{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T02:00:45Z","timestamp":1773712845144,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","award":["independent research grant"],"award-info":[{"award-number":["independent research grant"]}],"id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Patients with Failed Back Surgery Syndrome (FBSS) report a considerably lower health- related quality of life (HRQoL), compared to the general population. Spinal cord stimulation (SCS) is an effective treatment to offer pain relief in those patients. Despite initial treatment success of SCS, its effect sometimes wears off over time. This study investigates the added value of high dose SCS (HD-SCS) in patients with unsatisfactory conventional SCS, from a quality of life perspective. Seventy-eight FBSS patients who were treated with conventional SCS that failed to provide pain relief, were recruited in 15 centers. HRQoL was assessed before converting to HD-SCS (baseline) and three times after converting to HD-SCS using the EuroQol-5D-3L. Quality adjusted life years (QALY) were calculated and compared with conventional SCS. An overall significant increase over time was seen in utility values of the EQ5D-3L, as the mean value at baseline 0.283 (\u00b10.21) increased to 0.452 (\u00b10.29) at 12 months of HD-SCS. This average increase in utility coincides with an average increase of 0.153 (\u00b10.24) QALY\u2019s in comparison to continued conventional SCS. Besides the potential of HD-SCS to salvage patients with failed responses to conventional SCS, this treatment seems to be a more efficient treatment than conventional SCS.<\/jats:p>","DOI":"10.3390\/jcm9103126","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T10:39:58Z","timestamp":1601289598000},"page":"3126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Added Value of High Dose Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome after Conversion from Standard Spinal Cord Stimulation"],"prefix":"10.3390","volume":"9","author":[{"given":"Mats","family":"De Jaeger","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2271-9855","authenticated-orcid":false,"given":"Lisa","family":"Goudman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"},{"name":"Pain in Motion International Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education &amp; Physiotherapy (KIMA),Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium"},{"name":"Center for Neurosciences (C4N), Faculty of Medicine &amp; Pharmacy, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium"},{"name":"STIMULUS Consortium (reSearch and TeachIng neuroModULation Uz bruSsel), Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Putman","sequence":"additional","affiliation":[{"name":"Department of Public Health (GEWE), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium"},{"name":"I-CHER, Interuniversity Center for Health Economics Research, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"De Smedt","sequence":"additional","affiliation":[{"name":"Center for Neurosciences (C4N), Faculty of Medicine &amp; Pharmacy, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium"},{"name":"STIMULUS Consortium (reSearch and TeachIng neuroModULation Uz bruSsel), Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"},{"name":"Department of Physical Medicine and Rehabilitation, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Rigoard","sequence":"additional","affiliation":[{"name":"Spine &amp; Neuromodulation Functional Unit, Poitiers University Hospital, 86073 Poitiers, France"},{"name":"Institut Prime, UPR CNRS 3346, ISAE-ENSMA, University of Poitiers, 86073 Poitiers, France"},{"name":"PRISMATICS Lab (Predictive Research in Spine\/Neuromodulation Management and Thoracic Innovation\/Cardiac Surgery), Poitiers University Hospital, 86073 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wietse","family":"Geens","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"Moens","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"},{"name":"Center for Neurosciences (C4N), Faculty of Medicine &amp; Pharmacy, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium"},{"name":"STIMULUS Consortium (reSearch and TeachIng neuroModULation Uz bruSsel), Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"},{"name":"Department of Radiology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2147\/JPR.S92776","article-title":"Failed back surgery syndrome: Current perspectives","volume":"9","author":"Baber","year":"2016","journal-title":"J. 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