{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:09:39Z","timestamp":1760144979494,"version":"build-2065373602"},"reference-count":0,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tissue Bank of France (TBF)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Eye drops containing steroids and antibiotics are widely used to treat a large range of ocular diseases of the ocular surface. They require frequent instillation or a high dosage, which can affect quality of life. We developed a biomaterial from human umbilical cord that can be loaded with drugs before being placed in the inferior conjunctival fornix. In the present work, this viro-inactivated, freeze-dried, and sterile foam was loaded with dexamethasone phosphate. We studied the release kinetic of 100 mg of biomaterial loaded with 100 \u00b5g of dexamethasone phosphate. Assays have shown that the product can be loaded with 100 \u00b5g of dexamethasone and allows a progressive release over time for at least 48 h. In addition, when compared with the instillation of the same dexamethasone quantity (100 \u00b5g), instilled regularly via eye-drop solution at 0.79 mg\/mL, the drug penetration through corneal tissues was better with the dexamethasone-loaded biomaterial.<\/jats:p>","DOI":"10.3390\/jfb15060157","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T10:05:50Z","timestamp":1717581950000},"page":"157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro\/Ex Vivo Release Study of a Ground Umbilical Cord Matrix Loaded with Dexamethasone"],"prefix":"10.3390","volume":"15","author":[{"given":"Florine","family":"Grossetete","sequence":"first","affiliation":[{"name":"TBF\u2014Tissue Bank of France, 6 Rue d\u2019Italie, 69780 Mions, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6948-5208","authenticated-orcid":false,"given":"Charlotte","family":"Garot","sequence":"additional","affiliation":[{"name":"TBF\u2014Tissue Bank of France, 6 Rue d\u2019Italie, 69780 Mions, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-3580","authenticated-orcid":false,"given":"Emmanuel","family":"Crouzet","sequence":"additional","affiliation":[{"name":"Laboratory Biology, Engineering and Imaging for Ophthalmology, BiiO, Faculty of Medicine, Health Innovation Campus, 10 Rue de la Marandi\u00e8re, 42270 Saint-Priest en Jarez, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7134-0713","authenticated-orcid":false,"given":"Xavier","family":"Delavenne","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Unit, University Hospital of Saint Etienne, 42000 Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gain","sequence":"additional","affiliation":[{"name":"Laboratory Biology, Engineering and Imaging for Ophthalmology, BiiO, Faculty of Medicine, Health Innovation Campus, 10 Rue de la Marandi\u00e8re, 42270 Saint-Priest en Jarez, France"},{"name":"Ophthalmology Department, University Hospital of Saint Etienne, 42000 Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Barnouin","sequence":"additional","affiliation":[{"name":"TBF\u2014Tissue Bank of France, 6 Rue d\u2019Italie, 69780 Mions, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3486-2875","authenticated-orcid":false,"given":"Gilles","family":"Thuret","sequence":"additional","affiliation":[{"name":"Laboratory Biology, Engineering and Imaging for Ophthalmology, BiiO, Faculty of Medicine, Health Innovation Campus, 10 Rue de la Marandi\u00e8re, 42270 Saint-Priest en Jarez, France"},{"name":"Ophthalmology Department, University Hospital of Saint Etienne, 42000 Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,5]]},"container-title":["Journal of Functional Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4983\/15\/6\/157\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:54:16Z","timestamp":1760108056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4983\/15\/6\/157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jfb15060157"],"URL":"https:\/\/doi.org\/10.3390\/jfb15060157","relation":{},"ISSN":["2079-4983"],"issn-type":[{"type":"electronic","value":"2079-4983"}],"subject":[],"published":{"date-parts":[[2024,6,5]]}}}