{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:39:46Z","timestamp":1787506786771,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kemenristek Indonesia","award":["1318\/UN6.3.1\/PT.00\/2022"],"award-info":[{"award-number":["1318\/UN6.3.1\/PT.00\/2022"]}]},{"name":"Kemenristek Indonesia","award":["2203\/UN6.3.1\/PT.00\/2022"],"award-info":[{"award-number":["2203\/UN6.3.1\/PT.00\/2022"]}]},{"name":"Academic Leadership Grant of Universitas Padjadjaran 2022","award":["1318\/UN6.3.1\/PT.00\/2022"],"award-info":[{"award-number":["1318\/UN6.3.1\/PT.00\/2022"]}]},{"name":"Academic Leadership Grant of Universitas Padjadjaran 2022","award":["2203\/UN6.3.1\/PT.00\/2022"],"award-info":[{"award-number":["2203\/UN6.3.1\/PT.00\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Polydimethylsiloxane (PDMS) is a substitute for vitreous humour in vitreoretinal surgery and is usually produced from octamethylcyclotetrasiloxane (D4). In Indonesia, both commercial PDMS and D4 are limited and expensive. Dichlorodimethylsilane (DCMS) can be an alternative to produce PDMS. DCMS is cheaper and easier to obtain than D4. However, more extra effort is needed in order to produce PDMS from DCMS. Therefore, this study aimed to produce PDMS from DCMS by varying the ratio of DCMS precursor to dichloromethane (DCM) solvent at ratios of 1:1 and 1:4 through the hydrolysis\u2013condensation method under neutral conditions. The PDMS produced had medium- (2.06 Pa\u00b7s) and high viscosity (3.59 Pa\u00b7s), with densities ranging from 0.96 to 0.99 g\/mL. The refractive index was 1.4034\u20131.4036 and surface tension was 21 \u00d7 10\u22123 N\/m, while they were able to transmit ~100% visible light, which were similar values to the commercial PDMS characteristics. PDMS samples were characterized using IR and NMR spectroscopy, which confirmed they were of PDMS type. The most optimum DCMS:DCM ratio was 1:1 due to the medium-viscosity PDMS type that could be produced. The in vitro HET\u2013CAM toxicity test showed that samples were non-irritant, similar to PDMS produced from D4. PDMS from DCMS was non-toxic and ready to be used as a vitreous humuor substitution.<\/jats:p>","DOI":"10.3390\/jfb14080425","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T11:09:44Z","timestamp":1692097784000},"page":"425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity"],"prefix":"10.3390","volume":"14","author":[{"given":"Diba Grace","family":"Auliya","sequence":"first","affiliation":[{"name":"Doctor Program in Biotechnology, Graduate School, Universitas Padjadjaran, Jl. Dipati Ukur No. 35, Bandung 40132, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulfa","family":"Fauziah","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vira Fuji","family":"Arini","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soni","family":"Setiadji","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Technology, UIN Sunan Gunung Djati Bandung, Jl. A. H. Nasution No. 105 Cibiru, Bandung 40614, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fitrilawati","family":"Fitrilawati","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-8965","authenticated-orcid":false,"given":"Arief Sjamsulaksan","family":"Kartasasmita","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9746-165X","authenticated-orcid":false,"given":"Risdiana","family":"Risdiana","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Thacker, M., Tseng, C.-L., and Lin, F.-H. (2021). Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective. 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