{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:47:52Z","timestamp":1760143672285,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>The regenerative capacity of well-preserved blood clots may be enhanced by biologics like enamel matrix derivative (EMD). This retrospective analysis compares outcomes reported by three centers using different heterografts. Center 1 (C1) treated intrabony defects combining cross-linked high-molecular-weight hyaluronic acid (xHyA) with a xenograft; center 2 (C2) used EMD with an allograft combination to graft a residual pocket. Center 3 (C3) combined xHyA with the placement of a resorbable polymer membrane for defect cover. Clinical parameters, BoP reduction, and radiographically observed defect fill at 12-month examination are reported. The 12-month evaluation yielded significant improvements in PPD and CAL at each center (p &lt; 0.001, respectively). Analyses of Covariance revealed significant improvements in all parameters, and a significantly greater CAL gain was revealed for C2 vs. C1 (p = 0.006). Radiographic defect fill presented significantly higher scores for C2 and C3 vs. C1 (p = 0.003 and = 0.014; C2 vs. C3 p = 1.00). Gingival recession increased in C1 and C3 (p = 1.00), while C2 reported no GR after 12 months (C2:C1 p = 0.002; C2:C3 p = 0.005). BoP tendency and pocket closure rate shared similar rates. Within the limitations of the study, a data comparison indicated that xHyA showed a similar capacity to enhance the regenerative response, as known for EMD. Radiographic follow-up underlined xHyA\u2019s unique role in new attachment formation.<\/jats:p>","DOI":"10.3390\/jfb15020039","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T08:12:03Z","timestamp":1707466323000},"page":"39","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reconstructive Approach in Residual Periodontal Pockets with Biofunctionalized Heterografts\u2014A Retrospective Comparison of 12-Month Data from Three Centers"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8708-829X","authenticated-orcid":false,"given":"Anton","family":"Friedmann","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Health, Witten\/Herdecke University, Alfred-Herrhausen-Str. 50, 58455 Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pheline","family":"Liedloff","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Health, Witten\/Herdecke University, Alfred-Herrhausen-Str. 50, 58455 Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meizi","family":"Eliezer","sequence":"additional","affiliation":[{"name":"Independent Researcher, Tel Aviv 3640577, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Brincat","sequence":"additional","affiliation":[{"name":"Independent Researcher, 83000 Toulon, France"},{"name":"Department of Periodontology, Service of Odontology, AP-HM, UFR of Odontology, Aix-Marseille University, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-0701","authenticated-orcid":false,"given":"Thomas","family":"Ostermann","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Health, Witten\/Herdecke University, 58455 Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5809-3823","authenticated-orcid":false,"given":"Daniel","family":"Diehl","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Health, Witten\/Herdecke University, Alfred-Herrhausen-Str. 50, 58455 Witten, Germany"},{"name":"Institute of Pharmacology and Toxicology, Faculty of Health, Witten\/Herdecke University, 58453 Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1034\/j.1600-0757.2000.2220105.x","article-title":"Focus on intrabony defects\u2013conservative therapy","volume":"22","author":"Lang","year":"2000","journal-title":"Periodontology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I\u2013III periodontitis\u2014The EFP S3 level clinical practice guideline","volume":"47","author":"Sanz","year":"2020","journal-title":"J. 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