{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:22:44Z","timestamp":1761718964147,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Lactoferrin (LF), a multifunctional glycoprotein found in mammalian milk, is reported to have immunoregulatory effects. The present study aimed to evaluate whether enteric-coated LF (eLF) could improve symptoms in patients with atopic keratoconjunctivitis (AKC). This randomized double-blind placebo-controlled single-center trial comprised Japanese patients (n = 20; aged 22\u201360 years) with AKC. Patients treated with 0.1% tacrolimus ophthalmic suspension (TALYMUS\u00ae) were administered eLF (400 mg\/d of bovine LF) or placebo tablets for 12 weeks. Conjunctival injection was examined, papillae formation in the palpebral conjunctiva was evaluated, and corneal fluorescein score, itchy sensation in end-point itching scale, and serum allergic parameters were assessed. Conjunctival injection was significantly reduced in the LF group than in the placebo group (p = 0.0017, Mann\u2013Whitney U-test). Papillae formation in the palpebral conjunctiva showed a statistical decrease in the LF group than in the placebo group (p = 0.010, unpaired T-test). LF combined with TALYMUS\u00ae could be a promising treatment strategy to mitigate AKC.<\/jats:p>","DOI":"10.3390\/jcm9103093","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T08:57:32Z","timestamp":1601024252000},"page":"3093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Conjunctival Injection Reduction in Patients with Atopic Keratoconjunctivitis Due to Synergic Effect of Bovine Enteric-Coated Lactoferrin in 0.1% Tacrolimus Ophthalmic Suspension"],"prefix":"10.3390","volume":"9","author":[{"given":"Hiroshi","family":"Fujishima","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Tsurumi University School of Dental Medicine, Tsurumi, Yokohama 230-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tsurumi University School of Dental Medicine, Tsurumi, Yokohama 230-8501, Japan"},{"name":"Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama 362-0806, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-8578","authenticated-orcid":false,"given":"Eisuke","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5161-9880","authenticated-orcid":false,"given":"Shinji","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan"},{"name":"Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki 210-0821, Kanagawa, Japan"},{"name":"Transborder Medical Research Center, University of Tsukuba, Tsukuba 305-8575, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Tomita","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"ref_1","first-page":"231","article-title":"Immunoregulatory effects of a nutritional preparation containing bovine lactoferrin taken orally by healthy individuals","volume":"46","author":"Zimecki","year":"1998","journal-title":"Arch. 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