{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:24Z","timestamp":1787028684748,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology of ROC","award":["MOST 105-2221-E-008-025-MY3 and MOST 108-2218-E-110-001"],"award-info":[{"award-number":["MOST 105-2221-E-008-025-MY3 and MOST 108-2218-E-110-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to that of human bones, with pore sizes ranging from 75 to 250 \u03bcm. X-ray diffraction patterns and transmission electron microscopy images indicated that the amorphous structure of the TiZr-based BMG scaffolds remained in the amorphous state after hot pressing. Noncytotoxicity and extracellular calcium deposition of the TiZr-based BMG scaffolds at porosities of 32.8%, 48.8%, and 64.0% were examined by using the direct contact method. The results showed that the BMG scaffolds possess high cell viability and extracellular calcium deposition with average cell survival and deposition rates of approximately 170.1% and 130.9%, respectively. In addition, the resulting TiZr-based BMG scaffolds exhibited a considerable reduction in Young\u2019s moduli from 56.4 to 2.3 GPa, compressive strength from 979 to 19 MPa, and bending strength from 157 MPa to 49 MPa when the porosity was gradually increased from 2.0% to 72.4%. Based on the aforementioned specific characteristics, TiZr-based BMG scaffolds can be considered as potential candidates for biomedical applications in the human body.<\/jats:p>","DOI":"10.3390\/jfb11020028","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T03:29:39Z","timestamp":1588562979000},"page":"28","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4760-6870","authenticated-orcid":false,"given":"Van Tai","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, National Central University, Chung-Li 32001, Taiwan"},{"name":"Department of Mechanical Engineering, Can Tho University, 3\/2, Can Tho 900000, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-5616","authenticated-orcid":false,"given":"Xavier Pei-Chun","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin-Mao","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering, National Central University, Chung-Li 32001, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Hua","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering, National Central University, Chung-Li 32001, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-3248","authenticated-orcid":false,"given":"Jason Shian-Ching","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Central University, Chung-Li 32001, Taiwan"},{"name":"Institute of Materials Science and Engineering, National Central University, Chung-Li 32001, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-0791","authenticated-orcid":false,"given":"I-Yu","family":"Tsao","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering, National Central University, Chung-Li 32001, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Hsin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Cuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Can Tho University, 3\/2, Can Tho 900000, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2320\/matertrans.48.293","article-title":"Bioactive ceramic surface modification of \u03b2-type Ti-Nb-Ta-Zr system alloy by alkali solution treatment","volume":"48","author":"Akahori","year":"2007","journal-title":"Mater. 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