{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:25:37Z","timestamp":1772133937199,"version":"3.50.1"},"reference-count":19,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Transcatheter device closure of a secundum atrial septal defect (ASD) is followed by a noticeable change in the left atrium (LA) and left ventricle (LV) over a long-term follow-up. This study aimed to assess the remodeling of the atrial and ventricular myocardium with respect to diastolic function in adult ASD patients. Around 38 asymptomatic patients (age: 48.6 \u00b1 17.1 years, range: 23\u201369 years) diagnosed with ASD during routine health check-up and who underwent ASD device closure with the Amplatzer septal occluder were included in this retrospective study, and their medical records (containing echocardiographic data) were reviewed. The defect size was 21.77 + 6.79 mm, while the balloon measurement of the defect was 24.29 \u00b1 6.64 mm. The patients were divided into two groups, namely, Group I (with 18 patients aged &lt;50 years [mean: 33.06 \u00b1 9.43 years] and Group II (with 20 patients aged \u226550 years [mean: 62.55 \u00b1 7.54 years]). Comparison of echocardiographic data collected before closure and at a follow-up 2 years later revealed significant differences between pre-closure and post-closure states in the left ventricular end-diastolic dimension (40.76 \u00b1 3.28 vs. 43.39 \u00b1 3.52), left ventricular mass (99.64 \u00b1 28.81 vs. 116.57 \u00b1 32.03), and right ventricular pressure (36.88 \u00b1 12.20 vs. 31.81 \u00b1 11.11). Tissue Doppler measurements were significantly decreased 2 years after closure, while the post-closure E\/E\u2019 was higher than the pre-closure E\/E\u2019 (11.58 \u00b1 4.80 vs. 8.79 + 3.19, p &lt; 0.005). In both groups, mitral A and tissue Doppler E\u2019, A\u2019, and S\u2019 values decreased post-closure, while the E\/E\u2019 was higher in Group II than in Group I at both pre-closure and long-term follow-up measurements (pre-closure: 9.60 \u00b1 5.15 vs. 7.41 \u00b1 1.42, p &lt; 0.003; post-closure: 13.03 + 4.05 vs. 10.49 \u00b1 3.95, p &lt; 0.02). The LA size and LV function exhibited recognizable remodeling after transcatheter ASD closure. Because the LV preload elevation (i.e., E\/E\u2019) after ASD closure can be pronounced in older patients, caution should be provided more in older patients than in younger patients. Hence, it may be beneficial to close the ASD at an earlier age in adults even after a late diagnosis; a relatively younger age may be more suited for adaptation to the remodeling process to protect the myocardial function. Careful consideration should be given to the previous underloaded left heart after long-term closure.<\/jats:p>","DOI":"10.3390\/jcm9113637","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T20:17:52Z","timestamp":1605212272000},"page":"3637","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of the Change in Diastolic Dysfunction after Transcatheter Atrial Septal Defect Closure between Asymptomatic Younger and Older Age Groups"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4577-3168","authenticated-orcid":false,"given":"Lucy Youngmin","family":"Eun","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Ki","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/S0735-1097(02)01862-4","article-title":"Comparison between transcatheter and surgical closure of secundum atrial septal defect in children and adults","volume":"39","author":"Du","year":"2002","journal-title":"J. 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