{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:54:48Z","timestamp":1790740488507,"version":"4.1.0"},"reference-count":97,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This systematic review aims to investigate the role of the oral microbiome in the pathophysiology of mental health disorders and to appraise the methodological quality of research of the oral\u2013brain axis which is a growing interest area. The PRISMA guideline was adopted, to carry out an electronic search through the MEDLINE database, to identify studies that have explored the role of the oral microbiome in the pathophysiology of mental health disorders published from 2000 up to June 2020. The search resulted in 140 records; after exclusions, a total of 22 papers were included in the present review. In accordance with the role of the oral microbiome in the pathophysiology of mental disorders, four mental disorders were identified: Alzheimer\u2019s disease, dementia, and cognitive disorders; autism spectrum disorder; Down\u2019s syndrome and mental retardation; and Bipolar disorders. Studies argue for correlations between oral microbiota and Alzheimer\u2019s disease, autism spectrum disorders, Down\u2019s syndrome, and bipolar disorders. This field is still under-studied, and studies are needed to clarify the biological links and interconnections between the oral microbiota and the pathophysiology of all mental health disorders. Researchers should focus their efforts to develop research on the oral\u2013brain axis in the future.<\/jats:p>","DOI":"10.3390\/jcm9123876","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T21:55:31Z","timestamp":1606686931000},"page":"3876","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Did the Brain and Oral Microbiota Talk to Each Other? A Review of the Literature"],"prefix":"10.3390","volume":"9","author":[{"given":"Yoann","family":"Maitre","sequence":"first","affiliation":[{"name":"Emergency Department, Montpellier University Hospital, 34259 Montpellier, France"},{"name":"EA 2415, Aide \u00e0 la D\u00e9cision pour une M\u00e9decine Personnalis\u00e9e, Universit\u00e9 de Montpellier, 34090 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Micheneau","sequence":"additional","affiliation":[{"name":"Department of Odontology, Tours University Hospital, 37261 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Delpierre","sequence":"additional","affiliation":[{"name":"Department of Odontology, Tours University Hospital, 37261 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Mahalli","sequence":"additional","affiliation":[{"name":"Department of Odontology, Tours University Hospital, 37261 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Guerin","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Clermont-Ferrand University, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Amador","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Nantes University, 44035 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-8689","authenticated-orcid":false,"given":"Frederic","family":"Denis","sequence":"additional","affiliation":[{"name":"Department of Odontology, Tours University Hospital, 37261 Tours, France"},{"name":"Faculty of Dentistry, Nantes University, 44035 Nantes, France"},{"name":"EA 75-05 Education, Ethique, Sant\u00e9, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois-Rabelais, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1080\/09637486.2019.1580682","article-title":"The human-microbiome superorganism and its modulation to restore health","volume":"70","author":"Salvucci","year":"2019","journal-title":"Int. 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