{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:20:08Z","timestamp":1772914808808,"version":"3.50.1"},"reference-count":72,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Owing to its ease of application, noninvasive nature, and safety, echocardiography is an essential imaging modality to assess cardiac function in patients affected by ischemic heart disease (IHD). Over the past few decades, we have witnessed a continuous series of evolutions in the ultrasound field that have led to the introduction of innovative echocardiographic modalities which allowed to better understand the morphofunctional abnormalities occurring in cardiovascular diseases. This article offers an overview of some of the newest echocardiographic modalities and their promising application in IHD diagnosis, risk stratification, management, and monitoring after cardiac rehabilitation.<\/jats:p>","DOI":"10.3390\/jcm9103131","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T10:39:58Z","timestamp":1601289598000},"page":"3131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["New Ultrasound Technologies for Ischemic Heart Disease Assessment and Monitoring in Cardiac Rehabilitation"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9698-9145","authenticated-orcid":false,"given":"Antonello","family":"D\u2019Andrea","sequence":"first","affiliation":[{"name":"Unit of Cardiology, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Monaldi Hospital, 80131 Naples, Italy"},{"name":"Unit of Cardiology and Intensive Coronary Care, \u201cUmberto I\u201d Hospital, 84014 Nocera Inferiore (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-5255","authenticated-orcid":false,"given":"Simona","family":"Sperlongano","sequence":"additional","affiliation":[{"name":"Unit of Cardiology, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Pacileo","sequence":"additional","affiliation":[{"name":"Unit of Cardiology and Intensive Coronary Care, \u201cUmberto I\u201d Hospital, 84014 Nocera Inferiore (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7223-7574","authenticated-orcid":false,"given":"Elio","family":"Venturini","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Unit, Azienda USL Toscana Nord-Ovest, Cecina Civil Hospital, 57023 Cecina (LI), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Iannuzzo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-6375","authenticated-orcid":false,"given":"Marco","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Sperlongano","sequence":"additional","affiliation":[{"name":"Department of Experimental Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, 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Cardiovasc. Qual. Outcomes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ihj.2012.12.004","article-title":"How do I do it? Speckle-tracking echocardiography","volume":"65","author":"Bansal","year":"2012","journal-title":"Indian Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.21037\/cdt.2017.06.01","article-title":"Three-dimensional speckle-tracking echocardiography: Benefits and limitations of integrating myocardial mechanics with three-dimensional imaging","volume":"8","author":"Muraru","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/CIRCRESAHA.116.309128","article-title":"Advances in echocardiographic imaging in heart failure with reduced and preserved ejection fraction","volume":"119","author":"Omar","year":"2016","journal-title":"Circ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.echo.2006.01.024","article-title":"Sequential changes of myocardial function during acute myocardial infarction, in the early and chronic phase after coronary intervention described by ultrasonic strain rate imaging","volume":"19","author":"Weidemann","year":"2006","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/ehjci\/jes295","article-title":"Global and regional longitudinal strain assessed by two-dimensional speckle tracking echocardiography identifies early myocardial dysfunction and transmural extent of myocardial scar in patients with acute ST elevation myocardial infarction and relatively preserved LV function","volume":"14","author":"Cimino","year":"2012","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s10554-016-0959-0","article-title":"Multilayer longitudinal strain at rest may help to predict significant stenosis of the left anterior descending coronary artery in patients with suspected non-ST-elevation acute coronary syndrome","volume":"32","author":"Liu","year":"2016","journal-title":"Int. J. Cardiovasc. 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Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10554-014-0573-y","article-title":"Echocardiographic assessment of global longitudinal right ventricular function in patients with an acute inferior ST elevation myocardial infarction and proximal right coronary artery occlusion","volume":"31","author":"Hutyra","year":"2014","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/echo.13879","article-title":"Speckle tracking analysis in intensive care unit: A toy or a tool?","volume":"35","author":"Radmilovic","year":"2018","journal-title":"Echocardiography"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.amjcard.2011.03.052","article-title":"Prognostic value of serial global longitudinal strain measured by two-dimensional speckle tracking echocardiography in patients with ST-segment elevation myocardial infarction","volume":"108","author":"Woo","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.jacc.2010.06.044","article-title":"Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction","volume":"56","author":"Hung","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jcmg.2013.05.009","article-title":"Early echocardiographic deformation analysis for the prediction of sudden cardiac death and life-threatening arrhythmias after myocardial infarction","volume":"6","author":"Valeur","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1093\/eurheartj\/ehq198","article-title":"Time course of global left ventricular strain after acute myocardial infarction","volume":"31","author":"Antoni","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijcard.2016.01.084","article-title":"XStrain 4D analysis predicts left ventricular remodeling in patients with recent non-ST-segment elevation myocardial infarction","volume":"206","author":"Mele","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijcard.2010.08.025","article-title":"Global longitudinal speckle-tracking strain is predictive of left ventricular remodeling after coronary angioplasty in patients with recent non-st elevation myocardial infarction","volume":"153","author":"Cocchia","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/eurjhf\/hfn010","article-title":"Effects of global longitudinal strain and total scar burden on response to cardiac resynchronization therapy in patients with ischaemic dilated cardiomyopathy","volume":"11","author":"Caso","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/CIRCIMAGING.112.978296","article-title":"The prognostic value of left atrial peak reservoir strain in acute myocardial infarction is dependent on left ventricular longitudinal function and left atrial size","volume":"6","author":"Ersboll","year":"2013","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.amjcard.2018.04.047","article-title":"Relation of echocardiographic markers of left atrial fibrosis to atrial fibrillation burden","volume":"122","author":"Leung","year":"2018","journal-title":"Am. J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.echo.2016.09.007","article-title":"Normal ranges of left atrial strain by speckle-tracking echocardiography: A systematic review and meta-analysis","volume":"30","author":"Pathan","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijcard.2007.11.102","article-title":"Association between left atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy: A two-dimensional speckle strain study","volume":"132","author":"Caso","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1093\/eurheartj\/ehm443","article-title":"Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: A two-dimensional speckle strain study","volume":"28","author":"Caso","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/eurjhf\/hfp158","article-title":"Right atrial size and deformation in patients with dilated cardiomyopathy undergoing cardiac resynchronization therapy","volume":"11","author":"Scarafile","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/451042","article-title":"Left atrium by echocardiography in clinical practice: From conventional methods to new echocardiographic techniques","volume":"2014","author":"Ancona","year":"2014","journal-title":"Sci. World J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.echo.2012.11.016","article-title":"Two-dimensional atrial systolic strain imaging predicts atrial fibrillation at 4-year follow-up in asymptomatic rheumatic mitral stenosis","volume":"26","author":"Ancona","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"007696","DOI":"10.1161\/CIRCIMAGING.118.007696","article-title":"Left atrial reservoir function and outcome in heart failure with reduced ejection fraction","volume":"11","author":"Carluccio","year":"2018","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1540-8175.2011.01513.x","article-title":"Evaluation of Left Atrial Function in Patients with Coronary Artery Disease by Two-Dimensional Strain and Strain Rate Imaging","volume":"28","author":"Liu","year":"2011","journal-title":"Echocardiography"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ehj.2018.09.004","article-title":"Left atrial deformation analysis as a predictor of severity of coronary artery disease","volume":"70","author":"Othman","year":"2018","journal-title":"Egypt. Heart J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0735-1097(98)00623-8","article-title":"Effects of pacing-induced and balloon coronary occlusion ischemia on left atrial function in patients with coronary artery disease","volume":"33","author":"Stefanadis","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/157340312801215755","article-title":"Tissue Doppler imaging in coronary artery diseases and heart failure","volume":"8","author":"Correale","year":"2012","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1476-7120-10-47","article-title":"Tissue Doppler imaging for diagnosis of coronary artery disease: A systematic review and meta-analysis","volume":"10","author":"Agarwal","year":"2012","journal-title":"Cardiovasc. Ultrasound"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/ejechocard\/jer055","article-title":"Postsystolic shortening is a strong predictor of recovery of systolic function in patients with non-ST-elevation myocardial infarction","volume":"12","author":"Eek","year":"2011","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0735-1097(00)00634-3","article-title":"Measurement of postsystolic shortening to assess viability and predict recovery of left ventricular function after acute myocardial infarction","volume":"35","author":"Hosokawa","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/clc.4960270108","article-title":"Postsystolic thickening detected by doppler myocardial imaging: A marker of viability or ischemia in patients with myocardial infarction","volume":"27","author":"Song","year":"2006","journal-title":"Clin. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.echo.2006.10.004","article-title":"Does Postsystolic motion or shortening predict recovery of myocardial function after primary Percutanous coronary intervention?","volume":"20","author":"Terkelsen","year":"2007","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_38","first-page":"751","article-title":"Presence of post-systolic shortening is an independent predictor of heart failure in patients following ST-segment elevation myocardial infarction","volume":"34","author":"Brainin","year":"2017","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.echo.2018.10.018","article-title":"Intracardiac flow analysis: Techniques and potential clinical applications","volume":"32","author":"Mele","year":"2019","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/ehjci\/jeu106","article-title":"Quantitative analysis of intraventricular blood flow dynamics by echocardiographic particle image velocimetry in patients with acute myocardial infarction at different stages of left ventricular dysfunction","volume":"15","author":"Agati","year":"2014","journal-title":"Eur. Heart J.-Cardiovasc. Imaging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/MCA.0000000000000596","article-title":"Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts","volume":"29","author":"Chan","year":"2018","journal-title":"Coron. Artery Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.amjcard.2010.06.072","article-title":"Left ventricular muscle and fluid mechanics in acute myocardial infarction","volume":"106","author":"Nucifora","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1253\/circj.CJ-12-0360","article-title":"Abnormal left ventricular vortex flow patterns in association with left ventricular apical thrombus formation in patients with anterior myocardial infarction","volume":"76","author":"Son","year":"2012","journal-title":"Circ. J."},{"key":"ref_44","first-page":"309","article-title":"Italian Society of Cardiovascular Echography (SIEC) Consensus Conference on the state of the art of contrast echocardiography","volume":"5","author":"Trocino","year":"2004","journal-title":"Ital. Heart. J. Off. J. Ital. Fed. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Zagatina, A., Zhuravskaya, N., Shmatov, D., Ciampi, Q., Carpeggiani, C., and Picano, E. (2020). Exercise stress echocardiography with ABCDE protocol in unexplained dyspnoea. Int. J. Cardiovasc. Imaging, 1\u20139.","DOI":"10.1093\/eurheartj\/ehz746.0164"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jcmg.2018.10.017","article-title":"The functional meaning of B-Profile during stress lung ultrasound","volume":"12","author":"Scali","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e004875","DOI":"10.1161\/JAHA.116.004875","article-title":"Incremental value of transthoracic doppler echocardiography-assessed coronary flow reserve in patients with suspected myocardial ischemia undergoing myocardial perfusion Scintigraphy","volume":"6","author":"Gan","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijcard.2014.06.076","article-title":"Non-invasive evaluation of coronary flow reserve with transthoracic Doppler echocardiography predicts the presence of significant stenosis in coronary arteries","volume":"176","author":"Haraldsson","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.RES.0000246086.93555.f3","article-title":"Allograft Vasculopathy versus atherosclerosis","volume":"99","author":"Rahmani","year":"2006","journal-title":"Circ. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.echo.2014.01.020","article-title":"Follow-up of heart transplant recipients with serial echocardiographic coronary flow reserve and Dobutamine stress echocardiography to detect cardiac allograft Vasculopathy","volume":"27","author":"Sade","year":"2014","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Feola, M., Testa, M., Ferreri, C., Rosso, G., Rossi, A., and Ruocco, G. (2019). The analysis of arterial stiffness in heart failure patients in comparison with healthy subjects and patients with cardiovascular risk factors. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101721"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ikonomidis, I., Makavos, G., and Lekakis, J.P. (2015). Arterial stiffness and coronary artery disease. Curr. Opin. Cardiol., 30.","DOI":"10.1097\/HCO.0000000000000179"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.109.886655","article-title":"Arterial stiffness and cardiovascular events: The Framingham heart study","volume":"121","author":"Mitchell","year":"2010","journal-title":"Circulation"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jacc.2009.10.061","article-title":"Prediction of cardiovascular events and all-cause mortality with arterial stiffness: A systematic review and meta-analysis","volume":"55","author":"Vlachopoulos","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12928-012-0135-y","article-title":"Role of arterial stiffness and impaired renal function in the progression of new coronary lesions after percutaneous coronary intervention","volume":"28","author":"Kaneko","year":"2012","journal-title":"Cardiovasc. Interv. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/hr.2010.126","article-title":"Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease","volume":"33","author":"Nakamura","year":"2010","journal-title":"Hypertens. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/HYPERTENSIONAHA.113.02046","article-title":"Opposite predictive value of pulse pressure and aortic pulse wave velocity on heart failure with reduced left ventricular ejection fraction: Insights from an Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) substudy","volume":"63","author":"Regnault","year":"2014","journal-title":"Hypertension"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1600-0838.2010.01133.x","article-title":"Effects of exercise training on oxygen uptake in coronary heart disease: A systematic review and meta-analysis","volume":"20","author":"Valkeinen","year":"2010","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.amjmed.2004.01.009","article-title":"Exercise-based rehabilitation for patients with coronary heart disease: Systematic review and meta-analysis of randomized controlled trials","volume":"116","author":"Taylor","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.accreview.2003.09.021","article-title":"Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure results of the exercise in left ventricular dysfunction and chronic heart failure (ELVD-CHF) trial","volume":"12","author":"Giannuzzi","year":"2003","journal-title":"ACC Curr. J. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Heran, B.S., Chen, J.M., Ebrahim, S., Moxham, T., Oldridge, N., Rees, K., Thompson, D.R., and Taylor, R. (2011). Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst. Rev., 001800.","DOI":"10.1002\/14651858.CD001800.pub2"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Petrovic, M.T., Djordjevic-Dikic, A., Giga, V., Boskovic, N., Vukcevic, V., Cvetic, V., Mladenovic, A., Radmili, O., Markovic, Z., and Dobric, M. (2020). The coronary ARteriogenesis with combined Heparin and EXercise therapy in chronic refractory Angina (CARHEXA) trial: A double-blind, randomized, placebo-controlled stress echocardiographic study. Eur. J. Prev. Cardiol., 8.","DOI":"10.1177\/2047487320915661"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1745-6215-12-92","article-title":"A meta-analysis of the effects of exercise training on left ventricular remodeling following myocardial infarction: Start early and go longer for greatest exercise benefits on remodeling","volume":"12","author":"Haykowsky","year":"2011","journal-title":"Trials"},{"key":"ref_64","first-page":"447","article-title":"Stroke volume and cardiac output measurement in cardiac patients during a rehabilitation program: Comparison between tonometry, impedancemetry and echocardiography","volume":"36","author":"Mourot","year":"2019","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.rehab.2018.01.003","article-title":"Effect of exercise training on left ventricular mechanics after acute myocardial infarction\u2013an exploratory study","volume":"61","author":"McGregor","year":"2018","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/clc.23277","article-title":"The impact of high-intensity interval training on ventricular remodeling in patients with a recent acute myocardial infarction\u2014A randomized training intervention pilot study","volume":"42","author":"Trachsel","year":"2019","journal-title":"Clin. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1080\/00015385.2017.1305196","article-title":"A brief period of intensive cardiac rehabilitation improves global longitudinal strain and diastolic function after a first uncomplicated myocardial infarction","volume":"72","author":"Malfatto","year":"2017","journal-title":"Acta Cardiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.rehab.2014.01.001","article-title":"Effect of cardiac rehabilitation on left atrial functions in patients with acute myocardial infarction","volume":"57","author":"Acar","year":"2014","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_69","unstructured":"Bokhari, S., Schneider, R.H., Salerno, J.W., Rainforth, M.V., Gaylord-King, C., and Nidich, S.I. (2019). Effects of cardiac rehabilitation with and without meditation on myocardial blood flow using quantitative positron emission tomography: A pilot study. J. Nucl. Cardiol., 1\u201312."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.ijcard.2012.06.104","article-title":"Improvement in arterial stiffness following cardiac rehabilitation","volume":"167","author":"Laskey","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.atherosclerosis.2014.12.057","article-title":"Effect of exercise-based cardiac rehabilitation on arterial stiffness and inflammatory and endothelial dysfunction biomarkers: A randomized controlled trial of myocardial infarction patients","volume":"239","author":"Oliveira","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e287","DOI":"10.1097\/01.hjh.0000573660.54948.69","article-title":"Cardiac rehabilitation reduces arterial stiffness independently of the coexistence of arterial hypertension (forever study)","volume":"37","author":"Trzos","year":"2019","journal-title":"J. Hypertens."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/10\/3131\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:14:24Z","timestamp":1760177664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/10\/3131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,28]]},"references-count":72,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["jcm9103131"],"URL":"https:\/\/doi.org\/10.3390\/jcm9103131","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,28]]}}}