{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:06:19Z","timestamp":1792087579796,"version":"4.4.0"},"reference-count":107,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100483"],"award-info":[{"award-number":["32100483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GZNL2023A02007"],"award-info":[{"award-number":["GZNL2023A02007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GZNL2023A03005"],"award-info":[{"award-number":["GZNL2023A03005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Project of Guangzhou National Laboratory","award":["32100483"],"award-info":[{"award-number":["32100483"]}]},{"name":"Major Project of Guangzhou National Laboratory","award":["GZNL2023A02007"],"award-info":[{"award-number":["GZNL2023A02007"]}]},{"name":"Major Project of Guangzhou National Laboratory","award":["GZNL2023A03005"],"award-info":[{"award-number":["GZNL2023A03005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JDB"],"abstract":"<jats:p>The NR2F family, including NR2F1, NR2F2, and NR2F6, belongs to the nuclear receptor superfamily. NR2F family members function as transcription factors and play essential roles in the development of multiple organs or tissues in mammals, including the central nervous system, veins and arteries, kidneys, uterus, and vasculature. In the central nervous system, NR2F1\/2 coordinate with each other to regulate the development of specific brain subregions or cell types. In addition, NR2F family members are associated with various cancers, such as prostate cancer, breast cancer, and esophageal cancer. Nonetheless, the roles of the NR2F family in the development and diseases of the lung have not been systematically summarized. In this review, we mainly focus on the lung, including recent findings regarding the roles of the NR2F family in development, physiological function, and cancer.<\/jats:p>","DOI":"10.3390\/jdb12030024","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T02:34:49Z","timestamp":1726022089000},"page":"24","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Roles of the NR2F Family in the Development, Disease, and Cancer of the Lung"],"prefix":"10.3390","volume":"12","author":[{"given":"Jiaxin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Basic Research, Guangzhou National Laboratory, Guangzhou 510005, China"},{"name":"School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6394-2773","authenticated-orcid":false,"given":"Guizhong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Basic Research, Guangzhou National Laboratory, Guangzhou 510005, China"},{"name":"School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sever, R., and Glass, C.K. (2013). Signaling by nuclear receptors. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a016709"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Parris, T.Z. (2020). Pan-cancer analyses of human nuclear receptors reveal transcriptome diversity and prognostic value across cancer types. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-58842-6"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1530\/REP-21-0118","article-title":"Orphan nuclear receptors in angiogenesis and follicular development","volume":"162","author":"Guzman","year":"2021","journal-title":"Reproduction"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16080","DOI":"10.1016\/S0021-9258(18)47698-3","article-title":"Purification and characterization of chicken ovalbumin upstream promoter transcription factor from HeLa cells","volume":"262","author":"Wang","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref_5","first-page":"207","article-title":"The COUP-TFs compose a family of functionally related transcription factors","volume":"1","author":"Wang","year":"1991","journal-title":"Gene Expr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0378-1119(94)90283-6","article-title":"The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor","volume":"142","author":"Barnhart","year":"1994","journal-title":"Gene"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2302\/kjm.52.174","article-title":"Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions","volume":"52","author":"Park","year":"2003","journal-title":"Keio J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1128\/MCB.16.5.2332","article-title":"Molecular mechanisms of COUP-TF-mediated transcriptional repression: Evidence for transrepression and active repression","volume":"16","author":"Leng","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbagrm.2014.05.022","article-title":"COUP-TFs and eye development","volume":"1849","author":"Tang","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_10","first-page":"4153","article-title":"Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors","volume":"12","author":"Cooney","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kruse, S.W., Suino-Powell, K., Zhou, X.E., Kretschman, J.E., Reynolds, R., Vonrhein, C., Xu, Y., Wang, L., Tsai, S.Y., and Tsai, M.J. (2008). Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol., 6.","DOI":"10.1371\/journal.pbio.0060227"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/nn1958","article-title":"COUP-TFI regulates the balance of cortical patterning between frontal\/motor and sensory areas","volume":"10","author":"Armentano","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1523\/JNEUROSCI.6580-10.2011","article-title":"Loss of COUP-TFI alters the balance between caudal ganglionic eminence- and medial ganglionic eminence-derived cortical interneurons and results in resistance to epilepsy","volume":"31","author":"Lodato","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1093\/cercor\/bhx185","article-title":"The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon","volume":"27","author":"Lindsay","year":"2017","journal-title":"Cereb. Cortex"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"RP86940","DOI":"10.7554\/eLife.86940.3","article-title":"The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes","volume":"12","author":"Yang","year":"2023","journal-title":"eLife"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ajhg.2014.01.002","article-title":"NR2F1 mutations cause optic atrophy with intellectual disability","volume":"94","author":"Bosch","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/bs.ctdb.2016.12.002","article-title":"COUP-TF Genes, Human Diseases, and the Development of the Central Nervous System in Murine Models","volume":"125","author":"Yang","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107521","DOI":"10.1016\/j.celrep.2020.03.085","article-title":"Imbalance of Excitatory\/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1242\/dev.076299","article-title":"COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival","volume":"139","author":"Yu","year":"2012","journal-title":"Development"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1242\/dev.01808","article-title":"COUP-TFII is essential for radial and anteroposterior patterning of the stomach","volume":"132","author":"Takamoto","year":"2005","journal-title":"Development"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16351","DOI":"10.1073\/pnas.0507832102","article-title":"Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia","volume":"102","author":"You","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1074\/mcp.M114.045328","article-title":"A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation","volume":"14","author":"Barderas","year":"2015","journal-title":"Mol. Cell Proteom."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/s41467-018-04004-2","article-title":"Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1\/PD-1 cancer immune checkpoint blockade","volume":"9","author":"Klepsch","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1073\/pnas.0914619107","article-title":"COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis","volume":"107","author":"Qin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature11674","article-title":"COUP-TFII inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis","volume":"493","author":"Qin","year":"2013","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12943-019-1046-7","article-title":"Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/aps.2014.86","article-title":"The role of the orphan nuclear receptor COUP-TFII in tumorigenesis","volume":"36","author":"Xu","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Sajinovic, T., and Baier, G. (2023). New Insights into the Diverse Functions of the NR2F Nuclear Orphan Receptor Family. Front. Biosci., 28.","DOI":"10.31083\/j.fbl2801013"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbrc.2019.09.015","article-title":"NR2F1-induced NR2F1-AS1 promotes esophageal squamous cell carcinoma progression via activating Hedgehog signaling pathway","volume":"519","author":"Zhang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.brainres.2018.04.024","article-title":"The pleiotropic transcriptional regulator COUP-TFI plays multiple roles in neural development and disease","volume":"1705","author":"Bertacchi","year":"2019","journal-title":"Brain Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1242\/dev.098186","article-title":"Lung development: Orchestrating the generation and regeneration of a complex organ","volume":"141","author":"Herriges","year":"2014","journal-title":"Development"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1242\/dev.124.23.4867","article-title":"Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung","volume":"124","author":"Bellusci","year":"1997","journal-title":"Development"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/dbio.1998.8994","article-title":"FGF-10 is a chemotactic factor for distal epithelial buds during lung development","volume":"201","author":"Park","year":"1998","journal-title":"Dev. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1242\/dev.127.12.2695","article-title":"Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis","volume":"127","author":"Weaver","year":"2000","journal-title":"Development"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1242\/dev.034629","article-title":"Multiple roles for Sox2 in the developing and adult mouse trachea","volume":"136","author":"Que","year":"2009","journal-title":"Development"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1165\/rcmb.2010-0149OC","article-title":"Sox2 activates cell proliferation and differentiation in the respiratory epithelium","volume":"45","author":"Tompkins","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-016-2545-0","article-title":"Development of the lung","volume":"367","author":"Schittny","year":"2017","journal-title":"Cell Tissue Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/cs1030613","article-title":"Retinoid receptors in the developing human lung","volume":"103","author":"Kimura","year":"2002","journal-title":"Clin. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Miao, Y., Tan, C., Pek, N.M., Yu, Z., Iwasawa, K., Kechele, D.O., Sundaram, N., Pastrana-Gomez, V., Kishimoto, K., and Yang, M.C. (2024). Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids. bioRxiv.","DOI":"10.1101\/2024.02.06.577460"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/CIRCULATIONAHA.120.052318","article-title":"Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung","volume":"144","author":"Schupp","year":"2021","journal-title":"Circulation"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Shimamura, Y., Tanaka, J., Kakiuchi, M., Sarmah, H., Miura, A., Hwang, Y., Sawada, A., Ninish, Z., Yamada, K., and Mori, M. (2022). A developmental program that regulates mammalian organ size offsets evolutionary distance. bioRxiv.","DOI":"10.1101\/2022.10.19.512107"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41419-024-06610-z","article-title":"PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFR(L858R)-induced lung cancer progression","volume":"15","author":"Tran","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1086\/429842","article-title":"Congenital diaphragmatic hernia and chromosome 15q26: Determination of a candidate region by use of fluorescent in situ hybridization and array-based comparative genomic hybridization","volume":"76","author":"Klaassens","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1165\/rcmb.2023-0080OC","article-title":"Single-Cell RNA Sequencing Provides New Insights into Therapeutic Roles of Thyroid Hormone in Idiopathic Pulmonary Fibrosis","volume":"69","author":"Wang","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li, L., Galichon, P., Xiao, X., Figueroa-Ramirez, A.C., Tamayo, D., Lee, J.J.K., Kalocsay, M., Gonzalez-Sanchez, D., Chancay, S., and Bonventre, J.V. (2020). Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis. bioRxiv.","DOI":"10.1101\/2020.06.05.135889"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1900329","DOI":"10.1183\/13993003.00329-2019","article-title":"A genome-wide association study implicates NR2F2 in lymphangioleiomyomatosis pathogenesis","volume":"53","author":"Kim","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.molmed.2019.04.012","article-title":"Abandoning the Notion of Non-Small Cell Lung Cancer","volume":"25","author":"Relli","year":"2019","journal-title":"Trends Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1073\/pnas.91.13.5833","article-title":"DNA methylation prevents the amplification of TROP1, a tumor-associated cell surface antigen gene","volume":"91","author":"Alberti","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/sj.onc.1206248","article-title":"Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene","volume":"22","author":"Nasr","year":"2003","journal-title":"Oncogene"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41568-018-0024-5","article-title":"Deciphering the cells of origin of squamous cell carcinomas","volume":"18","author":"Blanpain","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"215601","DOI":"10.1016\/j.canlet.2022.215601","article-title":"ZEB1-regulated lnc-Nr2f1 promotes the migration and invasion of lung adenocarcinoma cells","volume":"533","author":"Kim","year":"2022","journal-title":"Cancer Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1158\/0008-5472.CAN-03-1185","article-title":"Expression of chicken ovalbumin upstream promoter-transcription factor II enhances invasiveness of human lung carcinoma cells","volume":"64","author":"Navab","year":"2004","journal-title":"Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1002\/ctm2.517","article-title":"Glutathione peroxidase 4-dependent glutathione high-consumption drives acquired platinum chemoresistance in lung cancer-derived brain metastasis","volume":"11","author":"Liu","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s13577-019-00258-0","article-title":"MiR-142-3p suppresses the proliferation, migration and invasion through inhibition of NR2F6 in lung adenocarcinoma","volume":"32","author":"Jin","year":"2019","journal-title":"Hum. Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/1759-7714.12478","article-title":"Association between polymorphisms in microRNA target sites and survival in early-stage non-small cell lung cancer","volume":"8","author":"Yoo","year":"2017","journal-title":"Thorac. Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Klepsch, V., Siegmund, K., and Baier, G. (2021). Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6. Cancers, 13.","DOI":"10.3390\/cancers13112600"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.jpedsurg.2009.04.027","article-title":"Prenatal retinoic acid up-regulates pulmonary gene expression of COUP-TFII, FOG2, and GATA4 in pulmonary hypoplasia","volume":"44","author":"Doi","year":"2009","journal-title":"J. Pediatr. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.18632\/aging.103564","article-title":"Long noncoding RNA NR2F1-AS1 promotes the malignancy of non-small cell lung cancer via sponging microRNA-493-5p and thereby increasing ITGB1 expression","volume":"13","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1515\/med-2021-0403","article-title":"Long noncoding RNA NR2F1-AS1 stimulates the tumorigenic behavior of non-small cell lung cancer cells by sponging miR-363-3p to increase SOX4","volume":"17","author":"Jin","year":"2022","journal-title":"Open Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41568-023-00602-5","article-title":"Cancers make their own luck: Theories of cancer origins","volume":"23","author":"Jassim","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41392-020-0134-x","article-title":"Molecular principles of metastasis: A hallmark of cancer revisited","volume":"5","author":"Fares","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41568-018-0081-9","article-title":"The lung microenvironment: An important regulator of tumour growth and metastasis","volume":"19","author":"Altorki","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cell.2013.10.029","article-title":"Mechanisms governing metastatic dormancy and reactivation","volume":"155","author":"Giancotti","year":"2013","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"112560","DOI":"10.1016\/j.celrep.2023.112560","article-title":"5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-beta-SMAD4 signaling","volume":"42","author":"Singh","year":"2023","journal-title":"Cell Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1038\/s41467-021-25552-0","article-title":"Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and DeltaNp63","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Gao, X.L., Zheng, M., Wang, H.F., Dai, L.L., Yu, X.H., Yang, X., Pang, X., Li, L., Zhang, M., and Wang, S.S. (2019). NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12\/CXCR4 pathway. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5925-5"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.7150\/jca.49674","article-title":"Fbxo21 regulates the epithelial-to-mesenchymal transition through ubiquitination of Nr2f2 in gastric cancer","volume":"12","author":"Jiang","year":"2021","journal-title":"J. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41419-022-04669-0","article-title":"Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1\/AKT\/mTOR axis","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1002\/pro.3496","article-title":"The nuclear receptor superfamily: A structural perspective","volume":"27","author":"Weikum","year":"2018","journal-title":"Protein Sci."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Gangwar, S.K., Kumar, A., Yap, K.C., Jose, S., Parama, D., Sethi, G., Kumar, A.P., and Kunnumakkara, A.B. (2022). Targeting Nuclear Receptors in Lung Cancer-Novel Therapeutic Prospects. Pharmaceuticals, 15.","DOI":"10.3390\/ph15050624"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Jeong, Y., Xie, Y., Xiao, G., Behrens, C., Girard, L., Wistuba, I.I., Minna, J.D., and Mangelsdorf, D.J. (2010). Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer. PLoS Med., 7.","DOI":"10.1371\/journal.pmed.1000378"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1677\/joe.0.1760083","article-title":"Activation of the MAP kinase pathway induces chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) expression in human breast cancer cell lines","volume":"176","author":"More","year":"2003","journal-title":"J. Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1093\/emboj\/cdf344","article-title":"Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK","volume":"21","author":"Metivier","year":"2002","journal-title":"EMBO J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/(SICI)1097-0215(19960729)67:3<357::AID-IJC9>3.0.CO;2-Q","article-title":"Steroid-hormone receptors in cell lines and tumor biopsies of human lung cancer","volume":"67","author":"Kaiser","year":"1996","journal-title":"Int. J. Cancer"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0022-5223(94)70232-2","article-title":"Sex hormone receptors in non-small-cell lung cancer in human beings","volume":"108","author":"Canver","year":"1994","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_77","first-page":"138","article-title":"Estrogen receptor in female lung carcinoma","volume":"15","author":"Yang","year":"1992","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/0300060516666229","article-title":"Clinicopathological significance of oestrogen receptor expression in non-small cell lung cancer","volume":"45","author":"Chen","year":"2017","journal-title":"J. Int. Med. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13046-018-0804-5","article-title":"17beta-estradiol upregulates IL6 expression through the ERbeta pathway to promote lung adenocarcinoma progression","volume":"37","author":"Huang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0092-8674(88)90059-1","article-title":"Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation","volume":"55","author":"Tsai","year":"1988","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/1878-0261.12704","article-title":"Long non-coding NR2F1-AS1 is associated with tumor recurrence in estrogen receptor-positive breast cancers","volume":"14","author":"Yamamoto","year":"2020","journal-title":"Mol. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1387\/ijdb.140069mw","article-title":"Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus","volume":"58","author":"Wetendorf","year":"2014","journal-title":"Int. J. Dev. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1158\/1078-0432.CCR-10-0992","article-title":"Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome","volume":"17","author":"Stabile","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1159\/000226069","article-title":"Influence of hormone therapy on human lung tumors transplanted into nude mice","volume":"42","author":"Mattern","year":"1985","journal-title":"Oncology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6430","DOI":"10.1093\/nar\/gkt367","article-title":"Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene","volume":"41","author":"Laursen","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1128\/MCB.20.3.957-970.2000","article-title":"Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells","volume":"20","author":"Lin","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.addr.2010.07.003","article-title":"Retinoid pathway and cancer therapeutics","volume":"62","author":"Bushue","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-pathol-011110-130303","article-title":"Retinoids, retinoic acid receptors, and cancer","volume":"6","author":"Tang","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"ref_89","first-page":"1859","article-title":"High frequency of retinoic acid receptor beta abnormalities in human lung cancer","volume":"6","author":"Gebert","year":"1991","journal-title":"Oncogene"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1073\/pnas.90.3.985","article-title":"Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells","volume":"90","author":"Houle","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/jnci\/89.9.624","article-title":"Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: Implications for lung cancer development","volume":"89","author":"Xu","year":"1997","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3349\/ymj.2004.45.3.435","article-title":"Retinoic acid receptor-beta expression in stage I non-small cell lung cancer and adjacent normal appearing bronchial epithelium","volume":"45","author":"Chang","year":"2004","journal-title":"Yonsei Med. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1124\/pr.58.4.7","article-title":"International Union of Pharmacology. LXIII. Retinoid X receptors","volume":"58","author":"Germain","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(95)90200-7","article-title":"The RXR heterodimers and orphan receptors","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1134\/S0026893316020138","article-title":"Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer","volume":"50","author":"Kuznetsova","year":"2016","journal-title":"Mol. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ai, X., Mao, F., Shen, S., Shentu, Y., Wang, J., and Lu, S. (2018). Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2\/PPARgamma\/PTEN\/mTOR signaling pathway. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4224-x"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1073\/pnas.0901676106","article-title":"COUP-TFII acts downstream of Wnt\/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis","volume":"106","author":"Okamura","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0169-5002(01)00449-4","article-title":"Decreased perioxisome proliferator-activated receptor gamma gene expression was correlated with poor prognosis in patients with lung cancer","volume":"36","author":"Sasaki","year":"2002","journal-title":"Lung Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/sj.onc.1206885","article-title":"Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer","volume":"23","author":"Keshamouni","year":"2004","journal-title":"Oncogene"},{"key":"ref_100","first-page":"2021","article-title":"1,25-Dihydroxyvitamin D3 receptors in human carcinomas: A pilot study","volume":"51","author":"Sandgren","year":"1991","journal-title":"Cancer Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jsbmb.2010.10.002","article-title":"Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer","volume":"123","author":"Srinivasan","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Mohamed, F., Abdelaziz, A.O., Kasem, A.H., Ellethy, T., and Gayyed, M.F. (2021). Thyroid hormone receptor alpha1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-86754-6"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1245\/s10434-010-0956-9","article-title":"Epigenetic inactivation of the thyroid hormone receptor beta1 gene at 3p24.2 in lung cancer","volume":"17","author":"Iwasaki","year":"2010","journal-title":"Ann. Surg. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.molonc.2013.02.010","article-title":"Mouse models for lung cancer","volume":"7","author":"Kwon","year":"2013","journal-title":"Mol. Oncol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.trecan.2020.11.007","article-title":"Targeting Nuclear Receptors for Cancer Therapy: Premises, Promises, and Challenges","volume":"7","author":"Yang","year":"2021","journal-title":"Trends Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.gde.2020.12.002","article-title":"Spatially resolved transcriptomics and its applications in cancer","volume":"66","author":"Maniatis","year":"2021","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1038\/s41467-022-33365-y","article-title":"The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Journal of Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2221-3759\/12\/3\/24\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:53:22Z","timestamp":1760111602000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2221-3759\/12\/3\/24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":107,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jdb12030024"],"URL":"https:\/\/doi.org\/10.3390\/jdb12030024","relation":{},"ISSN":["2221-3759"],"issn-type":[{"value":"2221-3759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,10]]}}}