{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:31:45Z","timestamp":1775280705927,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hallym University Research Fund","award":["NRF-2020R1C1C1008694"],"award-info":[{"award-number":["NRF-2020R1C1C1008694"]}]},{"name":"Hallym University Research Fund","award":["NRF-2020R1I1A3074575"],"award-info":[{"award-number":["NRF-2020R1I1A3074575"]}]},{"name":"Basic Science Research Program","award":["NRF-2020R1C1C1008694"],"award-info":[{"award-number":["NRF-2020R1C1C1008694"]}]},{"name":"Basic Science Research Program","award":["NRF-2020R1I1A3074575"],"award-info":[{"award-number":["NRF-2020R1I1A3074575"]}]},{"name":"Ministry of Education","award":["NRF-2020R1C1C1008694"],"award-info":[{"award-number":["NRF-2020R1C1C1008694"]}]},{"name":"Ministry of Education","award":["NRF-2020R1I1A3074575"],"award-info":[{"award-number":["NRF-2020R1I1A3074575"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["NRF-2020R1C1C1008694"],"award-info":[{"award-number":["NRF-2020R1C1C1008694"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["NRF-2020R1I1A3074575"],"award-info":[{"award-number":["NRF-2020R1I1A3074575"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Biomaterials are used as implants for bone and dental disabilities. However, wear particles from the implants cause osteolysis following total joint arthroplasty (TJA). Ceramic implants are considered safe and elicit a minimal response to cause periprosthetic osteolysis. However, few reports have highlighted the adverse effect of ceramic particles such as alumina (Al2O3) on various cell types. Hence, we aimed to investigate the effect of Al2O3 particles on osteoprogenitors. A comparative treatment of Al2O3, Ti, and UHMWPE particles to osteoprogenitors at a similar concentration of 200 \u03bcg\/mL showed that only Al2O3 particles were able to suppress the early and late differentiation markers of osteoprogenitors, including collagen synthesis, alkaline phosphatase (ALP) activity and mRNA expression of Runx2, OSX, Col1\u03b1, and OCN. Al2O3 particles even induced inflammation and activated the NFkB signaling pathway in osteoprogenitors. Moreover, bone-forming signals such as the WNT\/\u03b2-catenin signaling pathway were inhibited by the Al2O3 particles. Al2O3 particles were found to induce the mRNA expression of WNT\/\u03b2-catenin signaling antagonists such as DKK2, WIF, and sFRP1 several times in osteoprogenitors. Taken together, this study highlights a mechanistic view of the effect of Al2O3 particles on osteoprogenitors and suggests therapeutic targets such as NF\u0138B and WNT signaling pathways for ceramic particle-induced osteolysis.<\/jats:p>","DOI":"10.3390\/jfb13030105","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T22:43:26Z","timestamp":1659048206000},"page":"105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Alumina Particles on the Osteogenic Ability of Osteoblasts"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-6755","authenticated-orcid":false,"given":"Ashish Ranjan","family":"Sharma","sequence":"first","affiliation":[{"name":"Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buyankhishig","family":"Gankhuyag","sequence":"additional","affiliation":[{"name":"Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-239X","authenticated-orcid":false,"given":"Chiranjib","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Kolkata 700126, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-7581","authenticated-orcid":false,"given":"Sang-Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Marsh, M., and Newman, S. 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