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(WJD)"],"award-info":[{"award-number":["project-ID 322900939 (WJD)"]}]},{"name":"IFORES grant from the University Hospital Essen, Germany","award":["project-ID 403041552 (WJD)"],"award-info":[{"award-number":["project-ID 403041552 (WJD)"]}]},{"name":"IFORES grant from the University Hospital Essen, Germany","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"IFORES grant from the University Hospital Essen, Germany","award":["none"],"award-info":[{"award-number":["none"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Particle-induced osteolysis is a major cause of aseptic prosthetic loosening. Implant wear particles stimulate tissue macrophages inducing an aseptic inflammatory reaction, which ultimately results in bone loss. Fetuin-A is a key regulator of calcified matrix metabolism and an acute phase protein. We studied the influence of fetuin-A on particle-induced osteolysis in an established mouse model using fetuin-A-deficient mice. Ten fetuin-A-deficient (Ahsg\u2212\/\u2212) mice and ten wild-type animals (Ahsg+\/+) were assigned to test group receiving ultra-high molecular weight polyethylene (UHMWPE) particle implantation or to control group (sham surgery). After 14 days, bone metabolism parameters RANKL, osteoprotegerin (OPG), osteocalcin (OC), alkaline phosphatase (ALP), calcium, phosphate, and desoxypyridinoline (DPD) were examined. Bone volume was determined by microcomputed tomography (\u03bcCT); osteolytic regions and osteoclasts were histomorphometrically analyzed. After particle treatment, bone resorption was significantly increased in Ahsg\u2212\/\u2212 mice compared with corresponding Ahsg+\/+ wild-type mice (p = 0.007). Eroded surface areas in Ahsg\u2212\/\u2212 mice were significantly increased (p = 0.002) compared with Ahsg+\/+ mice, as well as the number of osteoclasts compared with control (p = 0.039). Fetuin-A deficiency revealed increased OPG (p = 0.002), and decreased levels of DPD (p = 0.038), OC (p = 0.036), ALP (p &lt; 0.001), and Ca (p = 0.001) compared with wild-type animals. Under osteolytic conditions in Ahsg\u2212\/\u2212 mice, OPG was increased (p = 0.013), ALP (p = 0.015) and DPD (p = 0.012) were decreased compared with the Ahsg+\/+ group. Osteolytic conditions lead to greater bone loss in fetuin-A-deficient mice compared with wild-type mice. Reduced fetuin-A serum levels may be a risk factor for particle-induced osteolysis while the protective effect of fetuin-A might be a future pathway for prophylaxis and treatment.<\/jats:p>","DOI":"10.3390\/jfb14010030","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T04:08:07Z","timestamp":1672805287000},"page":"30","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased UHMWPE Particle-Induced Osteolysis in Fetuin-A-Deficient Mice"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-4674","authenticated-orcid":false,"given":"Christina","family":"Polan","sequence":"first","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-0287","authenticated-orcid":false,"given":"Monika","family":"Herten","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-796X","authenticated-orcid":false,"given":"Gero","family":"Hilken","sequence":"additional","affiliation":[{"name":"Central Animal Laboratory, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Grabellus","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3472-4758","authenticated-orcid":false,"given":"Heinz-Lothar","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-7360","authenticated-orcid":false,"given":"Manuel","family":"Burggraf","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-5506","authenticated-orcid":false,"given":"Marcel","family":"Dudda","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1315-4407","authenticated-orcid":false,"given":"Willi","family":"Jahnen-Dechent","sequence":"additional","affiliation":[{"name":"Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-0209","authenticated-orcid":false,"given":"Christian","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, St. Barbara Hospital Gladbeck, 45964 Gladbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3795-6068","authenticated-orcid":false,"given":"Max Daniel","family":"Kauther","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery and Orthopedics, Pediatric Orthopedics, Agaplesion Diakonieklinikum Rotenburg (W\u00fcmme), 27356 Rotenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.arth.2013.01.012","article-title":"Revision surgery after total joint arthroplasty: A complication-based analysis using worldwide arthroplasty registers","volume":"28","author":"Sadoghi","year":"2013","journal-title":"J. Arthroplast."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/1753425912451779","article-title":"Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty","volume":"19","author":"Gallo","year":"2013","journal-title":"Innate. Immun."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Goodman, S.B., and Gallo, J. (2019). Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122091"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1243\/0954411971534638","article-title":"The size and shape of particulate polyethylene wear debris in total joint replacements","volume":"211","author":"Kobayashi","year":"1997","journal-title":"Proc. Inst. Mech. Eng. H"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/1097-4636(200011)52:2<296::AID-JBM8>3.0.CO;2-9","article-title":"Evaluation of the response of primary human peripheral blood mononuclear phagocytes to challenge with in vitro generated clinically relevant UHMWPE particles of known size and dose","volume":"52","author":"Matthews","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/jcp.2007.048868","article-title":"The cell biology of bone metabolism","volume":"61","author":"Datta","year":"2008","journal-title":"J. Clin. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ncprheum0428","article-title":"Mechanisms of disease: Molecular insights into aseptic loosening of orthopedic implants","volume":"3","author":"Drees","year":"2007","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1098\/rsif.2008.0142","article-title":"The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses","volume":"5","author":"Revell","year":"2008","journal-title":"J. R. Soc. Interface"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.142.12.8536","article-title":"Minireview: The OPG\/RANKL\/RANK system","volume":"142","author":"Khosla","year":"2001","journal-title":"Endocrinology"},{"key":"ref_10","first-page":"345","article-title":"Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: Maintaining the balance to prevent bone loss","volume":"5","author":"Trouvin","year":"2010","journal-title":"Clin. Interv. Aging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1243\/0954411001535219","article-title":"Biological reactions to wear debris in total joint replacement","volume":"214","author":"Ingham","year":"2000","journal-title":"Proc. Inst. Mech. Eng. H"},{"key":"ref_12","first-page":"1241","article-title":"Activation of NF-kappaB signalling and TNFalpha-expression in THP-1 macrophages by TiAlV- and polyethylene-wear particles","volume":"23","author":"Baumann","year":"2005","journal-title":"J. Orthop. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1172\/JCI200523394","article-title":"IL-1 mediates TNF-induced osteoclastogenesis","volume":"115","author":"Wei","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/256430a0","article-title":"Localisation of plasma alpha2HS glycoprotein in mineralising human bone","volume":"256","author":"Dickson","year":"1975","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/262226a0","article-title":"Origin of plasma alpha2HS-glycoprotein and its accumulation in bone","volume":"262","author":"Triffitt","year":"1976","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI17202","article-title":"The serum protein \u03b12\u2013Heremans-Schmid glycoprotein\/fetuin-A is a systemically acting inhibitor of ectopic calcification","volume":"112","author":"Heiss","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1161\/CIRCRESAHA.110.234260","article-title":"Fetuin-A regulation of calcified matrix metabolism","volume":"108","author":"Heiss","year":"2011","journal-title":"Circ. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20789","DOI":"10.1074\/jbc.271.34.20789","article-title":"The serum protein alpha2-HS glycoprotein\/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells. A possible role in mineralization and calcium homeostasis","volume":"271","author":"Schinke","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"14815","DOI":"10.1074\/jbc.M709938200","article-title":"Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles","volume":"283","author":"Heiss","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41467-020-20832-7","article-title":"Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress","volume":"12","author":"Rudloff","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/bs.acc.2018.12.003","article-title":"Clinical implications of fetuin-A","volume":"89","author":"Jirak","year":"2019","journal-title":"Adv. Clin. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2174\/156652412800620039","article-title":"Anti-inflammatory role of fetuin-A in injury and infection","volume":"12","author":"Wang","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0165-2478(97)00126-0","article-title":"Modification of macrophage response to lipopolysaccharide by fetuin","volume":"60","author":"Dziegielewska","year":"1998","journal-title":"Immunol. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00024382-200115030-00004","article-title":"Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan","volume":"15","author":"Ombrellino","year":"2001","journal-title":"Shock"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5312\/wjo.v8.i6.461","article-title":"Role of fetuin A in the diagnosis and treatment of joint arthritis","volume":"8","author":"Pappa","year":"2017","journal-title":"World J. Orthop."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bone.2017.09.006","article-title":"A single intraperitoneal injection of bovine fetuin-A attenuates bone resorption in a murine calvarial model of particle-induced osteolysis","volume":"105","author":"Jablonski","year":"2017","journal-title":"Bone"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)65266-2","article-title":"Tumor necrosis factor-alpha mediates orthopedic implant osteolysis","volume":"154","author":"Merkel","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1359\/jbmr.070408","article-title":"Polyethylene particle-induced bone resorption in alpha-calcitonin gene-related peptide-deficient mice","volume":"22","author":"Wedemeyer","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"31496","DOI":"10.1074\/jbc.272.50.31496","article-title":"Cloning and targeted deletion of the mouse fetuin gene","volume":"272","author":"Schinke","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/ndt\/gfm094","article-title":"Fetuin-A (AHSG) prevents extraosseous calcification induced by uraemia and phosphate challenge in mice","volume":"22","author":"Westenfeld","year":"2007","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1016\/j.biomaterials.2004.09.026","article-title":"Stimulation of bone formation by zoledronic acid in particle-induced osteolysis","volume":"26","author":"Wedemeyer","year":"2005","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kauther, M.D., Bachmann, H.S., Neuerburg, L., Broecker-Preuss, M., Hilken, G., Grabellus, F., Koehler, G., von Knoch, M., and Wedemeyer, C. (2011). Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis. BMC Musculoskelet Disord, 12.","DOI":"10.1186\/1471-2474-12-186"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF02556360","article-title":"Bone histomorphometry: Proposed system for standardization of nomenclature, symbols, and units","volume":"42","author":"Parfitt","year":"1988","journal-title":"Calcif. Tissue Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(05)62030-2","article-title":"Fetuin protects the fetus from TNF","volume":"350","author":"Wang","year":"1997","journal-title":"Lancet"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Li, W., Zhu, S., Li, J.H., Huang, Y., Zhou, R.R., Fan, X.G., Yang, H.A., Gong, X., Eissa, N.T., and Jahnen-Dechent, W. (2011). A Hepatic Protein, Fetuin-A, Occupies a Protective Role in Lethal Systemic Inflammation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016945"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.3389\/fimmu.2018.01991","article-title":"Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity","volume":"9","author":"Babler","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"633925","DOI":"10.3389\/fcell.2021.633925","article-title":"Live Imaging of Calciprotein Particle Clearance and Receptor Mediated Uptake: Role of Calciprotein Monomers","volume":"9","author":"Ghallab","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1016\/j.biomaterials.2006.01.006","article-title":"Over-expression of p53\/BAK in aseptic loosening after total hip replacement","volume":"27","author":"Landgraeber","year":"2006","journal-title":"Biomaterials"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1016\/j.biomaterials.2008.04.044","article-title":"Extrinsic and intrinsic pathways of apoptosis in aseptic loosening after total hip replacement","volume":"29","author":"Landgraeber","year":"2008","journal-title":"Biomaterials"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/CS20030126","article-title":"Fetuin\/alpha(2)-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages","volume":"105","author":"Jersmann","year":"2003","journal-title":"Clin. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Brylka, L.J., K\u00f6ppert, S., Babler, A., Kratz, B., Denecke, B., Yorgan, T.A., Etich, J., Costa, I.G., Brachvogel, B., and Boor, P. (2017). Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187030"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Seto, J., Busse, B., Gupta, H.S., Sch\u00e4fer, C., Krauss, S., Dunlop, J.W.C., Masic, A., Kerschnitzki, M., Zaslansky, P., and Boesecke, P. (2012). Accelerated Growth Plate Mineralization and Foreshortened Proximal Limb Bones in Fetuin-A Knockout Mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047338"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/jbmr.2475","article-title":"Association of Fetuin-A With Incident Fractures in Community-Dwelling Older Adults: The Cardiovascular Health Study","volume":"30","author":"Fink","year":"2015","journal-title":"J. Bone Min. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00402-019-03329-x","article-title":"Evaluation of fetuin-A as a predictor of outcome after surgery for osteoporotic fracture of the proximal femur","volume":"140","author":"Steffen","year":"2020","journal-title":"Arch. Orthop. Trauma. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Babler, A., Schmitz, C., Buescher, A., Herrmann, M., Gremse, F., Gorgels, T., Floege, J., and Jahnen-Dechent, W. (2020). Microvasculopathy and soft tissue calcification in mice are governed by fetuin-A, magnesium and pyrophosphate. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228938"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Herrmann, M., Babler, A., Moshkova, I., Gremse, F., Kiessling, F., Kusebauch, U., Nelea, V., Kramann, R., Moritz, R.L., and McKee, M.D. (2020). Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228503"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00264-010-1143-0","article-title":"New animal models of wear-particle osteolysis","volume":"35","author":"Langlois","year":"2011","journal-title":"Int. Orthop."}],"container-title":["Journal of Functional Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4983\/14\/1\/30\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:58:21Z","timestamp":1760119101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4983\/14\/1\/30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jfb14010030"],"URL":"https:\/\/doi.org\/10.3390\/jfb14010030","relation":{},"ISSN":["2079-4983"],"issn-type":[{"value":"2079-4983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]}}}