral fractures in cardiac transplant recipients","volume":"134","author":"Hofle","year":"2004","journal-title":"Swiss Med. Wkly."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00001573-200203000-00006","article-title":"Prevention of osteoporosis in cardiac transplant recipients","volume":"17","author":"Pisani","year":"2002","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1359\/jbmr.1997.12.4.607","article-title":"The role of testosterone in cyclosporine-induced osteopenia","volume":"12","author":"Bowman","year":"1997","journal-title":"J. Bone Min. Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/9\/2941\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:09:14Z","timestamp":1760177354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/9\/2941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,11]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["jcm9092941"],"URL":"https:\/\/doi.org\/10.3390\/jcm9092941","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,11]]}}}