{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:25:51Z","timestamp":1760239551569,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to analyze longitudinal changes in retinal microstructures following acute optic neuritis and to identify the factors that affect those changes using spectral-domain optical coherence tomography (OCT). Forty-eight eyes of 37 patients with a first episode of optic neuritis and 48 eyes of 48 healthy controls were enrolled. Patients underwent serial OCT and visual function testing for more than six months. Individual layers from macular OCT were segmented with an automated algorithm. The total retinal layer (TRL), nerve fiber layer (NFL), ganglion cell layer (GCL) and inner plexiform layer (IPL) of optic neuritis eyes showed significant thinning with time over 6\u201315 months (p &lt; 0.001 for all). The outer nuclear layer (ONL) showed a later decrease in thickness (p = 0.007). The outer retinal layer (ORL) showed an increase (p = 0.007) in thickness at two to five months which was sustained over time. Low visual acuity and neuromyelitis optica (NMO) immunoglobulin (Ig) G were associated with changes in the thickness of the GCL, IPL, and ONL over time (p &lt; 0.05 for all). Low visual acuity was also associated with changes in the thickness of the NFL over time (p = 0.033). Dynamic changes of retinal microstructures varied according to the retinal layer examined after an optic neuritis attack. Initial visual acuity and NMO-IgG were found to be significant factors affecting the changes in thickness of each retinal layer. These results will lead to a better understanding of the pathologic changes that occur in eyes with optic neuritis.<\/jats:p>","DOI":"10.3390\/jcm9123857","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T09:16:49Z","timestamp":1606468609000},"page":"3857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Factors Associated with Changes in Retinal Layers Following Acute Optic Neuritis: A Longitudinal Study Using Optical Coherence Tomography"],"prefix":"10.3390","volume":"9","author":[{"given":"Yumi","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"},{"name":"Department of Ophthalmology, Chuncheon Sacred Heart Hospital, Hallym University Medical Center, Chuncheon 24253, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Ah","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei Yeul","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Hong","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Optic Neuritis Study Group (2008). Multiple Sclerosis Risk After Optic Neuritis: Final optic neuritis treatment trial follow-up. Arch. Neurol., 65, 727\u2013732.","DOI":"10.1001\/archneur.65.6.727"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1212\/WNL.53.5.1107","article-title":"The clinical course of neuromyelitis optica (Devic\u2019s syndrome)","volume":"53","author":"Wingerchuk","year":"1999","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(13)70259-X","article-title":"Optic Neuritis","volume":"13","author":"Toosy","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archopht.1993.01090060061023","article-title":"Optic Neuritis Treatment Trial","volume":"111","author":"Beck","year":"1993","journal-title":"Arch. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Optic Neuritis Study Group (1991). The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Arch. Ophthalmol., 109, 1673\u20131678.","DOI":"10.1001\/archopht.1991.01080120057025"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0161-6420(87)33349-4","article-title":"Deficits in Visual Function after Resolution of Optic Neuritis","volume":"94","author":"Fleishman","year":"1987","journal-title":"Ophthalmology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/bjo.70.12.918","article-title":"Estimation of visual function after optic neuritis: A comparison of clinical tests","volume":"70","author":"Sanders","year":"1986","journal-title":"Br. J. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ana.20575","article-title":"Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis","volume":"58","author":"Trip","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/ana.24351","article-title":"Dynamics of retinal injury after acute optic neuritis","volume":"77","author":"Gabilondo","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Peng, C., Wang, W., Xu, Q., Zhao, S., Li, H., Yang, M., Cao, S., Zhou, H., and Wei, S. (2016). Structural Alterations of Segmented Macular Inner Layers in Aquaporin4-Antibody-Positive Optic Neuritis Patients in a Chinese Population. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157645"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/1352458515590646","article-title":"Outer retinal changes following acute optic neuritis","volume":"22","author":"Bhargava","year":"2016","journal-title":"Mult. Scler. J."},{"key":"ref_12","first-page":"57","article-title":"Analysis of spectral domain optical coherence tomography measurements in optic neuritis: Differences in neuromyelitis optica, multiple sclerosis, isolated optic neuritis and normal healthy controls","volume":"92","author":"Park","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/awr264","article-title":"Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis","volume":"135","author":"Syc","year":"2012","journal-title":"Brain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Early Treatment Diabetic Retinopathy Study Research Group (1987). Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema: Early Treatment Diabetic Retinopathy Study Report Number 2. Ophthalmology, 94, 761\u2013774.","DOI":"10.1016\/S0161-6420(87)33527-4"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1212\/WNL.0000000000002774","article-title":"The APOSTEL recommendations for reporting quantitative optical coherence tomography studies","volume":"86","author":"Balk","year":"2016","journal-title":"Neurology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/1352458514538110","article-title":"Quality control for retinal OCT in multiple sclerosis: Validation of the OSCAR-IB criteria","volume":"21","author":"Schippling","year":"2015","journal-title":"Mult. Scler. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/ane.13004","article-title":"Optical coherence tomography in acute optic neuritis: A population-based study","volume":"138","author":"Soelberg","year":"2018","journal-title":"Acta Neurol. Scand."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0161-6420(94)31103-1","article-title":"The Course of Visual Recovery after Optic Neuritis: Experience of the Optic Neuritis Treatment Trial","volume":"101","author":"Beck","year":"1994","journal-title":"Ophthalmology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/jnnp.2008.166207","article-title":"Distinctive retinal nerve fibre layer and vascular changes in neuromyelitis optica following optic neuritis","volume":"80","author":"Green","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1212\/01.wnl.0000345042.53843.d5","article-title":"Optical coherence tomography differs in neuromyelitis optica compared with multiple sclerosis","volume":"72","author":"Naismith","year":"2009","journal-title":"Neurology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s00417-010-1344-7","article-title":"Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica","volume":"248","author":"Nakamura","year":"2010","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1212\/WNL.0b013e3181af78b8","article-title":"Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies","volume":"73","author":"Ratchford","year":"2009","journal-title":"Neurology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1177\/1352458510382324","article-title":"Neuromyelitis optica: A demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes","volume":"16","author":"Parratt","year":"2010","journal-title":"Mult. Scler. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1212\/WNL.0b013e3181e2414b","article-title":"Astrocytic damage is far more severe than demyelination in NMO: A clinical CSF biomarker study","volume":"75","author":"Takano","year":"2010","journal-title":"Neurology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1073\/pnas.1109980108","article-title":"Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes","volume":"109","author":"Hinson","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12970","DOI":"10.3390\/ijms131012970","article-title":"Molecular Pathogenesis of Neuromyelitis Optica","volume":"13","author":"Bukhari","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/brain\/awp309","article-title":"Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice","volume":"133","author":"Saadoun","year":"2010","journal-title":"Brain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/brain\/awm047","article-title":"Loss of aquaporin 4 in lesions of neuromyelitis optica: Distinction from multiple sclerosis","volume":"130","author":"Misu","year":"2007","journal-title":"Brain"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/s41598-017-01933-8","article-title":"Progranulin deficiency causes the retinal ganglion cell loss during development","volume":"7","author":"Kuse","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Yonehara, K., Shintani, T., Suzuki, R., Sakuta, H., Takeuchi, Y., Nakamura-Yonehara, K., and Noda, M. (2008). Expression of SPIG1 Reveals Development of a Retinal Ganglion Cell Subtype Projecting to the Medial Terminal Nucleus in the Mouse. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001533"},{"key":"ref_33","first-page":"499","article-title":"Nerve fiber layer astrocytes of the primate retina: Morphology, distribution, and density","volume":"17","author":"Ogden","year":"1978","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/0042-6989(95)00322-3","article-title":"Structural Specializations of Human Retinal Glial Cells","volume":"36","author":"Salazar","year":"1996","journal-title":"Vis. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/332834a0","article-title":"Retinal astrocytes are immigrants from the optic nerve","volume":"332","author":"Watanabe","year":"1988","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.200706181","article-title":"Axons of retinal ganglion cells are insulted in the optic nerve early in DBA\/2J glaucoma","volume":"179","author":"Howell","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia\u2013neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-2094-9-14","article-title":"Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients","volume":"9","author":"Jarius","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/1756285616655264","article-title":"Usefulness of optical coherence tomography to distinguish optic neuritis associated with AQP4 or MOG in neuromyelitis optica spectrum disorders","volume":"9","author":"Sepulveda","year":"2016","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ophtha.2003.05.031","article-title":"Temporal variation in diabetic macular edema measured by optical coherence tomography","volume":"111","author":"Frank","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Diabetic Retinopathy Clinical Research Network, Danis, R.P., Glassman, A.R., Aiello, L.P., Antoszyk, A.N., Beck, R.W., Browning, D.J., Ciardella, A.P., Kinyoun, J.L., and Murtha, T.J. (2006). Diurnal Variation in Retinal Thickening Measurement by Optical Coherence Tomography in Center-Involved Diabetic Macular Edema. Arch. Ophthalmol., 124, 1701\u20131707.","DOI":"10.1001\/archopht.124.12.1701"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00417-008-1011-4","article-title":"Diurnal variation of macular oedema in CRVO: Prospective study","volume":"247","author":"Gupta","year":"2009","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1167\/iovs.11-7403","article-title":"Diurnal Variation of Retina Thickness Measured with Time Domain and Spectral Domain Optical Coherence Tomography in Healthy Subjects","volume":"52","author":"Jo","year":"2011","journal-title":"Investig. Opthalmology Vis. Sci."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/12\/3857\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:38:21Z","timestamp":1760179101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/12\/3857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,27]]},"references-count":43,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["jcm9123857"],"URL":"https:\/\/doi.org\/10.3390\/jcm9123857","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2020,11,27]]}}}