{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T23:06:27Z","timestamp":1792364787180,"version":"4.4.0"},"reference-count":37,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: to demonstrate the benefits of physiotherapy (PT) with pelvic floor biofeedback (BFB) in improving health-related quality of life when used as a complementary therapy after surgical treatment of cystocele, in cases in which perineal pain or discomfort persists. Materials and methods: prospective observational study in 226 women who received complementary therapy after surgical treatment of cystocele due to persistent perineal discomfort or pain. Groups: GA (n = 78): women treated with 25 mg of oral pregabalin every 12 h plus BFB, consisting of 20 once-weekly therapy sessions, each 20 min long, with perineal pregelled surface electrodes connected to a screen which provides visual feedback; GB (n = 148): women treated with oral pregabalin 25 mg every 12 h without BFB. Variables: age, body mass index (BMI), time since onset of cystocele prior to surgery (TO), SF-36 health-related quality of life survey score, diseases and concomitant health conditions, follow-up time, success, or failure of postsurgical treatment. Results: average age 67.88 years (SD 12.33, 30\u201388), with no difference between GA and GB. Average body mass index (BMI) 27.08 (SD 0.45, 18.74\u201346.22), with no difference between GA and GB. Time since onset of cystocele prior to surgery (TO) was 6.61 years (SD 0.6), with no difference between GA and GB. Pretreatment SF-36 score was lower in GA success than GB success. Treatment was successful in 141 (63.20%) women and failed in 82 (36.80%). PT and age were the main predictors of success, and the least important were pretreatment SF-36 and the time elapsed after the intervention. In GA, 63 women (80.80%) showed improvement while 15 (19.20%) did not. Age was the main predictor of treatment success, while the least important was BMI. In GB, 78 women (53.80%) showed improvement while 67 (46.20%) did not improve. The main predictor was time since cystocele onset prior to surgery, while the least important was age. The odds ratio (OR) of improving quality of life for each unit increase in SF-36 was 11.5% (OR = 0.115) in all patients, with no difference between success and failure; in GA it was 23.80% (OR = 0.238), with a difference between success and failure; in GB it was 11.11% (OR = 0.111), with no difference between success and failure. GA and GB success had more history of eutocic delivery. GA success had more rUTI. GB success and GA failure both had more history of UI corrective surgery. The \u201cfailure\u201d outcome had a higher number of patients with more than two concomitant pathological conditions. Conclusions: BFB as an adjunctive treatment improves quality of life in women suffering from persistent discomfort after surgery for cystocele. Young women who meet the criteria for recurrent urinary tract infection or who have a history of eutocic delivery show greater improvement. Body mass index does not influence response to treatment, while the presence of more than two concomitant conditions indicates a poor prognosis for improving quality of life.<\/jats:p>","DOI":"10.3390\/jcm9103310","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T05:45:51Z","timestamp":1602913551000},"page":"3310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects on Health-Related Quality of Life of Biofeedback Physiotherapy of the Pelvic Floor as an Adjunctive Treatment Following Surgical Repair of Cystocele"],"prefix":"10.3390","volume":"9","author":[{"given":"Pedro-Santiago","family":"Borrego-Jimenez","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37001 Salamanca, Spain"},{"name":"Physiotherapy Department of Institute of Applied Technology, Abu Dhabi 3798, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-6033","authenticated-orcid":false,"given":"B\u00e1rbara-Yolanda","family":"Padilla-Fernandez","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery, University La Laguna, 38200 San Crist\u00f3bal de la Laguna, (Santa Cruz de Tenerife), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-3262","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Valverde-Martinez","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37001 Salamanca, Spain"},{"name":"Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Urology of University Hospital of Avila, 05071 \u00c1vila, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Helena","family":"Garcia-Sanchez","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics of University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-de-la-O","family":"Rodriguez-Martin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics of University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Pilar","family":"Sanchez-Conde","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37001 Salamanca, Spain"},{"name":"Department of Anesthesiology of University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Carmen","family":"Flores-Fraile","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37001 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-0118","authenticated-orcid":false,"given":"Magaly","family":"Marquez-Sanchez","sequence":"additional","affiliation":[{"name":"Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-0551","authenticated-orcid":false,"given":"Javier","family":"Flores-Fraile","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37001 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Per\u00e1n-Teruel","sequence":"additional","affiliation":[{"name":"Department of Urology of Arnau de Vilanova Hospital, 46015 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-2761","authenticated-orcid":false,"given":"Jos\u00e9-Antonio","family":"Mir\u00f3n-Canelo","sequence":"additional","affiliation":[{"name":"Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Biomedical and Diagnostic Sciences of University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Bego\u00f1a","family":"Garc\u00eda-Cenador","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37001 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-3408","authenticated-orcid":false,"given":"Mar\u00eda-Fernanda","family":"Lorenzo-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of 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Rev."},{"key":"ref_3","unstructured":"Padilla-Fern\u00e1ndez, B.-Y., Garc\u00eda-Cenador, M.-B., Collazos-Robles, R.-E., Garc\u00eda-S\u00e1nchez, M.-H., Garc\u00eda-S\u00e1nchez, A., and Lorenzo-G\u00f3mez, M.-F. (2012, January 15\u201319). Cystourethrogram for the indication of cystocele\u2019s surgical correction after trasobturator tape due to urinary incontinence. Proceedings of the 42nd Annual meeting of the International Continence Society (ICS), Beijing, China."},{"key":"ref_4","unstructured":"Licameli-Castelli, P.-R. (2019). Factores Relacionados con el Riesgo Anest\u00e9sico que Influyen en la Recuperaci\u00f3n Funcional Despu\u00e9s de la Correcci\u00f3n Quir\u00fargica del Cistocele. [Original Experimental Research], Universidad de Salamanca."},{"key":"ref_5","unstructured":"Padilla-Fern\u00e1ndez, B., Rodr\u00edguez-Mart\u00edn, M.D.L.O., Garc\u00eda-S\u00e1nchez, M.-E., Navarro-Galmes, M.-A., L\u00f3pez-Dom\u00ednguez, E.-M., L\u00f3pez-Marcos, J., Garc\u00eda-Garc\u00eda, M.-A., and Lorenzo-G\u00f3mez, M.F. (2019, January 25\u201327). Long term results (14 years) of cystocele surgical correction with modified Shull\u2019s technique plus transobturatorsuburethral sling KIM-SYSTEM\u00ae. Proceedings of the VI Annual Meeting of the Mediterranean Incontinence and Pelvic Floor Society, Barcelona, Spain."},{"key":"ref_6","first-page":"765","article-title":"Etiopathogenic, therapeutic and histopathological aspects upon the anterior vaginal wall prolapse","volume":"56","author":"Badi","year":"2015","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_7","unstructured":"Salinas, J., and Rapariz, J. (1994). Reeducaci\u00f3n v\u00e9sico-esfinteriana. Urodin\u00e1mica Cl\u00ednica, Jarpyo."},{"key":"ref_8","unstructured":"Perry, J. (1994). General Letter for Insurance Appeals (Biofeedback) Pelvic Muscle Rehabilitation (EMG Biofeedback) for Urinary & Fecal Incontinence and Related Disorders Using Perry Vaginal TM and Perry Anal TM Sensors, Biofeedback Society of California."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/0002-9378(92)91567-T","article-title":"Preoperative and postoperative analysis of site-specific pelvic support defects in 81 women treated with sacrospinous ligament suspension and pelvic reconstruction","volume":"166","author":"Shull","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.acuro.2015.02.007","article-title":"Jurisprudencia espa\u00f1ola en denuncias relacionadas con la cirug\u00eda del suelo pelviano","volume":"39","year":"2015","journal-title":"Actas Urol. Esp."},{"key":"ref_11","first-page":"771","article-title":"The Spanish version of the SF-36 Health Survey (the SF-36 health questionnaire): An instrument for measuring clinical results","volume":"104","author":"Alonso","year":"1995","journal-title":"Med. Clin. (Barc.)"},{"key":"ref_12","unstructured":"Lorenzo-G\u00f3mez, M.F., Padilla-Fern\u00e1ndez, B., Rodr\u00edguez, A.J.V., Valverde-Mart\u00ednez, L.S., Garc\u00eda-Garc\u00eda, M.A., and Huertos, A.N. (2014, January 11\u201313). Acomodaci\u00f3n vesical y fugas con la tos seg\u00fan el grado de cistocele. Proceedings of the XIII Congreso Internacional Sinug (Sociedad Iberoamericana de Neurourolog\u00eda y Uroginecolog\u00eda), San Sebastian, Spain."},{"key":"ref_13","unstructured":"Lorenzo-G\u00f3mez, M.F., Padilla-Fern\u00e1ndez, B., Virseda-Rodr\u00edguez, A.J., Salvatierra-P\u00e9rez, C., Garc\u00eda-Garc\u00eda, M.A., and G\u00f3mez-Garc\u00eda, A. (2014, January 11\u201313). Hallazgos urodin\u00e1micos y segundos diagn\u00f3sticos en estudios urodin\u00e1micos indicados por cistocele. Proceedings of the XIII Congreso Internacional Sinug (Sociedad Iberoamericana de Neurourolog\u00eda y Uroginecolog\u00eda), San Sebastian, Spain."},{"key":"ref_14","unstructured":"Noya-Mourullo, A., Coderque-Mej\u00eda, M.-P., Hern\u00e1ndez-S\u00e1nchez, T., Rocha-De-Lossada, A., Padilla-Fern\u00e1ndez, B., Rodr\u00edguez-Martin, M.D.L.O., Garc\u00eda-S\u00e1nchez, M.H., L\u00f3pez-Dom\u00ednguez, E.M., L\u00f3pez-Marcos, J., and Garc\u00eda-Garc\u00eda, M.A. (2019, January 12\u201316). Evoluci\u00f3n a largo plazo (14 a\u00f1os) de la correcci\u00f3n del cistocele con la t\u00e9cnica de Shull modificada m\u00e1s colocaci\u00f3n de cinta suburetral transobturatriz KIM SYSTEM\u00ae. Proceedings of the LXXXIV Congreso Nacional de Urolog\u00eda, Bilbao, Spain."},{"key":"ref_15","unstructured":"Virseda-Rodr\u00edguez, A., Padilla-Fern\u00e1ndez, B., Collazos-Robles, R., Garc\u00eda-Cenador, M., Lorenzo-G\u00f3mez, A., Conde-Palacios, A., Garc\u00edaGarc\u00eda, M.\u00c1., and LorenzoG\u00f3mez, M.F. (2016, January 15\u201318). Resultados funcionales a largo plazo de la correcci\u00f3n del cistocele con la t\u00e9cnica de Shull modificada m\u00e1s colocaci\u00f3n de cinta suburetral transobturatriz. Proceedings of the LXXXI Congreso Nacional de Urolog\u00eda, Toledo, Spain."},{"key":"ref_16","unstructured":"Collazos-Robles, R., Corti\u00f1as-D\u00edez, I., Garc\u00eda-Cenador, M., Padilla-Fern\u00e1ndez, B., and Lorenzo-G\u00f3mez, M. (2016, January 14\u201316). Riesgo de recidiva despu\u00e9s de la correcci\u00f3n quir\u00fargica del cistocele sin malla m\u00e1s colocaci\u00f3n de cinta suburetral transobturatriz. Proceedings of the VIII Congreso Nacional de Suelo P\u00e9lvico, Granada, Spain."},{"key":"ref_17","unstructured":"Padilla-Fern\u00e1ndez, B., Gil-Vicente, A., Virseda-Rodr\u00edguez, A., Nieto-Huerto, A., Dur\u00e1n-\u00c1lvarez, C., Silva-Abu\u00edn, J., and Lorenzo-G\u00f3mez, M. (2013, January 12\u201316). Infecci\u00f3n urinaria y tratamiento quir\u00fargico en pacientes con cistocele con o sin incontinencia urinaria de esfuerzo previa. Proceedings of the LXXVIII Congreso Nacional de Urolog\u00eda, Granada, Spain."},{"key":"ref_18","unstructured":"Padilla-Fern\u00e1ndez, B., Gil-Vicente, A., Virseda-Rodr\u00edguez, A., Nieto-Huertos, A., Adriazola-Semino, M., Silva-Abu\u00edn, J., and Lorenzo-G\u00f3mez, M.-F. (2013, January 13\u201316). Tratamiento quir\u00fargico del cistocele con o sin incontinencia urinaria de esfuerzo previa con cinta suburetral simult\u00e1nea. Proceedings of the LXXVIII Congreso Nacional de Urolog\u00eda, Granada, Spain."},{"key":"ref_19","unstructured":"Collazos-Robles, R., Padilla-Fern\u00e1ndez, B., Garc\u00eda-Sanchez, M., Garc\u00eda-S\u00e1nchez, A., Garc\u00eda-Iglesias, A., and Lorenzo-G\u00f3mez, M. (2013, January 22\u201325). Correcci\u00f3n o Aparici\u00f3n de Incontinencia Urinaria en la Reparaci\u00f3n Quir\u00fargica del Cistocele. Proceedings of the XXXII Congreso Nacional de la Sociedad Espa\u00f1ola de Ginecolog\u00eda y Obstetricia (SEGO), Tenerife, Spain."},{"key":"ref_20","unstructured":"Collazos-Robles, R., Padilla-Fern\u00e1ndez, B., Garc\u00eda-Sanchez, M., Garc\u00eda-S\u00e1nchez, A., Garc\u00eda-Iglesias, A., Dur\u00e1n-\u00c1lvarez, C., and Lorenzo-G\u00f3mez, M.F. (2013, January 22\u201325). Correcci\u00f3n quir\u00fargica de cistocele e infecci\u00f3n urinaria. Proceedings of the XXXII Congreso Nacional de la Sociedad Espa\u00f1ola de Ginecolog\u00eda y Obstetricia (SEGO), Tenerife, Spain."},{"key":"ref_21","unstructured":"Dom\u00ednguez-G\u00f3mez, R., Barroso-L\u00f3pez, K., Cantero-Acedo, A., Dom\u00ednguez-Garc\u00eda, J., Duque-Holgera, V., and Elvira-Laffond, A. (April, January 30). Factores que influyen en los resultados de la correcci\u00f3n quir\u00fargica del cistocele. Proceedings of the XIII Congreso Nacional de Investigaci\u00f3n de Grado en cc de la Salud, Madrid, Spain."},{"key":"ref_22","unstructured":"S\u00e1nchez-Borrego, B., Livianos-Arias-Camis\u00f3n, P., Melgosa-Ramos, J., Refoyo-Matell\u00e1n, B., Santos-do-Vale, S., and Siesto-L\u00f3pez, G.M. (April, January 30). Resultados de la correcci\u00f3n del cistocele con la t\u00e9cnica de Shull modificada. Proceedings of the XIII Congreso Nacional de Investigaci\u00f3n de Grado en cc de la Salud, Madrid, Spain."},{"key":"ref_23","unstructured":"Garcia-Cenador, M., Padilla-Fernandez, B., Collazos-Robles, R., Garcia-Sanchez, M., Garcia-Sanchez, A., and Lorenzo-Gomez, M. (2013, January 26\u201330). Intraoperative and Postoperative Bleeding During cystocele\u2019s surgical Correction depending on Anticoagulant\/antiaggregant concurrent treatment. Proceedings of the 43rd Annual Meeting of the International Continence Society, Barcelona, Spain."},{"key":"ref_24","unstructured":"Lorenzo-Gomez, M.-F., Padilla-Fernandez, B.-Y., Valverde\u2013Martinez, L.-S., Virseda-Rodriguez, A., Gil-Vicente, A., Garcia-Criado, F.-J., and Silva-Abuin, J.-M. (2013, January 26\u201330). Cystocele and urinary incontinence correction using sling with whipstitch edges. Proceedings of the 43rd Annual Meeting of the International Continence Society, Barcelona, Spain."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0889-8545(05)70039-5","article-title":"Epidemiology and natural history of pelvic floor dysfunction","volume":"25","author":"Bump","year":"1998","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.acuro.2011.03.009","article-title":"Factores de riesgo de fracaso de la correcci\u00f3n quir\u00fargica de la incontinencia urinaria de esfuerzo mediante cinta suburetral transobturatriz","volume":"35","year":"2011","journal-title":"Actas Urol. Esp."},{"key":"ref_27","unstructured":"Bonkat, G., Bartoletti, R., Bruy\u00e8re, F., Cai, T., Geerlings, S.E., K\u00f6ves, B., Schubert, S., Wagenlehner, F., Mezei, T., and Pilatz, A. (2020). EAU Guidelines on Urological Infections, \u00a9European-Association-of-Urology-2020."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/1756287215576648","article-title":"Urinary tract infections in women with stress urinary incontinence treated with transobturator suburethral tape and benefit gained from the sublingual polibacterial vaccine","volume":"7","author":"Lorenzo","year":"2015","journal-title":"Ther. Adv. Urol."},{"key":"ref_29","unstructured":"Borrego-Jim\u00e9nez, P.-S. (2016). Fisioterapia y Calidad de Vida Relacionada con la Salud en los Trastornos Inflamatorios Cr\u00f3nicos, Infecciosos y no Infecciosos, del Tracto Urinario Inferior Femenino, Universidad de Salamanca."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.gyobfe.2010.09.007","article-title":"Postoperative pain after transvaginal repair of pelvic organ prolapse with or without mesh","volume":"38","author":"Niro","year":"2010","journal-title":"Gynecol. Obstet. Fertil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1001\/jama.2009.1268","article-title":"Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: A randomized controlled trial","volume":"302","author":"Daniels","year":"2009","journal-title":"JAMA"},{"key":"ref_32","unstructured":"FDA (2011). Urogynecologic Surgical Mesch: Update on the Safety and Effectiveness of Transvaginal Placement for Pelvic Organ Prolapse, FDA."},{"key":"ref_33","unstructured":"Escribano-Pati\u00f1o, G. (2006). Urolog\u00eda Femenina. Cirug\u00eda reconstructiva del Suelo P\u00e9lvico Incontinencia Urinaria y Prolapso de \u00d3rganos P\u00e9lvicos. I Curso Internacional de Cirug\u00eda de Incontinencia Urinaria y Suelo P\u00e9lvico, Hospital Cl\u00ednico San Carlos."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4081\/aiua.2013.3.149","article-title":"Results of the surgical correction of urinary stress incontinence according to the type of transobturator tape utilized","volume":"85","year":"2013","journal-title":"Arch. Ital. Urol. Androl."},{"key":"ref_35","unstructured":"Manzano-Tom\u00e9, C., Rodr\u00edguez-Mart\u00edn, M.D.L.O., Hern\u00e1ndez-S\u00e1nchez, T., N\u00fa\u00f1ez-Otero, J.-J., Coderque-Mej\u00eda, M.-P., and Lorenzo-G\u00f3mez, M.-F. (2017). Factores Relacionados con las Caracter\u00edsticas de los Biomateriales que Influyen en la Eficacia en Procedimientos en Suelo Pelviano. V Reuni\u00f3n Asturcastellanoleonesa de Urolog\u00eda San Zoilo, Asociaci\u00f3n-Castellano-Leonesa-de-Urolog\u00eda."},{"key":"ref_36","unstructured":"Lorenzo-Gomez, M.-F. (2018). Biomateriales. I Jornadas Nacionales de Terapias Biotecnol\u00f3gicas, Federaci\u00f3n-Espa\u00f1ola-de-Biotecn\u00f3logos-y-Asociaci\u00f3n-de-Biotecnolog\u00eda-de-Salamanca-ABSAL\u00a9."},{"key":"ref_37","first-page":"261","article-title":"Relaci\u00f3n de factores asociados con la inflamaci\u00f3n en el pron\u00f3stico de la utilizaci\u00f3n de biomateriales en suelo pelviano masculino","volume":"73","year":"2017","journal-title":"Sanid. Mil."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/10\/3310\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:21:50Z","timestamp":1760178110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/10\/3310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,15]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["jcm9103310"],"URL":"https:\/\/doi.org\/10.3390\/jcm9103310","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,15]]}}}