{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:26:31Z","timestamp":1790659591592,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT &amp; Future Planning","award":["NRF-2020R1A2B5B02001713 and NRF-2018R1A5A2025079"],"award-info":[{"award-number":["NRF-2020R1A2B5B02001713 and NRF-2018R1A5A2025079"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In children with concomitant food allergy and atopic dermatitis (AD), uncovering the causative food allergen is more arduous. We evaluated the basophil activation test (BAT) for its diagnostic value in children, including those with AD, for milk or egg allergy. We simultaneously measured serum-specific immunoglobulin E (sIgE) levels and performed BATs for cow\u2019s milk and egg white. We compared their overall diagnostic performance using the area under the receiver operating characteristic curve (AUC) with the Delong method and compared them in children with AD. Analyses were completed for 75 children for milk allergy and for 85 children for egg allergy. The sIgE and percentage of basophils with the expression of CD63 were correlated for both milk (r = 0.384, p &lt; 0.001) and egg (r = 0.557, p &lt; 0.001). The AUC of sIgE (0.701) for milk allergy was significantly increased when combined with the BAT (0.805; p = 0.029). In children with AD, the AUC of the BAT (0.924) for milk allergy was significantly larger than that of sIgE (0.701; p = 0.017). The BAT is a potentially useful diagnostic tool for milk allergy in children when combined with sIgE. Moreover, it may be a surrogate marker for milk allergy in children with AD.<\/jats:p>","DOI":"10.3390\/jcm9123942","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T11:50:49Z","timestamp":1607428249000},"page":"3942","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Investigation of Basophil Activation Test for Diagnosing Milk and Egg Allergy in Younger Children"],"prefix":"10.3390","volume":"9","author":[{"given":"Yoon Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Institute of Allergy, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea"},{"name":"Gangnam Severance Hospital, Seoul 06273, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Suh","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Allergy, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea"},{"name":"Severance Hospital, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younhee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Allergy, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea"},{"name":"Severance Hospital, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-6135","authenticated-orcid":false,"given":"Kyung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Allergy, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea"},{"name":"Severance Hospital, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-7740","authenticated-orcid":false,"given":"Hyon Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Hyun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Allergy, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea"},{"name":"Severance Hospital, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11882-018-0825-3","article-title":"Innovation in food challenge tests for food allergy","volume":"18","author":"Cox","year":"2018","journal-title":"Curr. 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