{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:25:15Z","timestamp":1772252715496,"version":"3.50.1"},"reference-count":80,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual disability worldwide. We focus on identifying clinical and molecular facts that may help elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches (biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography (HPLC), and Western blot\/immunoblotting) directed to evaluate the oxidative stress, inflammation, apoptosis, and neurodegeneration processes, we gather information to build a network of data to perform a computational bioinformatics analysis. Our results showed strong interaction of the above players and its downstream effectors in POAG pathogenesis. In conclusion, specific risk factors were identified, and molecules involved in multiple pathways were found in relation to anterior and posterior eye segment glaucoma changes, pointing to new theranostic challenges for better managing POAG progression.<\/jats:p>","DOI":"10.3390\/jcm9093032","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T08:18:01Z","timestamp":1600676281000},"page":"3032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Computational Analysis of Clinical and Molecular Markers and New Theranostic Possibilities in Primary Open-Angle Glaucoma"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-7837","authenticated-orcid":false,"given":"Mar\u00eda D.","family":"Pinazo-Dur\u00e1n","sequence":"first","affiliation":[{"name":"Ophthalmic Research Unit \u201cSantiago Grisol\u00eda\u201d\/FISABIO and Cellular and Molecular Ophthalmo-Biology Group of the University of Valencia, 46010 Valencia, Spain"},{"name":"Researchers of the Spanish Net of Ophthalmic Research \u201cOFTARED\u201d RD16\/0008\/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-7271","authenticated-orcid":false,"given":"Jos\u00e9 J.","family":"Garc\u00eda-Medina","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Unit \u201cSantiago Grisol\u00eda\u201d\/FISABIO and Cellular and Molecular Ophthalmo-Biology Group of the University of Valencia, 46010 Valencia, Spain"},{"name":"Researchers of the Spanish Net of Ophthalmic Research \u201cOFTARED\u201d RD16\/0008\/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Department of Ophthalmology at the University Hospital \u201cMorales Meseguer\u201d and Department of Ophthalmology at the Faculty of Medicine, University of Murcia, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Bolar\u00edn","sequence":"additional","affiliation":[{"name":"Center of Information and Communication Techniques (CENTIC), 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia M.","family":"Sanz-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Unit \u201cSantiago Grisol\u00eda\u201d\/FISABIO and Cellular and Molecular Ophthalmo-Biology Group of the University of Valencia, 46010 Valencia, Spain"},{"name":"Researchers of the Spanish Net of Ophthalmic Research \u201cOFTARED\u201d RD16\/0008\/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-9377","authenticated-orcid":false,"given":"Mar","family":"Valero-Vello","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Unit \u201cSantiago Grisol\u00eda\u201d\/FISABIO and Cellular and Molecular Ophthalmo-Biology Group of the University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Abell\u00e1n-Abenza","sequence":"additional","affiliation":[{"name":"Center of Information and Communication Techniques (CENTIC), 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-1592","authenticated-orcid":false,"given":"Vicente","family":"Zan\u00f3n-Moreno","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Unit \u201cSantiago Grisol\u00eda\u201d\/FISABIO and Cellular and Molecular Ophthalmo-Biology Group of the University of Valencia, 46010 Valencia, Spain"},{"name":"Researchers of the Spanish Net of Ophthalmic Research \u201cOFTARED\u201d RD16\/0008\/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Area of Health, Valencian International University, 46002 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Moreno-Monta\u00f1\u00e9s","sequence":"additional","affiliation":[{"name":"Researchers of the Spanish Net of Ophthalmic Research \u201cOFTARED\u201d RD16\/0008\/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Department of Ophthalmology at the Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"On behalf of the Vision Loss Expert Group of the Global Burden of Disease Study\u2020 et al., Vision loss expert group of the global burden of disease study. 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