{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:29:15Z","timestamp":1787992155229,"version":"build-2784847793"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271013"],"award-info":[{"award-number":["82271013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Guided bone regeneration (GBR) membrane has proven to be a fundamental tool in the realm of bone defect repair. In this study, we develop a mussel-inspired composite biomaterial through polydopamine-assisted, combining gelatin\u2013WPU matrix with the ion-release behavior of Cu\u2013MSNs for augmented bone regeneration. The optimized composite membrane exhibits enhanced mechanical stability, demonstrating a tensile strength of 11.23 MPa (representing a 2.3-fold increase compared to Bio-Gide\u00ae), coupled with significantly slower degradation kinetics that retained 73.3% structural integrity after 35-day immersion in physiological solution. Copper ions act as angiogenic agents to promote blood vessel growth and as antimicrobial agents to prevent potential infections. The combined effect of these components creates a biomimetic environment that is ideal for cell adhesion, growth, and differentiation. This research significantly contributes to the development of advanced biomaterials that combine regeneration and infection-prevention functions. It provides a versatile and effective solution for treating bone injuries and defects, offering new hope for patients in need.<\/jats:p>","DOI":"10.3390\/jfb16040122","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T11:08:40Z","timestamp":1743505720000},"page":"122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polydopamine-Coated Copper-Doped Mesoporous Silica\/Gelatin\u2013Waterborne Polyurethane Composite: A Multifunctional GBR Membrane for Bone Defect Repair"],"prefix":"10.3390","volume":"16","author":[{"given":"Mengmeng","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, China"},{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiwu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, China"},{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2102236","DOI":"10.1002\/adhm.202102236","article-title":"A Hierarchical-Structured Mineralized Nanofiber Scaffold with Osteoimmunomodulatory and Osteoinductive Functions for Enhanced Alveolar Bone Regeneration","volume":"11","author":"He","year":"2022","journal-title":"Adv. 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