{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:30:48Z","timestamp":1765269048690,"version":"build-2065373602"},"reference-count":64,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Innovation and Universities (MCIU), the State Research Agency (AEI) and the European Regional Development Fund (ERDF) of the European Union","award":["PID2024-158719OB-C33"],"award-info":[{"award-number":["PID2024-158719OB-C33"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>There is a knowledge gap about the effect of pharmaceutical agents on the biodegradation of Mg-based resorbable implants. The present work investigates how three common antibiotics and three anti-inflammatory drugs affect the corrosion of high-purity Mg, with and without ceramic and hybrid ceramic\/polymeric coatings, using electrochemical impedance spectroscopy and hydrogen evolution tests. A Ca-P-Si-based ceramic coating is developed using plasma electrolytic oxidation (PEO), after the AC voltage and frequency parameters are optimized. A hybrid coating included a PEO and a poly(\u03b5-caprolactone) (PCL) top layer formed by dip coating. High-purity Mg exhibited an instantaneous onset of corrosion with a corrosion rate of 90 \u03bcm\/year after 24 h of immersion in a modified \u03b1-MEM. A hybrid PEO\/PCL coating prevents the onset of corrosion for at least 5 h and reduces the H2 evolution during the following 90 h by two times by the precipitation of 5\u201340 \u03bcm thick Ca-P surface deposits. Gentamicin, naproxen, streptomycin, ciprofloxacin and paracetamol were found to be corrosion accelerators with respect to bare h.p. Mg, whereas aspirin was found to be an inhibitor. Streptomycin-functionalized PEO\/PCL system exhibited an active protection mechanism, triggered upon the release of the coating and substrate cations, associated with the coating defect-blocking action of the insoluble Me(II)-streptomycin chelates.<\/jats:p>","DOI":"10.3390\/jfb16110406","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:33:07Z","timestamp":1761881587000},"page":"406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Corrosion-Modulating Effect of Pharmaceutical Agents in a Hybrid Coating System on Pure Magnesium"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4139-6908","authenticated-orcid":false,"given":"Lara","family":"Moreno","sequence":"first","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y de Materiales, Facultad de Ciencias Qu\u00edmicas, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Materials Science Department, University of Mons, 20 Place du Parc, 7000 Mons, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Belarra-Rodriguez","sequence":"additional","affiliation":[{"name":"Departamento de Radiolog\u00eda, Rehabilitaci\u00f3n y Fisioterapia, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-3031","authenticated-orcid":false,"given":"Marta","family":"Mohedano","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y de Materiales, Facultad de Ciencias Qu\u00edmicas, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-5272","authenticated-orcid":false,"given":"Laura","family":"Castro","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y de Materiales, Facultad de Ciencias Qu\u00edmicas, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-9783","authenticated-orcid":false,"given":"Margarita","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Departamento de Radiolog\u00eda, Rehabilitaci\u00f3n y Fisioterapia, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-4049","authenticated-orcid":false,"given":"Raul","family":"Arrabal","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y de Materiales, Facultad de Ciencias Qu\u00edmicas, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endzhe","family":"Matykina","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y de Materiales, Facultad de Ciencias Qu\u00edmicas, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Unidad Asociada al ICTP-CSIC, Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC), Grupo de S\u00edntesis Org\u00e1nica y Bioevaluaci\u00f3n, Instituto Pluridisciplinar (UCM), Paseo de Juan XXIII 1, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","first-page":"184","article-title":"Development of Degradable Magnesium-Based Metal Implants and Their Function in Promoting Bone Metabolism (A Review)","volume":"36","author":"Shan","year":"2022","journal-title":"J. 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