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However, the mechanism through which LCS-SeNPs alleviate high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) remains unclear. Our results elucidated that LCS-SeNPs significantly inhibited fat accumulation and markedly improved the intestinal barrier by increasing mucus secretion from goblet cells. Moreover, LCS-SeNPs reshaped intestinal flora composition by increasing the abundance of mucus-associated microbiota (Bifidobacterium, Akkermansia, and Muribaculaceae_unclassified) and decreasing the abundance of obesity-contributed bacterium (Anaerotruncus, Lachnoclostridium, and Proteus). The modulation of intestinal microbiota by LCS-SeNPs influenced several metabolic pathways, including bile acid secretion, purine metabolites, and tryptophan derivation. Meanwhile, glycocholic acid and tauro-beta-muricholic acid were significantly reduced in the LCS-SeNP group. Our study suggests the crucial role of intestinal microbiota composition and metabolism, providing a new theoretical foundation for utilizing selenium polysaccharides in the intervention of HFD-induced NAFLD.<\/jats:p>","DOI":"10.3390\/jfb15080236","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T06:28:51Z","timestamp":1724308131000},"page":"236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota"],"prefix":"10.3390","volume":"15","author":[{"given":"Yuhang","family":"Luo","sequence":"first","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujiang","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Xianghu Laboratory, Hangzhou 311231, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiling","family":"Yang","sequence":"additional","affiliation":[{"name":"Xianghu Laboratory, Hangzhou 311231, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4135-553X","authenticated-orcid":false,"given":"Yuanxiang","family":"Jin","sequence":"additional","affiliation":[{"name":"Xianghu Laboratory, Hangzhou 311231, China"},{"name":"College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchi","family":"Wang","sequence":"additional","affiliation":[{"name":"Xianghu Laboratory, Hangzhou 311231, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengshun","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"},{"name":"Xianghu Laboratory, Hangzhou 311231, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.cmet.2023.07.011","article-title":"Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis","volume":"35","author":"Kuang","year":"2023","journal-title":"Cell Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic","volume":"10","author":"Loomba","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri1373","article-title":"Interactions between commensal intestinal bacteria and the immune system","volume":"4","author":"Macpherson","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/bph.14095","article-title":"Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease","volume":"175","author":"Wang","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1080\/10408398.2021.1966738","article-title":"Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): Focusing on the gut\u2013liver axis","volume":"63","author":"Han","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41574-021-00507-z","article-title":"Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus","volume":"17","author":"Ferguson","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.1039\/D2FO01009G","article-title":"Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats","volume":"13","author":"Zhong","year":"2022","journal-title":"Food Funct."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1039\/C9FO02026H","article-title":"Research progress on the biological activities of selenium polysaccharides","volume":"11","author":"Zhou","year":"2020","journal-title":"Food Funct."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.foodchem.2009.03.073","article-title":"Protective effect of selenium-polysaccharides from the mycelia of Coprinus comatus on alloxan-induced oxidative stress in mice","volume":"117","author":"Yu","year":"2009","journal-title":"Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1039\/C5FO00557D","article-title":"Selenium-containing polysaccharides from Ziyang green tea ameliorate high-fructose diet induced insulin resistance and hepatic oxidative stress in mice","volume":"6","author":"Ren","year":"2015","journal-title":"Food Funct."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.carbpol.2016.07.055","article-title":"Selenylation modification can enhance immune-enhancing activity of Chuanminshen violaceum polysaccharide","volume":"153","author":"Haibo","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tifs.2014.07.006","article-title":"Selenium enrichment of lactic acid bacteria and bifidobacteria: A functional food perspective","volume":"39","author":"Pophaly","year":"2014","journal-title":"Trends Food Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20386","DOI":"10.1021\/acs.jafc.3c00108","article-title":"Gut Microbiome and Metabolomics Study of Selenium-Enriched Kiwifruit Regulating Hyperlipidemia in Mice Induced by a High-Fat Diet","volume":"71","author":"He","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chen, Y., Liu, Y., Dong, Q., Xu, C., Deng, S., Kang, Y., Fan, M., and Li, L. (2023). Application of functionalized chitosan in food: A review. Int. J. Biol. Macromol., 235.","DOI":"10.1016\/j.ijbiomac.2023.123716"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1016\/j.ijbiomac.2020.09.042","article-title":"Chitosan: Structural modification, biological activity and application","volume":"164","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9947","DOI":"10.1039\/D0FO01871F","article-title":"Low molecular weight chitosan oligosaccharides (LMW-COSs) prevent obesity-related metabolic abnormalities in association with the modification of gut microbiota in high-fat diet (HFD)-fed mice","volume":"11","author":"He","year":"2020","journal-title":"Food Funct."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"120448","DOI":"10.1016\/j.carbpol.2022.120448","article-title":"A propitious role of marine sourced polysaccharides: Drug delivery and biomedical applications","volume":"308","author":"Sharma","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhang, G., Zhang, M., Pei, Y., Qian, K., Xie, J., Huang, Q., Liu, S., Xue, N., Zu, Y., and Wang, H. (2023). Enhancing stability of liposomes using high molecular weight chitosan to promote antioxidative stress effects and lipid-lowering activity of encapsulated lutein in vivo and in vitro. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.126564"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"119273","DOI":"10.1016\/j.carbpol.2022.119273","article-title":"N-trimethyl chitosan coated targeting nanoparticles improve the oral bioavailability and antioxidant activity of vitexin","volume":"286","author":"Li","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Peng, S.-J., Ye, D.-T., Zheng, J., Xue, Y.-R., Lin, L., Zhao, Y.-D., Miao, W.-H., Song, Y., Wen, Z.-S., and Zheng, B. (2022). Synthesis, characterization of low molecular weight chitosan selenium nanoparticles and its effect on dss-induced ulcerative colitis in mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415527"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/hep.24127","article-title":"Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: Distinct clinicopathologic meanings","volume":"53","author":"Brunt","year":"2011","journal-title":"Hepatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nrgastro.2013.175","article-title":"Noninvasive evaluation of NAFLD","volume":"10","author":"Castera","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.21327","article-title":"Long-term follow-up of patients with NAFLD and elevated liver enzymes","volume":"44","author":"Ekstedt","year":"2006","journal-title":"Hepatology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"113127","DOI":"10.1016\/j.foodres.2023.113127","article-title":"Oat bran prevents high-fat-diet induced muscular dysfunction, systemic inflammation and oxidative stress through reconstructing gut microbiome and circulating metabolome","volume":"172","author":"Dong","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","article-title":"Intestinal barrier function: Molecular regulation and disease pathogenesis","volume":"124","author":"Groschwitz","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1842990","DOI":"10.1080\/19490976.2020.1842990","article-title":"Phlorizin ameliorates obesity-associated endotoxemia and insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity","volume":"12","author":"Zhang","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"119405","DOI":"10.1016\/j.carbpol.2022.119405","article-title":"Chitosan oligosaccharide mitigates kidney injury in prediabetic rats by improving intestinal barrier and renal autophagy","volume":"288","author":"Sutthasupha","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10050","DOI":"10.1021\/acs.jafc.3c01881","article-title":"Heptamethoxyflavone Alleviates Metabolic Syndrome in High-Fat Diet-Fed Mice by Regulating the Composition, Function, and Metabolism of Gut Microbiota","volume":"71","author":"Feng","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41564-021-00880-5","article-title":"Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice","volume":"6","author":"Yoon","year":"2021","journal-title":"Nat. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2221485","DOI":"10.1080\/19490976.2023.2221485","article-title":"Akkermansia muciniphila inhibits nonalcoholic steatohepatitis by orchestrating TLR2-activated \u03b3\u03b4T17 cell and macrophage polarization","volume":"15","author":"Han","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"137499","DOI":"10.1016\/j.chemosphere.2022.137499","article-title":"Genus unclassified_Muribaculaceae and microbiota-derived butyrate and indole-3-propionic acid are involved in benzene-induced hematopoietic injury in mice","volume":"313","author":"Wang","year":"2023","journal-title":"Chemosphere"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"skab308","DOI":"10.1093\/jas\/skab308","article-title":"Effects of fermented wheat bran and yeast culture on growth performance, immunity, and intestinal microflora in growing-finishing pigs","volume":"99","author":"He","year":"2021","journal-title":"J. Anim. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"15195","DOI":"10.1021\/acs.jafc.1c06029","article-title":"Dietary Chito-oligosaccharides Improve Intestinal Immunity via Regulating Microbiota and Th17\/Treg Balance-Related Immune Signaling in Piglets Challenged by Enterotoxigenic E. coli","volume":"69","author":"Yu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yoon, S.J., Yu, J.S., Min, B.H., Gupta, H., Won, S.-M., Park, H.J., Han, S.H., Kim, B.-Y., Kim, K.H., and Kim, B.K. (2023). Bifidobacterium-derived short-chain fatty acids and indole compounds attenuate nonalcoholic fatty liver disease by modulating gut-liver axis. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1129904"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"104285","DOI":"10.1016\/j.jff.2020.104285","article-title":"Procyanidin B2 prevents dyslipidemia via modulation of gut microbiome and related metabolites in high-fat diet fed mice","volume":"75","author":"Xiao","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1021\/acs.jafc.3c04193","article-title":"Polysaccharide from Ziyang Selenium-Enriched Green Tea Prevents Obesity and Promotes Adipose Thermogenesis via Modulating the Gut Microbiota","volume":"71","author":"Li","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Yang, L., Wang, Y., Zheng, G., Li, Z., and Mei, J. (2023). Resveratrol-loaded selenium\/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer's disease. Int. J. Biol. Macromol., 239.","DOI":"10.1016\/j.ijbiomac.2023.124316"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ran, Q., Gan, Q., Zhu, Y., Song, L., Shen, L., Duan, X., Zhu, X., and Huang, W. (2024). Mechanism insights into the pleiotropic effects of nobiletin as a potential therapeutic agent on non-alcoholic fatty liver disease (NAFLD). Biomed. Pharmacother., 173.","DOI":"10.1016\/j.biopha.2024.116322"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"155478","DOI":"10.1016\/j.phymed.2024.155478","article-title":"Smilax China L. polysaccharide prevents HFD induced-NAFLD by regulating hepatic fat metabolism and gut microbiota","volume":"127","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2009.03.012","article-title":"AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome","volume":"9","author":"Zhang","year":"2009","journal-title":"Cell Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1194\/jlr.M090969","article-title":"CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway","volume":"60","author":"Li","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"736580","DOI":"10.1016\/j.aquaculture.2021.736580","article-title":"Nano-selenium supplements in high-fat diets relieve hepatopancreas injury and improve survival of grass carp Ctenopharyngodon Idella by reducing lipid deposition","volume":"538","author":"Liu","year":"2021","journal-title":"Aquaculture"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Tao, W., Sun, W., Liu, L., Wang, G., Xiao, Z., Pei, X., and Wang, M. (2019). Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL\/6 Mice. Mar. Drugs, 17.","DOI":"10.3390\/md17110645"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.redox.2017.11.002","article-title":"(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance","volume":"14","author":"Cremonini","year":"2018","journal-title":"Redox Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100346","DOI":"10.1016\/j.jhepr.2021.100346","article-title":"New targets for NAFLD","volume":"3","author":"Parlati","year":"2021","journal-title":"JHEP Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2400064","DOI":"10.1002\/adhm.202400064","article-title":"Biomimetic MicroRNAs-Selenium-Nanocomposites for Targeted and Combined Hyperlipidemia Therapy","volume":"13","author":"Li","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/gut.2007.140806","article-title":"Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: Involvement of soluble mediators","volume":"58","author":"Piche","year":"2009","journal-title":"Gut"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.addr.2005.01.009","article-title":"Occludin: Structure, function and regulation","volume":"57","author":"Feldman","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/acs.jafc.9b00080","article-title":"Intestinal Barrier Function\u2013Non-alcoholic Fatty Liver Disease Interactions and Possible Role of Gut Microbiota","volume":"67","author":"Cui","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.ijbiomac.2020.07.191","article-title":"The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression","volume":"164","author":"Liu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.1073\/pnas.0808722106","article-title":"The protein disulfide isomerase AGR2 is essential for production of intestinal mucus","volume":"106","author":"Park","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2152307","DOI":"10.1080\/19490976.2022.2152307","article-title":"Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion","volume":"14","author":"Paone","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Qian, M., Lyu, Q., Liu, Y., Hu, H., Wang, S., Pan, C., Duan, X., Gao, Y., Qi, L.-W., and Liu, W. (2019). Chitosan Oligosaccharide Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Mice. Mar. Drugs, 17.","DOI":"10.3390\/md17070391"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"10459","DOI":"10.1039\/D3FO03745B","article-title":"Ameliorating the effect and mechanism of chitosan oligosaccharide on nonalcoholic fatty liver disease in mice","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1007\/s12011-022-03247-x","article-title":"Selenium-Enriched Probiotic Alleviates Western Diet-Induced Non-alcoholic Fatty Liver Disease in Rats via Modulation of Autophagy Through AMPK\/SIRT-1 Pathway","volume":"201","author":"Pant","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","article-title":"Akkermansia muciniphila: Paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1892441","DOI":"10.1080\/19490976.2021.1892441","article-title":"Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development","volume":"13","author":"Kim","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1851986","DOI":"10.1080\/19490976.2020.1851986","article-title":"The role of gut vascular barrier in experimental alcoholic liver disease and A. muciniphila supplementation","volume":"12","author":"Grander","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1039\/C9FO02905B","article-title":"Bifidobacterium adolescentis and Lactobacillus rhamnosus alleviate non-alcoholic fatty liver disease induced by a high-fat, high-cholesterol diet through modulation of different gut microbiota-dependent pathways","volume":"11","author":"Wang","year":"2020","journal-title":"Food Funct."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1007\/s00394-022-02927-7","article-title":"Ferulic acid improves intestinal barrier function through altering gut microbiota composition in high-fat diet-induced mice","volume":"61","author":"Tian","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"20011","DOI":"10.1021\/acs.jafc.3c00596","article-title":"Preventive Effects of Apple Polyphenol Extract on High-Fat-Diet-Induced Hepatic Steatosis Are Related to the Regulation of Hepatic Lipid Metabolism, Autophagy, and Gut Microbiota in Aged Mice","volume":"71","author":"Yin","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.nut.2018.10.002","article-title":"Probiotics improve gut microbiota dysbiosis in obese mice fed a high-fat or high-sucrose diet","volume":"60","author":"Kong","year":"2019","journal-title":"Nutrition"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1021\/acs.jafc.1c01813","article-title":"Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice","volume":"69","author":"Duan","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1136\/gutjnl-2017-314307","article-title":"Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD","volume":"67","author":"Jiao","year":"2018","journal-title":"Gut"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tem.2017.11.002","article-title":"Role of Bile Acids in Metabolic Control","volume":"29","author":"Molinaro","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.cell.2020.08.007","article-title":"Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome","volume":"182","author":"Mars","year":"2020","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"eabo2794","DOI":"10.1126\/sciadv.abo2794","article-title":"Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury","volume":"8","author":"Li","year":"2022","journal-title":"Science Advances"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"357ra122","DOI":"10.1126\/scitranslmed.aaf4823","article-title":"Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet\u2013fed mice","volume":"8","author":"Rao","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.crfs.2022.10.021","article-title":"Dietary acetic acid suppress high-fat diet-induced obesity in mice by altering taurine conjugated bile acids metabolism","volume":"5","author":"Wang","year":"2022","journal-title":"Curr. Res. Food Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12986-021-00595-8","article-title":"Metabolomic signatures for liver tissue and cecum contents in high-fat diet-induced obese mice based on UHPLC-Q-TOF\/MS","volume":"18","author":"Cai","year":"2021","journal-title":"Nutr. Metab."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Li, H., Xi, Y., Xin, X., Tian, H., and Hu, Y. (2020). Salidroside improves high-fat diet-induced non-alcoholic steatohepatitis by regulating the gut microbiota\u2013bile acid\u2013farnesoid X receptor axis. Biomed. Pharmacother., 124.","DOI":"10.1016\/j.biopha.2020.109915"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Song, Z., Cai, Y., Lao, X., Wang, X., Lin, X., Cui, Y., Kalavagunta, P.K., Liao, J., Jin, L., and Shang, J. (2019). Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome. Microbiome, 7.","DOI":"10.1186\/s40168-019-0628-3"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1016\/j.fshw.2023.03.035","article-title":"Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism","volume":"12","author":"Lei","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00216-020-02996-9","article-title":"Analysis of serum lysophosphatidylethanolamine levels in patients with non-alcoholic fatty liver disease by liquid chromatography-tandem mass spectrometry","volume":"413","author":"Yamamoto","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.1039\/D3FO01016C","article-title":"Phenolamide extract of apricot bee pollen alleviates glucolipid metabolic disorders and modulates the gut microbiota and metabolites in high-fat diet-induced obese mice","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct."}],"container-title":["Journal of Functional Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4983\/15\/8\/236\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:41:04Z","timestamp":1760110864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4983\/15\/8\/236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":79,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jfb15080236"],"URL":"https:\/\/doi.org\/10.3390\/jfb15080236","relation":{},"ISSN":["2079-4983"],"issn-type":[{"value":"2079-4983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]}}}