{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:59:26Z","timestamp":1778547566149,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The aim of the study is to assess whether lung function of infants born preterm predicts wheezing in pre-school age. Methods: A survey of the core wheezing questionnaire of the International Study on Asthma and Allergy in Children was administered to parents of preterm newborns, to whom lung function tests were performed at a corrected age of six months, and who, at the time of the survey, were between three and nine years of age. Results: Low values of all lung function parameters measured, except FVC, were predictors of wheezing at some time in life, (FEV0.5 OR: 0.62 (95%CI 0.39; 0.995); FEV0.5\/FVC OR: 0.73 (0.54; 0.99)) FEF75 OR: 0.60 [0.37; 0.93]; FEF25-75 OR: 0.57 (0.37; 0.89)); and of wheezing in the past year (FEV0.5 OR: 0.36 (0.17; 0.76); FEV0.5\/FVC OR: 0.59 (0.38; 0.93); FEF75 OR: 0.38 [0.19; 0.76]; FEF25-75 OR: 0.35 (0.17; 0.70). In addition, FEV0.5\/FVC values lower than the lowest limit of normality, were predictive of hospital admissions due to wheezing (OR: 3.07; (1.02; 9.25)). Conclusions: Limited lung function in infancy is predictive of both future wheezing and hospitalization for a wheezing episode.<\/jats:p>","DOI":"10.3390\/jcm9103345","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T21:26:06Z","timestamp":1603056366000},"page":"3345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Preschool Asthma Symptoms in Children Born Preterm: The Relevance of Lung Function in Infancy"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9642-0613","authenticated-orcid":false,"given":"Manuel","family":"Sanchez-Solis","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Unit, Virgen de la Arrixaca University Hospital, Murcia University, 30003 Murcia, Spain"},{"name":"Department of Surgery, Pediatrics, Obstetrics and Gynecology, University of Murcia, 30003 Murcia, Spain"},{"name":"Arrixaca Bioresearch Institute of Murcia, 30003 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Soledad","family":"Parra-Carrillo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Pediatrics, Obstetrics and Gynecology, University of Murcia, 30003 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Mondejar-Lopez","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Virgen de la Arrixaca University Hospital, Murcia University, 30003 Murcia, Spain"},{"name":"Department of Surgery, Pediatrics, Obstetrics and Gynecology, University of Murcia, 30003 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia W","family":"Garcia-Marcos","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Virgen de la Arrixaca University Hospital, Murcia University, 30003 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0925-3851","authenticated-orcid":false,"given":"Luis","family":"Garcia-Marcos","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Virgen de la Arrixaca University Hospital, Murcia University, 30003 Murcia, Spain"},{"name":"Department of Surgery, Pediatrics, Obstetrics and Gynecology, University of Murcia, 30003 Murcia, Spain"},{"name":"Arrixaca Bioresearch Institute of Murcia, 30003 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.jaci.2013.12.1082","article-title":"Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children","volume":"133","author":"Arends","year":"2014","journal-title":"J. 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