{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:43:58Z","timestamp":1790214238331,"version":"4.1.0"},"reference-count":18,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Dilated Cardiomyopathy (DCM) has a straightforward and apparently \u201csimple\u201d definition: a heart muscle disease characterized by left ventricular (LV) or biventricular dilation and systolic dysfunction in the absence of either pressure or volume overload or coronary artery disease sufficient enough to explain the dysfunction [...]<\/jats:p>","DOI":"10.3390\/jcm9113385","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T02:01:42Z","timestamp":1603418502000},"page":"3385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dilated Cardiomyopathy: A Paradigm of Revolution in Medicine"],"prefix":"10.3390","volume":"9","author":[{"given":"Marco","family":"Merlo","sequence":"first","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-6297","authenticated-orcid":false,"given":"Antonio","family":"Cannat\u00e0","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, 34100 Trieste, Italy"},{"name":"James Black Centre, School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, 125 Coldharbour Lane, London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: A position statement from the european society of cardiology working group on myocardial and pericardial diseases","volume":"29","author":"Elliott","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Merlo, M., Cannat\u00e0, A., Loco, C.P., Stolfo, D., Barbati, G., Artico, J., Gentile, P., De Paris, V., Ramani, F., and Zecchin, M. Contemporary survival trends and aetiological characterization in non-ischaemic dilated cardiomyopathy. Eur. J. Heart Fail., 2020.","DOI":"10.1002\/ejhf.1914"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ejhf.1103","article-title":"Evolving concepts in dilated cardiomyopathy","volume":"20","author":"Merlo","year":"2018","journal-title":"Eur. J. Heart Fail."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sinagra, G., Elliott, P.M., and Merlo, M. (2019). Dilated cardiomyopathy: So many cardiomyopathies!. Eur. Heart J., ehz908.","DOI":"10.1007\/978-3-030-13864-6"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Law, M.L., Cohen, H., Martin, A.A., Angulski, A.B.B., and Metzger, J.M. (2020). Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020520"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Asatryan, B. (2019). Cardiac Sodium Channel Dysfunction and Dilated Cardiomyopathy: A Contemporary Reappraisal of Pathophysiological Concepts. J. Clin. Med., 8.","DOI":"10.3390\/jcm8071029"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Gi, W.-T., Haas, J., Sedaghat-Hamedani, F., Kayvanpour, E., Tappu, R., Lehmann, D.H., Shirvani Samani, O., Wisdom, M., Keller, A., and Katus, H.A. (2020). Epigenetic Regulation of Alternative mRNA Splicing in Dilated Cardiomyopathy. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051499"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1161\/CIRCRESAHA.119.313569","article-title":"Novel Therapies for Prevention and Early Treatment of Cardiomyopathies","volume":"124","author":"Repetti","year":"2019","journal-title":"Circ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1093\/hmg\/dds265","article-title":"Abnormal p38 mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A\/C gene mutation","volume":"21","author":"Muchir","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kub\u00e1nek, M., Schimerov\u00e1, T., Piherov\u00e1, L., Brodehl, A., Krebsov\u00e1, A., Ratnavadivel, S., Stanasiuk, C., Hans\u00edkov\u00e1, H., Zeman, J., and Pale\u010dek, T. (2020). Desminopathy: Novel Desmin Variants, a New Cardiac Phenotype, and Further Evidence for Secondary Mitochondrial Dysfunction. J. Clin. Med., 9.","DOI":"10.3390\/jcm9040937"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chmielewski, P., Michalak, E., Kowalik, I., Franaszczyk, M., Sobieszczanska-Malek, M., Truszkowska, G., Stepien-Wojno, M., Biernacka, E.K., Foss-Nieradko, B., and Lewandowski, M. (2020). Can Circulating Cardiac Biomarkers Be Helpful in the Assessment of LMNA Mutation Carriers?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051443"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Tharp, C., Mestroni, L., and Taylor, M. (2020). Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092770"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Stronati, G., Guerra, F., Urbinati, A., Ciliberti, G., Cipolletta, L., and Capucci, A. (2019). Tachycardiomyopathy in Patients without Underlying Structural Heart Disease. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091411"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Adorisio, R., Mencarelli, E., Cantarutti, N., Calvieri, C., Amato, L., Cicenia, M., Silvetti, M., D\u2019Amico, A., Grandinetti, M., and Drago, F. (2020). Duchenne Dilated Cardiomyopathy: Cardiac Management from Prevention to Advanced Cardiovascular Therapies. J. Clin. Med., 9.","DOI":"10.3390\/jcm9103186"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cannata, A., Manca, P., Nuzzi, V., Gregorio, C., Artico, J., Gentile, P., Pio Loco, C., Ramani, F., Barbati, G., and Merlo, M. (2020). Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling. J. Clin. Med., 9.","DOI":"10.3390\/jcm9082426"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Cojan-Minzat, B.O., Zlibut, A., Muresan, I.D., Cionca, C., Horvat, D., Kiss, E., Revnic, R., Florea, M., Ciortea, R., and Agoston-Coldea, L. (2020). Left Ventricular Geometry and Replacement Fibrosis Detected by cMRI Are Associated with Major Adverse Cardiovascular Events in Nonischemic Dilated Cardiomyopathy. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061997"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Byty\u00e7i, I., Bajraktari, G., Lindqvist, P., and Henein, M.Y. (2020). Improved Left Atrial Function in CRT Responders: A Systematic Review and Meta-Analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020298"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hirono, K., Hata, Y., Miyao, N., Okabe, M., Takarada, S., Nakaoka, H., Ibuki, K., Ozawa, S., Yoshimura, N., and Nishida, N. (2020). Left Ventricular Noncompaction and Congenital Heart Disease Increases the Risk of Congestive Heart Failure. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030785"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/11\/3385\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:25:50Z","timestamp":1760178350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/11\/3385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":18,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["jcm9113385"],"URL":"https:\/\/doi.org\/10.3390\/jcm9113385","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]}}}