{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:45:02Z","timestamp":1790808302806,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1C1C1005724"],"award-info":[{"award-number":["NRF-2020R1C1C1005724"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["a faculty research grant of Yonsei University College of  Medicine (3-2019-0161)"],"award-info":[{"award-number":["a faculty research grant of Yonsei University College of  Medicine (3-2019-0161)"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: Aging is a major risk factor for many neurological disorders and is associated with dural lymphatic dysfunction. We sought to evaluate the association of aging with the volume of the peri-sinus lymphatic space using contrast-enhanced 3T T1-weighted black-blood magnetic resonance imaging (MRI). Methods: In this retrospective study, 165 presumed neurologically normal subjects underwent brain MRIs for cancer staging between April and November 2018. The parasagittal peri-sinus lymphatic space was evaluated using contrast-enhanced 3D T1-weighted black-blood MRIs, and volumes were measured with semiautomatic method. We compared the volumes of normalized peri-sinus lymphatic spaces between the elderly (\u226565 years, n = 72) and non-elderly (n = 93) groups and performed multivariate logistic regression analyses to assess if aging is independently associated with the volume of normalized peri-sinus lymphatic spaces. Results: The normalized peri-sinus lymphatic space volume was significantly higher in the elderly than in the non-elderly (mean, 3323 \u00b1 758.7 mL vs. 2968.7 \u00b1 764.3 mL, p = 0.047). After adjusting the intracranial volume, age age was the strongest factor independently associated with peri-sinus lymphatic space volume (\u03b2 coefficient, 28.4 (5.7\u201351.2), p = 0.015) followed by male sex (\u03b2 coefficient, 672.4 (113.5\u20131230.8), p = 0.019). Conclusions: We found that the peri-sinus dural lymphatic space volume was higher in the elderly group than in the non-elderly group, and the increased peri-sinus lymphatic space was independently associated with aging. These findings indicate that the peri-sinus lymphatic space may be related with the aging process and lymphatic system dysfunction as well.<\/jats:p>","DOI":"10.3390\/jcm9103353","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T09:36:28Z","timestamp":1603100188000},"page":"3353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI"],"prefix":"10.3390","volume":"9","author":[{"given":"Mina","family":"Park","sequence":"first","affiliation":[{"name":"Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3155-0569","authenticated-orcid":false,"given":"Jin Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-4064","authenticated-orcid":false,"given":"Yoon Jin","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7098-4901","authenticated-orcid":false,"given":"Sang Hyun","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/268068a0","article-title":"Immunological tolerance and tumor allografts in the brain","volume":"268","author":"Hasek","year":"1977","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e121537","DOI":"10.1172\/jci.insight.121537","article-title":"Brain-wide glymphatic enhancement and clearance in humans assessed with mri","volume":"3","author":"Ringstad","year":"2018","journal-title":"JCI Insight"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1743-8454-7-9","article-title":"The function and structure of the cerebrospinal fluid outflow system","volume":"7","author":"Pollay","year":"2010","journal-title":"Cerebrospinal. 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