{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:18:58Z","timestamp":1785759538349,"version":"3.56.0"},"reference-count":119,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation","award":["#2019\/04185-1"],"award-info":[{"award-number":["#2019\/04185-1"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["# 2019\/07636-4"],"award-info":[{"award-number":["# 2019\/07636-4"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["# 2020\/12874-9"],"award-info":[{"award-number":["# 2020\/12874-9"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["# 2013\/07296"],"award-info":[{"award-number":["# 2013\/07296"]}]},{"name":"Centro de Desenvolvimento de Materiais Funcionais (CDMF)","award":["#2019\/04185-1"],"award-info":[{"award-number":["#2019\/04185-1"]}]},{"name":"Centro de Desenvolvimento de Materiais Funcionais (CDMF)","award":["# 2019\/07636-4"],"award-info":[{"award-number":["# 2019\/07636-4"]}]},{"name":"Centro de Desenvolvimento de Materiais Funcionais (CDMF)","award":["# 2020\/12874-9"],"award-info":[{"award-number":["# 2020\/12874-9"]}]},{"name":"Centro de Desenvolvimento de Materiais Funcionais (CDMF)","award":["# 2013\/07296"],"award-info":[{"award-number":["# 2013\/07296"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>With the increase in the population\u2019s life expectancy, there has also been an increase in the rate of osteoporosis, which has expanded the search for strategies to regenerate bone tissue. The ultrasonic sonochemical technique was chosen for the functionalization of the 45S5 bioglass. The samples after the sonochemical process were divided into (a) functionalized bioglass (BG) and (b) functionalized bioglass with 10% teriparatide (BGT). Isolated mesenchymal cells (hMSC) from femurs of ovariectomized rats were differentiated into osteoblasts and submitted to in vitro tests. Bilateral ovariectomy (OVX) and sham ovariectomy (Sham) surgeries were performed in fifty-five female Wistar rats. After a period of 60 days, critical bone defects of 5.0 mm were created in the calvaria of these animals. For biomechanical evaluation, critical bone defects of 3.0 mm were performed in the tibias of some of these rats. The groups were divided into the clot (control) group, the BG group, and the BGT group. After the sonochemical process, the samples showed modified chemical topographic and morphological characteristics, indicating that the surface was chemically altered by the functionalization of the particles. The cell environment was conducive to cell adhesion and differentiation, and the BG and BGT groups did not show cytotoxicity. In addition, the experimental groups exhibited characteristics of new bone formation with the presence of bone tissue in both periods, with the BGT group and the OVX group statistically differing from the other groups (p &lt; 0.05) in both periods. Local treatment with the drug teriparatide in ovariectomized animals promoted positive effects on bone tissue, and longitudinal studies should be carried out to provide additional information on the biological performance of the mutual action between the bioglass and the release of the drug teriparatide.<\/jats:p>","DOI":"10.3390\/jfb14020093","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T02:55:54Z","timestamp":1675911354000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Local Release of Teriparatide Incorporated in 45S5 Bioglass Promotes a Beneficial Effect on Osteogenic Cells and Bone Repair in Calvarial Defects in Ovariectomized Rats"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-1581","authenticated-orcid":false,"given":"Juliani Caroline Ribeiro","family":"de Ara\u00fajo","sequence":"first","affiliation":[{"name":"Department of Bioscience and Buccal Diagnose, Institute of Science and Technology, Sao Paulo State University, UNESP, Sao Paulo 12245-700, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-4423","authenticated-orcid":false,"given":"Leonardo Alvares","family":"Sobral Silva","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Buccal Diagnose, Institute of Science and Technology, Sao Paulo State University, UNESP, Sao Paulo 12245-700, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Almeida","family":"de Barros Lima","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Buccal Diagnose, Institute of Science and Technology, Sao Paulo State University, UNESP, Sao Paulo 12245-700, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Moreira","family":"Bastos Campos","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology, Bauru School of Dentistry, University of Sao Paulo, Bauru 17012-230, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Noronha","family":"Lisboa Filho","sequence":"additional","affiliation":[{"name":"Department of Physics, S\u00e3o Paulo State University, UNESP, Bauru 17033-360, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery and Integrated Clinic, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University, UNESP, Ara\u00e7atuba 16066-840, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-0578","authenticated-orcid":false,"given":"Luana Marotta Reis","family":"de Vasconcellos","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Buccal Diagnose, Institute of Science and Technology, Sao Paulo State University, UNESP, Sao Paulo 12245-700, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis","volume":"4","year":"2017","journal-title":"Eur. 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