{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:09:56Z","timestamp":1791230996682,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Complementary Plan for Biotechnology Applied to Health","award":["PRTR-C17. I1"],"award-info":[{"award-number":["PRTR-C17. I1"]}]},{"name":"Extremadura ERDF Operational Program 2021\u20132027","award":["PRTR-C17. I1"],"award-info":[{"award-number":["PRTR-C17. I1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Lymphedema presents significant challenges to patients\u2019 quality of life, prompting the exploration of innovative treatments, such as collagen scaffolds, aimed at treating and reducing the risk of lymphedema. We aimed to evaluate the preventive and therapeutic efficacy and the lymphangiogenic potential of implanted aligned nanofibrillar collagen scaffolds (BioBridgeTM) following the induction of secondary lymphedema in a rabbit model. Thirty rabbits were divided into treatment (G1), prevention (G2), and control (G3) groups. Secondary lymphedema was induced in all groups. BioBridgeTM implantation was performed in G2 and G1 on days 0 and 60, respectively. Follow-ups included hindlimb circumference measurements and indocyanine green lymphography at 0, 60, and 90 days. None of the study rabbits exhibited dermal backflow on day 0 before surgery. At 60 days, the incidence rates of dermal backflow in G1, G2, and G3 were 100%, 44.4%, and 90%, respectively. Furthermore, at 90 days, the incidence rates were 22.2%, 44.4%, and 90%, respectively. New linear lymphatic observation was seen in rabbits with resolved dermal backflow. The findings of this study demonstrated the capacity of BioBridgeTM scaffolds to induce new lymphatic vessel formation and reduce dermal backflow in secondary lymphedema in a rabbit model.<\/jats:p>","DOI":"10.3390\/jfb15080235","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T04:26:57Z","timestamp":1724300817000},"page":"235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds: An Experimental Rabbit Model"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-2454","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Campos","sequence":"first","affiliation":[{"name":"Department of Microsurgery, Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Pons","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-198X","authenticated-orcid":false,"given":"Ali M.","family":"Al-Sakkaf","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-9610","authenticated-orcid":false,"given":"Irene Laura","family":"Lusetti","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4131-0133","authenticated-orcid":false,"given":"Laura","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Microsurgery, Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-0601","authenticated-orcid":false,"given":"Francisco Javier","family":"Vela","sequence":"additional","affiliation":[{"name":"Department of Microsurgery, Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Microsurgery, Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-7029","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Cris\u00f3stomo","sequence":"additional","affiliation":[{"name":"Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, 10071 C\u00e1ceres, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-988X","authenticated-orcid":false,"given":"Francisco Miguel","family":"S\u00e1nchez-Margallo","sequence":"additional","affiliation":[{"name":"Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, 10071 C\u00e1ceres, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Abell\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Microsurgery, Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-9586","authenticated-orcid":false,"given":"Jaume","family":"Masi\u00e1","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/01.sap.0000257149.42922.7e","article-title":"Lymphedema: A comprehensive review","volume":"59","author":"Warren","year":"2007","journal-title":"Ann. 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