{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:01:33Z","timestamp":1771628493378,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Sarcopenia is a prevalent muscle abnormality characterized by progressive and generalized loss of skeletal muscle mass and strength, common among patients with decompensated advanced chronic liver disease (dACLD). Irisin is a recently identified myokine, which is mainly expressed and secreted by skeletal muscle. Pointing to the essential role of irisin in metabolic regulation and energy expenditure we hypothesize that it plays an important role in cirrhosis development and progression. Aim: To assess irisin serum levels in patients with dACLD, with different cirrhosis stage and etiology. To analyze relationship between sarcopenia and irisin serum levels. Methods: Serum irisin concentrations were measured with commercially available ELISA kits in 88 cirrhotic patients. Recorded parameters of muscle mass were hand-grip strength (HGS), mid-arm muscle circumference (MAC), and transversal psoas muscle index (TPMI). Results: There was no difference in serum irisin levels between cirrhotic patients with different Child-Pugh (CTP) and model of end-stage liver disease (MELD) score, and those with and without ascites. The Liver Frailty Index (LFI) was significantly higher in patients with more advanced liver disease according to CTP and MELD. There was no association between serum irisin level with MAC (r = 0.04, p = 0.74) nor with TPMI (r = 0.20, p = 0.06). We observed significant negative correlation between serum irisin level and age (r = \u22120.35, p &lt; 0.001). Conclusions: Serum irisin levels did not correlate with sarcopenia. There was no difference in serum irisin levels between cirrhotic patients with and without diabetes. There was no difference in serum irisin levels among patients with more severe dACLD, although we observed significant LFI increase among patients with more advanced liver disease.<\/jats:p>","DOI":"10.3390\/jcm9103158","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T08:43:27Z","timestamp":1601369007000},"page":"3158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Irisin in Liver Cirrhosis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-1094","authenticated-orcid":false,"given":"Micha\u0142","family":"Kukla","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Geriatrics, Jagiellonian University Medical College, 30-688 Cracow, Poland"},{"name":"Department of Endoscopy, University Hospital in Cracow, 30-688 Cracow, Poland"},{"name":"Department of Gastroenterology and Hepatology, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5171-3623","authenticated-orcid":false,"given":"Lubomir","family":"Skladany","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and HEGITO (Hepatology, Gastroenterology and Liver Transplantation), F.D. Roosevelt University Hospital, 975-17 Banska Bystrica, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Men\u017cyk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Acute Intoxication, Provincial Hospital, 33-100 Tarn\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Derra","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Centre of Upper Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika","family":"Stygar","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-9585","authenticated-orcid":false,"given":"Magdalena","family":"Skonieczna","sequence":"additional","affiliation":[{"name":"Department of Systems Biology and Engineering, Silesian University of Technology, 44-100 Gliwice, Poland"},{"name":"Biotechnology Centre, Silesian University of Technology, 44-100 Gliwice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-2314","authenticated-orcid":false,"given":"Dorota","family":"Hudy","sequence":"additional","affiliation":[{"name":"Department of Systems Biology and Engineering, Silesian University of Technology, 44-100 Gliwice, Poland"},{"name":"Biotechnology Centre, Silesian University of Technology, 44-100 Gliwice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0777-8048","authenticated-orcid":false,"given":"Katarzyna","family":"Nabrdalik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Diabetology and Nephrology in Zabrze, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Gumprecht","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Diabetology and Nephrology in Zabrze, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2649-5967","authenticated-orcid":false,"given":"Wojciech","family":"Marlicz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-489X","authenticated-orcid":false,"given":"Anastasios","family":"Koulaouzidis","sequence":"additional","affiliation":[{"name":"Centre for Liver and Digestive Disorders, The Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7418-0073","authenticated-orcid":false,"given":"Tomas","family":"Koller","sequence":"additional","affiliation":[{"name":"Subdivision of Gastroenterology and Hepatology, 5th Department of Medicine, Comenius University Faculty of Medicine in Bratislava, University Hospital Ruzinov, 821 01 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cgh.2011.08.028","article-title":"Muscle wasting is associated with mortality in patients with cirrhosis","volume":"10","author":"Prado","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/hep.30686","article-title":"Sarcopenia in cirrhosis: Looking beyond the skeletal muscle loss to see the systemic disease","volume":"70","author":"Bhanji","year":"2019","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/lt.23495","article-title":"Severe muscle depletion in patients on the liver transplant wait list: Its prevalence and independent prognostic value","volume":"18","author":"Tandon","year":"2012","journal-title":"Liver Transpl."},{"key":"ref_5","first-page":"357","article-title":"Prognostic usefulness of serum myostatin in advanced chronic liver disease: Its relation to gender and correlation with inflammatory status","volume":"70","author":"Skladany","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ebadi, M., Bhanji, R.A., Mazurak, V.C., and Montano-Loza, A.J. (2019). Sarcopenia in cirrhosis: From pathogenesis to interventions. J. Gastroenterol., 54.","DOI":"10.1007\/s00535-019-01605-6"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kim, G., Kang, S.H., Kim, M.Y., and Baik, S.K. (2017). Prognostic value of sarcopenia in patients with liver cirrhosis: A systematic review and meta-analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186990"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E983","DOI":"10.1152\/ajpendo.00183.2012","article-title":"Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis","volume":"303","author":"Qiu","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jhep.2006.02.016","article-title":"Inhibition of aromatase improves nutritional status following portacaval anastomosis in male rats","volume":"45","author":"Dasarathy","year":"2006","journal-title":"J. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0168-8278(94)80228-9","article-title":"Short-term effect of recombinant human growth hormone in patients with alcoholic cirrhosis","volume":"21","author":"Moller","year":"1994","journal-title":"J. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hep.29219","article-title":"Development of a novel frailty index to predict mortality in patients with end-stage liver disease","volume":"66","author":"Lai","year":"2017","journal-title":"Hepatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: Evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_13","first-page":"1","article-title":"Signatures of early frailty in the gut microbiota","volume":"8","author":"Jackson","year":"2016","journal-title":"Genome Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Munoz, I.Y.M., Romero, E.D.S.C., and Garcia, J.J.G. (2018). Irisin a novel metabolic biomarker: Present knowledge and future directions. Int. J. Endocrinol., 1\u20138.","DOI":"10.1155\/2018\/7816806"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fphys.2019.01085","article-title":"Irisin exerts inhibitory effect on adipogenesis through regulation of Wnt signaling","volume":"10","author":"Ma","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fendo.2019.00524","article-title":"Irisin: A hope in understanding and managing obesity and metabolic syndrome","volume":"10","author":"Arhire","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Korta, P., Pochec, E., and Mazur-Bia\u0142y, A. (2019). Irisin as a multifunctional protein: Implications for health and certain diseases. Medicina, 55.","DOI":"10.3390\/medicina55080485"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1111\/ggi.13030","article-title":"Circulating irisin levels as a predictive biomarker for sarcopenia: A cross-sectional community-based study","volume":"17","author":"Chang","year":"2017","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jhep.2014.02.026","article-title":"Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography","volume":"60","author":"Durand","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/hep.29003","article-title":"A practical approach to nutritional screening and assessment in cirrhosis","volume":"65","author":"Tandon","year":"2017","journal-title":"Hepatology"},{"key":"ref_21","unstructured":"World Health Organization (2006). Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO\/IDF Consultation, World Health Organization."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.jhep.2004.11.015","article-title":"Assessment of the prognosis of cirrhosis: Child-Pugh versus MELD","volume":"42","author":"Durand","year":"2005","journal-title":"J. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/lt.25449","article-title":"The range and reproducibility of the liver frailty index","volume":"25","author":"Wang","year":"2019","journal-title":"Liver Transplant."},{"key":"ref_24","unstructured":"(2014, June 17). FrAILT Functional Assessment in Liver Transplantation. Available online: https:\/\/liverfrailtyindex.ucsf.edu\/."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/261545","article-title":"Circulating sclerostin and irisin are related and interact with gender to influence adiposity in adults with prediabetes","volume":"2014","author":"Klangjareonchai","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/eci.12196","article-title":"Irisin as a predictor of glucose metabolism in children: Sexually dimorphic effects","volume":"44","author":"Alkharfy","year":"2014","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.metabol.2012.09.002","article-title":"FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise","volume":"61","author":"Huh","year":"2012","journal-title":"Metabolism"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1055\/s-0042-108730","article-title":"Lower circulating irisin level in patients with diabetes mellitus: A systematic review and meta-analysis","volume":"48","author":"Du","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"29898","DOI":"10.1038\/srep29898","article-title":"FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle","volume":"6","author":"Cordido","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1055\/a-0896-1130","article-title":"Effect of metformin treatment on insulin resistance markers, and circulating irisin in women with polycystic ovarian syndrome (PCOS)","volume":"51","author":"Masaeli","year":"2019","journal-title":"Horm. Metab. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s12020-017-1476-1","article-title":"Irisin in metabolic diseases","volume":"59","author":"Polyzos","year":"2018","journal-title":"Endocrine"},{"key":"ref_32","first-page":"243","article-title":"New insight into the direct anti-inflammatory activity of a myokine irisin against proinflammatory activation of adipocytes: Implication of exercise in obesity","volume":"68","author":"Bilski","year":"2017","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-511X-14-2","article-title":"Irisin: A new molecular marker and target in metabolic disorder","volume":"14","author":"Chen","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Roca-Rivada, A., Castelao, C., Senin, L.L., Landrove, M.O., Baltar, J., Crujeiras, A.B., Seoane, L.M., Casanueva, F.F., and Pardo, F. (2013). FNDC5\/irisin is not only a myokine but also an adipokine. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060563"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-019-0479-8","article-title":"The association of circulating irisin with metabolic risk factors in Chinese adults: A cross-sectional community-based study","volume":"19","author":"Tang","year":"2019","journal-title":"BMC Endocr. Disord."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/liv.13115","article-title":"Diabetes mellitus in patients with cirrhosis: Clinical implications and management","volume":"36","author":"Elkrief","year":"2016","journal-title":"Liver Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.atherosclerosis.2015.08.002","article-title":"Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients","volume":"242","author":"Lee","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12020-018-1814-y","article-title":"The novel myokine irisin: Clinical implications and potential role as a biomarker for sarcopenia in postmenopausal women","volume":"64","author":"Park","year":"2019","journal-title":"Endocrine"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1210\/jc.2014-1195","article-title":"Implication of circulating irisin levels with brown adipose tissue and sarcopenia in humans","volume":"99","author":"Choi","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/sms.12904","article-title":"Effect of an acute exercise bout on immediate post-exercise irisin concentration in adults: A meta-analysis","volume":"28","author":"Fox","year":"2018","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_41","first-page":"277","article-title":"Omentin, vaspin and irisin in chronic liver diseases","volume":"70","author":"Waluga","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/hepr.13453","article-title":"Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma","volume":"50","author":"Hirota","year":"2020","journal-title":"Hepatol. Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Endo, K., Kuroda, H., Kanazawa, J., Sato, T., Fujiwara, Y., Abe, T., Sato, H., Kooka, Y., Oikawa, T., and Sawara, K. (2020). Impact of grip strength in patients with unresectable hepatocellular carcinoma treated with Lenvatinib. Cancers, 12.","DOI":"10.20944\/preprints202007.0320.v1"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Marasco, G., Serenari, M., Renzulli, M., Alemanni, L.V., Rossini, B., Pettinari, I., Dajti, E., Ravaioli, F., Golfieri, R., and Cescon, M. (2020). Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments. J. Gastroenterol.","DOI":"10.1007\/s00535-020-01711-w"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Choi, K., Jang, H.Y., Ahn, J.M., Hwang, S.H., Chung, J.W., Choi, Y.S., Kim, J.-W., Jang, E.S., Choi, G.H., and Jeong, S.-H. (2020). The association of the serum levels of myostatin, follistatin, and interleukin-6 with sarcopenia, and their impacts on survival in patients with hepatocellular carcinoma. Clin. Mol. Hepatol.","DOI":"10.3350\/cmh.2020.0005"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/10\/3158\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:14:52Z","timestamp":1760177692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/10\/3158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["jcm9103158"],"URL":"https:\/\/doi.org\/10.3390\/jcm9103158","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,29]]}}}