{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:34:01Z","timestamp":1791912841492,"version":"4.3.4"},"reference-count":118,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["51972005"],"award-info":[{"award-number":["51972005"]}]},{"name":"National Natural Science Foundation of China","award":["82071172"],"award-info":[{"award-number":["82071172"]}]},{"name":"National Natural Science Foundation of China","award":["82001082"],"award-info":[{"award-number":["82001082"]}]},{"name":"National Natural Science Foundation of China","award":["82201017"],"award-info":[{"award-number":["82201017"]}]},{"name":"National Natural Science Foundation of China","award":["2021YFC2400403"],"award-info":[{"award-number":["2021YFC2400403"]}]},{"name":"National Natural Science Foundation of China","award":["PKUSSNKP-T202102"],"award-info":[{"award-number":["PKUSSNKP-T202102"]}]},{"name":"National Natural Science Foundation of China","award":["Z211100002921066"],"award-info":[{"award-number":["Z211100002921066"]}]},{"name":"National Natural Science Foundation of China","award":["2021M700282"],"award-info":[{"award-number":["2021M700282"]}]},{"name":"National Natural Science Foundation of China","award":["2022M710257"],"award-info":[{"award-number":["2022M710257"]}]},{"name":"National Natural Science Foundation of China","award":["PKUSS20210101"],"award-info":[{"award-number":["PKUSS20210101"]}]},{"name":"National Natural Science Foundation of China","award":["BMU2022PYB027"],"award-info":[{"award-number":["BMU2022PYB027"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["51972005"],"award-info":[{"award-number":["51972005"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["82071172"],"award-info":[{"award-number":["82071172"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["82001082"],"award-info":[{"award-number":["82001082"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["82201017"],"award-info":[{"award-number":["82201017"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2021YFC2400403"],"award-info":[{"award-number":["2021YFC2400403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["PKUSSNKP-T202102"],"award-info":[{"award-number":["PKUSSNKP-T202102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["Z211100002921066"],"award-info":[{"award-number":["Z211100002921066"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2021M700282"],"award-info":[{"award-number":["2021M700282"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2022M710257"],"award-info":[{"award-number":["2022M710257"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["PKUSS20210101"],"award-info":[{"award-number":["PKUSS20210101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["BMU2022PYB027"],"award-info":[{"award-number":["BMU2022PYB027"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National clinical key discipline construction project","award":["51972005"],"award-info":[{"award-number":["51972005"]}]},{"name":"National clinical key discipline construction project","award":["82071172"],"award-info":[{"award-number":["82071172"]}]},{"name":"National clinical key discipline construction project","award":["82001082"],"award-info":[{"award-number":["82001082"]}]},{"name":"National clinical key discipline construction project","award":["82201017"],"award-info":[{"award-number":["82201017"]}]},{"name":"National clinical key discipline construction project","award":["2021YFC2400403"],"award-info":[{"award-number":["2021YFC2400403"]}]},{"name":"National clinical key discipline construction project","award":["PKUSSNKP-T202102"],"award-info":[{"award-number":["PKUSSNKP-T202102"]}]},{"name":"National clinical key discipline construction project","award":["Z211100002921066"],"award-info":[{"award-number":["Z211100002921066"]}]},{"name":"National clinical key discipline construction project","award":["2021M700282"],"award-info":[{"award-number":["2021M700282"]}]},{"name":"National clinical key discipline construction project","award":["2022M710257"],"award-info":[{"award-number":["2022M710257"]}]},{"name":"National clinical key discipline construction project","award":["PKUSS20210101"],"award-info":[{"award-number":["PKUSS20210101"]}]},{"name":"National clinical key discipline construction project","award":["BMU2022PYB027"],"award-info":[{"award-number":["BMU2022PYB027"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["51972005"],"award-info":[{"award-number":["51972005"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["82071172"],"award-info":[{"award-number":["82071172"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["82001082"],"award-info":[{"award-number":["82001082"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["82201017"],"award-info":[{"award-number":["82201017"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["2021YFC2400403"],"award-info":[{"award-number":["2021YFC2400403"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["PKUSSNKP-T202102"],"award-info":[{"award-number":["PKUSSNKP-T202102"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["Z211100002921066"],"award-info":[{"award-number":["Z211100002921066"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["2021M700282"],"award-info":[{"award-number":["2021M700282"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["2022M710257"],"award-info":[{"award-number":["2022M710257"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["PKUSS20210101"],"award-info":[{"award-number":["PKUSS20210101"]}]},{"name":"Beijing Key Program for Research and Application of Clinical Diagnosis and Technology","award":["BMU2022PYB027"],"award-info":[{"award-number":["BMU2022PYB027"]}]},{"name":"China Postdoctoral Science Foundation","award":["51972005"],"award-info":[{"award-number":["51972005"]}]},{"name":"China Postdoctoral Science Foundation","award":["82071172"],"award-info":[{"award-number":["82071172"]}]},{"name":"China Postdoctoral Science Foundation","award":["82001082"],"award-info":[{"award-number":["82001082"]}]},{"name":"China Postdoctoral Science Foundation","award":["82201017"],"award-info":[{"award-number":["82201017"]}]},{"name":"China Postdoctoral Science Foundation","award":["2021YFC2400403"],"award-info":[{"award-number":["2021YFC2400403"]}]},{"name":"China Postdoctoral Science Foundation","award":["PKUSSNKP-T202102"],"award-info":[{"award-number":["PKUSSNKP-T202102"]}]},{"name":"China Postdoctoral Science Foundation","award":["Z211100002921066"],"award-info":[{"award-number":["Z211100002921066"]}]},{"name":"China Postdoctoral Science Foundation","award":["2021M700282"],"award-info":[{"award-number":["2021M700282"]}]},{"name":"China Postdoctoral Science Foundation","award":["2022M710257"],"award-info":[{"award-number":["2022M710257"]}]},{"name":"China Postdoctoral Science Foundation","award":["PKUSS20210101"],"award-info":[{"award-number":["PKUSS20210101"]}]},{"name":"China Postdoctoral Science Foundation","award":["BMU2022PYB027"],"award-info":[{"award-number":["BMU2022PYB027"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["51972005"],"award-info":[{"award-number":["51972005"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["82071172"],"award-info":[{"award-number":["82071172"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["82001082"],"award-info":[{"award-number":["82001082"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["82201017"],"award-info":[{"award-number":["82201017"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["2021YFC2400403"],"award-info":[{"award-number":["2021YFC2400403"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["PKUSSNKP-T202102"],"award-info":[{"award-number":["PKUSSNKP-T202102"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["Z211100002921066"],"award-info":[{"award-number":["Z211100002921066"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["2021M700282"],"award-info":[{"award-number":["2021M700282"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["2022M710257"],"award-info":[{"award-number":["2022M710257"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["PKUSS20210101"],"award-info":[{"award-number":["PKUSS20210101"]}]},{"name":"Research Foundation of Peking University School and Hospital of Stomatology","award":["BMU2022PYB027"],"award-info":[{"award-number":["BMU2022PYB027"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["51972005"],"award-info":[{"award-number":["51972005"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["82071172"],"award-info":[{"award-number":["82071172"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["82001082"],"award-info":[{"award-number":["82001082"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["82201017"],"award-info":[{"award-number":["82201017"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["2021YFC2400403"],"award-info":[{"award-number":["2021YFC2400403"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["PKUSSNKP-T202102"],"award-info":[{"award-number":["PKUSSNKP-T202102"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["Z211100002921066"],"award-info":[{"award-number":["Z211100002921066"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["2021M700282"],"award-info":[{"award-number":["2021M700282"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["2022M710257"],"award-info":[{"award-number":["2022M710257"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["PKUSS20210101"],"award-info":[{"award-number":["PKUSS20210101"]}]},{"name":"Peking University Medicine Fund of Fostering Young Scholars\u2019 Scientific and Technological Innovation","award":["BMU2022PYB027"],"award-info":[{"award-number":["BMU2022PYB027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Advanced periodontitis poses a significant threat to oral health, causing extensive damage and loss of both hard and soft periodontal tissues. While traditional therapies such as scaling and root planing can effectively halt the disease\u2019s progression, they often fail to fully restore the original architecture and function of periodontal tissues due to the limited capacity for spontaneous regeneration. To address this challenge, periodontal tissue engineering has emerged as a promising approach. This technology centers on the utilization of biomaterial scaffolds, which function as three-dimensional (3D) templates or frameworks, supporting and guiding the regeneration of periodontal tissues, including the periodontal ligament, cementum, alveolar bone, and gingival tissue. These scaffolds mimic the extracellular matrix (ECM) of native periodontal tissues, aiming to foster cell attachment, proliferation, differentiation, and, ultimately, the formation of new, functional periodontal structures. Despite the inherent challenges associated with preclinical testing, the intensification of research on biomaterial scaffolds, coupled with the continuous advancement of fabrication technology, leads us to anticipate a significant expansion in their application for periodontal tissue regeneration. This review comprehensively covers the recent advancements in biomaterial scaffolds engineered specifically for periodontal tissue regeneration, aiming to provide insights into the current state of the field and potential directions for future research.<\/jats:p>","DOI":"10.3390\/jfb15080233","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T06:07:35Z","timestamp":1724134055000},"page":"233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Biomaterial Scaffolds for Periodontal Tissue Engineering"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-627X","authenticated-orcid":false,"given":"Huanhuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenda","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-9159","authenticated-orcid":false,"given":"Yifan","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4584-1092","authenticated-orcid":false,"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int. Dent. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/jisp.jisp_294_21","article-title":"Models of periodontal disease pathogenesis: A journey through time","volume":"26","author":"Avula","year":"2022","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00103-021-03373-2","article-title":"Periodontitis-therapy of a widespread disease","volume":"64","author":"Dannewitz","year":"2021","journal-title":"Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chen, H., Zhang, Y., Yu, T., Song, G., Xu, T., Xin, T., Lin, Y., and Han, B. (2022). Nano-Based Drug Delivery Systems for Periodontal Tissue Regeneration. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14102250"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40510-023-00501-3","article-title":"Mechanical force increases tooth movement and promotes remodeling of alveolar bone defects augmented with bovine bone mineral","volume":"25","author":"Deng","year":"2024","journal-title":"Prog. Orthod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2174\/157488810791268672","article-title":"Periodontal Disease and Periodontal Tissue Regeneration","volume":"5","author":"Tobita","year":"2010","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1902\/jop.2015.140379","article-title":"Periodontal Regeneration\u2014Furcation Defects: A Systematic Review From the AAP Regeneration Workshop","volume":"86","author":"Reddy","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Iviglia, G., Kargozar, S., and Baino, F. (2019). Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration. J. Funct. Biomater., 10.","DOI":"10.3390\/jfb10010003"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chen, S., and Huang, X. (2022). Nanomaterials in Scaffolds for Periodontal Tissue Engineering: Frontiers and Prospects. Bioengineering, 9.","DOI":"10.3390\/bioengineering9090431"},{"key":"ref_10","first-page":"671","article-title":"Tissue engineering in periodontal regeneration: A brief review","volume":"9","author":"Dabra","year":"2012","journal-title":"Dent. Res. J."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Liu, J., Ruan, J., Weir, M.D., Ren, K., Schneider, A., Wang, P., Oates, T.W., Chang, X., and Xu, H.H.K. (2019). Periodontal Bone-Ligament-Cementum Regeneration via Scaffolds and Stem Cells. Cells, 8.","DOI":"10.3390\/cells8060537"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yu, T., Wang, J., Zhou, Y., Ma, C., Bai, R., Huang, C., Wang, S., Liu, K., and Han, B. (2024). Harnessing Engineered Extracellular Vesicles from Mesenchymal Stem Cells as Therapeutic Scaffolds for Bone-Related Diseases. Adv. Funct. Mater., early access.","DOI":"10.1002\/adfm.202402861"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1800457","DOI":"10.1002\/adhm.201800457","article-title":"Tissue Engineered Constructs for Periodontal Regeneration: Current Status and Future Perspectives","volume":"7","author":"Vaquette","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.32725\/jab.2022.020","article-title":"The use of periodontal membranes in the field of periodontology: Spotlight on collagen membranes","volume":"20","author":"Ayari","year":"2022","journal-title":"J. Appl. Biomed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e23499","DOI":"10.1002\/dvg.23499","article-title":"Novel approaches for periodontal tissue engineering","volume":"60","author":"Swanson","year":"2022","journal-title":"Genesis"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Liu, J., Weir, M.D., Schneider, A., Ma, T., Oates, T.W., Xu, H.H.K., Zhang, K., and Bai, Y. (2022). Periodontal ligament stem cell-based bioactive constructs for bone tissue engineering. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.1071472"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/sctm.18-0181","article-title":"Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations","volume":"8","author":"Xu","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2303509","DOI":"10.1002\/adfm.202303509","article-title":"Engineered Bicomponent Adhesives with Instantaneous and Superior Adhesion Performance for Wound Sealing and Healing Applications","volume":"33","author":"Zhao","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.11607\/jomi.5461","article-title":"Guided Bone Regeneration with Collagen Membranes and Particulate Graft Materials: A Systematic Review and Meta-Analysis","volume":"33","author":"Wessing","year":"2018","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Raveau, S., and Jordana, F. (2020). Tissue Engineering and Three-Dimensional Printing in Periodontal Regeneration: A Literature Review. J. Clin. Med., 9.","DOI":"10.3390\/jcm9124008"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1574888X13666180816113456","article-title":"Recent Advances of Useful Cell Sources in the Periodontal Regeneration","volume":"14","author":"Cho","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12967-023-03990-2","article-title":"The role of non-steroidal anti-inflammatory drugs as adjuncts to periodontal treatment and in periodontal regeneration","volume":"21","author":"Ren","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cden.2022.05.011","article-title":"Biomaterials for Periodontal Regeneration","volume":"66","author":"Deng","year":"2022","journal-title":"Dent. Clin. N. Am."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/prd.12201","article-title":"Nonsurgical and surgical treatment of periodontitis: How many options for one","volume":"75","author":"Graziani","year":"2017","journal-title":"Periodontology 2000"},{"key":"ref_25","first-page":"164","article-title":"Treatment of stage I\u2013III periodontitis-The EFP S3 level clinical practice guideline","volume":"48","author":"Sanz","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/jbm.b.35060","article-title":"Asymmetric resorbable-based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review","volume":"110","author":"Bee","year":"2022","journal-title":"J. Biomed. Mater. Res. Part B-Appl. Biomater."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ren, Y., Fan, L., Alkildani, S., Liu, L., Emmert, S., Najman, S., Rimashevskiy, D., Schnettler, R., Jung, O., and Xiong, X. (2022). Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314987"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.actbio.2014.09.008","article-title":"Porous magnesium\/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction","volume":"11","author":"Brown","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4012\/dmj.2019-437","article-title":"Experimental and clinical evaluation of BMP2-CPC graft versus deproteinized bovine bone graft for guided bone regeneration: A pilot study","volume":"40","author":"Shen","year":"2021","journal-title":"Dent. Mater. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jconrel.2023.05.042","article-title":"Scaffolds for drug delivery and tissue engineering: The role of genetics","volume":"359","author":"Zielinska","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cden.2021.06.004","article-title":"Scaffolds in Periodontal Regenerative Treatment","volume":"66","author":"Yamada","year":"2022","journal-title":"Dent. Clin. N. Am."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Liang, C., Liao, L., and Tian, W. (2023). Advances Focusing on the Application of Decellularized Extracellular Matrix in Periodontal Regeneration. Biomolecules, 13.","DOI":"10.3390\/biom13040673"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/ten.teb.2012.0437","article-title":"Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size","volume":"19","author":"Loh","year":"2013","journal-title":"Tissue Eng. Part B-Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/jre.12729","article-title":"Fibre guiding scaffolds for periodontal tissue engineering","volume":"55","author":"Staples","year":"2020","journal-title":"J. Periodontal Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s13770-023-00583-4","article-title":"AuNP-Loaded Electrospinning Membrane Cooperated with CDs for Periodontal Tissue Engineering","volume":"20","author":"Wang","year":"2023","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12015-009-9110-0","article-title":"Gene-Modified Stem Cells Combined with Rapid Prototyping Techniques: A Novel Strategy for Periodontal Regeneration","volume":"6","author":"He","year":"2010","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ding, T., Kang, W., Li, J., Yu, L., and Ge, S. (2021). An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-00992-4"},{"key":"ref_38","first-page":"e57844","article-title":"Formulation of a Novel Polymeric Hydrogel Membrane for Periodontal Tissue Regeneration Using Tricalcium Phosphate-Alginate Reinforcement","volume":"16","author":"Swetha","year":"2024","journal-title":"Cureus J. Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Dikici, B.A., Dikici, S., Reilly, G.C., MacNeil, S., and Claeyssens, F. (2019). A Novel Bilayer Polycaprolactone Membrane for Guided Bone Regeneration: Combining Electrospinning and Emulsion Templating. Materials, 12.","DOI":"10.3390\/ma12162643"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Miao, G., Liang, L., Li, W., Ma, C., Pan, Y., Zhao, H., Zhang, Q., Xiao, Y., and Yang, X. (2023). 3D Bioprinting of a Bioactive Composite Scaffold for Cell Delivery in Periodontal Tissue Regeneration. Biomolecules, 13.","DOI":"10.3390\/biom13071062"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhao, F., Zhang, Z., and Guo, W. (2024). The 3-dimensional printing for dental tissue regeneration: The state of the art and future challenges. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1356580"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Liang, H., Wang, Z., Wu, J., Li, X., and Semirumi, D.T. (2023). Microstructural and micromechanical modeling of gum-gelatin-based soft tissue engineering scaffolds. Int. J. Biol. Macromol., 241.","DOI":"10.1016\/j.ijbiomac.2023.124544"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, T., Zhou, Y., Zhang, W., Xue, Y., Xiao, Z., Zhou, Y., and Peng, X. (2024). Exosomes and exosome composite scaffolds in periodontal tissue engineering. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1287714"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.eng.2021.02.027","article-title":"Engineered Fabrication of Enamel-Mimetic Materials","volume":"14","author":"Zhang","year":"2022","journal-title":"Engineering"},{"key":"ref_45","first-page":"130","article-title":"Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration","volume":"11","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ali, M., Noor, S.N.F.M., Mohamad, H., Ullah, F., Javed, F., and Hamid, Z.A.A. (2024). Advances in guided bone regeneration membranes: A comprehensive review of materials and techniques. Biomed. Phys. Eng. Express, 10.","DOI":"10.1088\/2057-1976\/ad1e75"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Alqahtani, A.M. (2023). Guided Tissue and Bone Regeneration Membranes: A Review of Biomaterials and Techniques for Periodontal Treatments. Polymers, 15.","DOI":"10.3390\/polym15163355"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"153S","DOI":"10.1177\/0022034515588303","article-title":"3D-printed Bioresorbable Scaffold for Periodontal Repair","volume":"94","author":"Rasperini","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Chen, Y., Li, Y., Zhu, W., and Liu, Q. (2024). Biomimetic gradient scaffolds for the tissue engineering and regeneration of rotator cuff enthesis. Biofabrication, 16.","DOI":"10.1088\/1758-5090\/ad467d"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/ten.tec.2022.0106","article-title":"Challenges and Tissue Engineering Strategies of Periodontal-Guided Tissue Regeneration","volume":"28","author":"Liu","year":"2022","journal-title":"Tissue Eng. Part C-Methods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbrc.2006.03.106","article-title":"Novel chitosan\/collagen scaffold containing transforming growth factor-\u03b21 DNA for periodontal tissue engineering","volume":"344","author":"Zhang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Imber, J.-C., Roccuzzo, A., Staehli, A., Saulacic, N., Deschner, J., Sculean, A., and Bosshardt, D.D. (2021). Immunohistochemical Evaluation of Periodontal Regeneration Using a Porous Collagen Scaffold. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222010915"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10266-016-0267-0","article-title":"Collagen based barrier membranes for periodontal guided bone regeneration applications","volume":"105","author":"Sheikh","year":"2017","journal-title":"Odontology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jre.12954","article-title":"Periodontal tissue engineering using an apatite\/collagen scaffold obtained by a plasma- and precursor-assisted biomimetic process","volume":"57","author":"Kanemoto","year":"2022","journal-title":"J. Periodontal Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4103\/1119-3077.188711","article-title":"Platelet-rich fibrin combined with synthetic nanocrystalline hydroxy apatite granules in the management of radicular cyst","volume":"19","author":"Pradeep","year":"2016","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.actbio.2022.07.023","article-title":"Fibre-guiding biphasic scaffold for perpendicular periodontal ligament attachment","volume":"150","author":"Staples","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chen, K., Li, Y., Li, Y., Pan, W., and Tan, G. (2023). Silk Fibroin Combined with Electrospinning as a Promising Strategy for Tissue Regeneration. Macromol. Biosci., 23.","DOI":"10.1002\/mabi.202200380"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10856-019-6225-y","article-title":"Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration","volume":"30","author":"Geao","year":"2019","journal-title":"J. Mater. Sci.-Mater. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.msec.2019.01.055","article-title":"Ultrasound sonication prior to electrospinning tailors silk fibroin\/PEO membranes for periodontal regeneration","volume":"98","author":"Serodio","year":"2019","journal-title":"Mater. Sci. Eng. C-Mater. Biol. Appl."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"137970","DOI":"10.1016\/j.foodchem.2023.137970","article-title":"Methods for detection and quantification of gelatin from different sources","volume":"438","author":"Hassan","year":"2024","journal-title":"Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/jbm.a.36886","article-title":"Self-healing injectable gelatin hydrogels for localized therapeutic cell delivery","volume":"108","author":"Sisso","year":"2020","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"46145","DOI":"10.1021\/acsami.2c03705","article-title":"3D Polycaprolactone\/Gelatin-Oriented Electrospun Scaffolds Promote Periodontal Regeneration","volume":"14","author":"Xu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Cho, Y., Jeong, H., Kim, B., Jang, J., Song, Y.-S., and Lee, D.Y. (2023). Electrospun Poly(L-Lactic Acid)\/Gelatin Hybrid Polymer as a Barrier to Periodontal Tissue Regeneration. Polymers, 15.","DOI":"10.3390\/polym15183844"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"118078","DOI":"10.1016\/j.indcrop.2024.118078","article-title":"Cellulose based materials to accelerate the transition towards sustainability","volume":"210","author":"Verma","year":"2024","journal-title":"Ind. Crops Prod."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ultsonch.2011.12.002","article-title":"Ultrasound influence upon calcium carbonate precipitation on bacterial cellulose membranes","volume":"19","author":"Stroescu","year":"2012","journal-title":"Ultrason. Sonochem."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Chiaoprakobkij, N., Suwanmajo, T., Sanchavanakit, N., and Phisalaphong, M. (2020). Curcumin-Loaded Bacterial Cellulose\/Alginate\/Gelatin as A Multifunctional Biopolymer Composite Film. Molecules, 25.","DOI":"10.3390\/molecules25173800"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"An, S.-J., Lee, S.-H., Huh, J.-B., Jeong, S.I., Park, J.-S., Gwon, H.-J., Kang, E.-S., Jeong, C.-M., and Lim, Y.-M. (2017). Preparation and Characterization of Resorbable Bacterial Cellulose Membranes Treated by Electron Beam Irradiation for Guided Bone Regeneration. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112236"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Peng, W., Ren, S., Zhang, Y., Fan, R., Zhou, Y., Li, L., Xu, X., and Xu, Y. (2021). MgO Nanoparticles-Incorporated PCL\/Gelatin-Derived Coaxial Electrospinning Nanocellulose Membranes for Periodontal Tissue Regeneration. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.668428"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0142-9612(98)00107-0","article-title":"Alginate hydrogels as synthetic extracellular matrix materials","volume":"20","author":"Rowley","year":"1999","journal-title":"Biomaterials"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zhang, S., Jia, Y., Liu, J., Feng, F., Wei, Z., Zhang, M., and Xu, F. (2023). A viscoelastic alginate-based hydrogel network coordinated with spermidine for periodontal ligament regeneration. Regen. Biomater., 10.","DOI":"10.1093\/rb\/rbad009"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"104219","DOI":"10.1016\/j.jdent.2022.104219","article-title":"Human periodontal ligament stem cell encapsulation in alginate-fibrin-platelet lysate microbeads for dental and craniofacial regeneration","volume":"124","author":"Qiu","year":"2022","journal-title":"J. Dent."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Atia, G.A.N., Shalaby, H.K., Zehravi, M., Ghobashy, M.M., Attia, H.A.N., Ahmad, Z., Khan, F.S., Dey, A., Mukerjee, N., and Alexiou, A. (2022). Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration. Polymers, 14.","DOI":"10.3390\/polym14153192"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.ijbiomac.2020.08.153","article-title":"Antimicrobial and antioxidant properties of chitosan and its derivatives and their applications: A review","volume":"164","author":"Shafi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1208\/s12249-020-01708-x","article-title":"The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration","volume":"21","author":"Qasim","year":"2020","journal-title":"AAPS Pharmscitech"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2019.01.001","article-title":"An injectable and thermosensitive hydrogel: Promoting periodontal regeneration by controlled-release of aspirin and erythropoietin","volume":"86","author":"Xu","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Tan, N., Sabalic-Schoener, M., Nguyen, L., and D\u2019Aiuto, F. (2023). \u03b2-Tricalcium Phosphate-Loaded Chitosan-Based Thermosensitive Hydrogel for Periodontal Regeneration. Polymers, 15.","DOI":"10.3390\/polym15204146"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1055\/s-0040-1709955","article-title":"Periodontal Ligament Cell Sheets and RGD-Modified Chitosan Improved Regeneration in the Horizontal Periodontal Defect Model","volume":"14","author":"Amir","year":"2020","journal-title":"Eur. J. Dent."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.34172\/joddd.2022.001","article-title":"Biomaterials and biotechnology for periodontal tissue regeneration: Recent advances and perspectives","volume":"16","author":"Deng","year":"2022","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospect."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-3-319-76711-6_3","article-title":"Bioceramics for Osteochondral Tissue Engineering and Regeneration","volume":"Volume 1058","author":"Oliveira","year":"2018","journal-title":"Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-981-13-0947-2_16","article-title":"Bioceramics for Clinical Application in Regenerative Dentistry","volume":"Volume 1077","author":"Chun","year":"2018","journal-title":"Novel Biomaterials for Regenerative Medicine"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Nakagawa, S., Okada, R., Kushioka, J., Kodama, J., Tsukazaki, H., Bal, Z., Tateiwa, D., Ukon, Y., Hirai, H., and Makino, T. (2022). Effects of rhBMP-2-loaded hydroxyapatite granules\/beta-tricalcium phosphate hydrogel (HA\/\u03b2-TCP\/hydrogel) composite on a rat model of caudal intervertebral fusion. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-12082-y"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/jbm.b.35287","article-title":"A composite of polymethylmethacrylate, hydroxyapatite, and \u03b2-tricalcium phosphate for bone regeneration in an osteoporotic rat model","volume":"111","author":"Hossain","year":"2023","journal-title":"J. Biomed. Mater. Res. Part B-Appl. Biomater."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Makishi, S., Watanabe, T., Saito, K., and Ohshima, H. (2023). Effect of Hydroxyapatite\/\u03b2-Tricalcium Phosphate on Osseointegration after Implantation into Mouse Maxilla. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043124"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1039\/D2TB02191A","article-title":"Fabricating biodegradable calcium phosphate\/calcium sulfate cement reinforced with cellulose: In vitro and in vivo studies","volume":"11","author":"Li","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1002\/jbm.b.34350","article-title":"Calcium sulfate bone cements with nanoscaled silk fibroin as inducer","volume":"107","author":"Xu","year":"2019","journal-title":"J. Biomed. Mater. Res. Part B-Appl. Biomater."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.drudis.2018.05.027","article-title":"Bioactive glasses entering the mainstream","volume":"23","author":"Kargozar","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Skallevold, H.E., Rokaya, D., Khurshid, Z., and Zafar, M.S. (2019). Bioactive Glass Applications in Dentistry. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20235960"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sdentj.2013.12.001","article-title":"A review of the effect of various ions on the properties and the clinical applications of novel bioactive glasses in medicine and dentistry","volume":"26","author":"Ali","year":"2014","journal-title":"Saudi Dent. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jeurceramsoc.2017.11.001","article-title":"Boron-containing bioactive glasses in bone and soft tissue engineering","volume":"38","author":"Balasubramanian","year":"2018","journal-title":"J. Eur. Ceram. Soc."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1021\/acsbiomaterials.1c00414","article-title":"Cerium Containing Bioactive Glasses: A Review","volume":"7","author":"Zambon","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"122528","DOI":"10.1016\/j.matchemphys.2019.122528","article-title":"Common biocompatible polymeric materials for tissue engineering and regenerative medicine","volume":"242","author":"Asadi","year":"2020","journal-title":"Mater. Chem. Phys."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/acs.biomac.2c00047","article-title":"Biocompatible Synthetic Polymers for Tissue Engineering Purposes","volume":"23","author":"Terzopoulou","year":"2022","journal-title":"Biomacromolecules"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.actbio.2018.08.027","article-title":"Elastic materials for tissue engineering applications: Natural, synthetic, and hybrid polymers","volume":"79","author":"Coenen","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"112257","DOI":"10.1016\/j.eurpolymj.2023.112257","article-title":"Carbon nanotube-based biocompatible polymer nanocomposites as an emerging tool for biomedical applications","volume":"196","author":"Pathak","year":"2023","journal-title":"Eur. Polym. J."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Malekpour, Z., Akbari, V., Varshosaz, J., and Taheri, A. (2021). Preparation and characterization of poly (lactic-co-glycolic acid) nanofibers containing simvastatin coated with hyaluronic acid for using in periodontal tissue engineering. Biotechnol. Prog., 37.","DOI":"10.1002\/btpr.3195"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41536-023-00305-3","article-title":"Janus porous polylactic acid membranes with versatile metal-phenolic interface for biomimetic periodontal bone regeneration","volume":"8","author":"Zhang","year":"2023","journal-title":"NPJ Regen. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/08853282241248778","article-title":"Preparing gelatin-containing polycaprolactone\/polylactic acid nanofibrous membranes for periodontal tissue regeneration using side-by-side electrospinning technology","volume":"39","author":"Zhang","year":"2024","journal-title":"J. Biomater. Appl."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/clr.13755","article-title":"Vertical bone augmentation utilizing a titanium-reinforced PTFE mesh: A","volume":"32","author":"Urban","year":"2021","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Lee, U.-L., Yun, S., Cao, H.-L., Ahn, G., Shim, J.-H., Woo, S.-H., and Choung, P.-H. (2021). Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament. Cells, 10.","DOI":"10.3390\/cells10061337"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2041731413515670","DOI":"10.1177\/2041731413515670","article-title":"Enhanced in vitro osteoblast differentiation on TiO2 scaffold coated with alginate hydrogel containing simvastatin","volume":"4","author":"Pullisaar","year":"2013","journal-title":"J. Tissue Eng."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijbiomac.2020.06.173","article-title":"Biomimetic collagen-sodium alginate-titanium oxide (TiO(2)) 3D matrix supports differentiated periodontal ligament fibroblasts growth for periodontal tissue regeneration","volume":"163","author":"Elango","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Shoba, E., Lakra, R., Kiran, M.S., and Korrapati, P.S. (2020). 3D nano bilayered spatially and functionally graded scaffold impregnated bromelain conjugated magnesium doped hydroxyapatite nanoparticle for periodontal regeneration. J. Mech. Behav. Biomed. Mater., 109.","DOI":"10.1016\/j.jmbbm.2020.103822"},{"key":"ref_103","first-page":"e55502","article-title":"Osteogenic Potential of Magnesium Oxide Nanoparticles in Bone Regeneration: A Systematic Review","volume":"16","author":"Malaiappan","year":"2024","journal-title":"Cureus"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.actbio.2018.08.034","article-title":"Design of a migration assay for human gingival fibroblasts on biodegradable magnesium surfaces","volume":"79","author":"Amberg","year":"2018","journal-title":"Acta Biomater"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Hangyasi, D.B., K\u00f6rtv\u00e9lyessy, G., Bla\u0161kovi\u0107, M., Rider, P., Rogge, S., Siber, S., Ka\u010darevi\u0107, \u017d.P., and \u010candrli\u0107, M. (2023). Regeneration of Intrabony Defects Using a Novel Magnesium Membrane. Medicina, 59.","DOI":"10.3390\/medicina59112018"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Guo, W., Dong, H., and Wang, X. (2024). Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1380528"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Li, M., Lv, J., Yang, Y., Cheng, G., Guo, S., Liu, C., and Ding, Y. (2022). Advances of Hydrogel Therapy in Periodontal Regeneration-A Materials Perspective Review. Gels, 8.","DOI":"10.3390\/gels8100624"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2203734","DOI":"10.1002\/advs.202203734","article-title":"Mechanically Robust Hydrogels Facilitating Bone Regeneration through Epigenetic Modulation","volume":"9","author":"Yu","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Mensah, A., Rodgers, A.M., Larraneta, E., McMullan, L., Tambuwala, M., Callan, J.F., and Courtenay, A.J. (2023). Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems. Antibiotics, 12.","DOI":"10.3390\/antibiotics12061073"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Sun, H., Luan, J., and Dong, S. (2024). Hydrogels promote periodontal regeneration. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1411494"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Santos, M.S., dos Santos, A.B., and Carvalho, M.S. (2023). New Insights in Hydrogels for Periodontal Regeneration. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14110545"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.actbio.2023.12.017","article-title":"Rational design of viscoelastic hydrogels for periodontal ligament remodeling and repair","volume":"174","author":"Zhang","year":"2024","journal-title":"Acta Biomater."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.sdentj.2023.05.021","article-title":"Fabrication of hydroxyapatite reinforced polymeric hydrogel membrane for regeneration","volume":"35","author":"Kishen","year":"2023","journal-title":"Saudi Dent. J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.actbio.2020.06.011","article-title":"Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration","volume":"113","author":"Dubey","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2201665","DOI":"10.1002\/adhm.202201665","article-title":"Bioessential Inorganic Molecular Wire-Reinforced 3D-Printed Hydrogel Scaffold for Enhanced Bone Regeneration","volume":"12","author":"Lee","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Scribante, A., Gallo, S., Pascadopoli, M., Frani, M., and Butera, A. (2023). Ozonized gels vs chlorhexidine in non-surgical periodontal treatment: A randomized clinical trial. Oral Dis., online ahead of print.","DOI":"10.1111\/odi.14829"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Colombo, M., Gallo, S., Garofoli, A., Poggio, C., Arciola, C.R., and Scribante, A. (2021). Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application. Biology, 10.","DOI":"10.3390\/biology10070625"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Butera, A., Gallo, S., Pascadopoli, M., Taccardi, D., and Scribante, A. (2022). Home Oral Care of Periodontal Patients Using Antimicrobial Gel with Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial. Antibiotics, 11.","DOI":"10.3390\/antibiotics11010118"}],"container-title":["Journal of Functional Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4983\/15\/8\/233\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:39:21Z","timestamp":1760110761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4983\/15\/8\/233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":118,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jfb15080233"],"URL":"https:\/\/doi.org\/10.3390\/jfb15080233","relation":{},"ISSN":["2079-4983"],"issn-type":[{"value":"2079-4983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]}}}