{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:43Z","timestamp":1792686463592,"version":"4.5.0"},"reference-count":36,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>This study aimed to identify whether there is an ideal concentration for applying ozonized oil (OZ) in the post-exodontic alveoli of senescent rats treated with zoledronate (ZOL). Thirty-five female rats, aged 18 months, were divided into five groups: ZOL; ZOL+OZ500; ZOL+OZ600; ZOL+OZ700; and SAL. The groups treated with ZOL, and other concentrations of OZ received applications at a dose of 100 \u03bcg\/kg, while the SAL group received saline. After three weeks of ZOL application, the animals underwent extraction of the lower first molar. Subsequently, local therapies were initiated: group ZOL+OZ500 at 500 mEq\/kg; ZOL+Z600 at 600 mEq\/kg; and ZOL+OZ700 at 700 mEq\/kg at baseline, and on days 2 and 4 post-operation. Euthanasia was performed on day 28. The microtomographic parameter of bone volume and histometric data on the area of neoformed bone (NFBT) showed the highest values for the ZOL+OZ600 group (p &lt; 0.05). All OZ groups had smaller areas of non-vital bone than the ZOL group (p &lt; 0.05). The clinical appearance of the operated region showed the alveoli covered with soft tissue, particularly in the OZ groups. All the tested concentrations of OZ were able to prevent and modulate MRONJ. As it presents a greater amount of NFBT, the concentration of 600 mEq\/kg seems to be ideal.<\/jats:p>","DOI":"10.3390\/jfb15120353","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:11:54Z","timestamp":1732169514000},"page":"353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is There an Ideal Concentration of Ozonized Oil for the Prevention and Modulation of Zoledronate-Induced Mandibular Osteonecrosis? A Study on Senescent Rats"],"prefix":"10.3390","volume":"15","author":[{"given":"Mirela Caroline","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry, Sao Paulo State University (UNESP), Ara\u00e7atuba 16015-050, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela Fornazari","family":"Delamura","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry, Sao Paulo State University (UNESP), Ara\u00e7atuba 16015-050, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eloise","family":"de S\u00e1 Simon","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry, Sao Paulo State University (UNESP), Ara\u00e7atuba 16015-050, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefany","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry, Sao Paulo State University (UNESP), Ara\u00e7atuba 16015-050, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Tawei","family":"Ting","sequence":"additional","affiliation":[{"name":"Dental Research Division, Department of Periodontology and Oral Implantology, Federal Fluminense Univesity, Niteroi 21941-617, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Bechara","sequence":"additional","affiliation":[{"name":"Dental Research Division, Department of Periodontology and Oral Implantology, University of Guarulhos (UnG), Guarulhos 07115-230, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-0195","authenticated-orcid":false,"given":"Jamil Awad","family":"Shibli","sequence":"additional","affiliation":[{"name":"Dental Research Division, Department of Periodontology and Oral Implantology, University of Guarulhos (UnG), Guarulhos 07115-230, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-0222","authenticated-orcid":false,"given":"Carlos Fernando","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Translational Sciences, Tufts University School of Dental Medicine, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-4953","authenticated-orcid":false,"given":"Ana Paula Farnezi","family":"Bassi","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry, Sao Paulo State University (UNESP), Ara\u00e7atuba 16015-050, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba School of Dentistry, Sao Paulo State University (UNESP), Ara\u00e7atuba 16015-050, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-3048","authenticated-orcid":false,"given":"Leonardo Perez","family":"Faverani","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Division of Oral and Maxillofacial Surgery, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba 13414-903, Sao Paulo, Brazil"},{"name":"OMFS, School of Dentistry, S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J. 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