{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:47:20Z","timestamp":1791323240303,"version":"4.3.1"},"reference-count":63,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Chronic nightmares are very common in psychiatric disorders, affecting up to 70% of patients with personality or post-traumatic stress disorders. In other psychiatric disorders, the relationships with nightmares are poorly known. This review aimed to clarify the relationship between nightmares and both mood and psychotic disorders. We performed a systematic literature search using the PubMed, Cochrane Library and PsycINFO databases until December 2019, to identify studies of patients suffering from either a mood disorder or a psychotic disorder associated with nightmares. From the 1145 articles screened, 24 were retained, including 9 studies with patients with mood disorders, 11 studies with patients with psychotic disorders and 4 studies with either psychotic or mood disorders. Nightmares were more frequent in individuals with mood or psychotic disorders than in healthy controls (more than two-fold). Patients with frequent nightmares had higher suicidality scores and had more frequently a history of suicide attempt. The distress associated with nightmares, rather than the frequency of nightmares, was associated with the severity of the psychiatric disorder. Further studies assessing whether nightmare treatment not only improves patient\u2013sleep perception but also improves underlying psychiatric diseases are needed. In conclusion, nightmares are overrepresented in mood and psychotic disorders, with the frequency associated with suicidal behaviors and the distress associated with the psychiatric disorder severity. These findings emphasize major clinical and therapeutic implications.<\/jats:p>","DOI":"10.3390\/jcm9123990","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T20:18:22Z","timestamp":1607631502000},"page":"3990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Nightmares in Patients with Major Depressive Disorder, Bipolar Disorder, and Psychotic Disorders: A Systematic Review"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6961-3222","authenticated-orcid":false,"given":"Marine Ambar","family":"Akkaoui","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Addictive Medicine, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), University Hospital Bichat, 46 rue Henri Huchard, 75018 Paris, France"},{"name":"Centre Psychiatrique d\u2019Orientation et d\u2019Accueil (CPOA), GHU Paris\u2014Psychiatry &amp; Neurosciences, 1 rue Cabanis, 75014 Paris, France"},{"name":"Etablissement Publique de Sant\u00e9 Mentale de Ville Evrard, 202 Avenue Jean Jaur\u00e8s Neuilly-Sur-Marne, 93300 Neuilly-sur-Marne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lejoyeux","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictive Medicine, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), University Hospital Bichat, 46 rue Henri Huchard, 75018 Paris, France"},{"name":"Universit\u00e9 de Paris, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pia","family":"d\u2019Ortho","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, NeuroDiderot, Inserm UMR1141, F-75019 Paris, France"},{"name":"Department of Physiology and Sleep Center, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), University Hospital Bichat, 46 rue Henri Huchard, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-209X","authenticated-orcid":false,"given":"Pierre A.","family":"Geoffroy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictive Medicine, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), University Hospital Bichat, 46 rue Henri Huchard, 75018 Paris, France"},{"name":"Universit\u00e9 de Paris, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpsychires.2020.02.018","article-title":"Shorter and longer durations of sleep are associated with an increased twelve-month prevalence of psychiatric and substance use disorders: Findings from a nationally representative survey of US adults (NESARC-III)","volume":"124","author":"Geoffroy","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/sleep\/29.10.1313","article-title":"Nightmare Complaints in Treatment-Seeking Patients in Clinical Sleep Medicine Settings: Diagnostic and Treatment Implications","volume":"29","author":"Krakow","year":"2006","journal-title":"Sleep"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1440-1819.2007.01789.x","article-title":"Nightmare disorder, dream anxiety, and subjective sleep quality in patients with borderline personality disorder","volume":"62","author":"Semiz","year":"2008","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1160","DOI":"10.4088\/JCP.11r07586","article-title":"Meta-Analysis of Sleep Disturbance and Suicidal Thoughts and Behaviors","volume":"73","author":"Pigeon","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/sleep\/33.6.774","article-title":"Prevalence and Correlates of Frequent Nightmares: A Community-Based 2-Phase Study","volume":"33","author":"Li","year":"2010","journal-title":"Sleep"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.5665\/sleep.2806","article-title":"Nightmares: Prevalence among the Finnish General Adult Population and War Veterans during 1972\u20132007","volume":"36","author":"Sandman","year":"2013","journal-title":"Sleep"},{"key":"ref_7","first-page":"589","article-title":"Prevalence of sleep disturbances among young adults in three European countries","volume":"18","author":"Janson","year":"1995","journal-title":"Sleep"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00406-010-0112-3","article-title":"Nightmare frequency and nightmare topics in a representative German sample","volume":"260","author":"Schredl","year":"2010","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.sleep.2016.09.015","article-title":"Epidemiology of sleep and sleep disorders in The Netherlands","volume":"30","author":"Kerkhof","year":"2017","journal-title":"Sleep Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.smrv.2007.03.004","article-title":"Nightmares: A new neurocognitive model","volume":"11","author":"Nielsen","year":"2007","journal-title":"Sleep Med. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/A:1025718830026","article-title":"Imagery rehearsal in the treatment of posttraumatic nightmares in Australian veterans with chronic combat-related PTSD: 12-month follow-up data","volume":"16","author":"Forbes","year":"2003","journal-title":"J. Trauma. Stress"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0022-3956(02)00025-0","article-title":"Effects of comorbid diagnoses on sleep disturbance in PTSD","volume":"36","author":"Leskin","year":"2002","journal-title":"J. Psychiatr. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1176\/ajp.155.7.929","article-title":"Sleep Disturbances in the Vietnam Generation: Findings from a Nationally Representative Sample of Male Vietnam Veterans","volume":"155","author":"Neylan","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.133.3.482","article-title":"Disturbed dreaming, posttraumatic stress disorder, and affect distress: A review and neurocognitive model","volume":"133","author":"Levin","year":"2007","journal-title":"Psychol. Bull."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1891\/1933-3196.8.3.129","article-title":"Eye Movement Desensitization and Reprocessing Treatment of Nightmares: A Case Report","volume":"8","author":"Woo","year":"2014","journal-title":"J. EMDR Pr. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.14-0970","article-title":"International Classification of Sleep Disorders-Third Edition","volume":"146","author":"Sateia","year":"2014","journal-title":"Chest"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders: DSM-5, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Geoffroy, P.A., Oquendo, M., Courtet, P., Blanco, C., Olfson, M., Peyre, H., Lejoyeux, M., Limosin, F., and Hoertel, N. (2020). Sleep complaints are associated with increased suicide risk independently of psychiatric disorders: Results from a national 3-year prospective study. Mol. Psychiatry, 1\u201311.","DOI":"10.1038\/s41380-020-0735-3"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/1053-0797.16.1.1","article-title":"The impact of insomnia and sleep disturbances on depression and suicidality","volume":"16","author":"Cukrowicz","year":"2006","journal-title":"Dreaming"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.psychres.2008.09.006","article-title":"Persistent nightmares are associated with repeat suicide attempt","volume":"170","author":"Hetta","year":"2009","journal-title":"Psychiatry Res."},{"key":"ref_21","first-page":"845","article-title":"Nightmares as Predictors of Suicide","volume":"24","author":"Tanskanen","year":"2001","journal-title":"Sleep"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.5664\/jcsm.5592","article-title":"Nightmares and Suicide in Posttraumatic Stress Disorder: The Mediating Role of Defeat, Entrapment, and Hopelessness","volume":"12","author":"Littlewood","year":"2016","journal-title":"J. Clin. Sleep Med."},{"key":"ref_23","first-page":"159","article-title":"Nightmares and suicide: Predicting risk in depression","volume":"26","author":"Marinova","year":"2014","journal-title":"Psychiatr. Danub."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jad.2015.07.037","article-title":"Capability for suicide interacts with states of heightened arousal to predict death by suicide beyond the effects of depression and hopelessness","volume":"188","author":"Ribeiro","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/sltb.12273","article-title":"Positive and Negative Expectations of Hopelessness as Longitudinal Predictors of Depression, Suicidal Ideation, and Suicidal Behavior in High-Risk Adolescents","volume":"47","author":"Horwitz","year":"2017","journal-title":"Suicide Life-Threat. Behav."},{"key":"ref_26","first-page":"177","article-title":"Nightmare in schizophrenic and depressed patients","volume":"23","author":"Mume","year":"2009","journal-title":"Eur. J. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cpr.2009.06.004","article-title":"Unusual sleep experiences, dissociation, and schizotypy: Evidence for a common domain","volume":"29","author":"Koffel","year":"2009","journal-title":"Clin. Psychol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"For the PRISMA Group Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"ref_29","unstructured":"World Health Organization (2018). International Classification of Diseases for Mortality and Morbidity Statistics, (11th Revision), WHO."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0010-440X(98)90060-8","article-title":"Repetitive and frightening dreams and suicidal behavior in patients with major depression","volume":"39","author":"Cilli","year":"1998","journal-title":"Compr. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jad.2006.08.005","article-title":"Nightmares, suicide attempts, and melancholic features in patients with unipolar major depression","volume":"98","author":"Agargun","year":"2007","journal-title":"J. Affect. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.psychres.2004.12.001","article-title":"Nightmares and terminal insomnia in depressed patients with and without melancholic features","volume":"133","author":"Besiroglu","year":"2005","journal-title":"Psychiatry Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.brat.2012.05.006","article-title":"Effectiveness of a manualized imagery rehearsal therapy for patients suffering from nightmare disorders with and without a comorbidity of depression or PTSD","volume":"50","author":"Pietrowsky","year":"2012","journal-title":"Behav. Res. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.5665\/sleep.2008","article-title":"Residual Sleep Disturbances in Patients Remitted From Major Depressive Disorder: A 4-Year Naturalistic Follow-up Study","volume":"35","author":"Li","year":"2012","journal-title":"Sleep"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jpsychores.2013.10.020","article-title":"Familiality and clinical outcomes of sleep disturbances in major depressive and bipolar disorders","volume":"76","author":"Lai","year":"2014","journal-title":"J. Psychosom. Res."},{"key":"ref_36","first-page":"192","article-title":"Nightmares associated with the onset of mania: Three case reports","volume":"5","author":"Agargun","year":"2003","journal-title":"Sleep Hypn."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.5665\/sleep.5852","article-title":"Sleep Disturbances and Suicide Risk in an 8-Year Longitudinal Study of Schizophrenia-Spectrum Disorders","volume":"39","author":"Li","year":"2016","journal-title":"Sleep"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/schbul\/sby129","article-title":"Sleep Disorders in Early Psychosis: Incidence, Severity, and Association with Clinical Symptoms","volume":"45","author":"Reeve","year":"2019","journal-title":"Schizophr. Bull."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00005053-199201000-00014","article-title":"Psychotic Episodes and Nightmares: A Case Study","volume":"180","author":"Fennig","year":"1992","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/00332747.1998.11024832","article-title":"Nightmares and Schizotypy","volume":"61","author":"Levin","year":"1998","journal-title":"Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.schres.2009.03.032","article-title":"Dream content in chronically-treated persons with schizophrenia","volume":"112","author":"Lusignan","year":"2009","journal-title":"Schizophr. Res."},{"key":"ref_42","first-page":"9","article-title":"Nightmare frequency in schizophrenic patients, healthy relatives of schizophrenic patients, patients at high risk states for psychosis, and healthy controls","volume":"7","author":"Michels","year":"2014","journal-title":"Int. J. Dream Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/070674371506000804","article-title":"Nightmares in Patients with Psychosis: The Relation with Sleep, Psychotic, Affective, and Cognitive Symptoms","volume":"60","author":"Sheaves","year":"2015","journal-title":"Can. J. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0005-7916(74)90025-1","article-title":"Systematic desensitization treatment of a recurring nightmare and related insomnia","volume":"5","author":"Shorkey","year":"1974","journal-title":"J. Behav. Ther. Exp. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sheaves, B., Onwumere, J., Keen, N., and Kuipers, E. (2015). Treating your worst nightmare: A case-series of imagery rehearsal therapy for nightmares in individuals experiencing psychotic symptoms. Cogn. Behav. Ther., 8.","DOI":"10.1017\/S1754470X15000665"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5665\/sleep.5342","article-title":"Insomnia, Nightmares, and Chronotype as Markers of Risk for Severe Mental Illness: Results from a Student Population","volume":"39","author":"Sheaves","year":"2016","journal-title":"Sleep"},{"key":"ref_47","first-page":"686","article-title":"Cognitive Behavioural Therapy for Nightmares for Patients with Persecutory Delusions (Nites): An Assessor-Blind, Pilot Randomized Controlled Trial","volume":"64","author":"Sheaves","year":"2019","journal-title":"Can. J. Psychiatry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/sleep\/30.1.91","article-title":"Nightmares and Sleep Disturbances in Relation to Suicidality in Suicide Attempters","volume":"30","author":"Waern","year":"2007","journal-title":"Sleep"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.psychres.2018.03.053","article-title":"Nightmares and suicide risk in psychiatric patients: The roles of hopelessness and male depressive symptoms","volume":"264","author":"Lamis","year":"2018","journal-title":"Psychiatry Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.psychres.2018.07.009","article-title":"Prevalence and correlates of sleep disorder symptoms in psychiatric disorders","volume":"279","author":"Hombali","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_51","first-page":"28","article-title":"Comorbid Insomnia and Psychiatric Disorders: An Update","volume":"15","author":"Khurshid","year":"2018","journal-title":"Innov. Clin. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jad.2017.09.032","article-title":"Insomnia and hypersomnia in major depressive episode: Prevalence, sociodemographic characteristics and psychiatric comorbidity in a population-based study","volume":"226","author":"Geoffroy","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12888-017-1372-5","article-title":"Insomnia, psychiatric disorders and suicidal ideation in a National Representative Sample of active Canadian Forces members","volume":"17","author":"Richardson","year":"2017","journal-title":"BMC Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3109\/09540261.2014.888989","article-title":"Pharmacological and non-pharmacological treatments for nightmare disorder","volume":"26","author":"Nadorff","year":"2014","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00127-017-1408-7","article-title":"Nightmares in the general population: Identifying potential causal factors","volume":"52","author":"Rek","year":"2017","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.schres.2018.02.052","article-title":"Association between sleep, childhood trauma and psychosis-like experiences","volume":"199","author":"Andorko","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1192\/bjp.bp.113.144089","article-title":"Childhood sleep disturbance and risk of psychotic experiences at 18: UK birth cohort","volume":"207","author":"Thompson","year":"2015","journal-title":"Br. J. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e12820","DOI":"10.1111\/jsr.12820","article-title":"Aetiology and treatment of nightmare disorder: State of the art and future perspectives","volume":"28","author":"Gieselmann","year":"2019","journal-title":"J. Sleep Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.5664\/jcsm.7002","article-title":"Nightmare Themes: An Online Study of Most Recent Nightmares and Childhood Nightmares","volume":"14","author":"Schredl","year":"2018","journal-title":"J. Clin. Sleep Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5664\/jcsm.27883","article-title":"Best practice guide for the treatment of nightmare disorder in adults","volume":"6","author":"Nisha","year":"2010","journal-title":"J. Clin. Sleep Med."},{"key":"ref_61","first-page":"141","article-title":"The Mannheim Dream Questionnaire (MADRE): Retest reliability, age and gender effects","volume":"7","author":"Schredl","year":"2014","journal-title":"Int. J. Dream Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0887-6185(02)00093-2","article-title":"Nightmare frequency in sexual assault survivors with PTSD","volume":"16","author":"Krakow","year":"2002","journal-title":"J. Anxiety Disord."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11920-017-0816-4","article-title":"Effects of Antidepressants on Sleep","volume":"19","author":"Wichniak","year":"2017","journal-title":"Curr. Psychiatry Rep."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/12\/3990\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:42:54Z","timestamp":1760179374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/12\/3990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,9]]},"references-count":63,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["jcm9123990"],"URL":"https:\/\/doi.org\/10.3390\/jcm9123990","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,9]]}}}