{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:26:45Z","timestamp":1789147605192,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Psoriasis is an inflammatory skin disease presenting with erythematous and desquamative plaques with sharply demarcated margins, usually localized on extensor surface areas. Objective: To describe the common differential diagnosis of plaque psoriasis classified according to its topography in the scalp, trunk, extremities, folds (i.e., inverse), genital, palmoplantar, nail, and erythrodermic psoriasis. Methods: A narrative review based on an electronic database was performed including reviews and original articles published until 1 September 2020, assessing the clinical presentations and differential diagnosis for psoriasis. Results: Several differential diagnoses could be considered with other inflammatory, infectious, and\/or neoplastic disorders. Topographical differential diagnosis may include seborrheic dermatitis, tinea capitis, lichen planopilaris in the scalp; lupus erythematosus, dermatomyositis, cutaneous T-cell lymphomas, atopic dermatitis, syphilis, tinea corporis, pityriasis rubra pilaris in the trunk and arms; infectious intertrigo in the inguinal and intergluteal folds and eczema and palmoplantar keratoderma in the palms and soles. Conclusions: Diagnosis of psoriasis is usually straightforward but may at times be difficult and challenging. Skin cultures for dermatophytes and\/or skin biopsy for histological examination could be required for diagnostic confirmation of plaque psoriasis.<\/jats:p>","DOI":"10.3390\/jcm9113594","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T19:03:37Z","timestamp":1604862217000},"page":"3594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Topographic Differential Diagnosis of Chronic Plaque Psoriasis: Challenges and Tricks"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-9001","authenticated-orcid":false,"given":"Paolo","family":"Gisondi","sequence":"first","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-6921","authenticated-orcid":false,"given":"Francesco","family":"Bellinato","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-0493","authenticated-orcid":false,"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, Clinical Presentation, and Treatment of Psoriasis","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jaad.2019.08.023","article-title":"Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and \u03b2-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor \u03b1 inhibitor\u2013associated dermatitis","volume":"82","author":"Cohen","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ji, Y.-Z., and Liu, S.-R. (2019). Koebner phenomenon leading to the formation of new psoriatic lesions: Evidences and mechanisms. Biosci. Rep., 39.","DOI":"10.1042\/BSR20193266"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF01822714","article-title":"Ueber das verhaltniss der oberhaut zur papillarschicht","volume":"2","author":"Auspitz","year":"1870","journal-title":"Arch. Dermatol. Syph."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/00128071-200102030-00005","article-title":"Psoriasis of the Scalp","volume":"2","author":"Franssen","year":"2001","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1590\/abd1806-4841.20164951","article-title":"Pityriasis amiantacea: A study of seven cases","volume":"91","author":"Amorim","year":"2016","journal-title":"An. Bras. Dermatol."},{"key":"ref_8","first-page":"10","article-title":"Seborrheic Dermatitis and Dandruff: A Comprehensive Review","volume":"3","author":"Borda","year":"2015","journal-title":"J. Clin. Investig. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/jdv.15344","article-title":"Dermoscopic features of psoriasis of the skin, scalp and nails\u2014A systematic review","volume":"33","author":"Rudnicka","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(00)90001-X","article-title":"Tinea capitis: A current perspective","volume":"42","author":"Elewski","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11046-016-0058-8","article-title":"Tinea Capitis: Current Status","volume":"182","author":"Hay","year":"2017","journal-title":"Mycopathologia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7573\/dic.2020-9-3","article-title":"Tinea corporis: An updated review","volume":"9","author":"Leung","year":"2020","journal-title":"Drugs Context"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s13555-019-00350-1","article-title":"Trichoscopy of Tinea Capitis: A Systematic Review","volume":"10","author":"Rakowska","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.sder.2008.12.006","article-title":"Lichen planopilaris: Uptade on diagnosis and treatment","volume":"28","author":"Assouly","year":"2009","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1529-8019.2008.00206.x","article-title":"Lichen planopilaris","volume":"21","author":"Kang","year":"2008","journal-title":"Dermatol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Maurelli, M., Colato, C., Tessari, G., and Girolomoni, G. (2020). Lichen planopilaris coexisting with plaque psoriasis effectively treated with brodalumab. Dermatol. Ther., e13967.","DOI":"10.1111\/dth.13967"},{"key":"ref_17","first-page":"241","article-title":"To treat or not to treat? Management of guttate psoriasis and pityriasis rosea in patients with evidence of group A Streptococcal infection","volume":"9","author":"Krishnamurthy","year":"2010","journal-title":"J. Drugs Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3899\/jrheum.090216","article-title":"Differential Diagnosis of Psoriasis","volume":"83","author":"Balato","year":"2009","journal-title":"J. Rheumatol. Suppl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000445375","article-title":"Pityriasis Rosea: A Comprehensive Classification","volume":"232","author":"Drago","year":"2016","journal-title":"Dermatology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1046\/j.1365-4362.2002.01627.x","article-title":"Atypical pityriasis rosea or psoriasis guttata? Early examination is the key to a correct diagnosis","volume":"41","author":"Eslick","year":"2002","journal-title":"Int. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s40257-017-0338-1","article-title":"A Review on Pityriasis Rubra Pilaris","volume":"19","author":"Wang","year":"2018","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/11530070-000000000-00000","article-title":"Pityriasis Rubra Pilaris","volume":"11","author":"Klein","year":"2010","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1056\/NEJMra1901593","article-title":"The Modern Epidemic of Syphilis","volume":"382","author":"Ghanem","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/ijd.12518","article-title":"The great imitator revisited: The spectrum of atypical cutaneous manifestations of secondary syphilis","volume":"53","author":"Balagula","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11046-016-0038-z","article-title":"Diagnosis of Dermatophytosis Using Molecular Biology","volume":"182","author":"Verrier","year":"2016","journal-title":"Mycopathologia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jaad.2013.08.033","article-title":"Primary cutaneous T-cell lymphoma (mycosis fungoides and S\u00e9zary syndrome): Part I. Diagnosis: Clinical and histopathologic features and new molecular and biologic markers","volume":"70","author":"Jawed","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.clindermatol.2019.01.004","article-title":"Mycosis fungoides: A great imitator","volume":"37","author":"Hodak","year":"2019","journal-title":"Clin. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jaad.2005.07.058","article-title":"Pityriasis lichenoides and its subtypes","volume":"55","author":"Bowers","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2165\/00128071-200708010-00004","article-title":"Pityriasis lichenoides: Pathophysiology, classification, and treatment","volume":"8","author":"Khachemoune","year":"2007","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101440","DOI":"10.1016\/j.berh.2019.101440","article-title":"Suspected inflammatory rheumatic diseases in patients presenting with skin rashes","volume":"33","author":"Alves","year":"2019","journal-title":"Best Pr. Res. Clin. Rheumatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12016-017-8627-2","article-title":"The Cutaneous Spectrum of Lupus Erythematosus","volume":"53","author":"Ribero","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1001\/archderm.1990.01670250058008","article-title":"Histopathologic comparison of the subsets of lupus erythematosus","volume":"126","author":"Jerdan","year":"1990","journal-title":"Arch. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jaad.2018.02.010","article-title":"Lichen planus and lichenoid dermatoses","volume":"79","author":"Tziotzios","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_34","first-page":"136","article-title":"Lichen planus mimicking recalcitrant ulcerative psoriasis: When is it time to biopsy?","volume":"92","author":"Fisher","year":"2013","journal-title":"Cutis"},{"key":"ref_35","first-page":"302","article-title":"Atopic Dermatitis","volume":"396","author":"Beckner","year":"2011","journal-title":"Encycl. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/all.12112","article-title":"Characterization of different courses of atopic dermatitis in adolescent and adult patients","volume":"68","author":"Garmhausen","year":"2013","journal-title":"Allergy"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1046\/j.1529-8019.2003.01635.x","article-title":"Xerosis and pruritus in the elderly: Recognition and management","volume":"16","author":"Norman","year":"2003","journal-title":"Dermatol. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.clindermatol.2017.03.007","article-title":"Typical and atypical clinical appearance of atopic dermatitis","volume":"35","author":"Silverberg","year":"2017","journal-title":"Clin. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2147\/CCID.S189000","article-title":"Inverse Psoriasis: From Diagnosis to Current Treatment Options","volume":"12","author":"Micali","year":"2019","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s40272-015-0137-1","article-title":"Psoriasis in Children and Adolescents: Diagnosis, Management and Comorbidities","volume":"17","author":"Bronckers","year":"2015","journal-title":"Pediatr. Drugs"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2165\/00003495-200262080-00002","article-title":"Management of Cutaneous Erythrasma","volume":"62","author":"Holdiness","year":"2002","journal-title":"Drugs"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1439-0507.2007.01443.x","article-title":"Prevalence of Candida on the tongue and intertriginous areas of psoriatic and atopic dermatitis patients","volume":"51","author":"Leibovici","year":"2007","journal-title":"Mycoses"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2147\/CCID.S127841","article-title":"Recurrent candidal intertrigo: Challenges and solutions","volume":"11","author":"Metin","year":"2018","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_44","first-page":"98","article-title":"Seborrhoeic dermatitis: An update","volume":"20","author":"Bukvic","year":"2012","journal-title":"Acta Derm. Croat"},{"key":"ref_45","first-page":"61","article-title":"Allergic Contact Dermatitis","volume":"2","author":"Scharnagl","year":"2009","journal-title":"Encycl. Mol. Mech. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Quaranta, M., Eyerich, S., Knapp, B., Nasorri, F., Scarponi, C., Mattii, M., Garzorz, N., Harlfinger, A.T., Jaeger, T., and Grosber, M. (2014). Allergic Contact Dermatitis in Psoriasis Patients: Typical, Delayed, and Non-Interacting. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101814"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2133.1992.tb00658.x","article-title":"Hailey\u2013Hailey disease: The clinical features, response to treatment and prognosis","volume":"126","author":"Burge","year":"1992","journal-title":"Br. J. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/09546634.2018.1453125","article-title":"Prevalence of genital psoriasis in patients with psoriasis","volume":"29","author":"Meeuwis","year":"2018","journal-title":"J. Dermatol. Treat."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/PTT.S169389","article-title":"The impact of genital psoriasis on quality of life: A systematic review","volume":"8","author":"Yang","year":"2018","journal-title":"Psoriasis Targets Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/jdv.14096","article-title":"2016 European guideline for the management of vulval conditions","volume":"31","author":"Boffa","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1177\/0956462414533099","article-title":"2013 European guideline for the management of balanoposthitis","volume":"25","author":"Edwards","year":"2014","journal-title":"Int. J. STD AIDS"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clindermatol.2016.09.004","article-title":"Palmoplantar psoriasis","volume":"35","author":"Engin","year":"2017","journal-title":"Clin. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"392","DOI":"10.5114\/reum.2018.80718","article-title":"Psoriasis in special localizations","volume":"56","author":"Dopytalska","year":"2018","journal-title":"Reumatologia"},{"key":"ref_54","first-page":"1","article-title":"The two foot-one hand disease","volume":"13","author":"Curtis","year":"1964","journal-title":"Bull Assoc. Mil. Dermatol."},{"key":"ref_55","first-page":"S7","article-title":"Nail psoriasis","volume":"33","author":"Manhart","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jaad.2017.04.001","article-title":"Nail findings in patients with psoriatic arthritis: A cross-sectional study with special reference to transverse grooves","volume":"77","author":"Zenke","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2005.07.073","article-title":"Psoriasis of the nail: Anatomy, pathology, clinical presentation, and a review of the literature on therapy","volume":"57","author":"Jiaravuthisan","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.autrev.2014.01.008","article-title":"Diagnosis and classification of psoriasis","volume":"13","author":"Raychaudhuri","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"100","DOI":"10.12968\/hosp.2004.65.2.12068","article-title":"Erythroderma: 90% skin failure","volume":"65","author":"Balasubramaniam","year":"2004","journal-title":"Hosp. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1056\/NEJMra1505557","article-title":"Psoriatic arthritis","volume":"376","author":"Ritchlin","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_61","first-page":"173","article-title":"Histopathological aspects of psoriasis and its uncommon variants","volume":"153","author":"Ferreli","year":"2017","journal-title":"G. Ital. Dermatol. Venereol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/11\/3594\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:30:41Z","timestamp":1760178641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/11\/3594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,8]]},"references-count":61,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["jcm9113594"],"URL":"https:\/\/doi.org\/10.3390\/jcm9113594","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,8]]}}}