{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:18Z","timestamp":1787028678479,"version":"build-2736575974"},"reference-count":21,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Severe Plasmodium falciparum malaria remains the primary cause of mortality in several African countries, including Angola, where severe malaria patient admission into intensive care units (ICU) is mandatory. The present observational and prospective study enrolled 101 consecutive severe malaria patients admitted at the ICU of Am\u00e9rico Boavida University Hospital (Luanda, Angola). Malaria was confirmed by microscopy and RDT, and WHO criteria were used to define severe malaria. The Sequential Organ Failure Assessment (SOFA) score was used to monitor organ dysfunctions. Surviving and nonsurviving patients were compared using bivariate statistical methods. Two-step cluster analysis was used to find discriminant organ dysfunctions that may correlate better with the observed mortality (16.8%), which was much lower than the one generated by the SOFA score. The study population was young, and 87% of the patients were local native residents. There was no statistically significant correlation between the parasitemia and the outcome. Hematological and cerebral dysfunctions were prevalent but were not discriminant when cluster analyses were performed to detect homogeneous subgroups of patients. In conclusion, the SOFA score was readily applicable and efficient in monitoring daily organ dysfunction but was not effective enough in predicting the outcome of severe malaria patients.<\/jats:p>","DOI":"10.3390\/jcm9123862","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T09:16:49Z","timestamp":1606468609000},"page":"3862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Maria Lina","family":"Antunes","sequence":"first","affiliation":[{"name":"Hospital Am\u00e9rico Boavida, Luanda 160963, Angola"},{"name":"Global Health and Tropical Medicine R&amp;D Center, NOVA University, 1349-008 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Seixas","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine R&amp;D Center, NOVA University, 1349-008 Lisbon, Portugal"},{"name":"Institute of Hygiene and Tropical Medicine, NOVA University, 1349-008 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto E.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CERENA, Instituto Superior T\u00e9cnico, University of Lisbon, 1349-008 Lisbon, Portugal"},{"name":"Departamento de Qu\u00edmica Farmac\u00eautica e Terap\u00eautica (DQFT), Faculdade de Farm\u00e1cia, Universidade de Lisbon, 1349-008 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1000-0149","authenticated-orcid":false,"given":"Marcelo Sousa","family":"Silva","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine R&amp;D Center, NOVA University, 1349-008 Lisbon, Portugal"},{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal 59000-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"ref_1","unstructured":"Aregawi, M., Cibulskis, R.E., Otten, M., and Williams, R. 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