{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:38:35Z","timestamp":1785019115885,"version":"3.55.0"},"reference-count":77,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52071191"],"award-info":[{"award-number":["52071191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52101288"],"award-info":[{"award-number":["52101288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZR2020QE009"],"award-info":[{"award-number":["ZR2020QE009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["52071191"],"award-info":[{"award-number":["52071191"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["52101288"],"award-info":[{"award-number":["52101288"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020QE009"],"award-info":[{"award-number":["ZR2020QE009"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Photoactivated sterilization has received more attention in dealing with implant-associated infections due to its advantages of rapid and effective bacteriostasis and broad-spectrum antibacterial activity. Herein, a micro-arc oxidation (MAO)\/polymethyltrimethoxysilane (PMTMS)@hemin-induced calcium-bearing phosphate microsphere (Hemin-CaP) coating was prepared on pure magnesium (Mg) via MAO processing and dipping treatments. The morphology and composition of the coating were characterized via scanning electron microscopy, Fourier transform infrared spectrometer, X-ray diffractometer and X-ray photoelectron spectrometer. Corrosion behavior was evaluated through electrochemical and hydrogen evolution tests. The release of Fe3+ ions at different immersion times was measured with an atomic absorption spectrophotometer. Antibacterial performance and cytotoxicity were assessed using the spread plate method, MTT assay and live\/dead staining experiment. The results showed that the corrosion current density of the MAO\/PMTMS@(Hemin-CaP) coating (4.41 \u00d7 10\u22128 A\u00b7cm\u22122) was decreased by two orders of magnitude compared to that of pure Mg (3.12 \u00d7 10\u22126 A\u00b7cm\u22122). Photoactivated antibacterial efficiencies of the Hemin-CaP microspheres and MAO\/PMTMS@(Hemin-CaP) coating reached about 99% and 92%, respectively, which we attributed to the photothermal and photodynamic properties of hemin with a porphyrin ring. Moreover, based on the release of Fe3+ ions, the MC3T3-E1 pre-osteoblasts\u2019 viability reached up to 125% after a 72 h culture, indicating a positive effect of the coating in promoting cell growth. Thus, this novel composite coating holds a promising application as bone implants.<\/jats:p>","DOI":"10.3390\/jfb14010015","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T02:53:11Z","timestamp":1672109591000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium"],"prefix":"10.3390","volume":"14","author":[{"given":"Lixin","family":"Long","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-4075","authenticated-orcid":false,"given":"Lanyue","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoqi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-3851","authenticated-orcid":false,"given":"Rongchang","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China"},{"name":"School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.actbio.2019.05.027","article-title":"Osteogenic and pH stimuli-responsive self-healing coating on biomedical Mg-1Ca alloy","volume":"92","author":"Xiong","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jma.2019.01.004","article-title":"Corrosion resistance of bioinspired DNA-induced Ca\u2013P coating on biodegradable magnesium alloy","volume":"7","author":"Liu","year":"2019","journal-title":"J. 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