{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:32:03Z","timestamp":1775860323844,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Dental implants are widely recognized for their effectiveness in restoring missing teeth, yet their success is often compromised by infections or inadequate osseointegration. Propolis, a natural resinous substance with potent antimicrobial, anti-inflammatory, and osteogenic properties, has emerged as a promising adjunct in dental implantology. This systematic review critically evaluates the current evidence on the incorporation of propolis into dental implants, focusing on its impact on antimicrobial efficacy, bone healing, and overall implant stability. The study protocol was registered in PROSPERO under the registration number CRD42024577122. The PRISMA diagram visually represented the search strategy, screening, and inclusion process. Two reviewers conducted a comprehensive literature search across five databases: PubMed, PubMed Central, Embase, Scopus, and Web of Science. The review synthesized findings from 13 studies; in vitro, in vivo, and clinical studies, highlighting that propolis significantly enhances antibacterial and antifungal activities against pathogens such as Staphylococcus aureus, Candida albicans, and Streptococcus mutans, thereby reducing the risk of peri-implant infections. Additionally, propolis promotes osseointegration by stimulating osteoblast activity and reducing inflammatory cytokine expression, leading to improved bone formation and implant stability. The anti-inflammatory and antioxidant properties of propolis further contribute to a favorable healing environment, enhancing the long-term success of dental implants. The systematic review underscores the potential of propolis as a safe, biocompatible, and effective material for improving dental implant outcomes. However, it also identifies the need for more extensive clinical trials to fully establish standardized protocols for propolis application in implantology. This review provides an overview of propolis\u2019s potential role in dental implants and suggests promising avenues for future research to optimize its benefits in clinical practice.<\/jats:p>","DOI":"10.3390\/jfb15110339","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T06:28:32Z","timestamp":1731392912000},"page":"339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Propolis in Dental Implantology: A Systematic Review of Its Effects and Benefits"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-8216","authenticated-orcid":false,"given":"Magdalena","family":"Syci\u0144ska-Dziarnowska","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Orthopaedics and Orthodontics, Pomeranian Medical University in Szczecin, Al. Powst. Wlkp. 72, 70111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1103-1297","authenticated-orcid":false,"given":"Liliana","family":"Szyszka-Sommerfeld","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Orthopaedics and Orthodontics, Pomeranian Medical University in Szczecin, Al. Powst. Wlkp. 72, 70111 Szczecin, Poland"},{"name":"Laboratory for Propaedeutics of Orthodontics and Facial Congenital Defects, Pomeranian Medical University in Szczecin, Al. Powst. Wlkp. 72, 70111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-7137","authenticated-orcid":false,"given":"Magdalena","family":"Zi\u0105bka","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Ceramics, Department of Ceramics and Refractories, AGH University of Krakow, 30059 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Orthopaedics and Orthodontics, Pomeranian Medical University in Szczecin, Al. Powst. Wlkp. 72, 70111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3769-9786","authenticated-orcid":false,"given":"Gianrico","family":"Spagnuolo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples \u201cFederico II\u201d, 80131 Napoli, Italy"},{"name":"School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.sjbs.2021.11.063","article-title":"Propolis characterization and antimicrobial activities against Staphylococcus aureus and Candida albicans: A review","volume":"29","author":"Bouchelaghem","year":"2022","journal-title":"Saudi J. Biol. 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