{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:46:40Z","timestamp":1776934000285,"version":"3.51.2"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funding Authority for Studies and Projects","award":["FINEP #0041\/21"],"award-info":[{"award-number":["FINEP #0041\/21"]}]},{"name":"Funding Authority for Studies and Projects","award":["FAPERGS #19\/2551-0001726-0"],"award-info":[{"award-number":["FAPERGS #19\/2551-0001726-0"]}]},{"name":"Rio Grande do Sul State Research Support Foundation","award":["FINEP #0041\/21"],"award-info":[{"award-number":["FINEP #0041\/21"]}]},{"name":"Rio Grande do Sul State Research Support Foundation","award":["FAPERGS #19\/2551-0001726-0"],"award-info":[{"award-number":["FAPERGS #19\/2551-0001726-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>The aim of this study was to develop an experimental composite resin with the addition of myristyltrimethylammonium bromide (MYTAB) and \u03b1 -tricalcium phosphate (\u03b1-TCP) as an antibacterial and remineralizing material. Experimental composite resins composed of 75 wt% Bisphenol A-Glycidyl Methacrylate (BisGMA) and 25 wt% Triethylene Glycol Dimethacrylate (TEGDMA) were produced. Some 1 mol% Trimethyl benzoyl-diphenylphosphine oxide (TPO) was used as a photoinitiator, and butylated hydroxytoluene (BTH) was added as a polymerization inhibitor. Silica (1.5 wt%) and barium glass (65 wt%) particles were added as inorganic fillers. For remineralizing and antibacterial effect, \u03b1-TCP (10 wt%) and MYTAB (5 wt%) were incorporated into the resin matrix (\u03b1-TCP\/MYTAB group). A group without the addition of \u03b1-TCP\/MYTAB was used as a control. Resins were evaluated for their degree of conversion (n = 3) by Fourier Transform Infrared Spectroscopy (FTIR). The flexural strength (n = 5) was assessed based on ISO 4049:2019 requirements. Microhardness was assessed to calculate softening in solvent (n = 3) after ethanol immersion. The mineral deposition (n = 3) was evaluated after immersion in SBF, while cytotoxicity was tested with HaCaT cells (n = 5). Antimicrobial activity (n = 3) was analyzed against S. mutans. The degree of conversion was not influenced by the antibacterial and remineralizing compounds, and all groups reached values &gt; 60%. The \u03b1-TCP\/MYTAB addition promoted increased softening of polymers after immersion in ethanol and reduced their flexural strength and the viability of cells in vitro. A reduction in S. mutans viability was observed for the \u03b1-TCP\/MYTAB group in biofilm formation and planktonic bacteria, with an antibacterial effect &gt; 3log10 for the developed materials. Higher intensity of phosphate compounds on the sample\u2019s surface was detected in the \u03b1-TCP\/MYTAB group. The addition of \u03b1-TCP and MYTAB promoted remineralizing and antibacterial effects on the developed resins and may be a strategy for bioactive composites.<\/jats:p>","DOI":"10.3390\/jfb14060303","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T02:12:45Z","timestamp":1685585565000},"page":"303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Experimental Composite Resin with Myristyltrimethylammonium Bromide (MYTAB) and Alpha-Tricalcium Phosphate (\u03b1-TCP): Antibacterial and Remineralizing Effect"],"prefix":"10.3390","volume":"14","author":[{"given":"Juan Carlos","family":"Pontons-Melo","sequence":"first","affiliation":[{"name":"Department of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul. Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre 90035-003, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9076-2460","authenticated-orcid":false,"given":"Gabriela de Souza","family":"Balbinot","sequence":"additional","affiliation":[{"name":"Department of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul. Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre 90035-003, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-8776","authenticated-orcid":false,"given":"Salvatore","family":"Sauro","sequence":"additional","affiliation":[{"name":"Dental Biomaterials and Minimally Invasive Dentistry, Department of Dentistry, Cardenal Herrera-CEU University, CEU Universities, C\/Santiago Ram\u00f3n y Cajal, s\/n., Alfara del Patriarca, 46115 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-0150","authenticated-orcid":false,"given":"Fabr\u00edcio Mezzomo","family":"Collares","sequence":"additional","affiliation":[{"name":"Department of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul. Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre 90035-003, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"ref_1","first-page":"29","article-title":"Resin Composite--State of the Art","volume":"27","author":"Ferracane","year":"2011","journal-title":"Dent. Mater. Off. Publ. Acad. Dent. Mater."},{"key":"ref_2","first-page":"1232","article-title":"A Randomized Controlled 30 Years Follow up of Three Conventional Resin Composites in Class II Restorations","volume":"31","author":"Pallesen","year":"2015","journal-title":"Dent. Mater. Off. Publ. Acad. Dent. Mater."},{"key":"ref_3","first-page":"1","article-title":"Longevity of Composite Restorations Is Definitely Not Only about Materials","volume":"39","author":"Demarco","year":"2023","journal-title":"Dent. Mater. Off. Publ. Acad. Dent. 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