{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:40Z","timestamp":1760146840830,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)","award":["#309970\/2022-9","#314479\/2023-6"],"award-info":[{"award-number":["#309970\/2022-9","#314479\/2023-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>This study investigated the effect of platelet-rich fibrin (PRF) on bone healing around implants placed in elevated sinus cavities. Forty New Zealand albino rabbits were divided into eight groups, based on the time of sacrifice (14 or 40 days) and the material used: blood clot (control), hydroxyapatite (HA) from bovine bone, HA combined with PRF, and PRF alone. Each group consisted of five animals (n = 5). A histological analysis measured bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). The results showed significant increases in the BIC and BAFO values at 40 days compared to 14 days in most groups. At day 14, the HA+PRF group had higher BIC than the clot and the PRF alone groups. At 40 days, HA+PRF maintained the highest BIC across all groups (p &lt; 0.05), though it did not show an advantage for BAFO. These findings indicate that combining HA with PRF promotes better osseointegration around implants placed immediately in maxillary sinus augmentation. Given the limited research on PRF\u2019s biological impact, these results underscore the importance of evaluating PRF\u2019s role in peri-implant healing and its potential benefits for clinical use in sinus augmentation.<\/jats:p>","DOI":"10.3390\/jfb15120375","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T06:29:30Z","timestamp":1733984970000},"page":"375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits"],"prefix":"10.3390","volume":"15","author":[{"given":"Gustavo Augusto","family":"Grossi-Oliveira","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-5634","authenticated-orcid":false,"given":"Eduardo","family":"Dallazen","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1875-7402","authenticated-orcid":false,"given":"Thabet","family":"Asbi","sequence":"additional","affiliation":[{"name":"Maccabi-Dent Research Department, Tel-Aviv 6801298, Israel"},{"name":"Department of Periodontology, Rambam Health Care Campus, Haifa 3525408, Israel"},{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Matheus","family":"Fonseca-Santos","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Domingos","family":"Ribeiro-J\u00fanior","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, UNISAGRADO, Bauru 17011-160, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-0195","authenticated-orcid":false,"given":"Jamil A.","family":"Shibli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthya","family":"Massari Grecco","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Magro-Filho","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-0222","authenticated-orcid":false,"given":"Carlos Fernando","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Translational Sciences, School of Dental Medicine, Tufts University, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doron","family":"Haim","sequence":"additional","affiliation":[{"name":"Maccabi-Dent Research Department, Tel-Aviv 6801298, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-7961","authenticated-orcid":false,"given":"Yaniv","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rambam Health Care Campus, Haifa 3525408, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-3048","authenticated-orcid":false,"given":"Leonardo P.","family":"Faverani","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Division of Oral and Maxillofacial Surgery, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba 13414-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/odi.12571","article-title":"A principal components analysis: How pneumatization and edentulism contribute to maxillary atrophy","volume":"23","author":"Wagner","year":"2017","journal-title":"Oral Dis."},{"key":"ref_2","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne","year":"1980","journal-title":"J. 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