{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:00:34Z","timestamp":1782824434007,"version":"3.54.5"},"reference-count":63,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008993","name":"University of Zagreb","doi-asserted-by":"publisher","award":["UNIZG 2021"],"award-info":[{"award-number":["UNIZG 2021"]}],"id":[{"id":"10.13039\/100008993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Periodontitis is a chronic, multifactorial inflammatory disease characterized by the progressive destruction of the periodontal supporting tissues, including alveolar bone, potentially resulting in tooth loss. Etiopathogenesis involves a dysbiotic shift in the subgingival microbiota where the presence of pathogenic species such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Treponema denticola has been documented. This disbalance is combined with an inadequate host immune response, often exacerbated by other systemic comorbidities including diabetes mellitus and cardiovascular diseases. Conventional therapy typically comprises mechanical debridement and adjunctive local or systemic antimicrobials, but emerging antibiotic resistance highlights a need for alternative adjuvant therapeutic strategies. The present descriptive analysis of microbiome and clinical trends study evaluated the adjuvant effects of a clinoptilolite-based zeolite material, namely PMA-zeolite, with professional prophylaxis on clinical and microbiological parameters in patients with chronic periodontitis over a 10-week period. Clinical assessment revealed significant reductions in bleeding on probing (BoP) and periodontal pocket depth (PD), indicating improved inflammatory status. Microbiome profiling demonstrated a marked decrease in key periodontal pathogens, suggesting that PMA-zeolite can help rebalance the oral microbiome. These findings suggest that the combined therapy exhibits promising anti-inflammatory and antimicrobial properties, indicating its role in promoting microbial homeostasis and reducing periodontal inflammation. However, further investigation through larger, controlled clinical trials is needed to validate the efficacy of the therapy.<\/jats:p>","DOI":"10.3390\/jfb16080270","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:44:45Z","timestamp":1753184685000},"page":"270","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Enhancing Professional Periodontal Therapy with a Novel PMA-Zeolite Application: A Clinical Study on Periodontal Outcomes and Microbiological Changes"],"prefix":"10.3390","volume":"16","author":[{"given":"Ines","family":"\u0110api\u0107","sequence":"first","affiliation":[{"name":"Department of Periodontology, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Aurer","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurica","family":"\u017du\u010dko","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-8603","authenticated-orcid":false,"given":"Marinka","family":"Mravak-Stipeti\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Health, University Josip Juraj Strossmayer Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinka","family":"Baranovi\u0107 Bari\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Health, University Josip Juraj Strossmayer Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-6858","authenticated-orcid":false,"given":"Kre\u0161imir","family":"Paveli\u0107","sequence":"additional","affiliation":[{"name":"Medical Faculty, Juraj Dobrila University of Pula, 52000 Pula, Croatia"},{"name":"International Academy of Science and Arts in Bosnia and Herzegovina, Radni\u010dka cesta, 71000 Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1213-4957","authenticated-orcid":false,"given":"Fusun","family":"Ozer","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-673X","authenticated-orcid":false,"given":"Sandra","family":"Kraljevi\u0107 Paveli\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Health Studies, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/jcpe.12935","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions\u2014Introduction and key changes from the 1999 classification","volume":"45","author":"Caton","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1002\/JPER.17-0721","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1002\/JPER.18-0006","article-title":"Staging and grading of periodontitis: Framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.sdentj.2019.04.006","article-title":"Majors highlights of the new 2017 classification of periodontal peri-implant diseases conditions","volume":"31","author":"Babay","year":"2019","journal-title":"Saudi Dent J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41396-019-0544-3","article-title":"The subgingival microbiome associated with periodontitis in type 2 diabetes mellitus","volume":"14","author":"Shi","year":"2020","journal-title":"ISME J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: Consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.34172\/japid.2021.012","article-title":"Questions on the new classification of periodontal and preimplantation diseases","volume":"13","author":"Chitsazi","year":"2021","journal-title":"J. Adv. Periodontol. Implant Dent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.17096\/jiufd.90144","article-title":"Adjunctive use of antibiotics in periodontal therapy","volume":"49","author":"Barca","year":"2015","journal-title":"J. Istanb. Univ. Fac. Dent."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1902\/jop.2007.060437","article-title":"Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis","volume":"78","author":"Kaner","year":"2007","journal-title":"J. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1034\/j.1600-051X.29.s2.2.x","article-title":"The clinical significance of local chemotherapies","volume":"29","author":"Killoy","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1745-7599.2000.tb00171.x","article-title":"Periodontal disease: Diagnosis and management","volume":"2","author":"Ridgeway","year":"2000","journal-title":"J. Am. Acad. Nurse Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"EFP Workshop Participants and Methodological Consultants. Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e095","DOI":"10.1590\/1807-3107bor-2021.vol35.0095","article-title":"New tendencies in non-surgical periodontal therapy","volume":"35","author":"Haas","year":"2021","journal-title":"Braz. Oral Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa063186","article-title":"Treatment of periodontitis and endothelial function","volume":"356","author":"Tonetti","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4103\/1735-3327.104866","article-title":"Systemic antibiotic therapy in periodontics","volume":"9","author":"Kapoor","year":"2012","journal-title":"Dent. Res. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-0757.2010.00356.x","article-title":"Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery?","volume":"55","author":"Mombelli","year":"2011","journal-title":"Periodontol 2000"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s40496-023-00330-7","article-title":"A Review on Zeolites and Their Applications in Dentistry","volume":"10","author":"Deshpande","year":"2023","journal-title":"Curr. Oral Health Rep."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Li, L.J., Chu, C.-H., and Yu, O.Y. (2023). Application of Zeolites and Zeolitic Imidazolate Frameworks in Dentistry\u2014A Narrative Review. Nanomaterials, 13.","DOI":"10.3390\/nano13222973"},{"key":"ref_20","first-page":"1936","article-title":"Regulation of the Si\/Al ratios and Al distribution of zeolites and their impact on properties","volume":"14","author":"Li","year":"2023","journal-title":"Chem. Sci."},{"key":"ref_21","first-page":"196","article-title":"A review of the chemistry, structure, properties and applications of zeolites","volume":"7","author":"Moshoeshoe","year":"2017","journal-title":"Am. J. Mat. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/BF01912193","article-title":"Geopolymers: In organic plymeric new materials","volume":"37","author":"Davidovits","year":"1991","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1111\/jcpe.12341","article-title":"Professional mechanical plaque removal for prevention of periodontal diseases in adults\u2014Systematic review update","volume":"42","author":"Needleman","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00784-023-05392-6","article-title":"Systematic review and meta-analysis of randomized controlled trials evaluating the efficacy of non-surgical periodontal treatment in patients with concurrent systemic conditions","volume":"28","author":"Joseph","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Rizzatti, G., Lopetuso, L.R., Gibiino, G., Binda, C., and Gasbarrini, A. (2017). Proteobacteria: A Common Factor in Human Diseases. Biomed Res. Int., 2017.","DOI":"10.1155\/2017\/9351507"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41579-023-00963-6","article-title":"The oral microbiome: Diversity, biogeography and human health","volume":"22","author":"Baker","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.adaj.2015.01.028","article-title":"Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts","volume":"146","author":"Smiley","year":"2015","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jgar.2020.02.024","article-title":"Antimicrobial resistance of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythia in periodontitis patients","volume":"22","author":"Ardila","year":"2020","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pdpdt.2017.05.007","article-title":"Efficacy of photodynamic therapy versus antibiotics as an adjunct to scaling and root planing in the treatment of periodontitis: A systematic review and meta-analysis","volume":"19","author":"Akram","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_30","first-page":"E246","article-title":"Polyphenols and Lactobacillus reuteri n oral health","volume":"63","author":"Naureen","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sachelarie, L., Scrobota, I., Romanul, I., Iurcov, R., Potra Cicalau, G.I., and Todor, L. (2025). Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach. Medicina, 61.","DOI":"10.3390\/medicina61010126"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pdpdt.2016.11.011","article-title":"Clinical effectiveness of adjunctive antimicrobial photodynamic therapy for residual pockets during supportive periodontal therapy: A systematic review and meta-analysis","volume":"17","author":"Xue","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s12668-020-00761-x","article-title":"Inhibition of Biofilm Formation of Staphylococcus aureus Strains Through ZnO\/Zeolite Nanocomposite and Its Cytotoxicity Evaluation","volume":"10","author":"Partoazar","year":"2020","journal-title":"BioNanoScience"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Budeli, P., Moropeng, R.C., Mpenyana-Monyatsi, L., and Momba, M.N.B. (2018). Inhibition of biofilm formation on the surface of water storage containers using biosand zeolite silver-impregnated clay granular and silver impregnated porous pot filtration systems. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194715"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Amin, Z., Waly, N.A., and Arshad, S.E. (2021). Biofilm Inhibition and Antimicrobial Properties of Silver-Ion-Exchanged Zeolite A against Vibrio spp Marine Pathogens. Appl. Sci., 11.","DOI":"10.20944\/preprints202104.0144.v1"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2217\/fmb-2021-0174","article-title":"Zeolite 4A as a jammer of bacterial communication in Chromobacterium violaceum and Pseudomonas aeruginosa","volume":"17","author":"Ulusoy","year":"2022","journal-title":"Future Microbiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.20546\/ijcmas.2017.603.195","article-title":"Virulence Factors of Acinetobacter baumannii Environmental Isolates Their Inhibition by Natural Zeolite","volume":"6","author":"Dekic","year":"2017","journal-title":"Int. J. Curr. Microbiol. App. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J. Bacteriol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Saito, S., Aoki, Y., Tamahara, T., Goto, M., Matsui, H., Kawashima, J., Danjoh, I., Hozawa, A., Kuriyama, S., and Suzuki, Y. (2021). Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.604596"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Di Stefano, M., Polizzi, A., Santonocito, S., Romano, A., Lombardi, T., and Isola, G. (2022). Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095142"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12362","article-title":"Microbial signatures of health, gingivitis, and periodontitis","volume":"86","author":"Abusleme","year":"2021","journal-title":"Periodontol 2000"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12393","article-title":"The oral microbiome: Role of key organisms and complex networks in oral health and disease","volume":"87","author":"Sedghi","year":"2021","journal-title":"Periodontol 2000"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3934\/microbiol.2018.1.42","article-title":"Oral microbiome and health","volume":"4","author":"Sharma","year":"2018","journal-title":"AIMS Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Luo, S., Li, W., Li, Q., Zhang, M., Wang, X., Wu, S., and Li, Y. (2023). Causal effects of gut microbiota on the risk of periodontitis: A two-sample Mendelian randomization study. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1160993"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Willis, J.R., and Gabald\u00f3n, T. (2020). The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems. Microorganisms, 8.","DOI":"10.3390\/microorganisms8020308"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1177\/00220345231222800","article-title":"Effect of Periodontitis and Periodontal Therapy on Oral and Gut Microbiota","volume":"103","author":"Baima","year":"2024","journal-title":"J. Dent. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kawamoto, D., Borges, R., Ribeiro, R.A., de Souza, R.F., Amado, P.P.P., Saraiva, L., Horliana, A.C.R.T., Faveri, M., and Mayer, M.P.A. (2021). Oral Dysbiosis in Severe Forms of Periodontitis Is Associated With Gut Dysbiosis and Correlated With Salivary Inflammatory Mediators: A Preliminary Study. Front. Oral Health, 2.","DOI":"10.3389\/froh.2021.722495"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/MOG.0000000000000781","article-title":"Gut microbiota and sepsis: From pathogenesis to novel treatments","volume":"37","author":"Kullberg","year":"2021","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Sagheddu, V., Patrone, V., Miragoli, F., Puglisi, E., and Morelli, L. (2016). Infant Early Gut Colonization by Lachnospiraceae: High Frequency of Ruminococcus gnavus. Front. Pediatr., 4.","DOI":"10.3389\/fped.2016.00057"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/exd.14460","article-title":"Lachnospira is a signature of antihistamine efficacy in chronic spontaneous urticaria","volume":"31","author":"Liu","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/jcpe.13330","article-title":"Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis","volume":"47","author":"Nibali","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e02061-17","DOI":"10.1128\/mBio.02061-17","article-title":"Insights into the Evolution of Host Association through the Isolation and Characterization of a Novel Human Periodontal Pathobiont, Desulfobulbus oralis","volume":"9","author":"Cross","year":"2018","journal-title":"mBio"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cai, Z., Lin, S., Hu, S., and Zhao, L. (2021). Structure and Function of Oral Microbial Community in Periodontitis Based on Integrated Data. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.663756"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Lim, K.R., Son, J.S., and Moon, S.Y. (2023). The First Case of Infectious Spondylitis Caused by Gemella bergeri. Medicina, 59.","DOI":"10.3390\/medicina59010145"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Louren\u03c2o, T.G.B., Spencer, S.J., Alm, E.J., and Colombo, A.P.V. (2018). Defining the gut microbiota in individuals with periodontal diseases: An exploratory study. J. Oral Microbiol., 10.","DOI":"10.1080\/20002297.2018.1487741"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1177\/0022034514542468","article-title":"Newly identified pathogens associated with periodontitis: A systematic review","volume":"93","author":"Figueiredo","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ajodo.2019.11.026","article-title":"Salivary microbiome and periodontal status of patients with periodontitis during the initial stage of orthodontic treatment","volume":"159","author":"Guo","year":"2021","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Esparb\u00e8s, P., Legrand, A., Bandiaky, O.N., Ch\u00e9raud-Carpentier, M., Martin, H., Montassier, E., and Soueidan, A. (2021). Subgingival Microbiota and Cytokines Profile Changes in Patients with Periodontitis: A Pilot Study Comparing Healthy and Diseased Sites in the Same Oral Cavities. Microorganisms, 9.","DOI":"10.3390\/microorganisms9112364"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4103\/jpbs.JPBS_288_16","article-title":"Novel Pathogens in Periodontal Microbiology","volume":"9","author":"Hiranmayi","year":"2017","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.2169\/internalmedicine.5043-20","article-title":"The First Case Report of Mediastinal Abscess Caused by Gemella bergeri","volume":"60","author":"Toyoshima","year":"2021","journal-title":"Intern. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.15190\/d.2023.4","article-title":"Exploring the oral microbiome: An updated multidisciplinary oral healthcare perspective","volume":"11","author":"Chowdhry","year":"2023","journal-title":"Discoveries"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wolff, D., Frese, C., Schoilew, K., Dalpke, A., Wolff, B., and Boutin, S. (2019). Amplicon-based microbiome study highlights the loss of diversity and the establishment of a set of species in patients with dentin caries. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0219714"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/jre.13173","article-title":"New putative periodontopathogens and periodontal health-associated species: A systematic review and meta-analysis","volume":"58","author":"Antezack","year":"2023","journal-title":"J. Periodontal Res."}],"container-title":["Journal of Functional Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4983\/16\/8\/270\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:13:52Z","timestamp":1760033632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4983\/16\/8\/270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":63,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jfb16080270"],"URL":"https:\/\/doi.org\/10.3390\/jfb16080270","relation":{},"ISSN":["2079-4983"],"issn-type":[{"value":"2079-4983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]}}}