{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:27:17Z","timestamp":1790728037304,"version":"4.1.0"},"reference-count":149,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JDB"],"abstract":"<jats:p>Infertility is a major problem in farm animals, which has a negative economic effect on farm industries. Infertility can be defined as the inability of animals to achieve a successful pregnancy. Early pregnancy is crucial to establish a successful pregnancy, and it is reported that 70\u201380% and 20\u201330% of total embryonic loss occur in cattle and pigs, respectively, during the first month of pregnancy. The advanced high-throughput proteomics techniques provide valuable tools for in-depth understanding of the implantation process in farm animals. In the present review, our goal was to compile, assess, and integrate the latest proteomic research on farm animals, specifically focused on female reproduction, which involves endometrial tissues, uterine fluids, oviductal fluids, and microRNAs. The series of studies has provided in-depth insights into the events of the implantation process by unfolding the molecular landscape of the uterine tract. The discussed data are related to pregnant vs. non-pregnant animals, pregnancy vs. oestrous cycle, different days of the early pregnancy phase, and animals with uterine infections affecting reproduction health. Some of the studies have utilized non-invasive methods and in vitro models to decipher the molecular events of embryo-maternal interaction. The proteomics data are valuable sources for discovering biomarkers for infertility in ruminants and new regulatory pathways governing embryo-uterine interaction, endometrium receptivity, and embryonic development. Here, we envisage that the identified protein signatures can serve as potential therapeutic targets and biomarkers to develop new therapeutics against pregnancy diseases.<\/jats:p>","DOI":"10.3390\/jdb12010002","type":"journal-article","created":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T04:51:51Z","timestamp":1703998311000},"page":"2","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Proteomic Approaches to Unravel the Molecular Dynamics of Early Pregnancy in Farm Animals: An In-Depth Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Shradha","family":"Jamwal","sequence":"first","affiliation":[{"name":"Proteomics and Structural Biology Lab, Animal Biotechnology Centre, National Dairy Research Institute, Karnal 132001, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-8539","authenticated-orcid":false,"given":"Manoj Kumar","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4578-422X","authenticated-orcid":false,"given":"Nikunj","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Proteomics and Structural Biology Lab, Animal Biotechnology Centre, National Dairy Research Institute, Karnal 132001, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar","family":"Kancharla","sequence":"additional","affiliation":[{"name":"Devansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachetha","family":"Kolli","sequence":"additional","affiliation":[{"name":"Microgen Health Inc., 14225 Sullyfield Cir Suite E, Chantilly, VA 20151, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowtham","family":"Mandadapu","sequence":"additional","affiliation":[{"name":"Devansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-4307","authenticated-orcid":false,"given":"Sudarshan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Proteomics and Structural Biology Lab, Animal Biotechnology Centre, National Dairy Research Institute, Karnal 132001, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Mohanty","sequence":"additional","affiliation":[{"name":"ICAR\u2013Central Institute for Research on Cattle, Meerut Cantt 250001, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/scdb.2000.0155","article-title":"Cellular mechanisms of implantation in domestic farm animals","volume":"11","author":"Bowen","year":"2000","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1530\/rep.1.00340","article-title":"Animal models of implantation","volume":"128","author":"Lee","year":"2004","journal-title":"Reproduction"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/rep.1.00398","article-title":"Implantation mechanisms: Insights from the sheep","volume":"128","author":"Spencer","year":"2004","journal-title":"Reproduction"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1095\/biolreprod66.5.1430","article-title":"Implantation-associated changes in bovine uterine ex-pression of integrins and extracellular matrix","volume":"66","author":"MacIntyre","year":"2002","journal-title":"Biol. Reprod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/biolre\/ioab001","article-title":"Endometrial receptivity and embryo implantation in carnivores-commonalities and differences with other mammalian species","volume":"104","author":"Paulson","year":"2021","journal-title":"Biol. Reprod."},{"key":"ref_6","first-page":"1","article-title":"Endocrine Causes of Early Embryonic Death: An Overview","volume":"3","author":"Bajaj","year":"2011","journal-title":"Curr. Res. Dairy Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e20220097","DOI":"10.1590\/1984-3143-ar2022-0097","article-title":"Endometrial receptivity in cattle: The mutual reprogramming paradigm","volume":"19","author":"Binelli","year":"2022","journal-title":"Anim. Reprod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"106251","DOI":"10.1016\/j.anireprosci.2019.106251","article-title":"Pregnancy loss in beef cattle: A meta-analysis","volume":"212","author":"Reese","year":"2020","journal-title":"Anim. Reprod. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1439-0531.2008.01171.x","article-title":"Embryonic and early foetal losses in cattle and other ruminants","volume":"43","author":"Diskin","year":"2008","journal-title":"Reprod. Domest. Anim."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2527\/af.2013-0033","article-title":"Early pregnancy: Concepts, challenges, and potential solutions","volume":"3","author":"Spencer","year":"2013","journal-title":"Anim. Front."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"103526","DOI":"10.1016\/j.jprot.2019.103526","article-title":"Proteomic analysis of sheep uterus reveals its role in prolificacy","volume":"210","author":"La","year":"2020","journal-title":"J. Proteom."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hasin, Y., Seldin, M., and Lusis, A. (2017). Multi-omics approaches to disease. Genome Biol., 18.","DOI":"10.1186\/s13059-017-1215-1"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"eabk0734","DOI":"10.1126\/sciadv.abk0734","article-title":"Consortium for Top-Down Proteomics. The Human Proteoform Project: Defining the human proteome","volume":"7","author":"Smith","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cell.2007.07.032","article-title":"Is proteomics the new genomics?","volume":"130","author":"Cox","year":"2007","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/chromsci\/bmw167","article-title":"Proteomics: Technologies and Their Applications","volume":"55","author":"Aslam","year":"2017","journal-title":"J. Chromatogr. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Carbonara, K., Andonovski, M., and Coorssen, J.R. (2021). Proteomes Are of Proteoforms: Embracing the Complexity. Proteomes, 9.","DOI":"10.3390\/proteomes9030038"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nmeth.2369","article-title":"Proteoform: A single term describing protein complexity","volume":"10","author":"Smith","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ercan, H., Resch, U., Hsu, F., Mitulovic, G., Bileck, A., Gerner, C., Yang, J.W., Geiger, M., Miller, I., and Zellner, M. (2023). A Practical and Analytical Comparative Study of Gel-Based Top-Down and Gel-Free Bottom-Up Proteomics Including Unbiased Proteoform Detection. Cells, 12.","DOI":"10.3390\/cells12050747"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1389202911314020003","article-title":"Integrated analysis of transcriptomic and proteomic data","volume":"14","author":"Haider","year":"2013","journal-title":"Curr. Genom."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1038\/s41467-021-24030-x","article-title":"Systematic detection of functional proteoform groups from bottom-up proteomic datasets","volume":"12","author":"Bludau","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.5455\/javar.2018.e297","article-title":"Anatomical and histological changes of uterine horn of Aceh cattle with repeat breeding","volume":"5","author":"Thasmi","year":"2018","journal-title":"J. Adv. Vet. Anim. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2013.08.003","article-title":"Remodeling of bovine endometrium throughout the estrous cycle","volume":"142","author":"Arai","year":"2013","journal-title":"Anim. Reprod. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1017\/S1751731114000470","article-title":"Maternal-embryo interaction leading up to the initiation of implantation of pregnancy in cattle","volume":"8","author":"Lonergan","year":"2014","journal-title":"Animal"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1152\/physiolgenomics.00047.2010","article-title":"Bovine pretransfer endometrium and embryo transcriptome fingerprints as predictors of pregnancy success after embryo transfer","volume":"42","author":"Rings","year":"2010","journal-title":"Physiol. Genom."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.theriogenology.2021.09.026","article-title":"PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells","volume":"176","author":"Li","year":"2021","journal-title":"Theriogenology"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Deutsch, D.R., Fr\u00f6hlich, T., and Arnold, G.J. (2019). Proteomics of bovine endometrium, oocytes and early embryos. Biosci. Proc., 8.","DOI":"10.1530\/biosciprocs.8.003"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/mrd.20931","article-title":"Bovine endometrial legumain and TIMP-2 regulation in response to presence of a conceptus","volume":"76","author":"Ledgard","year":"2009","journal-title":"Mol. Reprod. Dev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1071\/RD13144","article-title":"Influence of pathogenic bacteria species present in the postpartum bovine uterus on proteome profiles","volume":"27","author":"Ledgard","year":"2015","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1021\/pr300144q","article-title":"Proteomic characterization of histotroph during the preimplantation phase of the estrous cycle in cattle","volume":"11","author":"Mullen","year":"2012","journal-title":"J. Proteome Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1002\/pmic.201100609","article-title":"A comparison of the bovine uterine and plasma proteome using iTRAQ proteomics","volume":"12","author":"Faulkner","year":"2012","journal-title":"Proteomics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1002\/pmic.201300204","article-title":"Composition of the bovine uterine proteome is associated with stage of cycle and concentration of systemic progesterone","volume":"13","author":"Faulkner","year":"2013","journal-title":"Proteomics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1530\/REP-13-0010","article-title":"Proteomic analysis of uterine fluid during the pre-implantation period of pregnancy in cattle","volume":"147","author":"Forde","year":"2014","journal-title":"Reproduction"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/biolre\/ioab190","article-title":"Proteomic determinants of uterine receptivity for pregnancy in early and mid-postpartum dairy cows","volume":"105","author":"Aranciaga","year":"2021","journal-title":"Biol. Reprod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.113.108696","article-title":"Proteomic Profiles of the Embryonic Chorioamnion and Uterine Caruncles in Buffaloes (Bubalus bubalis) with Normal and Retarded Embryonic Development","volume":"88","author":"Balestrieri","year":"2013","journal-title":"Bio. Reprod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/pmic.200401242","article-title":"Holistic differential analysis of embryo-induced alter-ations in the proteome of bovine endometrium in the preattachment period","volume":"5","author":"Berendt","year":"2005","journal-title":"Proteomics"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, C., Hou, Z., Miao, K., Zhao, H., Wang, R., Guo, M., Wu, Z., Tian, J., and An, L. (2013). Comparative analysis of proteomic profiles between endometrial caruncular and intercaruncular areas in ewes during the peri-implantation period. J. Anim. Sci. Biotechnol., 4.","DOI":"10.1186\/2049-1891-4-39"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1530\/REP-13-0600","article-title":"Proteomic analysis of the sheep caruncular and intercaruncular endometrium reveals changes in functional proteins crucial for the establishment of pregnancy","volume":"147","author":"Arianmanesh","year":"2014","journal-title":"Reproduction"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zhao, H., Sui, L., Miao, K., An, L., Wang, D., Hou, Z., Wang, R., Guo, M., Wang, Z., and Xu, J. (2015). Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period. J. Anim. Sci. Biotechnol., 6.","DOI":"10.1186\/s40104-015-0017-0"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.anireprosci.2016.11.001","article-title":"The sheep conceptus modulates proteome profiles in caruncular endometrium during early pregnancy","volume":"175","author":"Arianmanesh","year":"2016","journal-title":"Anim. Reprod. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1021\/pr100096b","article-title":"Proteomic profile of uterine luminal fluid from early pregnant ewes","volume":"9","author":"Koch","year":"2010","journal-title":"J. Proteome Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Brooks, K., Burns, G.W., Moraes, J.G., and Spencer, T.E. (2016). Analysis of the Uterine Epithelial and Conceptus Transcriptome and Luminal Fluid Proteome During the Peri-Implantation Period of Pregnancy in Sheep. Biol. Reprod., 95.","DOI":"10.1095\/biolreprod.116.141945"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/biolre\/iox078","article-title":"Pregnancy-induced changes in metabolome and proteome in ovine uterine flushings","volume":"97","author":"Romero","year":"2017","journal-title":"Biol. Reprod."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1477-5956-9-41","article-title":"Proteomic analysis of pregnancy-related proteins from pig uterus endometrium during pregnancy","volume":"9","author":"Chae","year":"2011","journal-title":"Proteome Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jprot.2015.05.003","article-title":"Proteomic analysis of porcine endometrial tissue during peri-implan-tation period reveals altered protein abundance","volume":"125","author":"Jalali","year":"2015","journal-title":"J. Proteom."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/mrd.22733","article-title":"Proteomic and network analysis of pregnancy-induced changes in the porcine endometrium on Day 12 of gestation","volume":"83","author":"Jalali","year":"2016","journal-title":"Mol. Reprod. Dev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Pierzcha\u0142a, D., Liput, K., Korwin-Kossakowska, A., Og\u0142uszka, M., Po\u0142awska, E., Nawrocka, A., Urba\u0144ski, P., Ciep\u0142och, A., Juszczuk-Kubiak, E., and Lepczy\u0144ski, A. (2021). Molecular Characterisation of Uterine Endometrial Proteins during Early Stages of Pregnancy in Pigs by MALDI TOF\/TOF. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136720"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, K., Yang, K., Xu, Q., Liu, Y., Li, W., Bai, Y., Wang, J., Ding, C., Liu, X., and Tang, Q. (2019). Protein expression profiles in Meishan and Duroc sows during mid-gestation reveal differences affecting uterine capacity, endometrial receptivity, and the maternal-fetal Interface. BMC Genom., 20.","DOI":"10.1186\/s12864-019-6353-2"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Liu, S., Cui, H., Li, Q., Zhang, L., Na, Q., and Liu, C. (2014). RhoGDI2 is expressed in human trophoblasts and involved in their migration by inhibiting the activation of RAC1. Biol. Reprod., 90.","DOI":"10.1095\/biolreprod.113.111153"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s11745-010-3437-9","article-title":"Acyl-CoA binding protein gene ablation induces pre-implantation embryonic lethality in mice","volume":"45","author":"Landrock","year":"2010","journal-title":"Lipids"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1262\/jrd.20045","article-title":"Involvement of 20\u03b1-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice","volume":"54","author":"Choi","year":"2008","journal-title":"J. Reprod. Dev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.theriogenology.2004.10.012","article-title":"Embryonic mortality in buffaloes synchronized and mated by AI during the seasonal decline in reproductive function","volume":"63","author":"Campanile","year":"2005","journal-title":"Theriogenology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/j.1439-0531.2009.01472.x","article-title":"Corpus luteum function and pregnancy outcome in buffaloes during the transition period from breeding to non-breeding season","volume":"45","author":"Russo","year":"2010","journal-title":"Reprod. Domest. Anim."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1472-6483(10)60429-4","article-title":"Cytokine profiling in endometrial secretions: A non-invasive window on endometrial receptivity","volume":"18","author":"Boomsma","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/biolre\/ioaa150","article-title":"The endometrial proteomic profile around the time of embryo implantation","volume":"104","author":"Guo","year":"2021","journal-title":"Biol. Reprod."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1095\/biolreprod.111.094722","article-title":"Uterine histotroph and conceptus development: Select nutrients and secreted phosphoprotein 1 affect mechanistic target of rapamycin cell signaling in ewes","volume":"85","author":"Bazer","year":"2011","journal-title":"Biol. Reprod."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Simintiras, C.A., Drum, J.N., Liu, H., Sofia Ortega, M., and Spencer, T.E. (2022). Uterine lumen fluid is metabolically semi-autonomous. Commun. Biol., 5.","DOI":"10.1038\/s42003-022-03134-0"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103884","DOI":"10.1016\/j.jprot.2020.103884","article-title":"Quantitative proteomic strategies to study reproduction in farm animals: Female reproductive flu-ids","volume":"225","author":"Brem","year":"2020","journal-title":"J. Proteom."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1071\/RD11225","article-title":"Effect of asynchronous transfer on bovine embryonic devel-opment and relationship with early cycle uterine proteome profiles","volume":"24","author":"Ledgard","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in Inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.placenta.2013.06.307","article-title":"Role of inflammatory proteins S100A8 and S100A9 in pathophysiology of recurrent early preg-nancy loss","volume":"34","author":"Nair","year":"2013","journal-title":"Placenta"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.domaniend.2013.10.003","article-title":"Global proteomic characterization of uterine histotroph recovered from beef heifers yielding good quality and degenerate day 7 embryos","volume":"46","author":"Beltman","year":"2014","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-0897.1996.tb00043.x","article-title":"Platelet activating factor and conception","volume":"35","author":"Minhas","year":"1996","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Tang, S., Ni, J., Chen, B., Sun, F., Huang, J., Ni, S., and Tang, Z. (2022). PAFAH1B3 predicts poor prognosis and promotes progression in lung adenocarcinoma. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09617-x"},{"key":"ref_65","first-page":"700","article-title":"Identification of PAFAH1B3 as Candidate Prognosis Marker and Potential Therapeutic Target for Hepatocellular Carcinoma","volume":"11","author":"Xu","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_66","first-page":"960","article-title":"S100A4 promotes the development of lipopolysaccharide-induced mouse endometritis","volume":"99","author":"Wu","year":"2018","journal-title":"Biol. Reprod."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Fei, F., Qu, J., Li, C., Wang, X., Li, Y., and Zhang, S. (2017). Role of metastasis-induced protein S100A4 in human non-tumor pathophysiologies. Cell Biosci., 7.","DOI":"10.1186\/s13578-017-0191-1"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/age.12721","article-title":"Pre- and post-puberty expression of genes and proteins in the uterus of Bos indicus heifers: The luteal phase effect post-puberty","volume":"49","author":"Fortes","year":"2018","journal-title":"Anim. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1530\/rep.1.01136","article-title":"A bovine oviduct epithelial cell suspension culture system suitable for studying embryo-maternal interactions: Morphological and functional characterization","volume":"132","author":"Rottmayer","year":"2006","journal-title":"Reproduction"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/molehr\/gaq056","article-title":"Oviductal secretions: Will they be key factors for the future ARTs?","volume":"16","author":"Coy","year":"2010","journal-title":"Mol. Hum. Reprod."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"32556","DOI":"10.1038\/srep32556","article-title":"The C-terminal region of OVGP1 remodels the zona pellucida and modifies fertility parameters","volume":"6","author":"Algarra","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10815-018-1231-4","article-title":"Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion","volume":"35","author":"Laheri","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1091\/mbc.e04-01-0048","article-title":"Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells","volume":"15","author":"Bertling","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1292\/jvms.63.11","article-title":"Immunolocalization of gastrin-releasing peptide in the bovine uterus and placenta","volume":"63","author":"Budipitoj","year":"2001","journal-title":"J. Vet. Med. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/biolre\/ioz197","article-title":"Analysis of the uterine lumen in fertility-classified heifers: II. Proteins and metabolites \u2020","volume":"102","author":"Moraes","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1017\/S1751731114000743","article-title":"Genetics and genomics of reproductive performance in dairy and beef cattle","volume":"8","author":"Berry","year":"2014","journal-title":"Animal"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/biolre\/ioz216","article-title":"Genetic merit for fertility alters the bovine uterine luminal fluid proteome \u2020","volume":"102","author":"Gegenfurtner","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Steinhauser, C.B., Landers, M., Myatt, L., Burghardt, R.C., Vallet, J.L., Bazer, F.W., and Johnson, G.A. (2016). Fructose Synthesis and Transport at the Uterine-Placental Interface of Pigs: Cell-Specific Localization of SLC2A5, SLC2A8, and Components of the Polyol Pathway. Biol. Reprod., 95.","DOI":"10.1095\/biolreprod.116.142174"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1439-0531.2011.01851.x","article-title":"Dry period management and optimization of post-partum reproductive management in dairy cattle","volume":"46","author":"Gumen","year":"2011","journal-title":"Reprod. Domest. Anim."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Jhamat, N., Niazi, A., Guo, Y., Chanrot, M., Ivanova, E., Kelsey, G., Bongcam-Rudloff, E., Andersson, G., and Humblot, P. (2020). LPS-treatment of bovine endometrial epithelial cells causes differential DNA methylation of genes associated with inflammation and endometrial function. BMC Genom., 21.","DOI":"10.1186\/s12864-020-06777-7"},{"key":"ref_81","first-page":"257","article-title":"Application of microfluidic technologies to human assisted reproduction","volume":"23","author":"Smith","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"bqab054","DOI":"10.1210\/endocr\/bqab054","article-title":"Endometrium On-a-Chip Reveals Insulin-and Glucose-induced Alterations in the Transcriptome and Proteomic Secretome","volume":"162","author":"Tinning","year":"2021","journal-title":"Endocrinology"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Goharitaban, S., Abedelahi, A., Hamdi, K., Khazaei, M., Esmaeilivand, M., and Niknafs, B. (2022). Role of endometrial microRNAs in repeated implantation failure (mini-review). Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.936173"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Liang, J., Wang, S., and Wang, Z. (2017). Role of microRNAs in embryo implantation. Reprod. Biol. Endocrinol., 15.","DOI":"10.1186\/s12958-017-0309-7"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"676791","DOI":"10.3389\/fgene.2021.676791","article-title":"Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions","volume":"12","author":"Kusama","year":"2021","journal-title":"Front. Genet."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Asea, A., and Kaur, P. (2019). Heat Shock Protein 90 in Human Diseases and Disorders, Springer.","DOI":"10.1007\/978-3-030-23158-3"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.3168\/jds.2017-14190","article-title":"Proteome profiling of exosomes derived from plasma of heifers with divergent genetic merit for fertility","volume":"101","author":"Koh","year":"2018","journal-title":"J. Dairy Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1530\/REP-12-0279","article-title":"Roles of the oviduct in mammalian fertilization","volume":"144","author":"Coy","year":"2012","journal-title":"Reproduction"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-16-0302","article-title":"Oviduct: Roles in fertilization and early embryo development","volume":"232","author":"Li","year":"2017","journal-title":"J. Endocrin."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1038\/s41598-022-07929-3","article-title":"Spatiotemporal profiling of the bovine oviduct fluid proteome around the time of ovulation","volume":"12","author":"Lavigne","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Saint-Dizier, M., Schoen, J., Chen, S., Banliat, C., and Mermillod, P. (2019). Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010223"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1530\/REP-16-0397","article-title":"Regulation of the bovine oviductal fluid proteome","volume":"152","author":"Lamy","year":"2016","journal-title":"Reproduction"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1152\/physrev.00030.2001","article-title":"Annexins: From structure to function","volume":"82","author":"Gerke","year":"2002","journal-title":"Physiol. Rev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12967-016-0843-7","article-title":"Annexins family: Insights into their functions and potential role in pathogenesis of sarcoidosis","volume":"14","author":"Mirsaeidi","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1242\/jcs.01245","article-title":"Annexins\u2013unique membrane binding proteins with diverse functions","volume":"117","author":"Rescher","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Alauddin, M., Salker, M.S., Umbach, A.T., Rajaxavier, J., Okumura, T., Singh, Y., Wagner, A., Brucker, S.Y., Wallwiener, D., and Brosens, J.J. (2020). Annexin A7 Regulates Endometrial Receptivity. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00770"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/molehr\/gaaa065","article-title":"Annexin A2 acts as an adherent molecule under the regulation of steroids during embryo implantation","volume":"26","author":"Wang","year":"2020","journal-title":"Mol. Hum. Reprod."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Wang, B., Ye, T.M., Lee, K.F., Chiu, P.C., Pang, R.T., Ng, E.H., and Yeung, W.S. (2015). Annexin A2 Acts as an Adhesion Molecule on the Endometrial Epithelium during Implantation in Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139506"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Pillai, V.V., Weber, D.M., Phinney, B.S., and Selvaraj, V. (2017). Profiling of proteins secreted in the bovine oviduct reveals diverse functions of this luminal microenvironment. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188105"},{"key":"ref_100","first-page":"153","article-title":"Oviduct extracellular vesicles protein content and their role during oviduct-embryo cross-talk","volume":"154","author":"Corbin","year":"2017","journal-title":"Reproduction"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Almi\u00f1ana, C., Tsikis, G., Labas, V., Uzbekov, R., da Silveira, J.C., Bauersachs, S., and Mermillod, P. (2018). Deciphering the oviductal extracellular vesicles content across the estrous cycle: Implica-tions for the gametes-oviduct interactions and the environment of the potential embryo. BMC Genom., 19.","DOI":"10.1186\/s12864-018-4982-5"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.theriogenology.2019.04.009","article-title":"A novel approach to study the bovine oviductal fluid proteome using transvaginal endoscopy","volume":"132","author":"Papp","year":"2019","journal-title":"Theriogenology"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Alonso, B., Maillo, V., Acu\u00f1a, O.S., L\u00f3pez-\u00dabeda, R., Torrecillas, A., Simintiras, C.A., Sturmey, R., Avil\u00e9s, M., Lonergan, P., and Rizos, D. (2020). Spatial and Pregnancy-Related Changes in the Protein, Amino Acid, and Car-bohydrate Composition of Bovine Oviduct Fluid. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051681"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/biolre\/ioz142","article-title":"Influence of metabolic status and genetic merit for fertility on proteomic composition of bovine oviduct fluid","volume":"101","author":"Gegenfurtner","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"12353","DOI":"10.1038\/s41598-020-69317-z","article-title":"Dynamics of uterine microbiota in postpartum dairy cows with clinical or subclinical endometritis","volume":"10","author":"Pascottini","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4196\/kjpp.2010.14.4.205","article-title":"Proteomic analysis of differentially expressed proteins in bovine endometrium with endome-tritis","volume":"14","author":"Choe","year":"2010","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1210\/en.2013-1822","article-title":"Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6","volume":"155","author":"Turner","year":"2014","journal-title":"Endocrinology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1751731114002602","article-title":"Animal board invited review: Advances in proteomics for animal and food sciences","volume":"9","author":"Almeida","year":"2015","journal-title":"Animal"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/elps.200500742","article-title":"Serum protein pattern during cow pregnancy: Acute-phase proteins increase in the peripartum period","volume":"27","author":"Cairoli","year":"2006","journal-title":"Electrophoresis"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3168\/jds.2020-19025","article-title":"Acute-phase protein \u03b1-1-acid glycoprotein is negatively associated with feed intake in postpartum dairy cows","volume":"104","author":"Brown","year":"2021","journal-title":"J. Dairy Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/09712119.2013.842485","article-title":"Changes in the concentrations of selected acute phase proteins and variables of energetic profile in dairy cows after parturition","volume":"42","author":"Nagy","year":"2014","journal-title":"J. Appl. Anim. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5194\/aab-65-329-2022","article-title":"Changes of acute-phase proteins, glucose, and lipid metabolism during pregnancy in lactating dairy cows","volume":"65","author":"Fazio","year":"2022","journal-title":"Arch. Anim. Breed."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1039\/C6MB00723F","article-title":"Changes in protein expression profiles in bovine endometrial epithelial cells exposed to E. coli LPS challenge","volume":"13","author":"Piras","year":"2017","journal-title":"Mol. BioSystems"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"9324","DOI":"10.3168\/jds.2016-12365","article-title":"Differential proteomic profiling of endometrium and plasma indicate the importance of hydrolysis in bovine endometritis","volume":"100","author":"Zhang","year":"2017","journal-title":"J. Dairy Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s12011-019-01999-7","article-title":"Comparative iTRAQ Proteomics Reveals Multiple Effects of Selenium Yeast on Dairy Cows in Parturition","volume":"197","author":"Ren","year":"2020","journal-title":"Biol. Trace Element Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"103421","DOI":"10.1016\/j.jprot.2019.103421","article-title":"Characterization of circulating plasma proteins in dairy cows with cytological endometritis","volume":"205","author":"Miller","year":"2019","journal-title":"J. Proteom."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.theriogenology.2019.09.016","article-title":"Novel sampling procedure to characterize bovine subclinical endometritis by uterine secretions and tissue","volume":"141","author":"Helfrich","year":"2020","journal-title":"Theriogenology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.2147\/IJN.S264498","article-title":"Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Liu, Y., Liu, H., and Tang, W.H. (2019). Exosomes: Biogenesis, biologic function and clinical potential. Cell Biosci., 9.","DOI":"10.1186\/s13578-019-0282-2"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.theriogenology.2018.03.024","article-title":"Proteomic content of circulating exosomes in dairy cows with or without uterine infection","volume":"114","author":"Almughlliq","year":"2018","journal-title":"Theriogenology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3389\/fimmu.2020.01757","article-title":"The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.3389\/fimmu.2019.02817","article-title":"Editorial: The Role of Pentraxins: From Inflammation, Tissue Repair and Immunity to Biomarkers","volume":"10","author":"Bottazzi","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"843","DOI":"10.21451\/1984-3143-AR2018-0014","article-title":"Cellular events during ovine implantation and impact for gestation","volume":"15","author":"Johnson","year":"2018","journal-title":"Anim. Reprod."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"27606","DOI":"10.1038\/srep27606","article-title":"Ovarian proteomic study reveals the possible molecular mechanism for hyperprolificacy of Small Tail Han sheep","volume":"6","author":"Miao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"103394","DOI":"10.1016\/j.jprot.2019.103394","article-title":"The genetic mechanism of high prolificacy in small tail han sheep by comparative proteomics of ovaries in the follicular and luteal stages","volume":"204","author":"Tang","year":"2019","journal-title":"J. Proteom."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1074\/mcp.M115.052332","article-title":"Proteomes of the Female Genital Tract During the Oestrous Cycle","volume":"15","author":"Soleilhavoup","year":"2016","journal-title":"Mol. Cell Proteom."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Yang, Q., Fu, W., Wang, Y., Miao, K., Zhao, H., Wang, R., Guo, M., Wang, Z., Tian, J., and An, L. (2020). The proteome of IVF-induced aberrant embryo-maternal crosstalk by implantation stage in ewes. J. Animal Sci. Biotechnol., 11.","DOI":"10.1186\/s40104-019-0405-y"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/humrep\/des397","article-title":"Post-implantation mortality of in vitro produced embryos is associated with DNA me-thyltransferase 1 dysfunction in sheep placenta","volume":"28","author":"Ptak","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Yang, Q., Liu, J., Wang, Y., Zhao, W., Wang, W., Cui, J., Yang, J., Yue, Y., Zhang, S., and Chu, M. (2022). A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling. J. Biol. Chem., 298.","DOI":"10.1016\/j.jbc.2021.101456"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/biolre\/ioaa019","article-title":"Characterization and regulation of extracellular vesicles in the lumen of the ovine uterus\u2020","volume":"102","author":"Burns","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Burns, G., Brooks, K., Wildung, M., Navakanitworakul, R., Christenson, L.K., and Spencer, T.E. (2014). Extracellular vesicles in luminal fluid of the ovine uterus. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090913"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Burns, G.W., Brooks, K.E., and Spencer, T.E. (2016). Extracellular Vesicles Originate from the Conceptus and Uterus During Early Pregnancy in Sheep. Biol. Reprod., 94.","DOI":"10.1095\/biolreprod.115.134973"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/mrd.23567","article-title":"Novel insights into conceptus-maternal signaling during preg-nancy establishment in pigs","volume":"90","author":"Kaczynski","year":"2023","journal-title":"Mol. Reprod. Dev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/mrd.22847","article-title":"Pregnancy and spontaneous fetal loss: A pig perspective","volume":"84","author":"Bidarimath","year":"2017","journal-title":"Mol. Reprod. Dev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cytogfr.2007.06.010","article-title":"Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy","volume":"18","author":"Roberts","year":"2007","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1002\/pmic.200800776","article-title":"Comparative proteomic and regulatory network analyses of the elongating pig conceptus","volume":"9","author":"Degrelle","year":"2009","journal-title":"Proteomics"},{"key":"ref_139","first-page":"1055","article-title":"Progress and challenges in the proteomics of domestic pig in research on the female reproductive system","volume":"21","author":"Kolakowska","year":"2016","journal-title":"J. Element."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1074\/mcp.M500119-MCP200","article-title":"Gametes alter the oviductal secretory proteome","volume":"4","author":"Georgiou","year":"2005","journal-title":"Mol. Cell Proteom."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"104570","DOI":"10.1016\/j.jprot.2022.104570","article-title":"iTRAQ-based quantitative proteomic analysis of porcine uterine fluid during pre-implantation period of pregnancy","volume":"261","author":"He","year":"2022","journal-title":"J. Proteom."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Padua, M.B., Lynch, V.J., Alvarez, N.V., Garthwaite, M.A., Golos, T.G., Bazer, F.W., Kalkunte, S., Sharma, S., Wagner, G.P., and Hansen, P.J. (2012). ACP5 (Uteroferrin): Phylogeny of an ancient and conserved gene expressed in the endometrium of mammals. Biol. Reprod., 86.","DOI":"10.1095\/biolreprod.111.097964"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1095\/biolreprod26.4.729","article-title":"Role of uteroferrin in iron transport and macromolecular uptake by allantoic epithelium of the porcine conceptus","volume":"26","author":"Ducsay","year":"1982","journal-title":"Biol. Reprod."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1071\/RD22105","article-title":"Global proteomic analysis of serum during early pregnancy in the pig using data-independent acquisition mass spectrometry with verification by parallel reaction monitoring","volume":"34","author":"Xin","year":"2022","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"100352","DOI":"10.1016\/j.animal.2021.100352","article-title":"Selection for litter size and litter birthweight in Large White pigs: Maximum, mean and variability of reproduc-tion traits","volume":"15","year":"2021","journal-title":"Animal"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/jpn.12679","article-title":"Arginine for gestating sows and foetal development: A systematic review","volume":"102","author":"Palencia","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/scdb.2000.0153","article-title":"Molecular signaling in uterine receptivity for implantation","volume":"11","author":"Paria","year":"2000","journal-title":"Semin Cell Dev Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1530\/REP-16-0331","article-title":"Uterine focal adhesions are retained at implantation after rat ovarian hyperstimu-lation","volume":"152","author":"Lindsay","year":"2016","journal-title":"Reproduction"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jmor.20010","article-title":"Focal Adhesion Kinase Localizes to Sites of Cell-to-Cell Contact In Vivo and Increases Apically in Rat Uterine Luminal Epithelium and the Blastocyst at the Time of Implantation","volume":"273","author":"Kaneko","year":"2012","journal-title":"J. Morphol."}],"container-title":["Journal of Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2221-3759\/12\/1\/2\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:45:04Z","timestamp":1760132704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2221-3759\/12\/1\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,30]]},"references-count":149,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jdb12010002"],"URL":"https:\/\/doi.org\/10.3390\/jdb12010002","relation":{},"ISSN":["2221-3759"],"issn-type":[{"value":"2221-3759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,30]]}}}