{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:59:10Z","timestamp":1784919550264,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council of Taiwan","award":["MOST-111-2314-B-038-099-MY3"],"award-info":[{"award-number":["MOST-111-2314-B-038-099-MY3"]}]},{"name":"National Science and Technology Council of Taiwan","award":["NSTC-112-2314-B-038-077"],"award-info":[{"award-number":["NSTC-112-2314-B-038-077"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>The nonunion and delayed union of bones are common challenges in orthopedic surgery, even when bone alignment is correct and sufficient mechanical stability is provided. To address this, artificial bone grafts are often applied to fracture gaps or defect sites to promote osteogenesis and enhance bone healing. In this study, we developed an alginate-based hydrogel incorporating gold nanoparticles (AuNPs) to enhance cell proliferation and facilitate bone healing through a photothermal effect induced by near-infrared (NIR) laser irradiation. The temperature was controlled by adjusting the AuNP content. The hydrogel\u2019s properties were characterized and cell viability was assessed. Our results indicate that while the incorporation of AuNPs slightly disrupted the hydrogel\u2019s cross-linking network at low concentrations, cell viability remained unaffected across both low and high AuNP contents. These findings suggest that this photothermal hydrogel holds great promise for orthopedic applications to improve bone healing.<\/jats:p>","DOI":"10.3390\/jfb16020063","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:08:51Z","timestamp":1739358531000},"page":"63","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Laser-Induced Photothermal Hydrogels Promote the Proliferation of MC3T3-E1 Preosteoblasts for Enhanced Bone Healing"],"prefix":"10.3390","volume":"16","author":[{"given":"Audrey L.","family":"Wu","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Morrison Academy Taipei, New Taipei 24449, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail F.","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Morrison Academy Taipei, New Taipei 24449, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaina Lily Hope","family":"Moreno","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan"},{"name":"Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Orthopedics Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan"},{"name":"Centers for Regional Anesthesia and Pain Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-5616","authenticated-orcid":false,"given":"Pei-Chun","family":"Wong","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bonr.2017.03.002","article-title":"Bone fracture healing in mechanobiological modeling: A review of principles and methods","volume":"6","author":"Ghiasi","year":"2017","journal-title":"Bone Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/adma.200802106","article-title":"Hydrogels in regenerative medicine","volume":"21","author":"Slaughter","year":"2009","journal-title":"Adv. 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