{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:51:05Z","timestamp":1787597465341,"version":"build-2736575974"},"reference-count":77,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T00:00:00Z","timestamp":1610841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","award":["2017-04670"],"award-info":[{"award-number":["2017-04670"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Acrylic bone cements modified with linoleic acid are a promising low-modulus alternative to traditional high-modulus bone cements. However, several key properties remain unexplored, including the effect of autoclave sterilization and the potential use of low-modulus cements in other applications than vertebral augmentation. In this work, we evaluate the effect of sterilization on the structure and stability of linoleic acid, as well as in the handling properties, glass transition temperature, mechanical properties, and screw augmentation potential of low-modulus cement containing the fatty acid. Neither 1H NMR nor SFC-MS\/MS analysis showed any detectable differences in autoclaved linoleic acid compared to fresh one. The peak polymerization temperature of the low-modulus cement was much lower (28\u201330 \u00b0C) than that of the high-modulus cement (67 \u00b0C), whereas the setting time remained comparable (20\u201325 min). The Tg of the low-modulus cement was lower (75\u201378 \u00b0C) than that of the high-stiffness cement (103 \u00b0C). It was shown that sterilization of linoleic acid by autoclaving did not significantly affect the functional properties of low-modulus PMMA bone cement, making the component suitable for sterile production. Ultimately, the low-modulus cement exhibited handling and mechanical properties that more closely match those of osteoporotic vertebral bone with a screw holding capacity of under 2000 N, making it a promising alternative for use in combination with orthopedic hardware in applications where high-stiffness augmentation materials can result in undesired effects.<\/jats:p>","DOI":"10.3390\/jfb12010005","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T02:36:05Z","timestamp":1611196565000},"page":"5","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Functional Properties of Low-Modulus PMMA Bone Cements Containing Linoleic Acid"],"prefix":"10.3390","volume":"12","author":[{"given":"C\u00e9line","family":"Robo","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering, Division of Applied Materials Science, Uppsala University, 751 21 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wenner","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Division of Applied Materials Science, Uppsala University, 751 21 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J. Kumari A.","family":"Ubhayasekera","sequence":"additional","affiliation":[{"name":"Department of Chemistry-BMC, Analytical Chemistry, Uppsala University, 751 23 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6ns","family":"Hilborn","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division of Polymer Chemistry, Uppsala University, 751 21 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2709-9541","authenticated-orcid":false,"given":"Caroline","family":"\u00d6hman-M\u00e4gi","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Division of Applied Materials Science, Uppsala University, 751 21 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-6536","authenticated-orcid":false,"given":"Cecilia","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Division of Applied Materials Science, Uppsala University, 751 21 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1302\/0301-620X.46B3.518","article-title":"The Classic: The bonding of Protheses to bone by Cement","volume":"46","author":"Charnley","year":"1964","journal-title":"J. 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