{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:04:08Z","timestamp":1790661848857,"version":"4.1.0"},"reference-count":88,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["25-73-20141"],"award-info":[{"award-number":["25-73-20141"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>The perforation of the tympanic membrane is a world-wide clinical problem resulting from trauma or infection and requiring effective regeneration methods. In recent years researchers have focused on natural polymers as promising materials for restoring the structure and function of the tympanic membrane. This review summarizes current advances in the use of natural polymers, such as silk fibroin, chitosan, hyaluronic acid, collagen, bacterial cellulose, alginates and others, for the treatment of tympanic membrane perforations. The key properties of these materials are discussed, including their biocompatibility, biodegradability, mechanical strength, and ability to support cell adhesion and proliferation. The review also covers the potential of natural polymers and their combinations in tympanic membrane regeneration and suggests the directions for future research.<\/jats:p>","DOI":"10.3390\/jfb16100384","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:41:29Z","timestamp":1760449289000},"page":"384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Natural Polymers, Their Modifications and Composites with Synthetic Polymers for Tympanic Membrane Regeneration"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1721-1044","authenticated-orcid":false,"given":"Roman O.","family":"Shaikenov","sequence":"first","affiliation":[{"name":"Institute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Prospekt, 49, Bldg. A, Saint Petersburg 197101, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8186-8342","authenticated-orcid":false,"given":"Polina G.","family":"Serbun","sequence":"additional","affiliation":[{"name":"Institute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Prospekt, 49, Bldg. A, Saint Petersburg 197101, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuobin","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-5709","authenticated-orcid":false,"given":"Petr P.","family":"Snetkov","sequence":"additional","affiliation":[{"name":"Institute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Prospekt, 49, Bldg. A, Saint Petersburg 197101, Russia"},{"name":"Medical Institute, Saint Petersburg State University, Universitetskaya Embankment, 7\u20139, Saint Petersburg 199034, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-0251","authenticated-orcid":false,"given":"Svetlana N.","family":"Morozkina","sequence":"additional","affiliation":[{"name":"Institute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Prospekt, 49, Bldg. A, Saint Petersburg 197101, Russia"},{"name":"Medical Institute, Saint Petersburg State University, Universitetskaya Embankment, 7\u20139, Saint Petersburg 199034, Russia"},{"name":"Progressive Materials and Additive Technologies Center, Kabardino-Balkarian State University Named After H.M. Berbekov, St. Chernyshevsky, 173, Nalchik 360004, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sun, W., Gregory, D.A., Tomeh, M.A., and Zhao, X. (2021). Silk Fibroin as a Functional Biomaterial for Tissue Engineering. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031499"},{"key":"ref_2","first-page":"106","article-title":"Measuring the tympanic membrane thickness using optical coherence tomography","volume":"10","author":"Novozhilov","year":"2023","journal-title":"Opera Med. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Monasta, L., Ronfani, L., Marchetti, F., Montico, M., Vecchi Brumatti, L., Bavcar, A., Grasso, D., Barbiero, C., and Tamburlini, G. (2012). Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates. 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