{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:15:27Z","timestamp":1778840127375,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Gitelman syndrome (GS) is a rare salt-losing tubulopathy caused by an inactivating mutation in the SLC12A3 gene, encoding the thiazide-sensitive sodium chloride cotransporter (NCC). Patients with GS frequently complain of vertigo, usually attributed to hypovolemia. Because NCC is also located in the endolymphatic sac, we hypothesized that patients with GS might have vestibular dysfunction. Between April 2013 and September 2016, 20 (22%) out of 90 patients followed at the reference center complained of vertigo in the absence of orthostatic hypotension. Sixteen of them were referred to an otology department for investigation of vestibular function. The vertigo was of short duration and triggered in half of them by head rotation. Seven patients (44%) had a vestibular syndrome. Vestibular syndrome was defined: (1) clinically, as nystagmus triggered by the head shaking test (n = 5); and\/or (2) paraclinically, as an abnormal video head impulse test (n = 0), abnormal kinetic test (n = 4) and\/or abnormal bithermal caloric test (n = 3). Five patients had associated auditory signs (tinnitus, aural fullness or hearing loss). In conclusion, we found a high frequency of vestibular disorder in GS patients suffering from vertigo, suggesting a role of NCC in the inner ear. Referent physicians of these patients should be aware of this extrarenal manifestation that requires specific investigations and treatment.<\/jats:p>","DOI":"10.3390\/jcm9113790","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T11:50:34Z","timestamp":1606132234000},"page":"3790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of Vestibular Function in Adult Patients with Gitelman Syndrome: Results of an Observational Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Mihaela","family":"Alexandru","sequence":"first","affiliation":[{"name":"AP-HP, Universit\u00e9 Paris Saclay, H\u00f4pital Bic\u00eatre, Service d\u2019Oto-Rhino-Laryngologie, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Courbebaisse","sequence":"additional","affiliation":[{"name":"AP-HP, Centre\u2014Universit\u00e9 de Paris, H\u00f4pital Europ\u00e9en Georges-Pompidou, Service de Physiologie-Exploration Fonctionnelles R\u00e9nales, 75015 Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine Paris Descartes, Universit\u00e9 de Paris, 75006 Paris, France"},{"name":"INSERM, U1151-CNRS UMR8253, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Le Pajolec","sequence":"additional","affiliation":[{"name":"AP-HP, Universit\u00e9 Paris Saclay, H\u00f4pital Bic\u00eatre, Service d\u2019Oto-Rhino-Laryngologie, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline","family":"M\u00e9nage","sequence":"additional","affiliation":[{"name":"AP-HP, Universit\u00e9 Paris Saclay, H\u00f4pital Bic\u00eatre, Service d\u2019Oto-Rhino-Laryngologie, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Papon","sequence":"additional","affiliation":[{"name":"AP-HP, Universit\u00e9 Paris Saclay, H\u00f4pital Bic\u00eatre, Service d\u2019Oto-Rhino-Laryngologie, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris-Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-0680","authenticated-orcid":false,"given":"Rosa","family":"Vargas-Poussou","sequence":"additional","affiliation":[{"name":"AP-HP, Centre\u2014Universit\u00e9 de Paris, H\u00f4pital Europ\u00e9en Georges-Pompidou, D\u00e9partement de G\u00e9n\u00e9tique et Biologie Mol\u00e9culaire, 75015 Paris, France"},{"name":"INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 75006 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l\u2019Enfant et de l\u2019Adulte (MARHEA), H\u00f4pital Europ\u00e9en Georges-Pompidou, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Nevoux","sequence":"additional","affiliation":[{"name":"AP-HP, Universit\u00e9 Paris Saclay, H\u00f4pital Bic\u00eatre, Service d\u2019Oto-Rhino-Laryngologie, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris-Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM, U1120, Institut Pasteur, 75724 Paris CEDEX 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-0586","authenticated-orcid":false,"given":"Anne","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Paris Descartes, Universit\u00e9 de Paris, 75006 Paris, France"},{"name":"INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 75006 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l\u2019Enfant et de l\u2019Adulte (MARHEA), H\u00f4pital Europ\u00e9en Georges-Pompidou, 75015 Paris, France"},{"name":"AP-HP, H\u00f4pital Europ\u00e9en Georges-Pompidou, Centre d\u2019Investigation Clinique 1418, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/hmg\/ddm318","article-title":"Subjects heterozygous for genetic loss of function of the thiazide-sensitive cotransporter have reduced blood pressure","volume":"17","author":"Fava","year":"2008","journal-title":"Hum. 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