{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:10:22Z","timestamp":1760123422119,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education and Science, Bulgaria","award":["K\u03a0-06-\u0414K1\/11"],"award-info":[{"award-number":["K\u03a0-06-\u0414K1\/11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>A study of the formation of copper (II) complexes with hemorphin peptide motifs in alkalic water solutions is presented. The effect of the peptide ligand on the complexing properties of the Cu (II) ion was quantified by giving the stoichiometry and stability of the complex compounds in the medium in which they are formed using voltammetric (cyclic) and spectral (UV-Vis and fluorimetric) analytical techniques. The resulting complexes were examined via IR spectroscopy to detect M-N and M-O oscillations and using the EPR approach in solution and in the solid phase to view the coordination and ligand binding regime. The possibility of the synergistic action of copper ions in the antivirus protection processes of cotton fibers coated in the same solvent with the newly obtained complex compounds was also investigated. One of the advantages is the formation of the complexes in an environment where the immobilization takes place, which contributes to increasing the efficiency of the process. The obtained results may serve as an aid for future more detailed biological studies of structure\u2013activity relationships (SARs).<\/jats:p>","DOI":"10.3390\/jfb14020106","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T02:41:56Z","timestamp":1676342516000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metal\u2013Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-6214","authenticated-orcid":false,"given":"Stela","family":"Georgieva","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8050-0149","authenticated-orcid":false,"given":"Petar","family":"Todorov","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-1222","authenticated-orcid":false,"given":"Desislava","family":"Staneva","sequence":"additional","affiliation":[{"name":"Department of Textile, Leathers and Fuels, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petar","family":"Grozdanov","sequence":"additional","affiliation":[{"name":"The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9130-6600","authenticated-orcid":false,"given":"Ivanka","family":"Nikolova","sequence":"additional","affiliation":[{"name":"The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-8183","authenticated-orcid":false,"given":"Ivo","family":"Grabchev","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sofia University \u201cSt. Kl. Ohridski\u201d, 1407 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"ref_1","unstructured":"Smith, A.M. (2015). Functional Metallosupramolecular Materials, Royal Society of Chemistry."},{"key":"ref_2","unstructured":"Cowan, J.A. (1997). Inorganic Biochemistry: An Introduction, John Wiley & Sons. [2nd ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pickart, L., and Margolina, A. (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071987"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.3389\/fbioe.2022.893936","article-title":"Peptide Biomaterials for Tissue Regeneration","volume":"10","author":"Ross","year":"2022","journal-title":"Front. Bioeng. 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