{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:41:13Z","timestamp":1790775673237,"version":"4.1.0"},"reference-count":274,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["U22A20316"],"award-info":[{"award-number":["U22A20316"]}]},{"name":"National Natural Science Foundation of China","award":["82001109"],"award-info":[{"award-number":["82001109"]}]},{"name":"National Natural Science Foundation of China","award":["2023A1515010205"],"award-info":[{"award-number":["2023A1515010205"]}]},{"name":"National Natural Science Foundation of China","award":["2024A04J4852"],"award-info":[{"award-number":["2024A04J4852"]}]},{"name":"National Natural Science Foundation of China","award":["2023B03J0037"],"award-info":[{"award-number":["2023B03J0037"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["U22A20316"],"award-info":[{"award-number":["U22A20316"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["82001109"],"award-info":[{"award-number":["82001109"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2023A1515010205"],"award-info":[{"award-number":["2023A1515010205"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2024A04J4852"],"award-info":[{"award-number":["2024A04J4852"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2023B03J0037"],"award-info":[{"award-number":["2023B03J0037"]}]},{"name":"Science and Technology Program of Guangzhou","award":["U22A20316"],"award-info":[{"award-number":["U22A20316"]}]},{"name":"Science and Technology Program of Guangzhou","award":["82001109"],"award-info":[{"award-number":["82001109"]}]},{"name":"Science and Technology Program of Guangzhou","award":["2023A1515010205"],"award-info":[{"award-number":["2023A1515010205"]}]},{"name":"Science and Technology Program of Guangzhou","award":["2024A04J4852"],"award-info":[{"award-number":["2024A04J4852"]}]},{"name":"Science and Technology Program of Guangzhou","award":["2023B03J0037"],"award-info":[{"award-number":["2023B03J0037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Oral diseases such as dental caries, periodontitis, and oral cancer are prevalent and present significant challenges to global public health. Although these diseases are typically treated through procedures like dental preparation and resin filling, scaling and root planning, or surgical excision, these interventions are often not entirely effective, and postoperative drug therapy is usually required. Traditional drug treatments, however, are limited by factors such as poor drug penetration, significant side effects, and the development of drug resistance. As a result, there is a growing need for novel drug delivery systems that can enhance therapeutic efficacy, reduce side effects, and improve treatment outcomes. In recent years, drug-loaded vesicles, such as liposomes, polymersomes, and extracellular vesicles (EVs), have emerged as promising drug delivery platforms due to their high drug encapsulation efficiency, controlled release properties, and excellent biocompatibility. This review provides an in-depth examination of the characteristics, advantages, and limitations of liposomes, polymersomes, and extracellular vesicles in the context of oral disease treatment. It further explores the reasons for their advantages and limitations and discusses the specific applications, development prospects, and strategies for optimizing these vesicle-based systems for improved clinical outcomes.<\/jats:p>","DOI":"10.3390\/jfb16010025","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:13:07Z","timestamp":1736835187000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7165-593X","authenticated-orcid":false,"given":"Pengjie","family":"Huang","sequence":"first","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichang","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiezhong","family":"Guan","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0339-0028","authenticated-orcid":false,"given":"Yibing","family":"Jia","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurun","family":"Chen","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyue","family":"Ou","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0694-0883","authenticated-orcid":false,"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kopra, E., Lahdentausta, L., Pieti\u00e4inen, M., Buhlin, K., M\u00e4ntyl\u00e4, P., H\u00f6rkk\u00f6, S., Persson, R., Paju, S., Sinisalo, J., and Salminen, A. (2021). Systemic Antibiotics Influence Periodontal Parameters and Oral Microbiota, But Not Serological Markers. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.774665"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/(SICI)1097-0142(19990915)86:6<921::AID-CNCR5>3.0.CO;2-6","article-title":"Topical application of vitamin A to oral leukoplakia: A clinical case series","volume":"86","author":"Epstein","year":"1999","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e2337","DOI":"10.1002\/rmv.2337","article-title":"Transmission and clearance of human papillomavirus infection in the oral cavity and its role in oropharyngeal carcinoma\u2014A review","volume":"33","author":"Wierzbicka","year":"2023","journal-title":"Rev. Med. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1039\/D2BM01036D","article-title":"Hydrogels for the treatment of oral and maxillofacial diseases: Current research, challenges, and future directions","volume":"10","author":"Huang","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6538","DOI":"10.1021\/acs.chemrev.7b00097","article-title":"Mimicking Complex Biological Membranes and Their Programmable Glycan Ligands with Dendrimersomes and Glycodendrimersomes","volume":"117","author":"Sherman","year":"2017","journal-title":"Chem. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"976","DOI":"10.7150\/thno.5116","article-title":"Plasmonic nanobubbles rapidly detect and destroy drug-resistant tumors","volume":"2","author":"Ren","year":"2012","journal-title":"Theranostics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e13026","DOI":"10.1111\/cpr.13026","article-title":"Periodontitis-compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA-378a promote local angiogenesis by targeting Sufu to activate the Hedgehog\/Gli1 signalling","volume":"54","author":"Zhou","year":"2021","journal-title":"Cell Prolif."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e2213154120","DOI":"10.1073\/pnas.2213154120","article-title":"Computational design of CRISPR guide RNAs to enable strain-specific control of microbial consortia","volume":"120","author":"Rottinghaus","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12155","DOI":"10.1002\/jev2.12155","article-title":"Cell trafficking and regulation of osteoblastogenesis by extracellular vesicle associated bone morphogenetic protein 2","volume":"10","author":"Yerneni","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.addr.2018.03.008","article-title":"Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems","volume":"128","author":"Maeki","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0022-2836(65)80094-8","article-title":"The action of steroids and streptolysin S on the permeability of phospholipid structures to cations","volume":"13","author":"Bangham","year":"1965","journal-title":"J. Mol. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tifs.2021.01.005","article-title":"The structure-mechanism relationship and mode of actions of antimicrobial peptides: A review","volume":"109","author":"Li","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2003679","DOI":"10.1002\/advs.202003679","article-title":"Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1093\/annonc\/mdq234","article-title":"Liposomal cisplatin combined with paclitaxel versus cisplatin and paclitaxel in non-small-cell lung cancer: A randomized phase III multicenter trial","volume":"21","author":"Stathopoulos","year":"2010","journal-title":"Ann. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1002\/adfm.201102664","article-title":"Ellipsoidal Polyaspartamide Polymersomes with Enhanced Cell-Targeting Ability","volume":"22","author":"Lai","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.bioeng.8.061505.095838","article-title":"Polymersomes","volume":"8","author":"Discher","year":"2006","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13798","DOI":"10.1021\/la301958v","article-title":"Biomimetic liposome- and polymersome-based multicompartmentalized assemblies","volume":"28","author":"Chandrawati","year":"2012","journal-title":"Langmuir"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1021\/ma400667n","article-title":"Structural Characteristics and Fusion Pathways of Onion-Like Multilayered Polymersome Formed by Amphiphilic Comb-Like Graft Copolymers","volume":"46","author":"Chang","year":"2013","journal-title":"Macromolecules"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/acsnano.6b07607","article-title":"Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics","volume":"11","author":"Armstrong","year":"2017","journal-title":"ACS Nano"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41569-020-0389-5","article-title":"Native and bioengineered extracellular vesicles for cardiovascular therapeutics","volume":"17","author":"Fernandes","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41565-021-00931-2","article-title":"Extracellular vesicles as a next-generation drug delivery platform","volume":"16","author":"Herrmann","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41557-021-00667-5","article-title":"Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation","volume":"13","author":"Yang","year":"2021","journal-title":"Nat. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8572","DOI":"10.1039\/C8CS00162F","article-title":"Liposomes and polymersomes: A comparative review towards cell mimicking","volume":"47","author":"Rideau","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.addr.2016.02.006","article-title":"Extracellular vesicles for drug delivery","volume":"106","author":"Vader","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biomaterials.2015.03.039","article-title":"Synthesis of a novel, sequentially active-targeted drug delivery nanoplatform for breast cancer therapy","volume":"59","author":"Satsangi","year":"2015","journal-title":"Biomaterials"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e1901489","DOI":"10.1002\/adhm.201901489","article-title":"Light-Triggered Cancer Cell Specific Targeting and Liposomal Drug Delivery in a Zebrafish Xenograft Model","volume":"9","author":"Kong","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"23737","DOI":"10.1021\/acsami.0c05308","article-title":"Magnetic Targeting and Ultrasound Activation of Liposome-Microbubble Conjugate for Enhanced Delivery of Anticancer Therapies","volume":"12","author":"Dwivedi","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.7150\/thno.75899","article-title":"Multiplexed strategies toward clinical translation of extracellular vesicles","volume":"12","author":"Song","year":"2022","journal-title":"Theranostics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1039\/C2CS35312A","article-title":"Multicompartmentalized polymeric systems: Towards biomimetic cellular structure and function","volume":"42","author":"Marguet","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Pinto-G\u00f3mez, C., P\u00e9rez-Murano, F., Bausells, J., Villanueva, L.G., and Fern\u00e1ndez-Reg\u00falez, M. (2020). Directed Self-Assembly of Block Copolymers for the Fabrication of Functional Devices. Polymers, 12.","DOI":"10.3390\/polym12102432"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wang, L., Gong, C., Yuan, X., and Wei, G. (2019). Controlling the Self-Assembly of Biomolecules into Functional Nanomaterials through Internal Interactions and External Stimulations: A Review. Nanomaterials, 9.","DOI":"10.3390\/nano9020285"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: A global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.dental.2015.09.023","article-title":"Effect of temperature and humidity on post-gel shrinkage, cusp deformation, bond strength and shrinkage stress\u2014Construction of a chamber to simulate the oral environment","volume":"31","author":"Bicalho","year":"2015","journal-title":"Dent. Mater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2105667","DOI":"10.1002\/adma.202105667","article-title":"Promoting Oral Mucosal Wound Healing with a Hydrogel Adhesive Based on a Phototriggered S-Nitrosylation Coupling Reaction","volume":"33","author":"Zhang","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/acs.accounts.6b00536","article-title":"Designing Hydrogels for On-Demand Therapy","volume":"50","author":"Oliva","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41368-020-0082-x","article-title":"Oral microbiome: Possible harbinger for children\u2019s health","volume":"12","author":"Xiao","year":"2020","journal-title":"Int. J. Oral Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41368-022-00163-7","article-title":"Oral microbiota in human systematic diseases","volume":"14","author":"Peng","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jaad.2009.06.022","article-title":"Lip and oral mucosal lesions in 100 renal transplant recipients","volume":"62","author":"Haberal","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Rossi, F., Amadoro, C., Gasperi, M., and Colavita, G. (2022). Lactobacilli Infection Case Reports in the Last Three Years and Safety Implications. Nutrients, 14.","DOI":"10.20944\/preprints202202.0248.v1"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Mets\u00e4niitty, M., Hasnat, S., Salo, T., and Salem, A. (2021). Oral Microbiota-A New Frontier in the Pathogenesis and Management of Head and Neck Cancers. Cancers, 14.","DOI":"10.3390\/cancers14010046"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1177\/0022034519845001","article-title":"The Role of Exopolysaccharides in Oral Biofilms","volume":"98","author":"Cugini","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/prd.12296","article-title":"The role of the microbiota in periodontal disease","volume":"83","author":"Curtis","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer\u2019s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/prd.12304","article-title":"Mechanisms underlying the association between periodontitis and atherosclerotic disease","volume":"83","author":"Schenkein","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1902\/jop.1992.63.7.576","article-title":"E-test: A new technique for antimicrobial susceptibility testing for periodontal microorganisms","volume":"63","author":"Nachnani","year":"1992","journal-title":"J. Periodontol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: Facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol. 2000"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1093\/jac\/dks212","article-title":"Liposomal encapsulation of vancomycin improves killing of methicillin-resistant Staphylococcus aureus in a murine infection model","volume":"67","author":"Sande","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Harrell, C.R., Jovicic, N., Djonov, V., Arsenijevic, N., and Volarevic, V. (2019). Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases. Cells, 8.","DOI":"10.3390\/cells8121605"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1021\/acs.chemmater.1c01872","article-title":"Polymersome Wound Dressing Spray Capable of Bacterial Inhibition and H2S Generation for Complete Diabetic Wound Healing","volume":"33","author":"Liu","year":"2021","journal-title":"Chem. Mater."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jaad.2007.08.048","article-title":"Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings","volume":"58","author":"Fonder","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_52","unstructured":"(2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1789\u20131858."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41368-021-00152-2","article-title":"Dental stem cell-derived extracellular vesicles as promising therapeutic agents in the treatment of diseases","volume":"14","author":"Li","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1002\/anie.201907484","article-title":"Polymer Nanocontainers for Intracellular Delivery","volume":"59","author":"Ravoo","year":"2020","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1039\/C4CS00274A","article-title":"Hyperbranched polymer vesicles: From self-assembly, characterization, mechanisms, and properties to applications","volume":"44","author":"Jiang","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1039\/C5CS00569H","article-title":"Bioinspired polymer vesicles and membranes for biological and medical applications","volume":"45","author":"Palivan","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"17982","DOI":"10.1021\/ja056514l","article-title":"pH-Sensitive Vesicles Based on a Biocompatible Zwitterionic Diblock Copolymer","volume":"127","author":"Du","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1002\/anie.200900255","article-title":"A new two-photon-sensitive block copolymer nanocarrier","volume":"48","author":"Babin","year":"2009","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1021\/bm070085x","article-title":"PEG-SS-PPS: Reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery","volume":"8","author":"Cerritelli","year":"2007","journal-title":"Biomacromolecules"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2305071","DOI":"10.1002\/adfm.202305071","article-title":"Recent Advances in Microfluidic Technologies for the Construction of Artificial Cells","volume":"33","author":"Tan","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.progpolymsci.2015.05.001","article-title":"Polymer vesicles: Mechanism, preparation, application, and responsive behavior","volume":"64","author":"Zhu","year":"2017","journal-title":"Prog. Polym. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Yang, B., Qiu, Y., Zhou, N., Ouyang, H., Ding, J., Cheng, B., and Sun, J. (2017). Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00197"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: Dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.chom.2023.02.009","article-title":"Oral polymicrobial communities: Assembly, function, and impact on diseases","volume":"31","author":"Hajishengallis","year":"2023","journal-title":"Cell Host Microbe"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/0022034520908533","article-title":"Global, Regional, and National Levels and Trends in Burden of Oral Conditions from 1990 to 2017: A Systematic Analysis for the Global Burden of Disease 2017 Study","volume":"99","author":"Bernabe","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e2023061350","DOI":"10.1542\/peds.2023-061350","article-title":"Antibiotic Exposure and Dental Health: A Systematic Review","volume":"152","author":"Ravindra","year":"2023","journal-title":"Pediatrics"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.archoralbio.2011.02.004","article-title":"Antimicrobial and DNA-binding activities of the peptide fragments of human lactoferrin and histatin 5 against Streptococcus mutans","volume":"56","author":"Huo","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.peptides.2010.07.016","article-title":"Nisin inhibits dental caries-associated microorganism in vitro","volume":"31","author":"Tong","year":"2010","journal-title":"Peptides"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2958.2008.06279.x","article-title":"The generation of nisin variants with enhanced activity against specific gram-positive pathogens","volume":"69","author":"Field","year":"2008","journal-title":"Mol. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/13880209.2012.717227","article-title":"Sustainable inhibition efficacy of liposome-encapsulated nisin on insoluble glucan-biofilm synthesis by Streptococcus mutans","volume":"51","author":"Yamakami","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0003-9969(99)00092-8","article-title":"Effects of topical application of free and liposome-encapsulated lactoferrin and lactoperoxidase on oral microbiota and dental caries in rats","volume":"44","author":"Planas","year":"1999","journal-title":"Arch. Oral Biol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Khane, Y., Benouis, K., Albukhaty, S., Sulaiman, G.M., Abomughaid, M.M., Al Ali, A., Aouf, D., Fenniche, F., Khane, S., and Chaibi, W. (2022). Green Synthesis of Silver Nanoparticles Using Aqueous Citrus limon Zest Extract: Characterization and Evaluation of Their Antioxidant and Antimicrobial Properties. Nanomaterials, 12.","DOI":"10.3390\/nano12122013"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/jam.12432","article-title":"In vitro activity of natural phenolic compounds against fluconazole-resistant Candida species: A quantitative structure-activity relationship analysis","volume":"116","author":"Gallucci","year":"2014","journal-title":"J. Appl. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Panda, S., Rout, L., Mohanty, N., Satpathy, A., Sankar Satapathy, B., Rath, S., and Gopinath, D. (2024). Exploring the photosensitizing potential of Nanoliposome Loaded Improved Toluidine Blue O (NLITBO) Against Streptococcus mutans: An in-vitro feasibility study. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0312521"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10103-011-0962-6","article-title":"Photodynamic therapy disinfection of carious tissue mediated by aluminum-chloride-phthalocyanine entrapped in cationic liposomes: An in vitro and clinical study","volume":"27","author":"Longo","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-5173(03)00136-4","article-title":"The antibacterial properties of solid supported liposomes on Streptococcus oralis biofilms","volume":"257","author":"Catuogno","year":"2003","journal-title":"Int. J. Pharm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/1874210616021001360","article-title":"Cationic Lipid Content in Liposome-Encapsulated Nisin Improves Sustainable Bactericidal Activity against Streptococcus mutans","volume":"10","author":"Yamakami","year":"2016","journal-title":"Open Dent. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.archoralbio.2015.02.004","article-title":"Development of novel formulations containing Lysozyme and Lactoferrin and evaluation of antibacterial effects on Mutans Streptococci and Lactobacilli","volume":"60","author":"Sandalli","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1039\/C7TB02682J","article-title":"pH-Activated nanoparticles with targeting for the treatment of oral plaque biofilm","volume":"6","author":"Zhou","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Hu, Z., Tang, Y., Jiang, B., Xu, Y., Liu, S., and Huang, C. (2023). Functional liposome loaded curcumin for the treatment of Streptococcus mutans biofilm. Front. Chem., 11.","DOI":"10.3389\/fchem.2023.1160521"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"21463","DOI":"10.1021\/acsami.0c03814","article-title":"Nanocapsule pH Regulator: Sustained Continuous Alkali Release from Thermosensitive Liposomes Reduces Acid Erosion","volume":"12","author":"Chong","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00784-023-05465-6","article-title":"Encapsulation of a novel peptide derived from histatin-1 in liposomes against initial enamel caries in vitro and in vivo","volume":"28","author":"Zhang","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1399-302X.1996.tb00354.x","article-title":"Properties of practical oral liposome-Streptococcus mutans glucosyltransferase vaccines for effective induction of caries protection","volume":"11","author":"Childers","year":"1996","journal-title":"Oral Microbiol. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Chen, L., Zhu, J., Li, Y., Lu, J., Gao, L., Xu, H., Fan, M., and Yang, X. (2013). Enhanced nasal mucosal delivery and immunogenicity of anti-caries DNA vaccine through incorporation of anionic liposomes in chitosan\/DNA complexes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071953"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jconrel.2020.06.006","article-title":"Controlled release of odontogenic exosomes from a biodegradable vehicle mediates dentinogenesis as a novel biomimetic pulp capping therapy","volume":"324","author":"Swanson","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1177\/00220345221150383","article-title":"Development of Rat Caries-Induced Pulpitis Model for Vital Pulp Therapy","volume":"102","author":"Huang","year":"2023","journal-title":"J. Dent. Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Brodzikowska, A., Ciechanowska, M., Kopka, M., Stachura, A., and W\u0142odarski, P.K. (2022). Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis-A Systematic Review. Biomolecules, 12.","DOI":"10.3390\/biom12010138"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jdent.2019.05.022","article-title":"Vital pulp therapy: Histopathology and histobacteriology-based guidelines to treat teeth with deep caries and pulp exposure","volume":"86","author":"Ricucci","year":"2019","journal-title":"J. Dent."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/154411130301400103","article-title":"The mechanical properties of human dentin: A critical review and re-evaluation of the dental literature","volume":"14","author":"Kinney","year":"2003","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_90","first-page":"110","article-title":"A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis","volume":"21","author":"Wang","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/jbmr.2444","article-title":"Wnt Acts as a Prosurvival Signal to Enhance Dentin Regeneration","volume":"30","author":"Hunter","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1177\/0022034518763151","article-title":"Wnt-Responsive Odontoblasts Secrete New Dentin after Superficial Tooth Injury","volume":"97","author":"Zhao","year":"2018","journal-title":"J. Dent. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"108","DOI":"10.22203\/eCM.v041a08","article-title":"Liposomes embedded with differentiating factors as a new strategy for enhancing DPSC osteogenic commitment","volume":"41","author":"Gallorini","year":"2021","journal-title":"Eur. Cell Mater."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.bbamem.2018.02.002","article-title":"When a transmembrane channel isn\u2019t, or how biophysics and biochemistry (mis)communicate","volume":"1860","author":"Reviakine","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4012\/dmj.2016-127","article-title":"Effects of phosphatidylserine-containing liposomes on odontogenic differentiation of human dental pulp cells","volume":"36","author":"Park","year":"2017","journal-title":"Dent. Mater. J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1089\/ten.tea.2017.0419","article-title":"Liposomal Delivery of Demineralized Dentin Matrix for Dental Tissue Regeneration","volume":"24","author":"Melling","year":"2018","journal-title":"Tissue Eng. Part. A"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1080\/10717544.2018.1526227","article-title":"Antitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice","volume":"25","author":"Chang","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Sinjari, B., Pizzicannella, J., D\u2019Aurora, M., Zappacosta, R., Gatta, V., Fontana, A., Trubiani, O., and Diomede, F. (2019). Curcumin\/Liposome Nanotechnology as Delivery Platform for Anti-inflammatory Activities via NFkB\/ERK\/pERK Pathway in Human Dental Pulp Treated With 2-HydroxyEthyl MethAcrylate (HEMA). Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00633"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/jbm.a.30622","article-title":"Enterococcus faecalis-mediated biomineralized biofilm formation on root canal dentine in vitro","volume":"77","author":"Kishen","year":"2006","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00784-014-1271-9","article-title":"Photodynamic killing of Enterococcus faecalis in dentinal tubules using mTHPC incorporated in liposomes and invasomes","volume":"19","author":"Ossmann","year":"2015","journal-title":"Clin. Oral Investig."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Ferrer, M., Villanueva-Badenas, E., S\u00e1nchez-S\u00e1nchez, R., S\u00e1nchez-L\u00f3pez, C.M., Baquero, M.C., Sep\u00falveda, P., and Dorronsoro, A. (2021). HIF-1\u03b1 and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073416"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"20417314221084095","DOI":"10.1177\/20417314221084095","article-title":"Extracellular vesicles delivering nuclear factor I\/C for hard tissue engineering: Treatment of apical periodontitis and dentin regeneration","volume":"13","author":"Yang","year":"2022","journal-title":"J. Tissue Eng."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1007\/s13346-023-01353-4","article-title":"Atorvastatin liposomes in a 3D-printed polymer film: A repurposing approach for local treatment of oral candidiasis","volume":"13","author":"Nour","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/prd.12378","article-title":"Fungal diseases: Oral dysbiosis in susceptible hosts","volume":"87","author":"Villar","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13054-019-2497-3","article-title":"Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: Results of the EUCANDICU project","volume":"23","author":"Bassetti","year":"2019","journal-title":"Crit. Care"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/s41385-021-00413-7","article-title":"Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis","volume":"14","author":"Lin","year":"2021","journal-title":"Mucosal Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Vadovics, M., Ho, J., Igaz, N., Alf\u00f6ldi, R., Rakk, D., Veres, \u00c9., Sz\u00fccs, B., Horv\u00e1th, M., T\u00f3th, R., and Sz\u00fccs, A. (2021). Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma In Vitro and In Vivo. mBio, 13.","DOI":"10.1101\/2021.03.31.437836"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"8249","DOI":"10.1080\/10408398.2021.1926905","article-title":"Application of probiotics in candidiasis management","volume":"62","author":"Andrade","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/CMR.12.1.40","article-title":"Current and emerging azole antifungal agents","volume":"12","author":"Sheehan","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJM200201243460403","article-title":"Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever","volume":"346","author":"Walsh","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijpharm.2009.01.003","article-title":"Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans","volume":"372","author":"Wasan","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1469-0691.12039","article-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012: Non-neutropenic adult patients","volume":"18","author":"Cornely","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ejps.2010.05.005","article-title":"Development of amphotericin B loaded polymersomes based on (PEG)(3)-PLA co-polymers: Factors affecting size and in vitro evaluation","volume":"40","author":"Jain","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1021\/mp100267k","article-title":"Amphotericin-B-loaded polymersomes formulation (PAMBO) based on (PEG)3-PLA copolymers: An in vivo evaluation in a murine model","volume":"8","author":"Jain","year":"2011","journal-title":"Mol. Pharm."},{"key":"ref_115","first-page":"368","article-title":"Antifungal effect of Atorvastatin against Candida species in comparison to Fluconazole and Nystatin","volume":"92","author":"Esfahani","year":"2019","journal-title":"Med. Pharm. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3201\/eid1001.030119","article-title":"Fungal biofilms and drug resistance","volume":"10","author":"Falkler","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"118959","DOI":"10.1016\/j.carbpol.2021.118959","article-title":"Chitosan-gum arabic embedded alizarin nanocarriers inhibit biofilm formation of multispecies microorganisms","volume":"284","author":"Raj","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"119096","DOI":"10.1016\/j.ijpharm.2020.119096","article-title":"A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms","volume":"578","author":"Bandara","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1080\/22221751.2022.2098058","article-title":"Induction of amphotericin B resistance in susceptible Candida auris by extracellular vesicles","volume":"11","author":"Chan","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Honorato, L., de Araujo, J.F.D., Ellis, C.C., Piffer, A.C., Pereira, Y., Frases, S., de Sousa Ara\u00fajo, G.R., Pontes, B., Mendes, M.T., and Pereira, M.D. (2022). Extracellular Vesicles Regulate Biofilm Formation and Yeast-to-Hypha Differentiation in Candida albicans. mBio, 13.","DOI":"10.1128\/mbio.00301-22"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1038\/s41467-021-26525-z","article-title":"Coordination of fungal biofilm development by extracellular vesicle cargo","volume":"12","author":"Zarnowski","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12616","article-title":"Periodontal disease: A systemic condition","volume":"96","author":"Villoria","year":"2024","journal-title":"Periodontol. 2000"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.mucimm.2024.07.004","article-title":"Bite-sized immunology; damage and microbes educating immunity at the gingiva","volume":"17","author":"Konkel","year":"2024","journal-title":"Mucosal Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: A polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1902\/jop.2008.080233","article-title":"Inflammation and bone loss in periodontal disease","volume":"79","author":"Cochran","year":"2008","journal-title":"J. Periodontol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cell.2020.05.048","article-title":"The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis","volume":"182","author":"Kitamoto","year":"2020","journal-title":"Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","article-title":"The case for periodontitis in the pathogenesis of rheumatoid arthritis","volume":"13","author":"Potempa","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2021.08.213","article-title":"GSK3\u03b2 is involved in promoting Alzheimer\u2019s disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor protein(NL-F\/NL-F) knock-in mice","volume":"98","author":"Jiang","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e377","DOI":"10.1016\/j.clinthera.2021.10.016","article-title":"Applications of Novel and Nanostructured Drug Delivery Systems for the Treatment of Oral Cavity Diseases","volume":"43","author":"Mehryab","year":"2021","journal-title":"Clin. Ther."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Zi\u0119ba, M., Chaber, P., Duale, K., Martinka Maksymiak, M.A.-O., Basczok, M., Kowalczuk, M.A.-O., and Adamus, G.A.-O. (2020). Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease. Polymers, 12.","DOI":"10.3390\/polym12071574"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1093\/clinids\/18.Supplement_3.S237","article-title":"Treatment of disseminated disease due to the Mycobacterium avium complex in patients with AIDS","volume":"18","author":"Benson","year":"1994","journal-title":"Clin. Infect. Dis."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.2217\/nnm-2017-0166","article-title":"Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis","volume":"12","author":"Poh","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8201","DOI":"10.1039\/C4TB01110D","article-title":"Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection","volume":"2","author":"Thamphiwatana","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1600-051X.1986.tb01491.x","article-title":"Attachment level changes in destructive periodontal diseases","volume":"13","author":"Haffajee","year":"1986","journal-title":"J. Clin. Periodontol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.ijbiomac.2018.09.057","article-title":"A novel pH-responsive quaternary ammonium chitosan-liposome nanoparticles for periodontal treatment","volume":"129","author":"Hu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"13645","DOI":"10.1021\/acsnano.9b03237","article-title":"Dual Corona Vesicles with Intrinsic Antibacterial and Enhanced Antibiotic Delivery Capabilities for Effective Treatment of Biofilm-Induced Periodontitis","volume":"13","author":"Xi","year":"2019","journal-title":"ACS Nano"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1021\/acs.macromol.5b01426","article-title":"The Copolymer Blending Method: A New Approach for Targeted Assembly of Micellar Nanoparticles","volume":"48","author":"Wright","year":"2015","journal-title":"Macromolecules"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1096\/fj.12-225219","article-title":"Polymersome-mediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells","volume":"27","author":"Wayakanon","year":"2013","journal-title":"FASEB J."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Saeidi, Z., Giti, R., Emami, A., Rostami, M., and Mohammadi, F. (2024). Thermosensitive and mucoadhesive gels containing solid lipid nanoparticles loaded with fluconazole and niosomes loaded with clindamycin for the treatment of periodontal diseases: A laboratory experiment. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04322-6"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.addr.2015.10.002","article-title":"A novel platform for cancer therapy using extracellular vesicles","volume":"95","author":"Tominaga","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Zhao, M., Zhang, M., Xu, K., Wu, K., Xie, R., Li, R., Wang, Q., Liu, W., Wang, W., and Wang, X. (2022). Antimicrobial Effect of Extracellular Vesicles Derived From Human Oral Mucosal Epithelial Cells on Candida albicans. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.777613"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.actbio.2021.12.005","article-title":"Bacterial outer membrane vesicles as potential biological nanomaterials for antibacterial therapy","volume":"140","author":"Huang","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.12.045","article-title":"Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy","volume":"86","author":"Liao","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2128604","DOI":"10.1080\/19490976.2022.2128604","article-title":"Extracellular vesicle miRNAs promote the intestinal microenvironment by interacting with microbes in colitis","volume":"14","author":"Shen","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/prd.12227","article-title":"Periodontal complications with age","volume":"78","author":"Persson","year":"2018","journal-title":"Periodontol. 2000"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1177\/00220345860650090601","article-title":"Antimicrobial properties of hydrogen peroxide and sodium bicarbonate individually and in combination against selected oral, gram-negative, facultative bacteria","volume":"65","author":"Miyasaki","year":"1986","journal-title":"J. Dent. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/bph.12139","article-title":"Minocycline: Far beyond an antibiotic","volume":"169","author":"Zarzuelo","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e21693","DOI":"10.1096\/fj.202100032R","article-title":"The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth","volume":"35","author":"Hatano","year":"2021","journal-title":"FASEB J."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Naruishi, K. (2022). Biological Roles of Fibroblasts in Periodontal Diseases. Cells, 11.","DOI":"10.3390\/cells11213345"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/prd.12325","article-title":"Primer on etiology and treatment of progressive\/severe periodontitis: A systemic health perspective","volume":"83","author":"Slots","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_151","first-page":"249","article-title":"An injectable in situ hexagonal mesophase system for local delivery of minocycline hydrochloride: Preparation and pharmacodynamics in rats","volume":"72","author":"Jiang","year":"2017","journal-title":"Pharmazie"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Sun, X., Gao, J., Meng, X., Lu, X., Zhang, L., and Chen, R. (2021). Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.763334"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1034\/j.1600-051x.2000.027012918.x","article-title":"Local delivery of liposome-encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles","volume":"27","author":"Petelin","year":"2000","journal-title":"J. Clin. Periodontol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","article-title":"Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages","volume":"148","author":"Fadok","year":"1992","journal-title":"J. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Shi, J., Zhang, Y., Zhang, X., Chen, R., Wei, J., Hou, J., Wang, B., Lai, H., and Huang, Y. (2021). Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-01175-x"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"153576","DOI":"10.1016\/j.prp.2021.153576","article-title":"Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2\/Keap1\/SLC7A11 pathway in a microglia cell line","volume":"225","author":"Li","year":"2021","journal-title":"Pathol. Res. Pract."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/prd.12368","article-title":"Maintaining homeostatic control of periodontal bone tissue","volume":"86","author":"Novince","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1080\/14756366.2017.1350658","article-title":"New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-\u03baB transcription factors","volume":"32","author":"Gabriele","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.2147\/IJN.S34036","article-title":"Minocycline hydrochloride nanoliposomes inhibit the production of TNF-\u03b1 in LPS-stimulated macrophages","volume":"7","author":"Liu","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1902\/jop.2012.120508","article-title":"Orally administered liposomal lactoferrin inhibits inflammation-related bone breakdown without interrupting orthodontic tooth movement","volume":"84","author":"Kawazoe","year":"2013","journal-title":"J. Periodontol."},{"key":"ref_162","first-page":"169","article-title":"Sustained Release of Liposomal Curcumin: Enhanced Periodontal Outcomes in Diabetic Patients","volume":"27","author":"Alaaeldin","year":"2024","journal-title":"Chin. J. Dent. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"eaba2987","DOI":"10.1126\/sciadv.aba2987","article-title":"Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation","volume":"6","author":"Dou","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/prd.12506","article-title":"Anatomical characteristics of the alveolar process and basal bone that have an effect on socket healing","volume":"93","author":"Dias","year":"2023","journal-title":"Periodontol. 2000"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/term.2134","article-title":"Advances and perspectives in tooth tissue engineering","volume":"11","author":"Monteiro","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/jre.12576","article-title":"Urokinase-plasminogen activator protects periodontal ligament fibroblast from oxidative induced-apoptosis and DNA damage","volume":"53","author":"Rokn","year":"2018","journal-title":"J. Periodontal Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"7892","DOI":"10.1016\/j.biomaterials.2010.07.019","article-title":"A review on endogenous regenerative technology in periodontal regenerative medicine","volume":"31","author":"Chen","year":"2010","journal-title":"Biomaterials"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Ye, S., Wei, B., and Zeng, L. (2022). Advances on Hydrogels for Oral Science Research. Gels, 8.","DOI":"10.3390\/gels8050302"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1002\/1529-0131(200109)44:9<2201::AID-ART374>3.0.CO;2-E","article-title":"The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: Evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis","volume":"44","author":"Frith","year":"2001","journal-title":"Arthritis Rheum."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0022034518821685","article-title":"Clodronate-Loaded Liposome Treatment Has Site-Specific Skeletal Effects","volume":"98","author":"Michalski","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/jre.12119","article-title":"Gene delivery to periodontal tissue using Bubble liposomes and ultrasound","volume":"49","author":"Sugano","year":"2014","journal-title":"J. Periodontal Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"10884","DOI":"10.1073\/pnas.1519676113","article-title":"Distinct biological events generated by ECM proteolysis by two homologous collagenases","volume":"113","author":"Solomonov","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1021\/acsnano.7b07983","article-title":"Proteolytic Nanoparticles Replace a Surgical Blade by Controllably Remodeling the Oral Connective Tissue","volume":"12","author":"Zinger","year":"2018","journal-title":"ACS Nano"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.archoralbio.2012.11.013","article-title":"TGF-\u03b21 and BMP-4 carried by liposomes enhance the healing process in alveolar bone","volume":"58","author":"Ferreira","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Wijetunge, S.S., Wen, J., Yeh, C.K., and Sun, Y. (2020). Wheat germ agglutinin liposomes with surface grafted cyclodextrins as bioadhesive dual-drug delivery nanocarriers to treat oral cells. Colloids Surf. B Biointerfaces, 185.","DOI":"10.1016\/j.colsurfb.2019.110572"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1021\/acs.biomac.7b01209","article-title":"Highly Effective Antibacterial Vesicles Based on Peptide-Mimetic Alternating Copolymers for Bone Repair","volume":"18","author":"Zhou","year":"2017","journal-title":"Biomacromolecules"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e2400966","DOI":"10.1002\/adhm.202400966","article-title":"Injectable Liposome-Loaded Hydrogel Formulations with Controlled Release of Curcumin and \u03b1-Tocopherol for Dental Tissue Engineering","volume":"13","author":"Atila","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41368-023-00249-w","article-title":"Oral squamous cell carcinomas: State of the field and emerging directions","volume":"15","author":"Tan","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e28148","DOI":"10.1016\/j.heliyon.2024.e28148","article-title":"Role of exosomes in the communication and treatment between OSCC and normal cells","volume":"10","author":"Ma","year":"2024","journal-title":"Heliyon"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrc3185","article-title":"Balancing repair and tolerance of DNA damage caused by alkylating agents","volume":"12","author":"Fu","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1016\/S1470-2045(19)30145-7","article-title":"Dose recommendations for anticancer drugs in patients with renal or hepatic impairment","volume":"20","author":"Krens","year":"2019","journal-title":"Lancet Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"106573","DOI":"10.1016\/j.oraloncology.2023.106573","article-title":"New insights into redox-related risk factors and therapeutic targets in oral squamous cell carcinoma","volume":"147","author":"Dewenter","year":"2023","journal-title":"Oral Oncol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/mp5000373","article-title":"Codelivery of Doxorubicin and Paclitaxel by Cross-Linked Multilamellar Liposome Enables Synergistic Antitumor Activity","volume":"11","author":"Liu","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Kirthiga Devi, S.S., Singh, S., Joga, R., Patil, S.Y., Meghana Devi, V., Chetan Dushantrao, S., Dwivedi, F., Kumar, G., Kumar Jindal, D., and Singh, C. (2024). Enhancing cancer immunotherapy: Exploring strategies to target the PD-1\/PD-L1 axis and analyzing the associated patent, regulatory, and clinical trial landscape. Eur. J. Pharm. Biopharm., 200.","DOI":"10.1016\/j.ejpb.2024.114323"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Haseeb, M., Khan, I., Kartal, Z., Mahfooz, S., and Hatiboglu, M.A. (2024). Status Quo in the Liposome-Based Therapeutic Strategies Against Glioblastoma: \u201cTargeting the Tumor and Tumor Microenvironment\u201d. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011271"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1039\/C2CS35259A","article-title":"Targeting and delivery of platinum-based anticancer drugs","volume":"42","author":"Wang","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"113974","DOI":"10.1016\/j.addr.2021.113974","article-title":"Biomembrane-based nanostructures for cancer targeting and therapy: From synthetic liposomes to natural biomembranes and membrane-vesicles","volume":"178","author":"Wang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41577-023-00982-7","article-title":"New immune cell engagers for cancer immunotherapy","volume":"24","author":"Fenis","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Shen, M., Wu, R.X., Zhao, L., Li, J., Guo, H.T., Fan, R., Cui, Y., Wang, Y.M., Yue, S.Q., and Pei, J.M. (2012). Resveratrol attenuates ischemia\/reperfusion injury in neonatal cardiomyocytes and its underlying mechanism. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051223"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1507\/endocrj.EJ11-0194","article-title":"Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic \u03b2-cell and the cleavage of poly (ADP-ribose) polymerase","volume":"59","author":"Ku","year":"2012","journal-title":"Endocr. J."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"ref_192","first-page":"1635","article-title":"Enhanced antiproliferative effect of resveratrol in head and neck squamous cell carcinoma using GE11 peptide conjugated liposome","volume":"43","author":"Zheng","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"6695","DOI":"10.7150\/thno.45164","article-title":"PEG-coated nanoparticles detachable in acidic microenvironments for the tumor-directed delivery of chemo- and gene therapies for head and neck cancer","volume":"10","author":"Lo","year":"2020","journal-title":"Theranostics"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"6774","DOI":"10.18632\/oncotarget.6725","article-title":"NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor","volume":"7","author":"Brand","year":"2016","journal-title":"Oncotarget"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1021\/nn4057269","article-title":"Cell-penetrating peptides: Design, synthesis, and applications","volume":"8","author":"Copolovici","year":"2014","journal-title":"ACS Nano"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2217\/nnm.12.134","article-title":"Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles","volume":"8","author":"Valencia","year":"2013","journal-title":"Nanomedicine"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Kciuk, M., Marciniak, B., and Kontek, R. (2020). Irinotecan-Still an Important Player in Cancer Chemotherapy: A Comprehensive Overview. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144919"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Lam, S.Y., Lau, H.L., and Kwok, C.K. (2022). Capture-SELEX: Selection Strategy, Aptamer Identification, and Biosensing Application. Biosensors, 12.","DOI":"10.3390\/bios12121142"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/prca.201200042","article-title":"Aptamers and the next generation of diagnostic reagents","volume":"6","author":"Thiviyanathan","year":"2012","journal-title":"Proteom. Clin. Appl."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1021\/acsnano.6b06815","article-title":"Magnetic Nanoliposomes as in Situ Microbubble Bombers for Multimodality Image-Guided Cancer Theranostics","volume":"11","author":"Liu","year":"2017","journal-title":"ACS Nano"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jconrel.2022.08.001","article-title":"Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches","volume":"351","author":"Ashrafizadeh","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.phymed.2018.11.007","article-title":"Effects of magnetic dihydroartemisinin nano-liposome in inhibiting the proliferation of head and neck squamous cell carcinomas","volume":"56","author":"Li","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/21655979.2021.2012951","article-title":"Dihydroartemisinin represses oral squamous cell carcinoma progression through downregulating mitochondrial calcium uniporter","volume":"13","author":"Zheng","year":"2022","journal-title":"Bioengineered"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Ambreen, G., Duse, L., Tariq, I., Ali, U., Ali, S., Pinnapireddy, S.R., Bette, M., Bakowsky, U., and Mandic, R. (2020). Sensitivity of Papilloma Virus-Associated Cell Lines to Photodynamic Therapy with Curcumin-Loaded Liposomes. Cancers, 12.","DOI":"10.3390\/cancers12113278"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1016\/S1470-2045(23)00615-0","article-title":"Non-surgical ablation for breast cancer: An emerging therapeutic option","volume":"25","author":"Toi","year":"2024","journal-title":"Lancet Oncol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S1051-0443(07)61670-4","article-title":"Image-guided radiofrequency tumor ablation: Challenges and opportunities--part I","volume":"12","author":"Dupuy","year":"2001","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1148\/radiol.11110361","article-title":"Chemoradionuclide therapy with 186Re-labeled liposomal doxorubicin in combination with radiofrequency ablation for effective treatment of head and neck cancer in a nude rat tumor xenograft model","volume":"261","author":"Soundararajan","year":"2011","journal-title":"Radiology"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Wang, P., Chen, J., Zhong, R., Xia, Y., Wu, Z., Zhang, C., and Yao, H. (2024). Recent advances of ultrasound-responsive nanosystems in tumor immunotherapy. Eur. J. Pharm. Biopharm., 198.","DOI":"10.1016\/j.ejpb.2024.114246"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Tian, L., Wang, L., Qiao, Y., Lu, L., Lee, P., Chang, A., Ravi, S., Rogers, T.A., and Melancon, M.P. (2019). Antitumor Efficacy of Liposome-Encapsulated NVP-BEZ235 Combined with Irreversible Electroporation for Head and Neck Cancer. Molecules, 24.","DOI":"10.3390\/molecules24193560"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Golberg, A., Bruinsma, B.G., Uygun, B.E., and Yarmush, M.L. (2015). Tissue heterogeneity in structure and conductivity contribute to cell survival during irreversible electroporation ablation by \u201celectric field sinks\u201d. Sci. Rep., 5.","DOI":"10.1038\/srep08485"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Ramasamy, T., Chen, X., Qin, B., Johnson, D.E., Grandis, J.R., and Villanueva, F.S. (2020). STAT3 decoy oligonucleotide-carrying microbubbles with pulsed ultrasound for enhanced therapeutic effect in head and neck tumors. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0242264"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1158\/2159-8290.CD-20-1808","article-title":"Therapeutic Targeting of the Tumor Microenvironment","volume":"11","author":"Bejarano","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Bailly, C., Vidal, A., Bonnemaire, C., Kraeber-Bod\u00e9r\u00e9, F., Ch\u00e9rel, M., Pallardy, A., Rousseau, C., Garcion, E., Lacoeuille, F., and Hindr\u00e9, F. (2019). Potential for Nuclear Medicine Therapy for Glioblastoma Treatment. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00772"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1158\/1078-0432.CCR-07-4149","article-title":"Intraoperative 186Re-liposome radionuclide therapy in a head and neck squamous cell carcinoma xenograft positive surgical margin model","volume":"14","author":"Wang","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijpharm.2009.02.009","article-title":"Intraoperative therapy with liposomal drug delivery: Retention and distribution in human head and neck squamous cell carcinoma xenograft model","volume":"373","author":"Wang","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Yakavets, I., Francois, A., Lamy, L., Piffoux, M., Gazeau, F., Wilhelm, C., Zorin, V., Silva, A.K.A., and Bezdetnaya, L. (2021). Effect of stroma on the behavior of temoporfin-loaded lipid nanovesicles inside the stroma-rich head and neck carcinoma spheroids. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-020-00743-x"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1021\/acs.accounts.1c00560","article-title":"How Do Biomolecules Cross the Cell Membrane?","volume":"55","author":"Pei","year":"2022","journal-title":"Acc. Chem. Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/acs.accounts.9b00177","article-title":"Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors","volume":"52","author":"Degors","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"114416","DOI":"10.1016\/j.addr.2022.114416","article-title":"The role of lipid components in lipid nanoparticles for vaccines and gene therapy","volume":"188","author":"Kulkarni","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1021\/mp400610b","article-title":"Polymersome-mediated delivery of combination anticancer therapy to head and neck cancer cells: 2D and 3D in vitro evaluation","volume":"11","author":"Colley","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.biocel.2012.06.018","article-title":"Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection","volume":"44","author":"Rana","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1446660","DOI":"10.1080\/20013078.2018.1446660","article-title":"Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8","volume":"7","author":"Berenguer","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrm1736","article-title":"Tetraspanin functions and associated microdomains","volume":"6","author":"Hemler","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Wang, L., Yu, X., Zhou, J., and Su, C. (2023). Extracellular Vesicles for Drug Delivery in Cancer Treatment. Biol. Proced. Online, 25.","DOI":"10.1186\/s12575-023-00220-3"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Aghali, A. (2021). Craniofacial Bone Tissue Engineering: Current Approaches and Potential Therapy. Cells, 10.","DOI":"10.3390\/cells10112993"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/00220345211037977","article-title":"Periodontitis and Accelerated Biological Aging: A Geroscience Approach","volume":"101","author":"Baima","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/j.biomaterials.2007.02.009","article-title":"The effect on bone regeneration of a liposomal vector to deliver BMP-2 gene to bone grafts in peri-implant bone defects","volume":"28","author":"Park","year":"2007","journal-title":"Biomaterials"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biomaterials.2014.12.014","article-title":"Reengineering autologous bone grafts with the stem cell activator WNT3A","volume":"47","author":"Jing","year":"2015","journal-title":"Biomaterials"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1021\/acsnano.9b00489","article-title":"A Biomimetic Hierarchical Nanointerface Orchestrates Macrophage Polarization and Mesenchymal Stem Cell Recruitment To Promote Endogenous Bone Regeneration","volume":"13","author":"Jin","year":"2019","journal-title":"ACS Nano"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-9657.2010.00896.x","article-title":"Geographic modelling of jaw fracture rates in Australia: A methodological model for healthcare planning","volume":"26","author":"Kruger","year":"2010","journal-title":"Dent. Traumatol."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Chen, H., Deng, J., Yao, X., He, Y., Li, H., Jian, Z., Tang, Y., Zhang, X., Zhang, J., and Dai, H. (2021). Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-01088-9"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1021\/acsnano.7b05103","article-title":"Fracture-Targeted Delivery of \u03b2-Catenin Agonists via Peptide-Functionalized Nanoparticles Augments Fracture Healing","volume":"11","author":"Wang","year":"2017","journal-title":"ACS Nano"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.devcel.2008.03.022","article-title":"Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion","volume":"14","author":"Zhao","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3803\/EnM.2015.30.4.429","article-title":"Emerging Therapies for Osteoporosis","volume":"30","author":"McClung","year":"2015","journal-title":"Endocrinol. Metab."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bone.2011.08.012","article-title":"Increased callus mass and enhanced strength during fracture healing in mice lacking the sclerostin gene","volume":"49","author":"Li","year":"2011","journal-title":"Bone"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.nano.2018.02.014","article-title":"Polymersome nanoparticles for delivery of Wnt-activating small molecules","volume":"14","author":"Scarpa","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"ra79","DOI":"10.1126\/scisignal.aaf3273","article-title":"Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling","volume":"9","author":"Carpio","year":"2016","journal-title":"Sci. Signal."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00004.2015","article-title":"Histone Deacetylases in Bone Development and Skeletal Disorders","volume":"95","author":"Bradley","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.2147\/DDDT.S263787","article-title":"Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification","volume":"14","author":"Zhou","year":"2020","journal-title":"Drug Des. Devel Ther."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.nano.2018.07.011","article-title":"Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice","volume":"14","author":"Liu","year":"2018","journal-title":"Nanomedicine"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1080\/10717544.2018.1474965","article-title":"Temporary suppression the sequestrated function of host macrophages for better nanoparticles tumor delivery","volume":"25","author":"Hao","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbm.a.37279","article-title":"Macrophage depletion increases target specificity of bone-targeted nanoparticles","volume":"110","author":"Xiao","year":"2022","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41419-020-2574-1","article-title":"Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p\/Hoxa10 axis","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1700611","DOI":"10.1002\/advs.201700611","article-title":"Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR\/Cas9 System in MSCs","volume":"5","author":"Lin","year":"2018","journal-title":"Adv. Sci."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Seow","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1101\/gr.171322.113","article-title":"Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins","volume":"24","author":"Kim","year":"2014","journal-title":"Genome Res."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.bioeng.1.1.19","article-title":"Tissue engineering: Orthopedic applications","volume":"1","author":"Laurencin","year":"1999","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/jps.21528","article-title":"From natural bone grafts to tissue engineering therapeutics: Brainstorming on pharmaceutical formulative requirements and challenges","volume":"98","author":"Baroli","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1021\/acs.nanolett.1c04356","article-title":"NIR-II Ratiometric Lanthanide-Dye Hybrid Nanoprobes Doped Bioscaffolds for In Situ Bone Repair Monitoring","volume":"22","author":"Pei","year":"2022","journal-title":"Nano Lett."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-biophys-070317-032905","article-title":"Hydrogel-Tissue Chemistry: Principles and Applications","volume":"47","author":"Gradinaru","year":"2018","journal-title":"Annu. Rev. Biophys."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, J., Gao, R., Liu, X., Feng, Z., Zhang, C., Huang, P., Dong, A., Kong, D., and Wang, W. (2022). Biomimetic glycopeptide hydrogel coated PCL\/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation. Biomaterials, 285.","DOI":"10.1016\/j.biomaterials.2022.121538"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1016\/S0142-9612(02)00134-5","article-title":"The effect of bone anchoring and micro-grooves on the soft tissue reaction to implants","volume":"23","author":"Parker","year":"2002","journal-title":"Biomaterials"},{"key":"ref_255","first-page":"5","article-title":"Drug delivery and targeting","volume":"392","author":"Langer","year":"1998","journal-title":"Nature"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/j.biomaterials.2011.03.063","article-title":"Effects of protein dose and delivery system on BMP-mediated bone regeneration","volume":"32","author":"Boerckel","year":"2011","journal-title":"Biomaterials"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/01.brs.0000201424.27509.72","article-title":"Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion","volume":"31","author":"Shields","year":"2006","journal-title":"Spine"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jconrel.2016.09.032","article-title":"Controlled bone formation using ultrasound-triggered release of BMP-2 from liposomes","volume":"243","author":"Crasto","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"8055","DOI":"10.1021\/acsnano.7b02702","article-title":"Design and Characterization of a Therapeutic Non-phospholipid Liposomal Nanocarrier with Osteoinductive Characteristics To Promote Bone Formation","volume":"11","author":"Cui","year":"2017","journal-title":"ACS Nano"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1021\/acs.molpharmaceut.0c01136","article-title":"Development of a Biomaterial Scaffold Integrated with Osteoinductive Oxysterol Liposomes to Enhance Hedgehog Signaling and Bone Repair","volume":"18","author":"Lee","year":"2021","journal-title":"Mol. Pharm."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.actbio.2020.09.052","article-title":"Scaffolds with controlled release of pro-mineralization exosomes to promote craniofacial bone healing without cell transplantation","volume":"118","author":"Swanson","year":"2020","journal-title":"Acta Biomater"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/j.biomaterials.2009.11.066","article-title":"The effect of zinc on hydroxyapatite-mediated activation of human polymorphonuclear neutrophils and bone implant-associated acute inflammation","volume":"31","author":"Velard","year":"2010","journal-title":"Biomaterials"},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Wu, L., Kim, Y., Seon, G.M., Choi, S.H., Park, H.C., Son, G., Kim, S.M., Lim, B.S., and Yang, H.C. (2021). Effects of RGD-grafted phosphatidylserine-containing liposomes on the polarization of macrophages and bone tissue regeneration. Biomaterials, 279.","DOI":"10.1016\/j.biomaterials.2021.121239"},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Brito Barrera, Y.A., Hause, G., Menzel, M., Schmelzer, C.E.H., Lehner, E., M\u00e4der, K., W\u00f6lk, C., and Groth, T. (2020). Engineering osteogenic microenvironments by combination of multilayers from collagen type I and chondroitin sulfate with novel cationic liposomes. Mater. Today Bio, 7.","DOI":"10.1016\/j.mtbio.2020.100071"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"17184","DOI":"10.1021\/acsami.9b01218","article-title":"Liposome-Encapsulated Curcumin-Loaded 3D Printed Scaffold for Bone Tissue Engineering","volume":"11","author":"Sarkar","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13287-018-0850-0","article-title":"Three-dimensional printed PLA scaffold and human gingival stem cell-derived extracellular vesicles: A new tool for bone defect repair","volume":"9","author":"Diomede","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Pizzicannella, J., Gugliandolo, A., Orsini, T., Fontana, A., Ventrella, A., Mazzon, E., Bramanti, P., Diomede, F., and Trubiani, O. (2019). Engineered Extracellular Vesicles From Human Periodontal-Ligament Stem Cells Increase VEGF\/VEGFR2 Expression During Bone Regeneration. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00512"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Ju, Y., Hu, Y., Yang, P., Xie, X., and Fang, B. (2023). Extracellular vesicle-loaded hydrogels for tissue repair and regeneration. Mater. Today Bio, 18.","DOI":"10.1016\/j.mtbio.2022.100522"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/prd.12335","article-title":"Breaking the wave of peri-implantitis","volume":"84","author":"Fu","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1038\/s41467-021-23069-0","article-title":"Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection","volume":"12","author":"Wu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/jcpe.12503","article-title":"Rescuing failed oral implants via Wnt activation","volume":"43","author":"Yin","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/jre.12633","article-title":"Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model","volume":"54","author":"Wang","year":"2019","journal-title":"J. Periodontal Res."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.colsurfb.2017.07.007","article-title":"Liposome-modified titanium surface: A strategy to locally deliver bioactive molecules","volume":"158","author":"Cimmarusti","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biomaterials.2019.05.014","article-title":"Triple-functional polyetheretherketone surface with enhanced bacteriostasis and anti-inflammatory and osseointegrative properties for implant application","volume":"212","author":"Xu","year":"2019","journal-title":"Biomaterials"}],"container-title":["Journal of Functional Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4983\/16\/1\/25\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:28:31Z","timestamp":1759919311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4983\/16\/1\/25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":274,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jfb16010025"],"URL":"https:\/\/doi.org\/10.3390\/jfb16010025","relation":{},"ISSN":["2079-4983"],"issn-type":[{"value":"2079-4983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]}}}