{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:12:53Z","timestamp":1784628773262,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006356","name":"University of Southern Denmark","doi-asserted-by":"publisher","award":["Mar 2017"],"award-info":[{"award-number":["Mar 2017"]}],"id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Region of Southern Denmark","award":["Aug 2016"],"award-info":[{"award-number":["Aug 2016"]}]},{"DOI":"10.13039\/501100004196","name":"Odense University Hospital","doi-asserted-by":"publisher","award":["Overl\u00e6ger\u00e5dets Forskningsfond Mar 2017"],"award-info":[{"award-number":["Overl\u00e6ger\u00e5dets Forskningsfond Mar 2017"]}],"id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"A.P M\u00f8ller Fonden","award":["18-L-0260"],"award-info":[{"award-number":["18-L-0260"]}]},{"name":"Svendborg Hospital","award":["Feb 2020"],"award-info":[{"award-number":["Feb 2020"]}]},{"name":"The Danish Rheumatism Association","award":["Peter Ryholts Scholarship; R150-A4422-B1108; R144-A4175-B1108; R142-A4154-B1108"],"award-info":[{"award-number":["Peter Ryholts Scholarship; R150-A4422-B1108; R144-A4175-B1108; R142-A4154-B1108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim of the study was to identify the prevalence of newly diagnosed malignancies in patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), with the aid of 18F-FDG PET\/CT scan compared to conventional imaging techniques: Chest X-ray (CXR) and abdominal ultrasound (US). Secondarily, to examine the relative diagnostic accuracy of these two imaging modalities for the detection of cancer. Eighty consecutive patients with newly diagnosed PMR, GCA, or concomitant PMR and GCA, were included and followed up for 40 weeks. All patients underwent an 18F-FDG PET\/CT scan, CXR, and abdominal US at diagnosis. Imaging findings were dichotomously categorized into malignant or benign. Among 80 patients, three patients were diagnosed with seronegative rheumatoid arthritis and were excluded from the analysis. Of the remaining 77, 64 (83.1%) patients were diagnosed with pure PMR, 3 (3.9%) with pure GCA, and 10 (13.0%) with concomitant PMR and GCA. Five types of cancer that were more prevalent than the one-year prevalence of 1.2% among the background population were found in four (5.2%; 95%CI: 1.4\u201312.8%) patients. CXR\/abdominal US could detect the solid cancer in one patient, whereas 18F-FDG PET\/CT could identify all four solid cancers. Furthermore, four (5.2%; 95%CI: 1.4\u201312.8%) cases of monoclonal gammopathy of undetermined significance (MGUS) were found. An increase in C reactive protein (CRP) implicated an increased risk for cancer of 2.4% (OR: 1.024, 95%CI: 1.001\u20131.047; p = 0.041). 18F-FDG PET\/CT can reveal occult cancers at an early stage with a high negative predictive value, and it is specifically beneficial in PMR\/GCA patients with nonspecific symptoms.<\/jats:p>","DOI":"10.3390\/jcm9123940","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T11:50:49Z","timestamp":1607428249000},"page":"3940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of Newly Diagnosed Malignancies in Patients with Polymyalgia Rheumatica and Giant Cell Arteritis, Comparison of 18F-FDG PET\/CT Scan with Chest X-ray and Abdominal Ultrasound: Data from a 40 Week Prospective, Exploratory, Single Centre Study"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-1364","authenticated-orcid":false,"given":"Amir","family":"Emamifar","sequence":"first","affiliation":[{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark"},{"name":"Diagnostic Center, Svendborg Hospital, OUH, 5700 Svendborg, Denmark"},{"name":"Department of Rheumatology, Svendborg Hospital, OUH, 5700 Svendborg, Denmark"},{"name":"OPEN, Odense Patient data Explorative Network, Odense University Hospital, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Hospital of Southwest Jutland, 6700 Esbjerg, Denmark"},{"name":"Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-4962","authenticated-orcid":false,"given":"Torkell","family":"Ellingsen","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit, Odense University Hospital and University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Due Kay","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Svendborg Hospital, OUH, 5700 Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Christian Bang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Svendborg Hospital, OUH, 5700 Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6335-3303","authenticated-orcid":false,"given":"Oke","family":"Gerke","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark"},{"name":"Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Syrak Hansen","sequence":"additional","affiliation":[{"name":"Diagnostic Center, Svendborg Hospital, OUH, 5700 Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziba","family":"Ahangarani Farahani","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark"},{"name":"Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Marcussen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Odense University Hospital, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger Marie","family":"Jensen Hansen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Svendborg Hospital, OUH, 5700 Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Thye R\u00f8nn","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark"},{"name":"Diagnostic Center, Svendborg Hospital, OUH, 5700 Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/rheumatology\/ken130","article-title":"Cancer risk in hospitalized rheumatoid arthritis patients","volume":"47","author":"Hemminki","year":"2008","journal-title":"Rheumatology"},{"key":"ref_2","first-page":"2143","article-title":"No increased frequency of malignant neoplasms in polymyalgia rheumatica and temporal arteritis. 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