{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:38:48Z","timestamp":1763037528629,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Osteonecrosis of the jaw (ONJ) is a disease that affects the jaw. It is mainly related to radiation or bisphosphonates therapy, and the symptoms and signs consist of pain, bone exposure, inflammation of the surrounding soft tissue swelling, and secondary infection or drainage. In the case of advanced disease of the mandibular area, the treatment of choice is mandibular resection and reconstruction. In the present study, we report a case series of patients affected by ONJ and treated with a customised bridging mandibular prosthesis-only technique. From 2016 to 2018, we treated five consecutive patients affected by ONJ: three patients were affected by biphosphonate-related osteonecrosis of the mandible (BRONJ) and two were affected by osteoradionecrosis of the mandible (ORNJ). Three patients needed a soft tissue free flap to permit optimal wound closure, intra- and\/or extraorally. All reconstructive procedures were carried out successfully, with no major or minor microvascular complication. The average postoperative follow-up was 24.8 (range 10\u201341) months. Considering that microvascular bone transfer is a high-risk procedure in BRONJ patients, we can conclude that the positioning of a customised bridging mandibular prosthesis (CBMP), whether or not associated with a microvascular soft tissue transfer, is a safe technique in terms of surgical outcome and feasibility.<\/jats:p>","DOI":"10.3390\/jcm9113516","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T09:29:32Z","timestamp":1604050172000},"page":"3516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of CAD\u2013CAM Bridging Mandibular Prosthesis in Osteonecrosis of the Jaw: The Experience of Our School"],"prefix":"10.3390","volume":"9","author":[{"given":"Francesco","family":"Ricotta","sequence":"first","affiliation":[{"name":"Oral and Maxillo-Facial Surgery Unit, IRCCS Policlinico di Sant\u2019Orsola, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40100 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Oral and Maxillo-Facial Surgery Unit, IRCCS Policlinico di Sant\u2019Orsola, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40100 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Bolognesi","sequence":"additional","affiliation":[{"name":"Oral and Maxillo-Facial Surgery Unit, IRCCS Policlinico di Sant\u2019Orsola, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40100 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ceccariglia","sequence":"additional","affiliation":[{"name":"Oral and Maxillo-Facial Surgery Unit, IRCCS Policlinico di Sant\u2019Orsola, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40100 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4178-4257","authenticated-orcid":false,"given":"Claudio","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Oral and Maxillo-Facial Surgery Unit, IRCCS Policlinico di Sant\u2019Orsola, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40100 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5815-7591","authenticated-orcid":false,"given":"Achille","family":"Tarsitano","sequence":"additional","affiliation":[{"name":"Oral and Maxillo-Facial Surgery Unit, IRCCS Policlinico di Sant\u2019Orsola, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40100 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM200507073530120","article-title":"Osteonecrosis of the jaw and bisphosphonates","volume":"353","author":"Durie","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4317\/jced.51213","article-title":"Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw-prognostic factors in the treatment of BRONJ","volume":"6","author":"Yoshiga","year":"2014","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/ans.13274","article-title":"Mandibular reconstruction: Meta-analysis of iliac versus fibula free flaps","volume":"86","author":"Lonie","year":"2016","journal-title":"ANZ J. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5999\/aps.2016.43.1.3","article-title":"Mandibular reconstruction using the free vascularized fibula graft: An overview of different modifications","volume":"43","author":"Kokosis","year":"2016","journal-title":"Arch. Plast. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.14639\/0392-100X-2408","article-title":"Use of a CAD-CAM inferior alveolar nerve salvage template during mandibular resection for benign lesions","volume":"39","author":"Ricotta","year":"2019","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1097\/SCS.0000000000006121","article-title":"Surgical Management of Primary Chronic Osteomyelitis of the Jaws: The Use of Computer-Aided-Design\/Computer-Aided Manufacturing Technology for Segmental Mandibular Resection","volume":"31","author":"Bolognesi","year":"2020","journal-title":"J. Craniofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jormas.2017.10.014","article-title":"Fibrous condylar dysplasia: Resection and reconstruction with a custom-made TMJ prosthesis using virtual surgical planning","volume":"119","year":"2018","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/hed.10181","article-title":"Primary oromandibular reconstruction using free flaps and thorp plates in cancer patients: A 5-year experience","volume":"25","author":"Poli","year":"2003","journal-title":"Head Neck"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/lary.24230","article-title":"Replacement of fractured reconstruction plate with customized mandible implant: A novel technique","volume":"124","author":"Bedogni","year":"2014","journal-title":"Laryngoscope"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1245\/s10434-014-4322-1","article-title":"Plate exposure after anterolateral thigh free-flap reconstruction in head and neck cancer patients with composite mandibular defects","volume":"22","author":"Fanzio","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0278-2391(92)90186-4","article-title":"Evaluation of mandibular reconstruction techniques following resection of malignant tumors in the oral region","volume":"50","author":"Kudo","year":"1992","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/micr.22090","article-title":"Clinical factors associated with postoperative complications and the functional outcome in mandibular reconstruction","volume":"33","author":"Tsuchiya","year":"2013","journal-title":"Microsurgery"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/SCS.0000000000000656","article-title":"Evaluation of plate-related complications and efficacy in fibula free flap mandibular reconstruction","volume":"25","author":"Zavattero","year":"2014","journal-title":"J. Craniofac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.14639\/0392-100X-1250","article-title":"Design of a customised bridging mandibular prosthesis for complex reconstruction: A pilot study","volume":"37","author":"Tarsitano","year":"2017","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.jcms.2015.08.006","article-title":"Mandibular reconstructions using computer-aided design\/computer-aided manufacturing: A systematic review of a defect-based reconstructive algorithm","volume":"43","author":"Tarsitano","year":"2015","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.jcms.2018.05.010","article-title":"Accuracy of CAD\/CAM mandibular reconstruction: A three-dimensional, fully virtual outcome evaluation method","volume":"46","author":"Tarsitano","year":"2018","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijom.2008.11.026","article-title":"A selective laser sintering guide for transferring a virtual plan to real time surgery in composite mandibular reconstruction with free fibula osseous flaps","volume":"38","author":"Leiggener","year":"2009","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/01.sap.0000205830.39108.9a","article-title":"Complications in a consecutive series of 250 free flap operations","volume":"56","author":"Classen","year":"2006","journal-title":"Ann. Plast. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.oraloncology.2005.03.006","article-title":"Long-term outcome and factors influencing bridging plates for mandibular reconstruction","volume":"41","author":"Okura","year":"2005","journal-title":"Oral Oncol."},{"key":"ref_22","first-page":"362","article-title":"Reporting fidelity in the literature for computer aided design and additive manufacture of implants and guides","volume":"23","author":"Burton","year":"2018","journal-title":"Addit. Manuf."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jcms.2016.04.003","article-title":"Is a computer-assisted design and computer-assisted manufacturing method for mandibular reconstruction economically viable?","volume":"44","author":"Tarsitano","year":"2016","journal-title":"J. Craniomaxillofac. 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