{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:19:08Z","timestamp":1777061948658,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACHyT","award":["A1-S-20148"],"award-info":[{"award-number":["A1-S-20148"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Bismuth lipophilic nanoparticles (BisBAL NPs) and cetylpyridinium chloride (CPC) are antineoplastic and antimicrobial in vitro. As a next pre-clinical step, a clinically viable dosage form for vaginal application was developed. Compendial pharmacopeial tests (mass uniformity, disintegration, and compressive mechanics) and inductively coupled plasma optical emission spectroscopy were conducted on in-house developed glycerinated gelatin (60:15 v\/w) vaginal ovules containing BisBAL NP-CPC. The antimycotic activity of BisBAL NP-CPC vaginal ovules was analyzed using disk diffusion and cell viability XTT assays. The antitumor properties of BisBAL NP-CPC vaginal ovules were assessed by cell viability MTT tests. BisBAL NP-CPC and drug-free vaginal ovules deposited into ex vivo porcine vaginas disaggregated without signs of adverse cytotoxicity within the timespan of clinical efficacy. BisBAL NP-CPC vaginal ovules demonstrated antifungal efficacy comparable to miconazole: C. albicans growth inhibition haloes in diffusion tests were 23 \u00b1 0.968 mm (n = 3) for BisBAL NP-CPC and 20.35 \u00b1 0.899 mm (n = 3) for miconazole. Likewise, BisBAL NP-CPC vaginal ovules reduced HeLa cell growth by 81%, outperforming the clinical reference of 500 \u03bcM 5-fluouracil, which induced a 70% growth inhibition. BisBAL NP-CPC incorporated into glycerinated gelatin vaginal ovules constitute an innovative drug delivery system for topical antimycotic and anti-cervical carcinoma treatments.<\/jats:p>","DOI":"10.3390\/jfb15080206","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T06:11:36Z","timestamp":1721887896000},"page":"206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vaginal Ovule Loaded with Bismuth Lipophilic Nanoparticles and Cetylpyridinium Chloride Inhibits Human Cervical Carcinoma and Candida albicans Growth"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-0111","authenticated-orcid":false,"given":"Claudio","family":"Cabral-Romero","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Hern\u00e1ndez-Delgadillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Alejandro","family":"Torres-Betancourt","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-5797","authenticated-orcid":false,"given":"Claudia Mar\u00eda","family":"Garc\u00eda-Cuellar","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda, Ciudad de M\u00e9xico 14080, Distrito Federal, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0103-9188","authenticated-orcid":false,"given":"Yesennia","family":"S\u00e1nchez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda, Ciudad de M\u00e9xico 14080, Distrito Federal, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Solis-Soto","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0609-3207","authenticated-orcid":false,"given":"Irene","family":"Meester","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Universidad de Monterrey, San Pedro Garza Garc\u00eda 66238, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-597X","authenticated-orcid":false,"given":"Nayely","family":"Pineda-Aguilar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Materiales Avanzados, S.C. (CIMAV), Subsede Monterrey, PIIT, Apodaca 66628, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Eduardo","family":"Nakagoshi-Cepeda","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-7794","authenticated-orcid":false,"given":"Juan Valerio","family":"Cauich-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, Unidad de Materiales, M\u00e9rida 97205, Yucat\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Argelia Akemi","family":"Nakagoshi-Cepeda","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"155136","DOI":"10.1016\/j.prp.2024.155136","article-title":"Cervical cancer: Novel treatment strategies offer renewed optimism","volume":"254","author":"Yadav","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/jnci\/93.4.284","article-title":"Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine","volume":"93","author":"Harro","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.16.1.1-17.2003","article-title":"Human papillomavirus and cervical cancer","volume":"16","author":"Burd","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/jnci\/87.11.779","article-title":"Cancer causes revisited: Human papillomavirus and cervical neoplasia","volume":"87","author":"Franco","year":"1995","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: An overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cetina-P\u00e9rez, L., Luvi\u00e1n-Morales, J., Delgadillo-Gonz\u00e1lez, M., Castro-Eguiluz, D., Galicia-Carmona, T., Rely, K., Vaca Gonz\u00e1lez, R., Lugo-Mart\u00ednez, G., Garc\u00eda-Barrientos, N., and Nateras, A. (2024). Sociodemographic characteristics and their association with survival in women with cervical cancer. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-11909-3"},{"key":"ref_8","first-page":"76","article-title":"Survival analysis and associated factors in patients with cervical cancer financed by the Seguro Popular in Mexico","volume":"64","year":"2022","journal-title":"Salud Publica Mex."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1363","DOI":"10.1634\/theoncologist.2019-0902","article-title":"Cervical Cancer in Young Women: Do They Have a Worse Prognosis? A Retrospective Cohort Analysis in a Population of Mexico","volume":"25","year":"2020","journal-title":"Oncologist"},{"key":"ref_10","first-page":"523","article-title":"Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines","volume":"10","author":"Andrei","year":"1998","journal-title":"Oncol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1099\/0022-1317-81-3-695","article-title":"The effects of interferon on the expression of human papillomavirus oncogenes","volume":"81","author":"Kim","year":"2000","journal-title":"J. Gen. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2147\/IJN.S269986","article-title":"Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances","volume":"17","author":"Zhang","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e2303772","DOI":"10.1002\/smll.202303772","article-title":"Advance in Nanomedicine for Improving Mucosal Penetration and Effective Therapy of Cervical Cancer","volume":"19","author":"Liu","year":"2023","journal-title":"Small"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.2174\/1871520622666220215124434","article-title":"Bismuth lipophilic nanoparticles (BisBAL NP) inhibit the growth of tumor cells in a mouse melanoma model","volume":"22","author":"Meester","year":"2022","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1049\/nbt2.12134","article-title":"A review of bismuth-based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy","volume":"17","author":"Choghazardi","year":"2023","journal-title":"IET Nanobiotechnol.\/IET"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gomez, C., Hallot, G., Laurent, S., and Port, M. (2021). Medical Applications of Metallic Bismuth Nanoparticles. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111793"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1007\/s11051-014-2456-5","article-title":"Synthesis and characterization of lipophilic bismuth dimercaptopropanol nanoparticles and their effects on oral microorganisms growth and biofilm formation","volume":"16","author":"Badireddy","year":"2014","journal-title":"J. Nanoparticle Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/CAD.0000000000000863","article-title":"Antitumor activity of a hydrogel loaded with lipophilic bismuth nanoparticles on cervical, prostate, and colon human cancer cells","volume":"31","author":"Meester","year":"2020","journal-title":"Anti-Cancer Drugs"},{"key":"ref_19","first-page":"588","article-title":"Efficacy of cetylpyridinium chloride used as oropharyngeal antiseptic","volume":"51","author":"Pitten","year":"2001","journal-title":"Arzneim.-Forsch."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/ijos.2016.18","article-title":"Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation","volume":"8","author":"Teng","year":"2016","journal-title":"Int. J. Oral Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10555-020-09880-z","article-title":"Glycosylation and raft endocytosis in cancer","volume":"39","author":"Johannes","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Cuellar, C.M., Hern\u00e1ndez-Delgadillo, R., Solis-Soto, J.M., Meester, I., S\u00e1nchez-P\u00e9rez, Y., Nakagoshi-Cepeda, S.E., Nakagoshi-Cepeda, M.A.A., Chellam, S., and Cabral-Romero, C. (2022). Cetylpyridinium chloride inhibits human breast tumor cells growth in a no-selective way. J. Appl. Biomater. Funct. Mater., 20.","DOI":"10.1177\/22808000221092157"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Cuellar, C.M., Hern\u00e1ndez-Delgadillo, R., Torres-Betancourt, J.A., Solis-Soto, J.M., Meester, I., S\u00e1nchez-P\u00e9rez, Y., Pineda-Aguilar, N., Nakagoshi-Cepeda, S.E., S\u00e1nchez-N\u00e1jera, R.I., and Nakagoshi-Cepeda, M.A.A. (2023). Cumulative antitumor effect of bismuth lipophilic nanoparticles and cetylpyridinium chloride in inhibiting the growth of lung cancer. J. Appl. Biomater. Funct. Mater., 21.","DOI":"10.1177\/22808000231161177"},{"key":"ref_24","first-page":"106501","article-title":"Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine diseases","volume":"188","author":"Teworte","year":"2023","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1590\/S0102-695X2012005000145","article-title":"Study of dissolution profiles and desintegration of capsules containing the dried hydroethanolic extract of Calophyllum brasiliense","volume":"23","author":"Carvalho","year":"2013","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Janeczko, M., and Kochanowicz, E. (2024). Biochanin A Inhibits the Growth and Biofilm of Candida Species. Pharmaceuticals, 17.","DOI":"10.3390\/ph17010089"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1471-4159.1997.69020581.x","article-title":"Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction","volume":"69","author":"Liu","year":"1997","journal-title":"J. Neurochem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, C.A., Pereira-da-Silva, G., Silveira, R., Mayer, P.C.M., Zilly, A., and Lopes-J\u00fanior, L.C. (2024). Safety, Efficacy, and Immunogenicity of Therapeutic Vaccines for Patients with High-Grade Cervical Intraepithelial Neoplasia (CIN 2\/3) Associated with Human Papillomavirus: A Systematic Review. Cancers, 16.","DOI":"10.3390\/cancers16030672"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1016\/j.jgyn.2007.11.019","article-title":"Human papillomavirus vaccines","volume":"37","author":"Brun","year":"2008","journal-title":"J. Gynecol. Obstet. Biol. Reprod."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1016\/j.vaccine.2007.01.016","article-title":"Human papilloma virus (HPV) prophylactic vaccination: Challenges for public health and implications for screening","volume":"25","author":"Adams","year":"2007","journal-title":"Vaccine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/myc.13248","article-title":"Guideline: Vulvovaginal candidosis (AWMF 015\/072, level S2k)","volume":"64","author":"Farr","year":"2021","journal-title":"Mycoses"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/jps.23451","article-title":"Preparation and characterization of mucoadhesive thermoresponsive systems containing propolis for the treatment of vulvovaginal candidiasis","volume":"102","author":"Pereira","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"114293","DOI":"10.1016\/j.addr.2022.114293","article-title":"Advances and future perspectives in epithelial drug delivery","volume":"186","author":"Mohammed","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/13625187.2014.980501","article-title":"Women\u2019s experiences, preferences and perceptions regarding vaginal products: Results from a cross-sectional web-based survey in Portugal","volume":"20","author":"Duarte","year":"2015","journal-title":"Eur. J. Contracept. Reprod. Health Care Off. J. Eur. Soc. Contracept."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"114133","DOI":"10.1016\/j.addr.2022.114133","article-title":"Women\u2019s preferences and acceptance for different drug delivery routes and products","volume":"182","author":"Oliveira","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rajan, S.S., Chandran, R., and Abrahamse, H. (2024). Overcoming challenges in cancer treatment: Nano-enabled photodynamic therapy as a viable solution. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 16.","DOI":"10.1002\/wnan.1942"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2217\/nnm-2023-0302","article-title":"Biopolymer-based tumor microenvironment-responsive nanomedicine for targeted cancer therapy","volume":"19","author":"Jha","year":"2024","journal-title":"Nanomedicine"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Khan, H., Shahab, U., Alshammari, A., Alyahyawi, A.R., Akasha, R., Alharazi, T., Ahmad, R., Khanam, A., Habib, S., and Kaur, K. (2024). Nano-therapeutics: The upcoming nanomedicine to treat cancer. IUBMB Life.","DOI":"10.1002\/iub.2814"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Avgoustakis, K., and Angelopoulou, A. (2024). Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16020179"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"113990","DOI":"10.1016\/j.addr.2021.113990","article-title":"Additive manufacturing in drug delivery: Innovative drug product design and opportunities for industrial application","volume":"178","author":"Ragelle","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Mao, X., Calero-P\u00e9rez, P., Montpey\u00f3, D., Bruna, J., Yuste, V.J., Candiota, A.P., Lorenzo, J., Novio, F., and Ruiz-Molina, D. (2022). Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy. Nanomaterials, 12.","DOI":"10.3390\/nano12071221"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Petre, I., Sirbu, D.T., Petrita, R., Toma, A.D., Peta, E., and Dimcevici-Poesina, F. (2023). Real-world study of Cerviron(\u00ae) vaginal ovules in the treatment of cervical lesions of various etiologies. Biomed. Rep., 19.","DOI":"10.3892\/br.2023.1618"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijpharm.2018.12.011","article-title":"Chitosan-hydroxypropyl methylcellulose tioconazole films: A promising alternative dosage form for the treatment of vaginal candidiasis","volume":"556","author":"Calvo","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/156720109787846289","article-title":"A novel intravaginal delivery system for itraconazole: In vitro and in vivo evaluation","volume":"6","author":"Dobaria","year":"2009","journal-title":"Curr. Drug Deliv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1179\/joc.2004.16.2.179","article-title":"Fenticonazole nitrate for treatment of vulvovaginitis: Efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen","volume":"16","author":"Dibildox","year":"2004","journal-title":"J. Chemother."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000488410","article-title":"Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model","volume":"46","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e24460","DOI":"10.1016\/j.heliyon.2024.e24460","article-title":"Human serum albumin-bound paclitaxel nanoparticle inhibits cervical carcinoma cell proliferation and oxidative damage through CYP3A4 and CYP2C8","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"575","DOI":"10.31557\/APJCP.2024.25.2.575","article-title":"Investigation of in-vitro Anti-Cancer and Apoptotic Potential of Garlic-Derived Nanovesicles against Prostate and Cervical Cancer Cell Lines","volume":"25","author":"Sharma","year":"2024","journal-title":"Asian Pac. J. Cancer Prev. APJCP"}],"container-title":["Journal of Functional Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4983\/15\/8\/206\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:22:54Z","timestamp":1760109774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4983\/15\/8\/206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":48,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jfb15080206"],"URL":"https:\/\/doi.org\/10.3390\/jfb15080206","relation":{},"ISSN":["2079-4983"],"issn-type":[{"value":"2079-4983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]}}}