{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:38:37Z","timestamp":1791337117073,"version":"4.3.1"},"reference-count":70,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JDB"],"abstract":"<jats:p>The development process of the heart and cardiovascular system is fundamental in human development and highly regulated by genetic factors. This process needs to be highly regulated to prevent malformations. Nevertheless, some heart defects may be identified, especially with modern imaging methodology. Atrial septal defects (ASDs) are particularly common. Understanding the mechanisms involved in ASD formation is fundamental for developing new treatment strategies. In this article, we explore cardiac development and embryology, with a focus on atrial septal defects and their clinical implications.<\/jats:p>","DOI":"10.3390\/jdb13030028","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T14:23:19Z","timestamp":1754403799000},"page":"28","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Congenital Malformation of the Interatrial Septum\u2014A Review of Its Development and Embryology with Clinical Implications"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-8059","authenticated-orcid":false,"given":"Rui Caetano","family":"Oliveira","sequence":"first","affiliation":[{"name":"Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade de Coimbra, 3000-370 Coimbra, Portugal"},{"name":"Centro de Anatomia Patol\u00f3gica Germano de Sousa, 3030-075 Coimbra, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o em Meio Ambiente, Gen\u00e9tica e Oncobiologia (CIMAGO), 3001-301 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Martins","sequence":"additional","affiliation":[{"name":"Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade de Coimbra, 3000-370 Coimbra, Portugal"},{"name":"Unidade Local de Sa\u00fade, 3000-075 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de F\u00e1tima","family":"Martins","sequence":"additional","affiliation":[{"name":"Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade de Coimbra, 3000-370 Coimbra, Portugal"},{"name":"Unidade Local de Sa\u00fade, 3000-075 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000338003","article-title":"Fetal Cardiac Function: Technical Considerations and Potential Research and Clinical Applications","volume":"32","author":"Crispi","year":"2012","journal-title":"Fetal Diagn. 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