{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:46:32Z","timestamp":1790847992373,"version":"4.1.0"},"reference-count":69,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000523"],"award-info":[{"award-number":["82000523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021TD15"],"award-info":[{"award-number":["2021TD15"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023-JC-QN-081"],"award-info":[{"award-number":["2023-JC-QN-081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Innovation Team of Xi\u2019an Medical University","award":["82000523"],"award-info":[{"award-number":["82000523"]}]},{"name":"the Innovation Team of Xi\u2019an Medical University","award":["2021TD15"],"award-info":[{"award-number":["2021TD15"]}]},{"name":"the Innovation Team of Xi\u2019an Medical University","award":["2023-JC-QN-081"],"award-info":[{"award-number":["2023-JC-QN-081"]}]},{"name":"the National Science Foundation of Shaanxi","award":["82000523"],"award-info":[{"award-number":["82000523"]}]},{"name":"the National Science Foundation of Shaanxi","award":["2021TD15"],"award-info":[{"award-number":["2021TD15"]}]},{"name":"the National Science Foundation of Shaanxi","award":["2023-JC-QN-081"],"award-info":[{"award-number":["2023-JC-QN-081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Ulcerative colitis (UC) is a refractory chronic inflammatory disease involving the colon and rectum, falling under the category of inflammatory bowel disease (IBD). The accumulation of reactive oxygen species (ROS) in local tissues has been identified as a crucial contributor to the escalation of inflammatory responses. Therefore, eliminating ROS in the inflamed colon is a promising approach to treating UC. Nanomaterials with intrinsic enzyme-like activities (nanozymes) have shown significant therapeutic potential in UC. In this study, we found that platinum nanoparticles (Pt NPs) exhibited remarkable superoxide dismutase (SOD) and catalase (CAT) cascade catalytic activities, as well as effective hydroxyl radical (\u2022OH) scavenging ability. The in vitro experiments showed that Pt NPs could eliminate excessive ROS to protect cells against oxidative stress. In the colitis model, oral administration of Pt NPs (loaded in chitosan\/alginate hydrogel) could significantly alleviate UC, including reducing the colon length, the damaged epithelium, and the infiltration of inflammatory cells. Without appreciable systemic toxicity, Pt NPs represent a novel therapeutic approach to UC and are expected to achieve long-term inflammatory remission.<\/jats:p>","DOI":"10.3390\/jfb14110548","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T10:57:46Z","timestamp":1700045866000},"page":"548","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Oral Administration of Platinum Nanoparticles with SOD\/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis"],"prefix":"10.3390","volume":"14","author":[{"given":"Hao","family":"Liu","sequence":"first","affiliation":[{"name":"Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-234X","authenticated-orcid":false,"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-6526","authenticated-orcid":false,"given":"Mingzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an 710077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-3387","authenticated-orcid":false,"given":"Mingxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an 710077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100851","DOI":"10.1016\/j.disamonth.2019.02.004","article-title":"A comprehensive review and update on ulcerative colitis","volume":"65","author":"Gajendran","year":"2019","journal-title":"Dis. 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